ID   OR1B1_HUMAN             Reviewed;         318 AA.
AC   Q8NGR6; Q6IFN3;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   24-JAN-2024, entry version 156.
DE   RecName: Full=Olfactory receptor 1B1;
DE   AltName: Full=Olfactory receptor 9-B;
DE            Short=OR9-B;
DE   AltName: Full=Olfactory receptor OR9-26;
GN   Name=OR1B1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN   [5]
RP   POLYMORPHISM.
RX   PubMed=12730696; DOI=10.1038/ng1160;
RA   Menashe I., Man O., Lancet D., Gilad Y.;
RT   "Different noses for different people.";
RL   Nat. Genet. 34:143-144(2003).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- POLYMORPHISM: A stop codon at position Arg-192 in the gene coding for
CC       this protein is responsible for functional diversity thus producing a
CC       pseudogene. The stop codon is more frequent in non-Africans than in
CC       African-Americans.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=DAA04627.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1B1";
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DR   EMBL; AB065723; BAC05944.1; -; Genomic_DNA.
DR   EMBL; AL162254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK004229; DAA04627.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_001004450.1; NM_001004450.1.
DR   RefSeq; XP_016870184.1; XM_017014695.1.
DR   RefSeq; XP_016870185.1; XM_017014696.1.
DR   AlphaFoldDB; Q8NGR6; -.
DR   SMR; Q8NGR6; -.
DR   STRING; 9606.ENSP00000485577; -.
DR   GlyCosmos; Q8NGR6; 2 sites, No reported glycans.
DR   GlyGen; Q8NGR6; 2 sites.
DR   PhosphoSitePlus; Q8NGR6; -.
DR   BioMuta; OR1B1; -.
DR   DMDM; 166214963; -.
DR   jPOST; Q8NGR6; -.
DR   MassIVE; Q8NGR6; -.
DR   PaxDb; 9606-ENSP00000303151; -.
DR   PeptideAtlas; Q8NGR6; -.
DR   Antibodypedia; 78801; 55 antibodies from 16 providers.
DR   DNASU; 347169; -.
DR   Ensembl; ENST00000623530.2; ENSP00000485577.2; ENSG00000280094.3.
DR   GeneID; 347169; -.
DR   KEGG; hsa:347169; -.
DR   MANE-Select; ENST00000623530.2; ENSP00000485577.2; NM_001004450.3; NP_001004450.2.
DR   UCSC; uc011lyz.2; human.
DR   AGR; HGNC:8181; -.
DR   CTD; 347169; -.
DR   DisGeNET; 347169; -.
DR   GeneCards; OR1B1; -.
DR   HGNC; HGNC:8181; OR1B1.
DR   HPA; ENSG00000280094; Not detected.
DR   neXtProt; NX_Q8NGR6; -.
DR   PharmGKB; PA32055; -.
DR   VEuPathDB; HostDB:ENSG00000280094; -.
DR   eggNOG; ENOG502QWKX; Eukaryota.
DR   HOGENOM; CLU_012526_0_1_1; -.
DR   InParanoid; Q8NGR6; -.
DR   OMA; VSVVHTM; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NGR6; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; Q8NGR6; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 347169; 9 hits in 738 CRISPR screens.
DR   GeneWiki; OR1B1; -.
DR   GenomeRNAi; 347169; -.
DR   Pharos; Q8NGR6; Tdark.
DR   PRO; PR:Q8NGR6; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8NGR6; Protein.
DR   Bgee; ENSG00000280094; Expressed in cortical plate and 8 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd15235; 7tmA_OR1A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48001:SF125; OLFACTORY RECEPTOR 1B1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..318
FT                   /note="Olfactory receptor 1B1"
FT                   /id="PRO_0000150416"
FT   TOPO_DOM        1..30
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..67
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..145
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        167..202
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        224..249
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        271..277
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..318
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        7
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        23
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        99..185
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         149
FT                   /note="L -> S (in dbSNP:rs1536929)"
FT                   /id="VAR_053114"
FT   VARIANT         230
FT                   /note="A -> T (in dbSNP:rs1476859)"
FT                   /id="VAR_053115"
FT   VARIANT         263
FT                   /note="C -> W (in dbSNP:rs1476858)"
FT                   /id="VAR_053116"
FT   VARIANT         314
FT                   /note="V -> G (in dbSNP:rs1556189)"
FT                   /id="VAR_053117"
SQ   SEQUENCE   318 AA;  35293 MW;  0CA0D7808259807B CRC64;
     MMSFAPNASH SPVFLLLGFS RANISYTLLF FLFLAIYLTT ILGNVTLVLL ISWDSRLHSP
     MYYLLRGLSV IDMGLSTVTL PQLLAHLVSH YPTIPAARCL AQFFFFYAFG VTDTLVIAVM
     ALDRYVAICD PLHYALVMNH QRCACLLALS WVVSILHTML RVGLVLPLCW TGDAGGNVNL
     PHFFCDHRPL LRASCSDIHS NELAIFFEGG FLMLGPCALI VLSYVRIGAA ILRLPSAAGR
     RRAVSTCGSH LTMVGFLYGT IICVYFQPPF QNSQYQDMVA SVMYTAITPL ANPFVYSLHN
     KDVKGALCRL LEWVKVDP
//