Q8NGR9 (OR1N2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 1N2

Alternative name(s):
Olfactory receptor OR9-23

Gene names

Name:

OR1N2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence BAC05941.1 differs from that shown. Reason: Erroneous initiation. The sequence CAM45738.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Olfactory receptor 1N2		PRO_0000150449
Regions
	Topological domain	1 – 42	42	Extracellular Potential
	Transmembrane	43 – 66	24	Helical; Name=1; Potential
	Topological domain	67 – 74	8	Cytoplasmic Potential
	Transmembrane	75 – 96	22	Helical; Name=2; Potential
	Topological domain	97 – 117	21	Extracellular Potential
	Transmembrane	118 – 137	20	Helical; Name=3; Potential
	Topological domain	138 – 156	19	Cytoplasmic Potential
	Transmembrane	157 – 175	19	Helical; Name=4; Potential
	Topological domain	176 – 213	38	Extracellular Potential
	Transmembrane	214 – 236	23	Helical; Name=5; Potential
	Topological domain	237 – 253	17	Cytoplasmic Potential
	Transmembrane	254 – 276	23	Helical; Name=6; Potential
	Topological domain	277 – 289	13	Extracellular Potential
	Transmembrane	290 – 309	20	Helical; Name=7; Potential
	Topological domain	310 – 330	21	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	22	1	N-linked (GlcNAc...) Potential
	Disulfide bond	114 ↔ 206		By similarity
Natural variations
	Natural variant	37	1	W → R. Ref.3 Corresponds to variant rs1831370 [ dbSNP | Ensembl ].		VAR_048028
	Natural variant	237	1	R → C. Corresponds to variant rs41316976 [ dbSNP | Ensembl ].		VAR_062012
	Natural variant	244	1	V → G. Ref.3 Corresponds to variant rs1341044 [ dbSNP | Ensembl ].		VAR_048029
	Natural variant	301	1	T → M. Ref.3 Corresponds to variant rs1411272 [ dbSNP | Ensembl ].		VAR_048030

Sequences

	Sequence		Length	Mass (Da)
	Q8NGR9 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: 242D45D016841C4A	FASTA	330	36,889
	10 20 30 40 50 60 MEGFYLRRSH ELQGMGKPGR VNQTTVSDFL LLGLSEWPEE QPLLFGIFLG MYLVTMVGNL 70 80 90 100 110 120 LIILAISSDP HLHTPMYFFL ANLSLTDACF TSASIPKMLA NIHTQSQIIS YSGCLAQLYF 130 140 150 160 170 180 LLMFGGLDNC LLAVMAYDRY VAICQPLHYS TSMSPQLCAL MLGVCWVLTN CPALMHTLLL 190 200 210 220 230 240 TRVAFCAQKA IPHFYCDPSA LLKLACSDTH VNELMIITMG LLFLTVPLLL IVFSYVRIFW 250 260 270 280 290 300 AVFVISSPGG RWKAFSTCGS HLTVVLLFYG SLMGVYLLPP STYSTERESR AAVLYMVIIP 310 320 330 TLNPFIYSLR NRDMKEALGK LFVSGKTFFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-37; GLY-244 AND MET-301.
[4]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-301.
[5]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065720 Genomic DNA. Translation: BAC05941.1. Different initiation. AL359636 Genomic DNA. Translation: CAM45738.1. Different initiation. BC137182 mRNA. Translation: AAI37183.1. BC137183 mRNA. Translation: AAI37184.1. AF399536 Genomic DNA. Translation: AAK95021.1. BK004445 Genomic DNA. Translation: DAA04843.1.
IPI	IPI00303622.
RefSeq	NP_001004457.1. NM_001004457.1.
UniGene	Hs.632682.
3D structure databases
ProteinModelPortal	Q8NGR9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000362792.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	218511727.
Proteomic databases
PaxDb	Q8NGR9.
PRIDE	Q8NGR9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373688; ENSP00000362792; ENSG00000171501.
GeneID	138882.
KEGG	hsa:138882.
UCSC	uc011lyx.2. human.
Organism-specific databases
CTD	138882.
GeneCards	GC09P125315.
HGNC	HGNC:15111. OR1N2.
neXtProt	NX_Q8NGR9.
PharmGKB	PA32091.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG150582.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q8NGR9.
KO	K04257.
OMA	VLYMVII.
OrthoDB	EOG4QZ7M9.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR1N2.
Genevestigator	Q8NGR9.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	83862.

Entry information

Entry name

OR1N2_HUMAN

Accession

Primary (citable) accession number: Q8NGR9
Secondary accession number(s): A3KFM2 , B2RNY4, Q6IF17, Q96RA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.