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Protein

Olfactory receptor 1J2

Gene

OR1J2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
  3. transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception Source: GO_Central
  2. G-protein coupled receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1J2
Alternative name(s):
HSA5
HTPCRX15
OST044
Olfactory receptor 1J3
Olfactory receptor 1J5
Olfactory receptor OR9-19
Gene namesi
Name:OR1J2
Synonyms:OR1J3, OR1J5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8209. OR1J2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19638ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21923Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31321CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32080.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 1J2PRO_0000150439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS2.
PRIDEiQ8NGS2.

Expressioni

Gene expression databases

BgeeiQ8NGS2.
CleanExiHS_OR1J2.
GenevestigatoriQ8NGS2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335575.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS2.
SMRiQ8NGS2. Positions 9-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287131.
GeneTreeiENSGT00760000118845.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGS2.
KOiK04257.
OMAiEECISQM.
OrthoDBiEOG7K9K3N.
PhylomeDBiQ8NGS2.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPENQSSVS EFLLLGLPIR PEQQAVFFTL FLGMYLTTVL GNLLIMLLIQ
60 70 80 90 100
LDSHLHTPMY FFLSHLALTD ISFSSVTVPK MLMDMRTKYK SILYEECISQ
110 120 130 140 150
MYFFIFFTDL DSFLITSMAY DRYVAICHPL HYTVIMREEL CVFLVAVSWI
160 170 180 190 200
LSCASSLSHT LLLTRLSFCA ANTIPHVFCD LAALLKLSCS DIFLNELVMF
210 220 230 240 250
TVGVVVITLP FMCILVSYGY IGATILRVPS TKGIHKALST CGSHLSVVSL
260 270 280 290 300
YYGSIFGQYL FPTVSSSIDK DVIVALMYTV VTPMLNPFIY SLRNRDMKEA
310
LGKLFSRATF FSW
Length:313
Mass (Da):35,385
Last modified:September 30, 2002 - v1
Checksum:i8408D57426DA3001
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti148 – 1481S → T in AAF40352 (PubMed:10706615).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti119 – 1191A → T.
Corresponds to variant rs41277120 [ dbSNP | Ensembl ].
VAR_062010
Natural varianti165 – 1651R → Q.
Corresponds to variant rs4836891 [ dbSNP | Ensembl ].
VAR_053123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065717 Genomic DNA. Translation: BAC05938.1.
AL359636 Genomic DNA. Translation: CAM45735.1.
CH471090 Genomic DNA. Translation: EAW87531.1.
AF399552 Genomic DNA. Translation: AAK95037.1.
AF179767 Genomic DNA. Translation: AAF40352.1.
X64989 mRNA. No translation available.
BK004448 Genomic DNA. Translation: DAA04846.1.
CCDSiCCDS35121.1.
RefSeqiNP_473448.1. NM_054107.1.
XP_005251977.1. XM_005251920.1.
UniGeneiHs.460145.
Hs.745497.

Genome annotation databases

EnsembliENST00000335302; ENSP00000335575; ENSG00000197233.
GeneIDi26740.
KEGGihsa:26740.
UCSCiuc004bmj.2. human.

Polymorphism databases

DMDMi38372761.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065717 Genomic DNA. Translation: BAC05938.1.
AL359636 Genomic DNA. Translation: CAM45735.1.
CH471090 Genomic DNA. Translation: EAW87531.1.
AF399552 Genomic DNA. Translation: AAK95037.1.
AF179767 Genomic DNA. Translation: AAF40352.1.
X64989 mRNA. No translation available.
BK004448 Genomic DNA. Translation: DAA04846.1.
CCDSiCCDS35121.1.
RefSeqiNP_473448.1. NM_054107.1.
XP_005251977.1. XM_005251920.1.
UniGeneiHs.460145.
Hs.745497.

3D structure databases

ProteinModelPortaliQ8NGS2.
SMRiQ8NGS2. Positions 9-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000335575.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi38372761.

Proteomic databases

PaxDbiQ8NGS2.
PRIDEiQ8NGS2.

Protocols and materials databases

DNASUi26740.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335302; ENSP00000335575; ENSG00000197233.
GeneIDi26740.
KEGGihsa:26740.
UCSCiuc004bmj.2. human.

Organism-specific databases

CTDi26740.
GeneCardsiGC09P125273.
HGNCiHGNC:8209. OR1J2.
neXtProtiNX_Q8NGS2.
PharmGKBiPA32080.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG287131.
GeneTreeiENSGT00760000118845.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGS2.
KOiK04257.
OMAiEECISQM.
OrthoDBiEOG7K9K3N.
PhylomeDBiQ8NGS2.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1J2.
GenomeRNAii26740.
NextBioi49097.
PROiQ8NGS2.

Gene expression databases

BgeeiQ8NGS2.
CleanExiHS_OR1J2.
GenevestigatoriQ8NGS2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  5. "The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates."
    Rouquier S., Blancher A., Giorgi D.
    Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 124-285.
  6. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
    Tissue: Testis.
  7. Cited for: IDENTIFICATION.
  8. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiOR1J2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS2
Secondary accession number(s): A3KFL9
, Q6IF14, Q96R90, Q9NZP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 9, 2003
Last sequence update: September 30, 2002
Last modified: February 3, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.