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Q8NGR6 (OR1B1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1B1
Alternative name(s):
Olfactory receptor 9-B
Short name=OR9-B
Olfactory receptor OR9-26
Gene names
Name:OR1B1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Polymorphism

A stop codon at position Arg-192 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence CAI16289.1 differs from that shown. Reason: Erroneous initiation.

The sequence DAA04627.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Olfactory receptor 1B1
PRO_0000150416

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5121Helical; Name=1; Potential
Topological domain52 – 6716Cytoplasmic Potential
Transmembrane68 – 8821Helical; Name=2; Potential
Topological domain89 – 9911Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 14525Cytoplasmic Potential
Transmembrane146 – 16621Helical; Name=4; Potential
Topological domain167 – 20236Extracellular Potential
Transmembrane203 – 22321Helical; Name=5; Potential
Topological domain224 – 24926Cytoplasmic Potential
Transmembrane250 – 27021Helical; Name=6; Potential
Topological domain271 – 2777Extracellular Potential
Transmembrane278 – 29821Helical; Name=7; Potential
Topological domain299 – 31820Cytoplasmic Potential

Amino acid modifications

Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation231N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 185 By similarity

Natural variations

Natural variant1491L → S.
Corresponds to variant rs1536929 [ dbSNP | Ensembl ].
VAR_053114
Natural variant2301A → T.
Corresponds to variant rs1476859 [ dbSNP | Ensembl ].
VAR_053115
Natural variant2631C → W.
Corresponds to variant rs1476858 [ dbSNP | Ensembl ].
VAR_053116
Natural variant3141V → G.
Corresponds to variant rs1556189 [ dbSNP | Ensembl ].
VAR_053117

Sequences

Sequence LengthMass (Da)Tools
Q8NGR6 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 0CA0D7808259807B

FASTA31835,293
        10         20         30         40         50         60 
MMSFAPNASH SPVFLLLGFS RANISYTLLF FLFLAIYLTT ILGNVTLVLL ISWDSRLHSP 

        70         80         90        100        110        120 
MYYLLRGLSV IDMGLSTVTL PQLLAHLVSH YPTIPAARCL AQFFFFYAFG VTDTLVIAVM 

       130        140        150        160        170        180 
ALDRYVAICD PLHYALVMNH QRCACLLALS WVVSILHTML RVGLVLPLCW TGDAGGNVNL 

       190        200        210        220        230        240 
PHFFCDHRPL LRASCSDIHS NELAIFFEGG FLMLGPCALI VLSYVRIGAA ILRLPSAAGR 

       250        260        270        280        290        300 
RRAVSTCGSH LTMVGFLYGT IICVYFQPPF QNSQYQDMVA SVMYTAITPL ANPFVYSLHN 

       310 
KDVKGALCRL LEWVKVDP 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[5]"Different noses for different people."
Menashe I., Man O., Lancet D., Gilad Y.
Nat. Genet. 34:143-144(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065723 Genomic DNA. Translation: BAC05944.1.
AL162254 Genomic DNA. Translation: CAI16289.1. Different initiation.
BK004229 Genomic DNA. Translation: DAA04627.1. Different initiation.
CCDSCCDS35126.1.
RefSeqNP_001004450.1. NM_001004450.1.
UniGeneHs.553710.

3D structure databases

ProteinModelPortalQ8NGR6.
SMRQ8NGR6. Positions 28-311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000303151.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM166214963.

Proteomic databases

PaxDbQ8NGR6.
PRIDEQ8NGR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304833; ENSP00000303151; ENSG00000171484.
GeneID347169.
KEGGhsa:347169.
UCSCuc011lyz.2. human.

Organism-specific databases

CTD347169.
GeneCardsGC09M125390.
HGNCHGNC:8181. OR1B1.
HPAHPA058654.
neXtProtNX_Q8NGR6.
PharmGKBPA32055.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46614.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGR6.
KOK04257.
OMAVLLISWD.
OrthoDBEOG71K63J.
PhylomeDBQ8NGR6.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR1B1.
GenevestigatorQ8NGR6.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1B1.
GenomeRNAi347169.
NextBio99059.
PROQ8NGR6.

Entry information

Entry nameOR1B1_HUMAN
AccessionPrimary (citable) accession number: Q8NGR6
Secondary accession number(s): Q6IFN3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries