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Protein

Olfactory receptor 1B1

Gene

OR1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
  3. transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception Source: GO_Central
  2. G-protein coupled receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1B1
Alternative name(s):
Olfactory receptor 9-B
Short name:
OR9-B
Olfactory receptor OR9-26
Gene namesi
Name:OR1B1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8181. OR1B1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini52 – 6716CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini89 – 9911ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 14525CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei146 – 16621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini167 – 20236ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini224 – 24926CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei250 – 27021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini271 – 2777ExtracellularSequence Analysis
Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini299 – 31820CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32055.

Polymorphism and mutation databases

BioMutaiOR1B1.
DMDMi166214963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 1B1PRO_0000150416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 185PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR6.
PRIDEiQ8NGR6.

Expressioni

Gene expression databases

CleanExiHS_OR1B1.
GenevestigatoriQ8NGR6.

Organism-specific databases

HPAiHPA058654.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303151.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR6.
SMRiQ8NGR6. Positions 28-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46614.
GeneTreeiENSGT00730000111535.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR6.
KOiK04257.
OMAiVLLISWD.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGR6.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSFAPNASH SPVFLLLGFS RANISYTLLF FLFLAIYLTT ILGNVTLVLL
60 70 80 90 100
ISWDSRLHSP MYYLLRGLSV IDMGLSTVTL PQLLAHLVSH YPTIPAARCL
110 120 130 140 150
AQFFFFYAFG VTDTLVIAVM ALDRYVAICD PLHYALVMNH QRCACLLALS
160 170 180 190 200
WVVSILHTML RVGLVLPLCW TGDAGGNVNL PHFFCDHRPL LRASCSDIHS
210 220 230 240 250
NELAIFFEGG FLMLGPCALI VLSYVRIGAA ILRLPSAAGR RRAVSTCGSH
260 270 280 290 300
LTMVGFLYGT IICVYFQPPF QNSQYQDMVA SVMYTAITPL ANPFVYSLHN
310
KDVKGALCRL LEWVKVDP
Length:318
Mass (Da):35,293
Last modified:January 15, 2008 - v2
Checksum:i0CA0D7808259807B
GO

Sequence cautioni

The sequence CAI16289.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence DAA04627.1 differs from that shown. Reason: Erroneous initiation. Curated

Polymorphismi

A stop codon at position Arg-192 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491L → S.
Corresponds to variant rs1536929 [ dbSNP | Ensembl ].
VAR_053114
Natural varianti230 – 2301A → T.
Corresponds to variant rs1476859 [ dbSNP | Ensembl ].
VAR_053115
Natural varianti263 – 2631C → W.
Corresponds to variant rs1476858 [ dbSNP | Ensembl ].
VAR_053116
Natural varianti314 – 3141V → G.
Corresponds to variant rs1556189 [ dbSNP | Ensembl ].
VAR_053117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065723 Genomic DNA. Translation: BAC05944.1.
AL162254 Genomic DNA. Translation: CAI16289.1. Different initiation.
BK004229 Genomic DNA. Translation: DAA04627.1. Different initiation.
CCDSiCCDS35126.1.
RefSeqiNP_001004450.1. NM_001004450.1.
UniGeneiHs.553710.

Genome annotation databases

EnsembliENST00000304833; ENSP00000303151; ENSG00000171484.
ENST00000623530; ENSP00000485577; ENSG00000280094.
ENST00000624439; ENSP00000485111; ENSG00000280094.
GeneIDi347169.
KEGGihsa:347169.
UCSCiuc011lyz.2. human.

Polymorphism and mutation databases

BioMutaiOR1B1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065723 Genomic DNA. Translation: BAC05944.1.
AL162254 Genomic DNA. Translation: CAI16289.1. Different initiation.
BK004229 Genomic DNA. Translation: DAA04627.1. Different initiation.
CCDSiCCDS35126.1.
RefSeqiNP_001004450.1. NM_001004450.1.
UniGeneiHs.553710.

3D structure databases

ProteinModelPortaliQ8NGR6.
SMRiQ8NGR6. Positions 28-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303151.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR1B1.
DMDMi166214963.

Proteomic databases

PaxDbiQ8NGR6.
PRIDEiQ8NGR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304833; ENSP00000303151; ENSG00000171484.
ENST00000623530; ENSP00000485577; ENSG00000280094.
ENST00000624439; ENSP00000485111; ENSG00000280094.
GeneIDi347169.
KEGGihsa:347169.
UCSCiuc011lyz.2. human.

Organism-specific databases

CTDi347169.
GeneCardsiGC09M125390.
HGNCiHGNC:8181. OR1B1.
HPAiHPA058654.
neXtProtiNX_Q8NGR6.
PharmGKBiPA32055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46614.
GeneTreeiENSGT00730000111535.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR6.
KOiK04257.
OMAiVLLISWD.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGR6.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1B1.
GenomeRNAii347169.
NextBioi99059.
PROiQ8NGR6.

Gene expression databases

CleanExiHS_OR1B1.
GenevestigatoriQ8NGR6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  5. Cited for: POLYMORPHISM.

Entry informationi

Entry nameiOR1B1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR6
Secondary accession number(s): Q6IFN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 15, 2008
Last modified: April 29, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.