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Q8NGR8 (OR1L8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1L8
Alternative name(s):
Olfactory receptor OR9-24
Gene names
Name:OR1L8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Olfactory receptor 1L8
PRO_0000150446

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 5024Helical; Name=1; Potential
Topological domain51 – 588Cytoplasmic Potential
Transmembrane59 – 8022Helical; Name=2; Potential
Topological domain81 – 10121Extracellular Potential
Transmembrane102 – 12120Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 15919Helical; Name=4; Potential
Topological domain160 – 19738Extracellular Potential
Transmembrane198 – 22023Helical; Name=5; Potential
Topological domain221 – 23717Cytoplasmic Potential
Transmembrane238 – 26023Helical; Name=6; Potential
Topological domain261 – 27212Extracellular Potential
Transmembrane273 – 29220Helical; Name=7; Potential
Topological domain293 – 30917Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant271T → P.
Corresponds to variant rs10985704 [ dbSNP | Ensembl ].
VAR_024087
Natural variant2111R → P. Ref.4
Corresponds to variant rs10739614 [ dbSNP | Ensembl ].
VAR_024088

Sequences

Sequence LengthMass (Da)Tools
Q8NGR8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: CA8113D975B09361

FASTA30935,083
        10         20         30         40         50         60 
MERINHTSSV SEFILLGLSS RPEDQKTLFV LFLIVYLVTI TGNLLIILAI RFNPHLQTPM 

        70         80         90        100        110        120 
YFFLSFLSLT DICFTTSVVP KMLMNFLSEK KTISYAGCLT QMYFLYALGN SDSCLLAVMA 

       130        140        150        160        170        180 
FDRYVAVCDP FHYVTTMSHH HCVLLVAFSC SFPHLHSLLH TLLLNRLTFC DSNVIHHFLC 

       190        200        210        220        230        240 
DLSPVLKLSC SSIFVNEIVQ MTEAPIVLVT RFLCIAFSYI RILTTVLKIP STSGKRKAFS 

       250        260        270        280        290        300 
TCGFYLTVVT LFYGSIFCVY LQPPSTYAVK DHVATIVYTV LSSMLNPFIY SLRNKDLKQG 


LRKLMSKRS 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-211.
[5]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-283.
[6]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065721 Genomic DNA. Translation: BAC05942.1.
AL359636 Genomic DNA. Translation: CAM45739.1.
CH471090 Genomic DNA. Translation: EAW87536.1.
BC140910 mRNA. Translation: AAI40911.1.
AF399564 Genomic DNA. Translation: AAK95049.1.
BK004447 Genomic DNA. Translation: DAA04845.1.
RefSeqNP_001004454.1. NM_001004454.1.
UniGeneHs.632695.

3D structure databases

ProteinModelPortalQ8NGR8.
SMRQ8NGR8. Positions 26-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000306607.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGR8.

Polymorphism databases

DMDM38372757.

Proteomic databases

PaxDbQ8NGR8.
PRIDEQ8NGR8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304865; ENSP00000306607; ENSG00000171496.
GeneID138881.
KEGGhsa:138881.
UCSCuc004bmp.1. human.

Organism-specific databases

CTD138881.
GeneCardsGC09M125329.
HGNCHGNC:15110. OR1L8.
neXtProtNX_Q8NGR8.
PharmGKBPA32088.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44632.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGR8.
KOK04257.
OMAIVIVTEG.
OrthoDBEOG7D85WJ.
PhylomeDBQ8NGR8.
TreeFamTF341149.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR1L8.
GenevestigatorQ8NGR8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1L8.
GenomeRNAi138881.
NextBio83858.
PROQ8NGR8.

Entry information

Entry nameOR1L8_HUMAN
AccessionPrimary (citable) accession number: Q8NGR8
Secondary accession number(s): A3KFM3 expand/collapse secondary AC list , B9EIR6, Q6IF15, Q96R79
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries