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Protein

Olfactory receptor 1N1

Gene

OR1N1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1N1
Alternative name(s):
Olfactory receptor 1-26
Short name:
OR1-26
Olfactory receptor 1N3
Olfactory receptor OR9-22
Gene namesi
Name:OR1N1
Synonyms:OR1N3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8221. OR1N1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 194ExtracellularSequence analysisAdd BLAST38
Transmembranei195 – 217Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini218 – 234CytoplasmicSequence analysisAdd BLAST17
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 311CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi138883.
OpenTargetsiENSG00000171505.
PharmGKBiPA32090.

Polymorphism and mutation databases

BioMutaiOR1N1.
DMDMi38372759.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504481 – 311Olfactory receptor 1N1Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS0.
PRIDEiQ8NGS0.

Expressioni

Gene expression databases

CleanExiHS_OR1N1.
ExpressionAtlasiQ8NGS0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306974.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9R3. Eukaryota.
ENOG41113AW. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS0.
KOiK04257.
OMAiTHINEMM.
PhylomeDBiQ8NGS0.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENQSSISEF FLRGISAPPE QQQSLFGIFL CMYLVTLTGN LLIILAIGSD
60 70 80 90 100
LHLHTPMYFF LANLSFVDMG LTSSTVTKML VNIQTRHHTI SYTGCLTQMY
110 120 130 140 150
FFLMFGDLDS FFLAAMAYDR YVAICHPLCY STVMRPQVCA LMLALCWVLT
160 170 180 190 200
NIVALTHTFL MARLSFCVTG EIAHFFCDIT PVLKLSCSDT HINEMMVFVL
210 220 230 240 250
GGTVLIVPFL CIVTSYIHIV PAILRVRTRG GVGKAFSTCS SHLCVVCVFY
260 270 280 290 300
GTLFSAYLCP PSIASEEKDI AAAAMYTIVT PMLNPFIYSL RNKDMKGALK
310
RLFSHRSIVS S
Length:311
Mass (Da):34,650
Last modified:October 1, 2002 - v1
Checksum:i6B82AE0B4A836180
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91S → T in AAC39612 (PubMed:9500546).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02408918P → S.Corresponds to variant rs10818708dbSNPEnsembl.1
Natural variantiVAR_036208190T → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_062011227R → Q.Corresponds to variant rs58226717dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065719 Genomic DNA. Translation: BAC05940.1.
AL359636 Genomic DNA. Translation: CAM45737.1.
CH471090 Genomic DNA. Translation: EAW87534.1.
U86216 Genomic DNA. Translation: AAC39612.1.
AF399547 Genomic DNA. Translation: AAK95032.1.
BK004446 Genomic DNA. Translation: DAA04844.1.
CCDSiCCDS6844.1.
RefSeqiNP_036495.1. NM_012363.1.
UniGeneiHs.553604.

Genome annotation databases

EnsembliENST00000304880; ENSP00000306974; ENSG00000171505.
GeneIDi138883.
KEGGihsa:138883.
UCSCiuc004bmn.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065719 Genomic DNA. Translation: BAC05940.1.
AL359636 Genomic DNA. Translation: CAM45737.1.
CH471090 Genomic DNA. Translation: EAW87534.1.
U86216 Genomic DNA. Translation: AAC39612.1.
AF399547 Genomic DNA. Translation: AAK95032.1.
BK004446 Genomic DNA. Translation: DAA04844.1.
CCDSiCCDS6844.1.
RefSeqiNP_036495.1. NM_012363.1.
UniGeneiHs.553604.

3D structure databases

ProteinModelPortaliQ8NGS0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000306974.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR1N1.
DMDMi38372759.

Proteomic databases

PaxDbiQ8NGS0.
PRIDEiQ8NGS0.

Protocols and materials databases

DNASUi138883.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304880; ENSP00000306974; ENSG00000171505.
GeneIDi138883.
KEGGihsa:138883.
UCSCiuc004bmn.1. human.

Organism-specific databases

CTDi138883.
DisGeNETi138883.
GeneCardsiOR1N1.
HGNCiHGNC:8221. OR1N1.
neXtProtiNX_Q8NGS0.
OpenTargetsiENSG00000171505.
PharmGKBiPA32090.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9R3. Eukaryota.
ENOG41113AW. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS0.
KOiK04257.
OMAiTHINEMM.
PhylomeDBiQ8NGS0.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

ChiTaRSiOR1N1. human.
GeneWikiiOR1N1.
GenomeRNAii138883.
PROiQ8NGS0.

Gene expression databases

CleanExiHS_OR1N1.
ExpressionAtlasiQ8NGS0. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1N1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS0
Secondary accession number(s): A3KFM1
, O43870, Q6IF16, Q96R93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.