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Q8NGS2

- OR1J2_HUMAN

UniProt

Q8NGS2 - OR1J2_HUMAN

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Protein
Olfactory receptor 1J2
Gene
OR1J2, OR1J3, OR1J5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1J2
    Alternative name(s):
    HSA5
    HTPCRX15
    OST044
    Olfactory receptor 1J3
    Olfactory receptor 1J5
    Olfactory receptor OR9-19
    Gene namesi
    Name:OR1J2
    Synonyms:OR1J3, OR1J5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:8209. OR1J2.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei26 – 4924Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini50 – 578Cytoplasmic Reviewed prediction
    Transmembranei58 – 7922Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini80 – 10021Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei101 – 12020Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini121 – 13919Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei140 – 15819Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini159 – 19638Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei197 – 21923Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini220 – 23617Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei237 – 25923Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini260 – 27213Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei273 – 29220Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini293 – 31321Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32080.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Olfactory receptor 1J2
    PRO_0000150439Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi97 ↔ 189 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGS2.
    PRIDEiQ8NGS2.

    Expressioni

    Gene expression databases

    BgeeiQ8NGS2.
    CleanExiHS_OR1J2.
    GenevestigatoriQ8NGS2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000335575.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGS2.
    SMRiQ8NGS2. Positions 9-305.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG287131.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGS2.
    KOiK04257.
    OMAiEECISQM.
    OrthoDBiEOG7K9K3N.
    PhylomeDBiQ8NGS2.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGS2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPENQSSVS EFLLLGLPIR PEQQAVFFTL FLGMYLTTVL GNLLIMLLIQ    50
    LDSHLHTPMY FFLSHLALTD ISFSSVTVPK MLMDMRTKYK SILYEECISQ 100
    MYFFIFFTDL DSFLITSMAY DRYVAICHPL HYTVIMREEL CVFLVAVSWI 150
    LSCASSLSHT LLLTRLSFCA ANTIPHVFCD LAALLKLSCS DIFLNELVMF 200
    TVGVVVITLP FMCILVSYGY IGATILRVPS TKGIHKALST CGSHLSVVSL 250
    YYGSIFGQYL FPTVSSSIDK DVIVALMYTV VTPMLNPFIY SLRNRDMKEA 300
    LGKLFSRATF FSW 313
    Length:313
    Mass (Da):35,385
    Last modified:October 1, 2002 - v1
    Checksum:i8408D57426DA3001
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti119 – 1191A → T.
    Corresponds to variant rs41277120 [ dbSNP | Ensembl ].
    VAR_062010
    Natural varianti165 – 1651R → Q.
    Corresponds to variant rs4836891 [ dbSNP | Ensembl ].
    VAR_053123

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti148 – 1481S → T in AAF40352. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065717 Genomic DNA. Translation: BAC05938.1.
    AL359636 Genomic DNA. Translation: CAM45735.1.
    CH471090 Genomic DNA. Translation: EAW87531.1.
    AF399552 Genomic DNA. Translation: AAK95037.1.
    AF179767 Genomic DNA. Translation: AAF40352.1.
    X64989 mRNA. No translation available.
    BK004448 Genomic DNA. Translation: DAA04846.1.
    CCDSiCCDS35121.1.
    RefSeqiNP_473448.1. NM_054107.1.
    XP_005251977.1. XM_005251920.1.
    UniGeneiHs.460145.
    Hs.745497.

    Genome annotation databases

    EnsembliENST00000335302; ENSP00000335575; ENSG00000197233.
    GeneIDi26740.
    KEGGihsa:26740.
    UCSCiuc004bmj.2. human.

    Polymorphism databases

    DMDMi38372761.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065717 Genomic DNA. Translation: BAC05938.1 .
    AL359636 Genomic DNA. Translation: CAM45735.1 .
    CH471090 Genomic DNA. Translation: EAW87531.1 .
    AF399552 Genomic DNA. Translation: AAK95037.1 .
    AF179767 Genomic DNA. Translation: AAF40352.1 .
    X64989 mRNA. No translation available.
    BK004448 Genomic DNA. Translation: DAA04846.1 .
    CCDSi CCDS35121.1.
    RefSeqi NP_473448.1. NM_054107.1.
    XP_005251977.1. XM_005251920.1.
    UniGenei Hs.460145.
    Hs.745497.

    3D structure databases

    ProteinModelPortali Q8NGS2.
    SMRi Q8NGS2. Positions 9-305.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000335575.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372761.

    Proteomic databases

    PaxDbi Q8NGS2.
    PRIDEi Q8NGS2.

    Protocols and materials databases

    DNASUi 26740.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335302 ; ENSP00000335575 ; ENSG00000197233 .
    GeneIDi 26740.
    KEGGi hsa:26740.
    UCSCi uc004bmj.2. human.

    Organism-specific databases

    CTDi 26740.
    GeneCardsi GC09P125273.
    HGNCi HGNC:8209. OR1J2.
    neXtProti NX_Q8NGS2.
    PharmGKBi PA32080.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG287131.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGS2.
    KOi K04257.
    OMAi EECISQM.
    OrthoDBi EOG7K9K3N.
    PhylomeDBi Q8NGS2.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1J2.
    GenomeRNAii 26740.
    NextBioi 49097.
    PROi Q8NGS2.

    Gene expression databases

    Bgeei Q8NGS2.
    CleanExi HS_OR1J2.
    Genevestigatori Q8NGS2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    5. "The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates."
      Rouquier S., Blancher A., Giorgi D.
      Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 124-285.
    6. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
      Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
      Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
      Tissue: Testis.
    7. Cited for: IDENTIFICATION.
    8. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR1J2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGS2
    Secondary accession number(s): A3KFL9
    , Q6IF14, Q96R90, Q9NZP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: September 3, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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