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Q8NGS0

- OR1N1_HUMAN

UniProt

Q8NGS0 - OR1N1_HUMAN

Protein

Olfactory receptor 1N1

Gene

OR1N1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1N1
    Alternative name(s):
    Olfactory receptor 1-26
    Short name:
    OR1-26
    Olfactory receptor 1N3
    Olfactory receptor OR9-22
    Gene namesi
    Name:OR1N1
    Synonyms:OR1N3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:8221. OR1N1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32090.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 1N1PRO_0000150448Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGS0.
    PRIDEiQ8NGS0.

    Expressioni

    Gene expression databases

    CleanExiHS_OR1N1.
    GenevestigatoriQ8NGS0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000306974.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGS0.
    SMRiQ8NGS0. Positions 30-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 558CytoplasmicSequence Analysis
    Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini157 – 19438ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini291 – 31121CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21723Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25723Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29020Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149121.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGS0.
    KOiK04257.
    OMAiCPPSIAS.
    OrthoDBiEOG783MVT.
    PhylomeDBiQ8NGS0.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGS0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENQSSISEF FLRGISAPPE QQQSLFGIFL CMYLVTLTGN LLIILAIGSD    50
    LHLHTPMYFF LANLSFVDMG LTSSTVTKML VNIQTRHHTI SYTGCLTQMY 100
    FFLMFGDLDS FFLAAMAYDR YVAICHPLCY STVMRPQVCA LMLALCWVLT 150
    NIVALTHTFL MARLSFCVTG EIAHFFCDIT PVLKLSCSDT HINEMMVFVL 200
    GGTVLIVPFL CIVTSYIHIV PAILRVRTRG GVGKAFSTCS SHLCVVCVFY 250
    GTLFSAYLCP PSIASEEKDI AAAAMYTIVT PMLNPFIYSL RNKDMKGALK 300
    RLFSHRSIVS S 311
    Length:311
    Mass (Da):34,650
    Last modified:October 1, 2002 - v1
    Checksum:i6B82AE0B4A836180
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911S → T in AAC39612. (PubMed:9500546)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181P → S.
    Corresponds to variant rs10818708 [ dbSNP | Ensembl ].
    VAR_024089
    Natural varianti190 – 1901T → N in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036208
    Natural varianti227 – 2271R → Q.
    Corresponds to variant rs58226717 [ dbSNP | Ensembl ].
    VAR_062011

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065719 Genomic DNA. Translation: BAC05940.1.
    AL359636 Genomic DNA. Translation: CAM45737.1.
    CH471090 Genomic DNA. Translation: EAW87534.1.
    U86216 Genomic DNA. Translation: AAC39612.1.
    AF399547 Genomic DNA. Translation: AAK95032.1.
    BK004446 Genomic DNA. Translation: DAA04844.1.
    CCDSiCCDS6844.1.
    RefSeqiNP_036495.1. NM_012363.1.
    UniGeneiHs.553604.

    Genome annotation databases

    EnsembliENST00000304880; ENSP00000306974; ENSG00000171505.
    GeneIDi138883.
    KEGGihsa:138883.
    UCSCiuc004bmn.1. human.

    Polymorphism databases

    DMDMi38372759.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065719 Genomic DNA. Translation: BAC05940.1 .
    AL359636 Genomic DNA. Translation: CAM45737.1 .
    CH471090 Genomic DNA. Translation: EAW87534.1 .
    U86216 Genomic DNA. Translation: AAC39612.1 .
    AF399547 Genomic DNA. Translation: AAK95032.1 .
    BK004446 Genomic DNA. Translation: DAA04844.1 .
    CCDSi CCDS6844.1.
    RefSeqi NP_036495.1. NM_012363.1.
    UniGenei Hs.553604.

    3D structure databases

    ProteinModelPortali Q8NGS0.
    SMRi Q8NGS0. Positions 30-302.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000306974.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372759.

    Proteomic databases

    PaxDbi Q8NGS0.
    PRIDEi Q8NGS0.

    Protocols and materials databases

    DNASUi 138883.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304880 ; ENSP00000306974 ; ENSG00000171505 .
    GeneIDi 138883.
    KEGGi hsa:138883.
    UCSCi uc004bmn.1. human.

    Organism-specific databases

    CTDi 138883.
    GeneCardsi GC09M125288.
    HGNCi HGNC:8221. OR1N1.
    neXtProti NX_Q8NGS0.
    PharmGKBi PA32090.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149121.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGS0.
    KOi K04257.
    OMAi CPPSIAS.
    OrthoDBi EOG783MVT.
    PhylomeDBi Q8NGS0.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1N1.
    GenomeRNAii 138883.
    NextBioi 83866.
    PROi Q8NGS0.

    Gene expression databases

    CleanExi HS_OR1N1.
    Genevestigatori Q8NGS0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
    6. Cited for: IDENTIFICATION.
    7. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-190.

    Entry informationi

    Entry nameiOR1N1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGS0
    Secondary accession number(s): A3KFM1
    , O43870, Q6IF16, Q96R93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3