Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 1N2

Gene

OR1N2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171501-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1N2
Alternative name(s):
Olfactory receptor OR9-23
Gene namesi
Name:OR1N2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:15111. OR1N2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 66Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini67 – 74CytoplasmicSequence analysis8
Transmembranei75 – 96Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini97 – 117ExtracellularSequence analysisAdd BLAST21
Transmembranei118 – 137Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini138 – 156CytoplasmicSequence analysisAdd BLAST19
Transmembranei157 – 175Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini176 – 213ExtracellularSequence analysisAdd BLAST38
Transmembranei214 – 236Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini237 – 253CytoplasmicSequence analysisAdd BLAST17
Transmembranei254 – 276Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini277 – 289ExtracellularSequence analysisAdd BLAST13
Transmembranei290 – 309Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini310 – 330CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi138882.
OpenTargetsiENSG00000171501.
PharmGKBiPA32091.

Polymorphism and mutation databases

BioMutaiOR1N2.
DMDMi218511727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504491 – 330Olfactory receptor 1N2Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 206PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR9.
PRIDEiQ8NGR9.

PTM databases

iPTMnetiQ8NGR9.
PhosphoSitePlusiQ8NGR9.

Expressioni

Gene expression databases

CleanExiHS_OR1N2.
ExpressionAtlasiQ8NGR9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362792.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9R3. Eukaryota.
ENOG41113AW. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR9.
KOiK04257.
OMAiVLYMVII.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NGR9.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGFYLRRSH ELQGMGKPGR VNQTTVSDFL LLGLSEWPEE QPLLFGIFLG
60 70 80 90 100
MYLVTMVGNL LIILAISSDP HLHTPMYFFL ANLSLTDACF TSASIPKMLA
110 120 130 140 150
NIHTQSQIIS YSGCLAQLYF LLMFGGLDNC LLAVMAYDRY VAICQPLHYS
160 170 180 190 200
TSMSPQLCAL MLGVCWVLTN CPALMHTLLL TRVAFCAQKA IPHFYCDPSA
210 220 230 240 250
LLKLACSDTH VNELMIITMG LLFLTVPLLL IVFSYVRIFW AVFVISSPGG
260 270 280 290 300
RWKAFSTCGS HLTVVLLFYG SLMGVYLLPP STYSTERESR AAVLYMVIIP
310 320 330
TLNPFIYSLR NRDMKEALGK LFVSGKTFFL
Length:330
Mass (Da):36,889
Last modified:December 16, 2008 - v2
Checksum:i242D45D016841C4A
GO

Sequence cautioni

The sequence BAC05941 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM45738 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04802837W → R.1 PublicationCorresponds to variant rs1831370dbSNPEnsembl.1
Natural variantiVAR_062012237R → C.Corresponds to variant rs41316976dbSNPEnsembl.1
Natural variantiVAR_048029244V → G.1 PublicationCorresponds to variant rs1341044dbSNPEnsembl.1
Natural variantiVAR_048030301T → M.1 PublicationCorresponds to variant rs1411272dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065720 Genomic DNA. Translation: BAC05941.1. Different initiation.
AL359636 Genomic DNA. Translation: CAM45738.1. Different initiation.
BC137182 mRNA. Translation: AAI37183.1.
BC137183 mRNA. Translation: AAI37184.1.
AF399536 Genomic DNA. Translation: AAK95021.1.
BK004445 Genomic DNA. Translation: DAA04843.1.
CCDSiCCDS35123.1.
RefSeqiNP_001004457.1. NM_001004457.1.
UniGeneiHs.632682.

Genome annotation databases

EnsembliENST00000373688; ENSP00000362792; ENSG00000171501.
GeneIDi138882.
KEGGihsa:138882.
UCSCiuc011lyx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065720 Genomic DNA. Translation: BAC05941.1. Different initiation.
AL359636 Genomic DNA. Translation: CAM45738.1. Different initiation.
BC137182 mRNA. Translation: AAI37183.1.
BC137183 mRNA. Translation: AAI37184.1.
AF399536 Genomic DNA. Translation: AAK95021.1.
BK004445 Genomic DNA. Translation: DAA04843.1.
CCDSiCCDS35123.1.
RefSeqiNP_001004457.1. NM_001004457.1.
UniGeneiHs.632682.

3D structure databases

ProteinModelPortaliQ8NGR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362792.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGR9.
PhosphoSitePlusiQ8NGR9.

Polymorphism and mutation databases

BioMutaiOR1N2.
DMDMi218511727.

Proteomic databases

PaxDbiQ8NGR9.
PRIDEiQ8NGR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373688; ENSP00000362792; ENSG00000171501.
GeneIDi138882.
KEGGihsa:138882.
UCSCiuc011lyx.3. human.

Organism-specific databases

CTDi138882.
DisGeNETi138882.
GeneCardsiOR1N2.
HGNCiHGNC:15111. OR1N2.
neXtProtiNX_Q8NGR9.
OpenTargetsiENSG00000171501.
PharmGKBiPA32091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9R3. Eukaryota.
ENOG41113AW. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR9.
KOiK04257.
OMAiVLYMVII.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NGR9.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171501-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1N2.
GenomeRNAii138882.
PROiQ8NGR9.

Gene expression databases

CleanExiHS_OR1N2.
ExpressionAtlasiQ8NGR9. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1N2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR9
Secondary accession number(s): A3KFM2
, B2RNY4, Q6IF17, Q96RA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.