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Q8NGS0

- OR1N1_HUMAN

UniProt

Q8NGS0 - OR1N1_HUMAN

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Protein

Olfactory receptor 1N1

Gene

OR1N1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1N1
Alternative name(s):
Olfactory receptor 1-26
Short name:
OR1-26
Olfactory receptor 1N3
Olfactory receptor OR9-22
Gene namesi
Name:OR1N1
Synonyms:OR1N3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:8221. OR1N1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 1N1PRO_0000150448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS0.
PRIDEiQ8NGS0.

Expressioni

Gene expression databases

CleanExiHS_OR1N1.
GenevestigatoriQ8NGS0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306974.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS0.
SMRiQ8NGS0. Positions 30-302.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini157 – 19438ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 23417CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
BLAST
Topological domaini291 – 31121CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei195 – 21723Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei235 – 25723Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei271 – 29020Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149121.
GeneTreeiENSGT00760000118845.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS0.
KOiK04257.
OMAiCPPSIAS.
OrthoDBiEOG783MVT.
PhylomeDBiQ8NGS0.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENQSSISEF FLRGISAPPE QQQSLFGIFL CMYLVTLTGN LLIILAIGSD
60 70 80 90 100
LHLHTPMYFF LANLSFVDMG LTSSTVTKML VNIQTRHHTI SYTGCLTQMY
110 120 130 140 150
FFLMFGDLDS FFLAAMAYDR YVAICHPLCY STVMRPQVCA LMLALCWVLT
160 170 180 190 200
NIVALTHTFL MARLSFCVTG EIAHFFCDIT PVLKLSCSDT HINEMMVFVL
210 220 230 240 250
GGTVLIVPFL CIVTSYIHIV PAILRVRTRG GVGKAFSTCS SHLCVVCVFY
260 270 280 290 300
GTLFSAYLCP PSIASEEKDI AAAAMYTIVT PMLNPFIYSL RNKDMKGALK
310
RLFSHRSIVS S
Length:311
Mass (Da):34,650
Last modified:October 1, 2002 - v1
Checksum:i6B82AE0B4A836180
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911S → T in AAC39612. (PubMed:9500546)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181P → S.
Corresponds to variant rs10818708 [ dbSNP | Ensembl ].
VAR_024089
Natural varianti190 – 1901T → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_036208
Natural varianti227 – 2271R → Q.
Corresponds to variant rs58226717 [ dbSNP | Ensembl ].
VAR_062011

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065719 Genomic DNA. Translation: BAC05940.1.
AL359636 Genomic DNA. Translation: CAM45737.1.
CH471090 Genomic DNA. Translation: EAW87534.1.
U86216 Genomic DNA. Translation: AAC39612.1.
AF399547 Genomic DNA. Translation: AAK95032.1.
BK004446 Genomic DNA. Translation: DAA04844.1.
CCDSiCCDS6844.1.
RefSeqiNP_036495.1. NM_012363.1.
UniGeneiHs.553604.

Genome annotation databases

EnsembliENST00000304880; ENSP00000306974; ENSG00000171505.
GeneIDi138883.
KEGGihsa:138883.
UCSCiuc004bmn.1. human.

Polymorphism databases

DMDMi38372759.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065719 Genomic DNA. Translation: BAC05940.1 .
AL359636 Genomic DNA. Translation: CAM45737.1 .
CH471090 Genomic DNA. Translation: EAW87534.1 .
U86216 Genomic DNA. Translation: AAC39612.1 .
AF399547 Genomic DNA. Translation: AAK95032.1 .
BK004446 Genomic DNA. Translation: DAA04844.1 .
CCDSi CCDS6844.1.
RefSeqi NP_036495.1. NM_012363.1.
UniGenei Hs.553604.

3D structure databases

ProteinModelPortali Q8NGS0.
SMRi Q8NGS0. Positions 30-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000306974.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372759.

Proteomic databases

PaxDbi Q8NGS0.
PRIDEi Q8NGS0.

Protocols and materials databases

DNASUi 138883.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304880 ; ENSP00000306974 ; ENSG00000171505 .
GeneIDi 138883.
KEGGi hsa:138883.
UCSCi uc004bmn.1. human.

Organism-specific databases

CTDi 138883.
GeneCardsi GC09M125288.
HGNCi HGNC:8221. OR1N1.
neXtProti NX_Q8NGS0.
PharmGKBi PA32090.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149121.
GeneTreei ENSGT00760000118845.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGS0.
KOi K04257.
OMAi CPPSIAS.
OrthoDBi EOG783MVT.
PhylomeDBi Q8NGS0.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1N1.
GenomeRNAii 138883.
NextBioi 83866.
PROi Q8NGS0.

Gene expression databases

CleanExi HS_OR1N1.
Genevestigatori Q8NGS0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-190.

Entry informationi

Entry nameiOR1N1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS0
Secondary accession number(s): A3KFM1
, O43870, Q6IF16, Q96R93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3