Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NGR9 (OR1N2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1N2
Alternative name(s):
Olfactory receptor OR9-23
Gene names
Name:OR1N2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAC05941.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAM45738.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Olfactory receptor 1N2
PRO_0000150449

Regions

Topological domain1 – 4242Extracellular Potential
Transmembrane43 – 6624Helical; Name=1; Potential
Topological domain67 – 748Cytoplasmic Potential
Transmembrane75 – 9622Helical; Name=2; Potential
Topological domain97 – 11721Extracellular Potential
Transmembrane118 – 13720Helical; Name=3; Potential
Topological domain138 – 15619Cytoplasmic Potential
Transmembrane157 – 17519Helical; Name=4; Potential
Topological domain176 – 21338Extracellular Potential
Transmembrane214 – 23623Helical; Name=5; Potential
Topological domain237 – 25317Cytoplasmic Potential
Transmembrane254 – 27623Helical; Name=6; Potential
Topological domain277 – 28913Extracellular Potential
Transmembrane290 – 30920Helical; Name=7; Potential
Topological domain310 – 33021Cytoplasmic Potential

Amino acid modifications

Glycosylation221N-linked (GlcNAc...) Potential
Disulfide bond114 ↔ 206 By similarity

Natural variations

Natural variant371W → R. Ref.3
Corresponds to variant rs1831370 [ dbSNP | Ensembl ].
VAR_048028
Natural variant2371R → C.
Corresponds to variant rs41316976 [ dbSNP | Ensembl ].
VAR_062012
Natural variant2441V → G. Ref.3
Corresponds to variant rs1341044 [ dbSNP | Ensembl ].
VAR_048029
Natural variant3011T → M. Ref.3
Corresponds to variant rs1411272 [ dbSNP | Ensembl ].
VAR_048030

Sequences

Sequence LengthMass (Da)Tools
Q8NGR9 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 242D45D016841C4A

FASTA33036,889
        10         20         30         40         50         60 
MEGFYLRRSH ELQGMGKPGR VNQTTVSDFL LLGLSEWPEE QPLLFGIFLG MYLVTMVGNL 

        70         80         90        100        110        120 
LIILAISSDP HLHTPMYFFL ANLSLTDACF TSASIPKMLA NIHTQSQIIS YSGCLAQLYF 

       130        140        150        160        170        180 
LLMFGGLDNC LLAVMAYDRY VAICQPLHYS TSMSPQLCAL MLGVCWVLTN CPALMHTLLL 

       190        200        210        220        230        240 
TRVAFCAQKA IPHFYCDPSA LLKLACSDTH VNELMIITMG LLFLTVPLLL IVFSYVRIFW 

       250        260        270        280        290        300 
AVFVISSPGG RWKAFSTCGS HLTVVLLFYG SLMGVYLLPP STYSTERESR AAVLYMVIIP 

       310        320        330 
TLNPFIYSLR NRDMKEALGK LFVSGKTFFL 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-37; GLY-244 AND MET-301.
[4]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-301.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065720 Genomic DNA. Translation: BAC05941.1. Different initiation.
AL359636 Genomic DNA. Translation: CAM45738.1. Different initiation.
BC137182 mRNA. Translation: AAI37183.1.
BC137183 mRNA. Translation: AAI37184.1.
AF399536 Genomic DNA. Translation: AAK95021.1.
BK004445 Genomic DNA. Translation: DAA04843.1.
CCDSCCDS35123.1.
RefSeqNP_001004457.1. NM_001004457.1.
UniGeneHs.632682.

3D structure databases

ProteinModelPortalQ8NGR9.
SMRQ8NGR9. Positions 49-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000362792.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM218511727.

Proteomic databases

PaxDbQ8NGR9.
PRIDEQ8NGR9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373688; ENSP00000362792; ENSG00000171501.
GeneID138882.
KEGGhsa:138882.
UCSCuc011lyx.2. human.

Organism-specific databases

CTD138882.
GeneCardsGC09P125315.
HGNCHGNC:15111. OR1N2.
neXtProtNX_Q8NGR9.
PharmGKBPA32091.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150582.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGR9.
KOK04257.
OMAVLYMVII.
OrthoDBEOG71K63J.
PhylomeDBQ8NGR9.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR1N2.
GenevestigatorQ8NGR9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1N2.
NextBio83862.
PROQ8NGR9.

Entry information

Entry nameOR1N2_HUMAN
AccessionPrimary (citable) accession number: Q8NGR9
Secondary accession number(s): A3KFM2 expand/collapse secondary AC list , B2RNY4, Q6IF17, Q96RA3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries