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Protein

Olfactory receptor 1L8

Gene

OR1L8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1L8
Alternative name(s):
Olfactory receptor OR9-24
Gene namesi
Name:OR1L8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000171496.3
HGNCiHGNC:15110 OR1L8
neXtProtiNX_Q8NGR8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 50Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 101ExtracellularSequence analysisAdd BLAST21
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 159Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini160 – 197ExtracellularSequence analysisAdd BLAST38
Transmembranei198 – 220Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini221 – 237CytoplasmicSequence analysisAdd BLAST17
Transmembranei238 – 260Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini261 – 272ExtracellularSequence analysisAdd BLAST12
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 309CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32088

Polymorphism and mutation databases

BioMutaiOR1L8
DMDMi38372757

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504461 – 309Olfactory receptor 1L8Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR8
PeptideAtlasiQ8NGR8
PRIDEiQ8NGR8
ProteomicsDBi73585

PTM databases

iPTMnetiQ8NGR8
PhosphoSitePlusiQ8NGR8

Expressioni

Gene expression databases

BgeeiENSG00000171496
CleanExiHS_OR1L8
ExpressionAtlasiQ8NGR8 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306607

Structurei

3D structure databases

ProteinModelPortaliQ8NGR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFXJ Eukaryota
ENOG41114P7 LUCA
GeneTreeiENSGT00910000144098
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGR8
KOiK04257
OMAiERINHTS
OrthoDBiEOG091G0B53
PhylomeDBiQ8NGR8
TreeFamiTF341149

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERINHTSSV SEFILLGLSS RPEDQKTLFV LFLIVYLVTI TGNLLIILAI
60 70 80 90 100
RFNPHLQTPM YFFLSFLSLT DICFTTSVVP KMLMNFLSEK KTISYAGCLT
110 120 130 140 150
QMYFLYALGN SDSCLLAVMA FDRYVAVCDP FHYVTTMSHH HCVLLVAFSC
160 170 180 190 200
SFPHLHSLLH TLLLNRLTFC DSNVIHHFLC DLSPVLKLSC SSIFVNEIVQ
210 220 230 240 250
MTEAPIVLVT RFLCIAFSYI RILTTVLKIP STSGKRKAFS TCGFYLTVVT
260 270 280 290 300
LFYGSIFCVY LQPPSTYAVK DHVATIVYTV LSSMLNPFIY SLRNKDLKQG

LRKLMSKRS
Length:309
Mass (Da):35,083
Last modified:October 1, 2002 - v1
Checksum:iCA8113D975B09361
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02408727T → P. Corresponds to variant dbSNP:rs10985704Ensembl.1
Natural variantiVAR_024088211R → P1 PublicationCorresponds to variant dbSNP:rs10739614Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065721 Genomic DNA Translation: BAC05942.1
AL359636 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87536.1
BC140910 mRNA Translation: AAI40911.1
AF399564 Genomic DNA Translation: AAK95049.1
BK004447 Genomic DNA Translation: DAA04845.1
CCDSiCCDS35124.1
RefSeqiNP_001004454.1, NM_001004454.1
XP_016869773.1, XM_017014284.1
XP_016869774.1, XM_017014285.1
XP_016869775.1, XM_017014286.1
UniGeneiHs.632695

Genome annotation databases

EnsembliENST00000304865; ENSP00000306607; ENSG00000171496
ENST00000641027; ENSP00000493411; ENSG00000171496
GeneIDi138881
KEGGihsa:138881
UCSCiuc004bmp.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR1L8_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR8
Secondary accession number(s): A3KFM3
, B9EIR6, Q6IF15, Q96R79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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