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Q8NGR9

- OR1N2_HUMAN

UniProt

Q8NGR9 - OR1N2_HUMAN

Protein

Olfactory receptor 1N2

Gene

OR1N2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1N2
    Alternative name(s):
    Olfactory receptor OR9-23
    Gene namesi
    Name:OR1N2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:15111. OR1N2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32091.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Olfactory receptor 1N2PRO_0000150449Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 206PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGR9.
    PRIDEiQ8NGR9.

    Expressioni

    Gene expression databases

    CleanExiHS_OR1N2.
    GenevestigatoriQ8NGR9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000362792.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGR9.
    SMRiQ8NGR9. Positions 49-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 748CytoplasmicSequence Analysis
    Topological domaini97 – 11721ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 21338ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini237 – 25317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini277 – 28913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 33021CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6624Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9622Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei118 – 13720Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei157 – 17519Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei214 – 23623Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27623Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 30920Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150582.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGR9.
    KOiK04257.
    OMAiVLYMVII.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGR9.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGR9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGFYLRRSH ELQGMGKPGR VNQTTVSDFL LLGLSEWPEE QPLLFGIFLG    50
    MYLVTMVGNL LIILAISSDP HLHTPMYFFL ANLSLTDACF TSASIPKMLA 100
    NIHTQSQIIS YSGCLAQLYF LLMFGGLDNC LLAVMAYDRY VAICQPLHYS 150
    TSMSPQLCAL MLGVCWVLTN CPALMHTLLL TRVAFCAQKA IPHFYCDPSA 200
    LLKLACSDTH VNELMIITMG LLFLTVPLLL IVFSYVRIFW AVFVISSPGG 250
    RWKAFSTCGS HLTVVLLFYG SLMGVYLLPP STYSTERESR AAVLYMVIIP 300
    TLNPFIYSLR NRDMKEALGK LFVSGKTFFL 330
    Length:330
    Mass (Da):36,889
    Last modified:December 16, 2008 - v2
    Checksum:i242D45D016841C4A
    GO

    Sequence cautioni

    The sequence BAC05941.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAM45738.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371W → R.1 Publication
    Corresponds to variant rs1831370 [ dbSNP | Ensembl ].
    VAR_048028
    Natural varianti237 – 2371R → C.
    Corresponds to variant rs41316976 [ dbSNP | Ensembl ].
    VAR_062012
    Natural varianti244 – 2441V → G.1 Publication
    Corresponds to variant rs1341044 [ dbSNP | Ensembl ].
    VAR_048029
    Natural varianti301 – 3011T → M.1 Publication
    Corresponds to variant rs1411272 [ dbSNP | Ensembl ].
    VAR_048030

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065720 Genomic DNA. Translation: BAC05941.1. Different initiation.
    AL359636 Genomic DNA. Translation: CAM45738.1. Different initiation.
    BC137182 mRNA. Translation: AAI37183.1.
    BC137183 mRNA. Translation: AAI37184.1.
    AF399536 Genomic DNA. Translation: AAK95021.1.
    BK004445 Genomic DNA. Translation: DAA04843.1.
    CCDSiCCDS35123.1.
    RefSeqiNP_001004457.1. NM_001004457.1.
    UniGeneiHs.632682.

    Genome annotation databases

    EnsembliENST00000373688; ENSP00000362792; ENSG00000171501.
    GeneIDi138882.
    KEGGihsa:138882.
    UCSCiuc011lyx.2. human.

    Polymorphism databases

    DMDMi218511727.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065720 Genomic DNA. Translation: BAC05941.1 . Different initiation.
    AL359636 Genomic DNA. Translation: CAM45738.1 . Different initiation.
    BC137182 mRNA. Translation: AAI37183.1 .
    BC137183 mRNA. Translation: AAI37184.1 .
    AF399536 Genomic DNA. Translation: AAK95021.1 .
    BK004445 Genomic DNA. Translation: DAA04843.1 .
    CCDSi CCDS35123.1.
    RefSeqi NP_001004457.1. NM_001004457.1.
    UniGenei Hs.632682.

    3D structure databases

    ProteinModelPortali Q8NGR9.
    SMRi Q8NGR9. Positions 49-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000362792.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 218511727.

    Proteomic databases

    PaxDbi Q8NGR9.
    PRIDEi Q8NGR9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373688 ; ENSP00000362792 ; ENSG00000171501 .
    GeneIDi 138882.
    KEGGi hsa:138882.
    UCSCi uc011lyx.2. human.

    Organism-specific databases

    CTDi 138882.
    GeneCardsi GC09P125315.
    HGNCi HGNC:15111. OR1N2.
    neXtProti NX_Q8NGR9.
    PharmGKBi PA32091.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150582.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGR9.
    KOi K04257.
    OMAi VLYMVII.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGR9.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1N2.
    NextBioi 83862.
    PROi Q8NGR9.

    Gene expression databases

    CleanExi HS_OR1N2.
    Genevestigatori Q8NGR9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-37; GLY-244 AND MET-301.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-301.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR1N2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGR9
    Secondary accession number(s): A3KFM2
    , B2RNY4, Q6IF17, Q96RA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3