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Q8NGS2

- OR1J2_HUMAN

UniProt

Q8NGS2 - OR1J2_HUMAN

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Protein

Olfactory receptor 1J2

Gene

OR1J2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1J2
Alternative name(s):
HSA5
HTPCRX15
OST044
Olfactory receptor 1J3
Olfactory receptor 1J5
Olfactory receptor OR9-19
Gene namesi
Name:OR1J2
Synonyms:OR1J3, OR1J5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:8209. OR1J2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32080.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 1J2PRO_0000150439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS2.
PRIDEiQ8NGS2.

Expressioni

Gene expression databases

BgeeiQ8NGS2.
CleanExiHS_OR1J2.
GenevestigatoriQ8NGS2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335575.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS2.
SMRiQ8NGS2. Positions 9-305.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini159 – 19638ExtracellularSequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Topological domaini293 – 31321CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei197 – 21923Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287131.
GeneTreeiENSGT00760000118845.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGS2.
KOiK04257.
OMAiEECISQM.
OrthoDBiEOG7K9K3N.
PhylomeDBiQ8NGS2.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPENQSSVS EFLLLGLPIR PEQQAVFFTL FLGMYLTTVL GNLLIMLLIQ
60 70 80 90 100
LDSHLHTPMY FFLSHLALTD ISFSSVTVPK MLMDMRTKYK SILYEECISQ
110 120 130 140 150
MYFFIFFTDL DSFLITSMAY DRYVAICHPL HYTVIMREEL CVFLVAVSWI
160 170 180 190 200
LSCASSLSHT LLLTRLSFCA ANTIPHVFCD LAALLKLSCS DIFLNELVMF
210 220 230 240 250
TVGVVVITLP FMCILVSYGY IGATILRVPS TKGIHKALST CGSHLSVVSL
260 270 280 290 300
YYGSIFGQYL FPTVSSSIDK DVIVALMYTV VTPMLNPFIY SLRNRDMKEA
310
LGKLFSRATF FSW
Length:313
Mass (Da):35,385
Last modified:October 1, 2002 - v1
Checksum:i8408D57426DA3001
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti148 – 1481S → T in AAF40352. (PubMed:10706615)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti119 – 1191A → T.
Corresponds to variant rs41277120 [ dbSNP | Ensembl ].
VAR_062010
Natural varianti165 – 1651R → Q.
Corresponds to variant rs4836891 [ dbSNP | Ensembl ].
VAR_053123

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065717 Genomic DNA. Translation: BAC05938.1.
AL359636 Genomic DNA. Translation: CAM45735.1.
CH471090 Genomic DNA. Translation: EAW87531.1.
AF399552 Genomic DNA. Translation: AAK95037.1.
AF179767 Genomic DNA. Translation: AAF40352.1.
X64989 mRNA. No translation available.
BK004448 Genomic DNA. Translation: DAA04846.1.
CCDSiCCDS35121.1.
RefSeqiNP_473448.1. NM_054107.1.
XP_005251977.1. XM_005251920.1.
UniGeneiHs.460145.
Hs.745497.

Genome annotation databases

EnsembliENST00000335302; ENSP00000335575; ENSG00000197233.
GeneIDi26740.
KEGGihsa:26740.
UCSCiuc004bmj.2. human.

Polymorphism databases

DMDMi38372761.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065717 Genomic DNA. Translation: BAC05938.1 .
AL359636 Genomic DNA. Translation: CAM45735.1 .
CH471090 Genomic DNA. Translation: EAW87531.1 .
AF399552 Genomic DNA. Translation: AAK95037.1 .
AF179767 Genomic DNA. Translation: AAF40352.1 .
X64989 mRNA. No translation available.
BK004448 Genomic DNA. Translation: DAA04846.1 .
CCDSi CCDS35121.1.
RefSeqi NP_473448.1. NM_054107.1.
XP_005251977.1. XM_005251920.1.
UniGenei Hs.460145.
Hs.745497.

3D structure databases

ProteinModelPortali Q8NGS2.
SMRi Q8NGS2. Positions 9-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000335575.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372761.

Proteomic databases

PaxDbi Q8NGS2.
PRIDEi Q8NGS2.

Protocols and materials databases

DNASUi 26740.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335302 ; ENSP00000335575 ; ENSG00000197233 .
GeneIDi 26740.
KEGGi hsa:26740.
UCSCi uc004bmj.2. human.

Organism-specific databases

CTDi 26740.
GeneCardsi GC09P125273.
HGNCi HGNC:8209. OR1J2.
neXtProti NX_Q8NGS2.
PharmGKBi PA32080.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287131.
GeneTreei ENSGT00760000118845.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGS2.
KOi K04257.
OMAi EECISQM.
OrthoDBi EOG7K9K3N.
PhylomeDBi Q8NGS2.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1J2.
GenomeRNAii 26740.
NextBioi 49097.
PROi Q8NGS2.

Gene expression databases

Bgeei Q8NGS2.
CleanExi HS_OR1J2.
Genevestigatori Q8NGS2.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  5. "The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates."
    Rouquier S., Blancher A., Giorgi D.
    Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 124-285.
  6. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
    Tissue: Testis.
  7. Cited for: IDENTIFICATION.
  8. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1J2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS2
Secondary accession number(s): A3KFL9
, Q6IF14, Q96R90, Q9NZP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3