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Protein

Olfactory receptor 1B1

Gene

OR1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171484-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1B1
Alternative name(s):
Olfactory receptor 9-B
Short name:
OR9-B
Olfactory receptor OR9-26
Gene namesi
Name:OR1B1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8181. OR1B1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 67CytoplasmicSequence analysisAdd BLAST16
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 99ExtracellularSequence analysisAdd BLAST11
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 145CytoplasmicSequence analysisAdd BLAST25
Transmembranei146 – 166Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini167 – 202ExtracellularSequence analysisAdd BLAST36
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 249CytoplasmicSequence analysisAdd BLAST26
Transmembranei250 – 270Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini271 – 277ExtracellularSequence analysis7
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 318CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000280094.
PharmGKBiPA32055.

Polymorphism and mutation databases

BioMutaiOR1B1.
DMDMi166214963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504161 – 318Olfactory receptor 1B1Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 185PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR6.
PeptideAtlasiQ8NGR6.
PRIDEiQ8NGR6.

PTM databases

PhosphoSitePlusiQ8NGR6.

Expressioni

Gene expression databases

CleanExiHS_OR1B1.

Organism-specific databases

HPAiHPA058654.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303151.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR6.
SMRiQ8NGR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVEK. Eukaryota.
ENOG4111570. LUCA.
GeneTreeiENSGT00840000129998.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR6.
KOiK04257.
OMAiQRCACLL.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGR6.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSFAPNASH SPVFLLLGFS RANISYTLLF FLFLAIYLTT ILGNVTLVLL
60 70 80 90 100
ISWDSRLHSP MYYLLRGLSV IDMGLSTVTL PQLLAHLVSH YPTIPAARCL
110 120 130 140 150
AQFFFFYAFG VTDTLVIAVM ALDRYVAICD PLHYALVMNH QRCACLLALS
160 170 180 190 200
WVVSILHTML RVGLVLPLCW TGDAGGNVNL PHFFCDHRPL LRASCSDIHS
210 220 230 240 250
NELAIFFEGG FLMLGPCALI VLSYVRIGAA ILRLPSAAGR RRAVSTCGSH
260 270 280 290 300
LTMVGFLYGT IICVYFQPPF QNSQYQDMVA SVMYTAITPL ANPFVYSLHN
310
KDVKGALCRL LEWVKVDP
Length:318
Mass (Da):35,293
Last modified:January 15, 2008 - v2
Checksum:i0CA0D7808259807B
GO

Sequence cautioni

The sequence CAI16289 differs from that shown. Reason: Erroneous initiation.Curated
The sequence DAA04627 differs from that shown. Reason: Erroneous initiation.Curated

Polymorphismi

A stop codon at position Arg-192 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053114149L → S.Corresponds to variant rs1536929dbSNPEnsembl.1
Natural variantiVAR_053115230A → T.Corresponds to variant rs1476859dbSNPEnsembl.1
Natural variantiVAR_053116263C → W.Corresponds to variant rs1476858dbSNPEnsembl.1
Natural variantiVAR_053117314V → G.Corresponds to variant rs1556189dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065723 Genomic DNA. Translation: BAC05944.1.
AL162254 Genomic DNA. Translation: CAI16289.1. Different initiation.
BK004229 Genomic DNA. Translation: DAA04627.1. Different initiation.
RefSeqiNP_001004450.1. NM_001004450.1.
XP_016870184.1. XM_017014695.1.
XP_016870185.1. XM_017014696.1.
UniGeneiHs.553710.

Genome annotation databases

EnsembliENST00000623530; ENSP00000485577; ENSG00000280094.
GeneIDi347169.
KEGGihsa:347169.
UCSCiuc011lyz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065723 Genomic DNA. Translation: BAC05944.1.
AL162254 Genomic DNA. Translation: CAI16289.1. Different initiation.
BK004229 Genomic DNA. Translation: DAA04627.1. Different initiation.
RefSeqiNP_001004450.1. NM_001004450.1.
XP_016870184.1. XM_017014695.1.
XP_016870185.1. XM_017014696.1.
UniGeneiHs.553710.

3D structure databases

ProteinModelPortaliQ8NGR6.
SMRiQ8NGR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303151.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8NGR6.

Polymorphism and mutation databases

BioMutaiOR1B1.
DMDMi166214963.

Proteomic databases

PaxDbiQ8NGR6.
PeptideAtlasiQ8NGR6.
PRIDEiQ8NGR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000623530; ENSP00000485577; ENSG00000280094.
GeneIDi347169.
KEGGihsa:347169.
UCSCiuc011lyz.2. human.

Organism-specific databases

CTDi347169.
GeneCardsiOR1B1.
HGNCiHGNC:8181. OR1B1.
HPAiHPA058654.
neXtProtiNX_Q8NGR6.
OpenTargetsiENSG00000280094.
PharmGKBiPA32055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVEK. Eukaryota.
ENOG4111570. LUCA.
GeneTreeiENSGT00840000129998.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR6.
KOiK04257.
OMAiQRCACLL.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGR6.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171484-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1B1.
GenomeRNAii347169.
PROiQ8NGR6.

Gene expression databases

CleanExiHS_OR1B1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1B1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR6
Secondary accession number(s): Q6IFN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.