ID   OR1N2_HUMAN             Reviewed;         316 AA.
AC   Q8NGR9; A0A126GW94; A3KFM2; B2RNY4; Q6IF17; Q96RA3;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2024, sequence version 3.
DT   27-MAR-2024, entry version 157.
DE   RecName: Full=Olfactory receptor 1N2;
DE   AltName: Full=Olfactory receptor OR9-23;
GN   Name=OR1N2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=25977809; DOI=10.1038/sdata.2015.2;
RA   Mainland J.D., Li Y.R., Zhou T., Liu W.L., Matsunami H.;
RT   "Human olfactory receptor responses to odorants.";
RL   Sci. Data 2:150002-150002(2015).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-23; GLY-230 AND
RP   MET-287.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-287.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [7]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1N2";
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DR   EMBL; AB065720; BAC05941.1; -; Genomic_DNA.
DR   EMBL; KP290529; ALI87690.1; -; Genomic_DNA.
DR   EMBL; AL359636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC137182; AAI37183.1; -; mRNA.
DR   EMBL; BC137183; AAI37184.1; -; mRNA.
DR   EMBL; AF399536; AAK95021.1; -; Genomic_DNA.
DR   EMBL; BK004445; DAA04843.1; -; Genomic_DNA.
DR   RefSeq; NP_001004457.1; NM_001004457.1.
DR   AlphaFoldDB; Q8NGR9; -.
DR   SMR; Q8NGR9; -.
DR   STRING; 9606.ENSP00000483293; -.
DR   GlyCosmos; Q8NGR9; 1 site, No reported glycans.
DR   GlyGen; Q8NGR9; 1 site.
DR   iPTMnet; Q8NGR9; -.
DR   PhosphoSitePlus; Q8NGR9; -.
DR   BioMuta; OR1N2; -.
DR   DMDM; 218511727; -.
DR   MassIVE; Q8NGR9; -.
DR   PaxDb; 9606-ENSP00000362792; -.
DR   Antibodypedia; 30315; 77 antibodies from 15 providers.
DR   DNASU; 138882; -.
DR   Ensembl; ENST00000373688.3; ENSP00000362792.3; ENSG00000171501.11.
DR   GeneID; 138882; -.
DR   KEGG; hsa:138882; -.
DR   MANE-Select; ENST00000373688.3; ENSP00000362792.3; NM_001004457.2; NP_001004457.2.
DR   UCSC; uc011lyx.3; human.
DR   AGR; HGNC:15111; -.
DR   CTD; 138882; -.
DR   GeneCards; OR1N2; -.
DR   HGNC; HGNC:15111; OR1N2.
DR   HPA; ENSG00000171501; Not detected.
DR   neXtProt; NX_Q8NGR9; -.
DR   PharmGKB; PA32091; -.
DR   VEuPathDB; HostDB:ENSG00000171501; -.
DR   eggNOG; ENOG502SMIM; Eukaryota.
DR   GeneTree; ENSGT00940000163103; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q8NGR9; -.
DR   OMA; LMLSICW; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NGR9; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; Q8NGR9; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 138882; 11 hits in 748 CRISPR screens.
DR   GeneWiki; OR1N2; -.
DR   GenomeRNAi; 138882; -.
DR   Pharos; Q8NGR9; Tdark.
DR   PRO; PR:Q8NGR9; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8NGR9; Protein.
DR   Bgee; ENSG00000171501; Expressed in male germ line stem cell (sensu Vertebrata) in testis.
DR   ExpressionAtlas; Q8NGR9; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd15918; 7tmA_OR1_7-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48001:SF135; OLFACTORY RECEPTOR 1N2; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..316
FT                   /note="Olfactory receptor 1N2"
FT                   /id="PRO_0000150449"
FT   TOPO_DOM        1..28
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..60
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        82..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..145
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        167..199
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..243
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        265..274
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        100..182
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         23
FT                   /note="W -> R (in dbSNP:rs1831370)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_048028"
FT   VARIANT         223
FT                   /note="R -> C (in dbSNP:rs41316976)"
FT                   /id="VAR_062012"
FT   VARIANT         230
FT                   /note="V -> G (in dbSNP:rs1341044)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_048029"
FT   VARIANT         287
FT                   /note="T -> M (in dbSNP:rs1411272)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_048030"
SQ   SEQUENCE   316 AA;  35184 MW;  21388E3BF4746A3F CRC64;
     MGKPGRVNQT TVSDFLLLGL SEWPEEQPLL FGIFLGMYLV TMVGNLLIIL AISSDPHLHT
     PMYFFLANLS LTDACFTSAS IPKMLANIHT QSQIISYSGC LAQLYFLLMF GGLDNCLLAV
     MAYDRYVAIC QPLHYSTSMS PQLCALMLGV CWVLTNCPAL MHTLLLTRVA FCAQKAIPHF
     YCDPSALLKL ACSDTHVNEL MIITMGLLFL TVPLLLIVFS YVRIFWAVFV ISSPGGRWKA
     FSTCGSHLTV VLLFYGSLMG VYLLPPSTYS TERESRAAVL YMVIIPTLNP FIYSLRNRDM
     KEALGKLFVS GKTFFL
//