Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8NGR8

- OR1L8_HUMAN

UniProt

Q8NGR8 - OR1L8_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Olfactory receptor 1L8

Gene

OR1L8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1L8
Alternative name(s):
Olfactory receptor OR9-24
Gene namesi
Name:OR1L8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:15110. OR1L8.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32088.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 1L8PRO_0000150446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR8.
PRIDEiQ8NGR8.

PTM databases

PhosphoSiteiQ8NGR8.

Expressioni

Gene expression databases

CleanExiHS_OR1L8.
GenevestigatoriQ8NGR8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306607.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR8.
SMRiQ8NGR8. Positions 26-305.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Topological domaini51 – 588CytoplasmicSequence Analysis
Topological domaini81 – 10121ExtracellularSequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini160 – 19738ExtracellularSequence AnalysisAdd
BLAST
Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini261 – 27212ExtracellularSequence AnalysisAdd
BLAST
Topological domaini293 – 30917CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 5024Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei141 – 15919Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei198 – 22023Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44632.
GeneTreeiENSGT00760000119207.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR8.
KOiK04257.
OMAiIVIVTEG.
OrthoDBiEOG7D85WJ.
PhylomeDBiQ8NGR8.
TreeFamiTF341149.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERINHTSSV SEFILLGLSS RPEDQKTLFV LFLIVYLVTI TGNLLIILAI
60 70 80 90 100
RFNPHLQTPM YFFLSFLSLT DICFTTSVVP KMLMNFLSEK KTISYAGCLT
110 120 130 140 150
QMYFLYALGN SDSCLLAVMA FDRYVAVCDP FHYVTTMSHH HCVLLVAFSC
160 170 180 190 200
SFPHLHSLLH TLLLNRLTFC DSNVIHHFLC DLSPVLKLSC SSIFVNEIVQ
210 220 230 240 250
MTEAPIVLVT RFLCIAFSYI RILTTVLKIP STSGKRKAFS TCGFYLTVVT
260 270 280 290 300
LFYGSIFCVY LQPPSTYAVK DHVATIVYTV LSSMLNPFIY SLRNKDLKQG

LRKLMSKRS
Length:309
Mass (Da):35,083
Last modified:October 1, 2002 - v1
Checksum:iCA8113D975B09361
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271T → P.
Corresponds to variant rs10985704 [ dbSNP | Ensembl ].
VAR_024087
Natural varianti211 – 2111R → P.1 Publication
Corresponds to variant rs10739614 [ dbSNP | Ensembl ].
VAR_024088

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065721 Genomic DNA. Translation: BAC05942.1.
AL359636 Genomic DNA. Translation: CAM45739.1.
CH471090 Genomic DNA. Translation: EAW87536.1.
BC140910 mRNA. Translation: AAI40911.1.
AF399564 Genomic DNA. Translation: AAK95049.1.
BK004447 Genomic DNA. Translation: DAA04845.1.
CCDSiCCDS35124.1.
RefSeqiNP_001004454.1. NM_001004454.1.
UniGeneiHs.632695.

Genome annotation databases

EnsembliENST00000304865; ENSP00000306607; ENSG00000171496.
GeneIDi138881.
KEGGihsa:138881.
UCSCiuc004bmp.1. human.

Polymorphism databases

DMDMi38372757.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065721 Genomic DNA. Translation: BAC05942.1 .
AL359636 Genomic DNA. Translation: CAM45739.1 .
CH471090 Genomic DNA. Translation: EAW87536.1 .
BC140910 mRNA. Translation: AAI40911.1 .
AF399564 Genomic DNA. Translation: AAK95049.1 .
BK004447 Genomic DNA. Translation: DAA04845.1 .
CCDSi CCDS35124.1.
RefSeqi NP_001004454.1. NM_001004454.1.
UniGenei Hs.632695.

3D structure databases

ProteinModelPortali Q8NGR8.
SMRi Q8NGR8. Positions 26-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000306607.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGR8.

Polymorphism databases

DMDMi 38372757.

Proteomic databases

PaxDbi Q8NGR8.
PRIDEi Q8NGR8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304865 ; ENSP00000306607 ; ENSG00000171496 .
GeneIDi 138881.
KEGGi hsa:138881.
UCSCi uc004bmp.1. human.

Organism-specific databases

CTDi 138881.
GeneCardsi GC09M125329.
HGNCi HGNC:15110. OR1L8.
neXtProti NX_Q8NGR8.
PharmGKBi PA32088.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44632.
GeneTreei ENSGT00760000119207.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGR8.
KOi K04257.
OMAi IVIVTEG.
OrthoDBi EOG7D85WJ.
PhylomeDBi Q8NGR8.
TreeFami TF341149.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1L8.
GenomeRNAii 138881.
NextBioi 83858.
PROi Q8NGR8.

Gene expression databases

CleanExi HS_OR1L8.
Genevestigatori Q8NGR8.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-211.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-283.
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1L8_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR8
Secondary accession number(s): A3KFM3
, B9EIR6, Q6IF15, Q96R79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3