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Q8NGR6

- OR1B1_HUMAN

UniProt

Q8NGR6 - OR1B1_HUMAN

Protein

Olfactory receptor 1B1

Gene

OR1B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1B1
    Alternative name(s):
    Olfactory receptor 9-B
    Short name:
    OR9-B
    Olfactory receptor OR9-26
    Gene namesi
    Name:OR1B1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:8181. OR1B1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32055.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Olfactory receptor 1B1PRO_0000150416Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 185PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGR6.
    PRIDEiQ8NGR6.

    Expressioni

    Gene expression databases

    CleanExiHS_OR1B1.
    GenevestigatoriQ8NGR6.

    Organism-specific databases

    HPAiHPA058654.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000303151.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGR6.
    SMRiQ8NGR6. Positions 28-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 6716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini89 – 9911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 14525CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini167 – 20236ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 24926CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini271 – 2777ExtracellularSequence Analysis
    Topological domaini299 – 31820CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei250 – 27021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46614.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGR6.
    KOiK04257.
    OMAiVLLISWD.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGR6.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGR6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMSFAPNASH SPVFLLLGFS RANISYTLLF FLFLAIYLTT ILGNVTLVLL    50
    ISWDSRLHSP MYYLLRGLSV IDMGLSTVTL PQLLAHLVSH YPTIPAARCL 100
    AQFFFFYAFG VTDTLVIAVM ALDRYVAICD PLHYALVMNH QRCACLLALS 150
    WVVSILHTML RVGLVLPLCW TGDAGGNVNL PHFFCDHRPL LRASCSDIHS 200
    NELAIFFEGG FLMLGPCALI VLSYVRIGAA ILRLPSAAGR RRAVSTCGSH 250
    LTMVGFLYGT IICVYFQPPF QNSQYQDMVA SVMYTAITPL ANPFVYSLHN 300
    KDVKGALCRL LEWVKVDP 318
    Length:318
    Mass (Da):35,293
    Last modified:January 15, 2008 - v2
    Checksum:i0CA0D7808259807B
    GO

    Sequence cautioni

    The sequence CAI16289.1 differs from that shown. Reason: Erroneous initiation.
    The sequence DAA04627.1 differs from that shown. Reason: Erroneous initiation.

    Polymorphismi

    A stop codon at position Arg-192 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti149 – 1491L → S.
    Corresponds to variant rs1536929 [ dbSNP | Ensembl ].
    VAR_053114
    Natural varianti230 – 2301A → T.
    Corresponds to variant rs1476859 [ dbSNP | Ensembl ].
    VAR_053115
    Natural varianti263 – 2631C → W.
    Corresponds to variant rs1476858 [ dbSNP | Ensembl ].
    VAR_053116
    Natural varianti314 – 3141V → G.
    Corresponds to variant rs1556189 [ dbSNP | Ensembl ].
    VAR_053117

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065723 Genomic DNA. Translation: BAC05944.1.
    AL162254 Genomic DNA. Translation: CAI16289.1. Different initiation.
    BK004229 Genomic DNA. Translation: DAA04627.1. Different initiation.
    CCDSiCCDS35126.1.
    RefSeqiNP_001004450.1. NM_001004450.1.
    UniGeneiHs.553710.

    Genome annotation databases

    EnsembliENST00000304833; ENSP00000303151; ENSG00000171484.
    GeneIDi347169.
    KEGGihsa:347169.
    UCSCiuc011lyz.2. human.

    Polymorphism databases

    DMDMi166214963.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065723 Genomic DNA. Translation: BAC05944.1 .
    AL162254 Genomic DNA. Translation: CAI16289.1 . Different initiation.
    BK004229 Genomic DNA. Translation: DAA04627.1 . Different initiation.
    CCDSi CCDS35126.1.
    RefSeqi NP_001004450.1. NM_001004450.1.
    UniGenei Hs.553710.

    3D structure databases

    ProteinModelPortali Q8NGR6.
    SMRi Q8NGR6. Positions 28-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000303151.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 166214963.

    Proteomic databases

    PaxDbi Q8NGR6.
    PRIDEi Q8NGR6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304833 ; ENSP00000303151 ; ENSG00000171484 .
    GeneIDi 347169.
    KEGGi hsa:347169.
    UCSCi uc011lyz.2. human.

    Organism-specific databases

    CTDi 347169.
    GeneCardsi GC09M125390.
    HGNCi HGNC:8181. OR1B1.
    HPAi HPA058654.
    neXtProti NX_Q8NGR6.
    PharmGKBi PA32055.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46614.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGR6.
    KOi K04257.
    OMAi VLLISWD.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGR6.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1B1.
    GenomeRNAii 347169.
    NextBioi 99059.
    PROi Q8NGR6.

    Gene expression databases

    CleanExi HS_OR1B1.
    Genevestigatori Q8NGR6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
    5. Cited for: POLYMORPHISM.

    Entry informationi

    Entry nameiOR1B1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGR6
    Secondary accession number(s): Q6IFN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3