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Q8NGS0 (OR1N1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1N1
Alternative name(s):
Olfactory receptor 1-26
Short name=OR1-26
Olfactory receptor 1N3
Olfactory receptor OR9-22
Gene names
Name:OR1N1
Synonyms:OR1N3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Olfactory receptor 1N1
PRO_0000150448

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4724Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7722Helical; Name=2; Potential
Topological domain78 – 9821Extracellular Potential
Transmembrane99 – 11820Helical; Name=3; Potential
Topological domain119 – 13719Cytoplasmic Potential
Transmembrane138 – 15619Helical; Name=4; Potential
Topological domain157 – 19438Extracellular Potential
Transmembrane195 – 21723Helical; Name=5; Potential
Topological domain218 – 23417Cytoplasmic Potential
Transmembrane235 – 25723Helical; Name=6; Potential
Topological domain258 – 27013Extracellular Potential
Transmembrane271 – 29020Helical; Name=7; Potential
Topological domain291 – 31121Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 187 By similarity

Natural variations

Natural variant181P → S.
Corresponds to variant rs10818708 [ dbSNP | Ensembl ].
VAR_024089
Natural variant1901T → N in a breast cancer sample; somatic mutation. Ref.8
VAR_036208
Natural variant2271R → Q.
Corresponds to variant rs58226717 [ dbSNP | Ensembl ].
VAR_062011

Experimental info

Sequence conflict911S → T in AAC39612. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8NGS0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 6B82AE0B4A836180

FASTA31134,650
        10         20         30         40         50         60 
MENQSSISEF FLRGISAPPE QQQSLFGIFL CMYLVTLTGN LLIILAIGSD LHLHTPMYFF 

        70         80         90        100        110        120 
LANLSFVDMG LTSSTVTKML VNIQTRHHTI SYTGCLTQMY FFLMFGDLDS FFLAAMAYDR 

       130        140        150        160        170        180 
YVAICHPLCY STVMRPQVCA LMLALCWVLT NIVALTHTFL MARLSFCVTG EIAHFFCDIT 

       190        200        210        220        230        240 
PVLKLSCSDT HINEMMVFVL GGTVLIVPFL CIVTSYIHIV PAILRVRTRG GVGKAFSTCS 

       250        260        270        280        290        300 
SHLCVVCVFY GTLFSAYLCP PSIASEEKDI AAAAMYTIVT PMLNPFIYSL RNKDMKGALK 

       310 
RLFSHRSIVS S 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Distribution of olfactory receptor genes in the human genome."
Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G., Demaille J.G., Giorgi D.
Nat. Genet. 18:243-250(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
[5]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
[6]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-190.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065719 Genomic DNA. Translation: BAC05940.1.
AL359636 Genomic DNA. Translation: CAM45737.1.
CH471090 Genomic DNA. Translation: EAW87534.1.
U86216 Genomic DNA. Translation: AAC39612.1.
AF399547 Genomic DNA. Translation: AAK95032.1.
BK004446 Genomic DNA. Translation: DAA04844.1.
CCDSCCDS6844.1.
RefSeqNP_036495.1. NM_012363.1.
UniGeneHs.553604.

3D structure databases

ProteinModelPortalQ8NGS0.
SMRQ8NGS0. Positions 30-302.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000306974.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372759.

Proteomic databases

PaxDbQ8NGS0.
PRIDEQ8NGS0.

Protocols and materials databases

DNASU138883.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304880; ENSP00000306974; ENSG00000171505.
GeneID138883.
KEGGhsa:138883.
UCSCuc004bmn.1. human.

Organism-specific databases

CTD138883.
GeneCardsGC09M125288.
HGNCHGNC:8221. OR1N1.
neXtProtNX_Q8NGS0.
PharmGKBPA32090.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149121.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGS0.
KOK04257.
OMACPPSIAS.
OrthoDBEOG783MVT.
PhylomeDBQ8NGS0.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR1N1.
GenevestigatorQ8NGS0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1N1.
GenomeRNAi138883.
NextBio83866.
PROQ8NGS0.

Entry information

Entry nameOR1N1_HUMAN
AccessionPrimary (citable) accession number: Q8NGS0
Secondary accession number(s): A3KFM1 expand/collapse secondary AC list , O43870, Q6IF16, Q96R93
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries