Q8NGR6 (OR1B1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 1B1

Alternative name(s):
Olfactory receptor 9-B
Short name=OR9-B
Olfactory receptor OR9-26

Gene names

Name:

OR1B1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Polymorphism	A stop codon at position Arg-192 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence CAI16289.1 differs from that shown. Reason: Erroneous initiation. The sequence DAA04627.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Olfactory receptor 1B1		PRO_0000150416
Regions
	Topological domain	1 – 30	30	Extracellular Potential
	Transmembrane	31 – 51	21	Helical; Name=1; Potential
	Topological domain	52 – 67	16	Cytoplasmic Potential
	Transmembrane	68 – 88	21	Helical; Name=2; Potential
	Topological domain	89 – 99	11	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 145	25	Cytoplasmic Potential
	Transmembrane	146 – 166	21	Helical; Name=4; Potential
	Topological domain	167 – 202	36	Extracellular Potential
	Transmembrane	203 – 223	21	Helical; Name=5; Potential
	Topological domain	224 – 249	26	Cytoplasmic Potential
	Transmembrane	250 – 270	21	Helical; Name=6; Potential
	Topological domain	271 – 277	7	Extracellular Potential
	Transmembrane	278 – 298	21	Helical; Name=7; Potential
	Topological domain	299 – 318	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Glycosylation	23	1	N-linked (GlcNAc...) Potential
	Disulfide bond	99 ↔ 185		By similarity
Natural variations
	Natural variant	149	1	L → S. Corresponds to variant rs1536929 [ dbSNP | Ensembl ].		VAR_053114
	Natural variant	230	1	A → T. Corresponds to variant rs1476859 [ dbSNP | Ensembl ].		VAR_053115
	Natural variant	263	1	C → W. Corresponds to variant rs1476858 [ dbSNP | Ensembl ].		VAR_053116
	Natural variant	314	1	V → G. Corresponds to variant rs1556189 [ dbSNP | Ensembl ].		VAR_053117

Sequences

	Sequence		Length	Mass (Da)
	Q8NGR6 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 0CA0D7808259807B	FASTA	318	35,293
	10 20 30 40 50 60 MMSFAPNASH SPVFLLLGFS RANISYTLLF FLFLAIYLTT ILGNVTLVLL ISWDSRLHSP 70 80 90 100 110 120 MYYLLRGLSV IDMGLSTVTL PQLLAHLVSH YPTIPAARCL AQFFFFYAFG VTDTLVIAVM 130 140 150 160 170 180 ALDRYVAICD PLHYALVMNH QRCACLLALS WVVSILHTML RVGLVLPLCW TGDAGGNVNL 190 200 210 220 230 240 PHFFCDHRPL LRASCSDIHS NELAIFFEGG FLMLGPCALI VLSYVRIGAA ILRLPSAAGR 250 260 270 280 290 300 RRAVSTCGSH LTMVGFLYGT IICVYFQPPF QNSQYQDMVA SVMYTAITPL ANPFVYSLHN 310 KDVKGALCRL LEWVKVDP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[5]	"Different noses for different people." Menashe I., Man O., Lancet D., Gilad Y. Nat. Genet. 34:143-144(2003) [PubMed] [Europe PMC] [Abstract] Cited for: POLYMORPHISM.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065723 Genomic DNA. Translation: BAC05944.1. AL162254 Genomic DNA. Translation: CAI16289.1. Different initiation. BK004229 Genomic DNA. Translation: DAA04627.1. Different initiation.
IPI	IPI00169100.
RefSeq	NP_001004450.1. NM_001004450.1.
UniGene	Hs.553710.
3D structure databases
ProteinModelPortal	Q8NGR6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000303151.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	166214963.
Proteomic databases
PaxDb	Q8NGR6.
PRIDE	Q8NGR6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304833; ENSP00000303151; ENSG00000171484.
GeneID	347169.
KEGG	hsa:347169.
UCSC	uc011lyz.2. human.
Organism-specific databases
CTD	347169.
GeneCards	GC09M125390.
HGNC	HGNC:8181. OR1B1.
neXtProt	NX_Q8NGR6.
PharmGKB	PA32055.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46614.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q8NGR6.
KO	K04257.
OMA	VLLISWD.
OrthoDB	EOG437RFB.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR1B1.
Genevestigator	Q8NGR6.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	347169.
NextBio	99059.

Entry information

Entry name

OR1B1_HUMAN

Accession

Primary (citable) accession number: Q8NGR6
Secondary accession number(s): Q6IFN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.