Q8NGS0 (OR1N1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 1N1

Alternative name(s):
Olfactory receptor 1-26
Short name=OR1-26
Olfactory receptor 1N3
Olfactory receptor OR9-22

Gene names

Name:	OR1N1
Synonyms:	OR1N3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Olfactory receptor 1N1		PRO_0000150448
Regions
	Topological domain	1 – 23	23	Extracellular Potential
	Transmembrane	24 – 47	24	Helical; Name=1; Potential
	Topological domain	48 – 55	8	Cytoplasmic Potential
	Transmembrane	56 – 77	22	Helical; Name=2; Potential
	Topological domain	78 – 98	21	Extracellular Potential
	Transmembrane	99 – 118	20	Helical; Name=3; Potential
	Topological domain	119 – 137	19	Cytoplasmic Potential
	Transmembrane	138 – 156	19	Helical; Name=4; Potential
	Topological domain	157 – 194	38	Extracellular Potential
	Transmembrane	195 – 217	23	Helical; Name=5; Potential
	Topological domain	218 – 234	17	Cytoplasmic Potential
	Transmembrane	235 – 257	23	Helical; Name=6; Potential
	Topological domain	258 – 270	13	Extracellular Potential
	Transmembrane	271 – 290	20	Helical; Name=7; Potential
	Topological domain	291 – 311	21	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 187		By similarity
Natural variations
	Natural variant	18	1	P → S. Corresponds to variant rs10818708 [ dbSNP | Ensembl ].		VAR_024089
	Natural variant	190	1	T → N in a breast cancer sample; somatic mutation. Ref.8		VAR_036208
	Natural variant	227	1	R → Q. Corresponds to variant rs58226717 [ dbSNP | Ensembl ].		VAR_062011
Experimental info
	Sequence conflict	91	1	S → T in AAC39612. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q8NGS0 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 6B82AE0B4A836180	FASTA	311	34,650
	10 20 30 40 50 60 MENQSSISEF FLRGISAPPE QQQSLFGIFL CMYLVTLTGN LLIILAIGSD LHLHTPMYFF 70 80 90 100 110 120 LANLSFVDMG LTSSTVTKML VNIQTRHHTI SYTGCLTQMY FFLMFGDLDS FFLAAMAYDR 130 140 150 160 170 180 YVAICHPLCY STVMRPQVCA LMLALCWVLT NIVALTHTFL MARLSFCVTG EIAHFFCDIT 190 200 210 220 230 240 PVLKLSCSDT HINEMMVFVL GGTVLIVPFL CIVTSYIHIV PAILRVRTRG GVGKAFSTCS 250 260 270 280 290 300 SHLCVVCVFY GTLFSAYLCP PSIASEEKDI AAAAMYTIVT PMLNPFIYSL RNKDMKGALK 310 RLFSHRSIVS S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Distribution of olfactory receptor genes in the human genome." Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G., Demaille J.G., Giorgi D. Nat. Genet. 18:243-250(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
[5]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
[6]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-190.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065719 Genomic DNA. Translation: BAC05940.1. AL359636 Genomic DNA. Translation: CAM45737.1. CH471090 Genomic DNA. Translation: EAW87534.1. U86216 Genomic DNA. Translation: AAC39612.1. AF399547 Genomic DNA. Translation: AAK95032.1. BK004446 Genomic DNA. Translation: DAA04844.1.
IPI	IPI00377165.
RefSeq	NP_036495.1. NM_012363.1.
UniGene	Hs.553604.
3D structure databases
ProteinModelPortal	Q8NGS0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000306974.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38372759.
Proteomic databases
PaxDb	Q8NGS0.
PRIDE	Q8NGS0.
Protocols and materials databases
DNASU	138883.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304880; ENSP00000306974; ENSG00000171505.
GeneID	138883.
KEGG	hsa:138883.
UCSC	uc004bmn.1. human.
Organism-specific databases
CTD	138883.
GeneCards	GC09M125288.
HGNC	HGNC:8221. OR1N1.
neXtProt	NX_Q8NGS0.
PharmGKB	PA32090.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG149121.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q8NGS0.
KO	K04257.
OMA	FGIFLCM.
OrthoDB	EOG4JT05X.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR1N1.
Genevestigator	Q8NGS0.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	138883.
NextBio	83866.

Entry information

Entry name

OR1N1_HUMAN

Accession

Primary (citable) accession number: Q8NGS0
Secondary accession number(s): A3KFM1 , O43870, Q6IF16, Q96R93

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.