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Protein

Olfactory receptor 1N2

Gene

OR1N2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1N2
Alternative name(s):
Olfactory receptor OR9-23
Gene namesi
Name:OR1N2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:15111. OR1N2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
BLAST
Transmembranei43 – 6624Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini67 – 748CytoplasmicSequence Analysis
Transmembranei75 – 9622Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini97 – 11721ExtracellularSequence AnalysisAdd
BLAST
Transmembranei118 – 13720Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini138 – 15619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei157 – 17519Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini176 – 21338ExtracellularSequence AnalysisAdd
BLAST
Transmembranei214 – 23623Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini237 – 25317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei254 – 27623Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini277 – 28913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei290 – 30920Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini310 – 33021CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32091.

Polymorphism and mutation databases

BioMutaiOR1N2.
DMDMi218511727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Olfactory receptor 1N2PRO_0000150449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi114 ↔ 206PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR9.
PRIDEiQ8NGR9.

Expressioni

Gene expression databases

CleanExiHS_OR1N2.
ExpressionAtlasiQ8NGR9. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362792.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR9.
SMRiQ8NGR9. Positions 49-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150582.
GeneTreeiENSGT00800000124028.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR9.
KOiK04257.
OMAiVLYMVII.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGR9.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGFYLRRSH ELQGMGKPGR VNQTTVSDFL LLGLSEWPEE QPLLFGIFLG
60 70 80 90 100
MYLVTMVGNL LIILAISSDP HLHTPMYFFL ANLSLTDACF TSASIPKMLA
110 120 130 140 150
NIHTQSQIIS YSGCLAQLYF LLMFGGLDNC LLAVMAYDRY VAICQPLHYS
160 170 180 190 200
TSMSPQLCAL MLGVCWVLTN CPALMHTLLL TRVAFCAQKA IPHFYCDPSA
210 220 230 240 250
LLKLACSDTH VNELMIITMG LLFLTVPLLL IVFSYVRIFW AVFVISSPGG
260 270 280 290 300
RWKAFSTCGS HLTVVLLFYG SLMGVYLLPP STYSTERESR AAVLYMVIIP
310 320 330
TLNPFIYSLR NRDMKEALGK LFVSGKTFFL
Length:330
Mass (Da):36,889
Last modified:December 16, 2008 - v2
Checksum:i242D45D016841C4A
GO

Sequence cautioni

The sequence BAC05941.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAM45738.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371W → R.1 Publication
Corresponds to variant rs1831370 [ dbSNP | Ensembl ].
VAR_048028
Natural varianti237 – 2371R → C.
Corresponds to variant rs41316976 [ dbSNP | Ensembl ].
VAR_062012
Natural varianti244 – 2441V → G.1 Publication
Corresponds to variant rs1341044 [ dbSNP | Ensembl ].
VAR_048029
Natural varianti301 – 3011T → M.1 Publication
Corresponds to variant rs1411272 [ dbSNP | Ensembl ].
VAR_048030

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065720 Genomic DNA. Translation: BAC05941.1. Different initiation.
AL359636 Genomic DNA. Translation: CAM45738.1. Different initiation.
BC137182 mRNA. Translation: AAI37183.1.
BC137183 mRNA. Translation: AAI37184.1.
AF399536 Genomic DNA. Translation: AAK95021.1.
BK004445 Genomic DNA. Translation: DAA04843.1.
CCDSiCCDS35123.1.
RefSeqiNP_001004457.1. NM_001004457.1.
UniGeneiHs.632682.

Genome annotation databases

EnsembliENST00000373688; ENSP00000362792; ENSG00000171501.
GeneIDi138882.
KEGGihsa:138882.
UCSCiuc011lyx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065720 Genomic DNA. Translation: BAC05941.1. Different initiation.
AL359636 Genomic DNA. Translation: CAM45738.1. Different initiation.
BC137182 mRNA. Translation: AAI37183.1.
BC137183 mRNA. Translation: AAI37184.1.
AF399536 Genomic DNA. Translation: AAK95021.1.
BK004445 Genomic DNA. Translation: DAA04843.1.
CCDSiCCDS35123.1.
RefSeqiNP_001004457.1. NM_001004457.1.
UniGeneiHs.632682.

3D structure databases

ProteinModelPortaliQ8NGR9.
SMRiQ8NGR9. Positions 49-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362792.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR1N2.
DMDMi218511727.

Proteomic databases

PaxDbiQ8NGR9.
PRIDEiQ8NGR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373688; ENSP00000362792; ENSG00000171501.
GeneIDi138882.
KEGGihsa:138882.
UCSCiuc011lyx.2. human.

Organism-specific databases

CTDi138882.
GeneCardsiGC09P125315.
HGNCiHGNC:15111. OR1N2.
neXtProtiNX_Q8NGR9.
PharmGKBiPA32091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG150582.
GeneTreeiENSGT00800000124028.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR9.
KOiK04257.
OMAiVLYMVII.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGR9.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1N2.
GenomeRNAii138882.
NextBioi83862.
PROiQ8NGR9.

Gene expression databases

CleanExiHS_OR1N2.
ExpressionAtlasiQ8NGR9. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-37; GLY-244 AND MET-301.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-301.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1N2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR9
Secondary accession number(s): A3KFM2
, B2RNY4, Q6IF17, Q96RA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: July 22, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.