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Q8NGR6

- OR1B1_HUMAN

UniProt

Q8NGR6 - OR1B1_HUMAN

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Protein

Olfactory receptor 1B1

Gene
OR1B1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1B1
Alternative name(s):
Olfactory receptor 9-B
Short name:
OR9-B
Olfactory receptor OR9-26
Gene namesi
Name:OR1B1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:8181. OR1B1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Extracellular Reviewed predictionAdd
BLAST
Transmembranei31 – 5121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini52 – 6716Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei68 – 8821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini89 – 9911Extracellular Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 14525Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei146 – 16621Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini167 – 20236Extracellular Reviewed predictionAdd
BLAST
Transmembranei203 – 22321Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini224 – 24926Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei250 – 27021Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini271 – 2777Extracellular Reviewed prediction
Transmembranei278 – 29821Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini299 – 31820Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 1B1PRO_0000150416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...) Reviewed prediction
Glycosylationi23 – 231N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi99 ↔ 185 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR6.
PRIDEiQ8NGR6.

Expressioni

Gene expression databases

CleanExiHS_OR1B1.
GenevestigatoriQ8NGR6.

Organism-specific databases

HPAiHPA058654.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303151.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR6.
SMRiQ8NGR6. Positions 28-311.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46614.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR6.
KOiK04257.
OMAiVLLISWD.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGR6.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR6-1 [UniParc]FASTAAdd to Basket

« Hide

MMSFAPNASH SPVFLLLGFS RANISYTLLF FLFLAIYLTT ILGNVTLVLL    50
ISWDSRLHSP MYYLLRGLSV IDMGLSTVTL PQLLAHLVSH YPTIPAARCL 100
AQFFFFYAFG VTDTLVIAVM ALDRYVAICD PLHYALVMNH QRCACLLALS 150
WVVSILHTML RVGLVLPLCW TGDAGGNVNL PHFFCDHRPL LRASCSDIHS 200
NELAIFFEGG FLMLGPCALI VLSYVRIGAA ILRLPSAAGR RRAVSTCGSH 250
LTMVGFLYGT IICVYFQPPF QNSQYQDMVA SVMYTAITPL ANPFVYSLHN 300
KDVKGALCRL LEWVKVDP 318
Length:318
Mass (Da):35,293
Last modified:January 15, 2008 - v2
Checksum:i0CA0D7808259807B
GO

Sequence cautioni

The sequence CAI16289.1 differs from that shown. Reason: Erroneous initiation.
The sequence DAA04627.1 differs from that shown. Reason: Erroneous initiation.

Polymorphismi

A stop codon at position Arg-192 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491L → S.
Corresponds to variant rs1536929 [ dbSNP | Ensembl ].
VAR_053114
Natural varianti230 – 2301A → T.
Corresponds to variant rs1476859 [ dbSNP | Ensembl ].
VAR_053115
Natural varianti263 – 2631C → W.
Corresponds to variant rs1476858 [ dbSNP | Ensembl ].
VAR_053116
Natural varianti314 – 3141V → G.
Corresponds to variant rs1556189 [ dbSNP | Ensembl ].
VAR_053117

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065723 Genomic DNA. Translation: BAC05944.1.
AL162254 Genomic DNA. Translation: CAI16289.1. Different initiation.
BK004229 Genomic DNA. Translation: DAA04627.1. Different initiation.
CCDSiCCDS35126.1.
RefSeqiNP_001004450.1. NM_001004450.1.
UniGeneiHs.553710.

Genome annotation databases

EnsembliENST00000304833; ENSP00000303151; ENSG00000171484.
GeneIDi347169.
KEGGihsa:347169.
UCSCiuc011lyz.2. human.

Polymorphism databases

DMDMi166214963.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065723 Genomic DNA. Translation: BAC05944.1 .
AL162254 Genomic DNA. Translation: CAI16289.1 . Different initiation.
BK004229 Genomic DNA. Translation: DAA04627.1 . Different initiation.
CCDSi CCDS35126.1.
RefSeqi NP_001004450.1. NM_001004450.1.
UniGenei Hs.553710.

3D structure databases

ProteinModelPortali Q8NGR6.
SMRi Q8NGR6. Positions 28-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000303151.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 166214963.

Proteomic databases

PaxDbi Q8NGR6.
PRIDEi Q8NGR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304833 ; ENSP00000303151 ; ENSG00000171484 .
GeneIDi 347169.
KEGGi hsa:347169.
UCSCi uc011lyz.2. human.

Organism-specific databases

CTDi 347169.
GeneCardsi GC09M125390.
HGNCi HGNC:8181. OR1B1.
HPAi HPA058654.
neXtProti NX_Q8NGR6.
PharmGKBi PA32055.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46614.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGR6.
KOi K04257.
OMAi VLLISWD.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGR6.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1B1.
GenomeRNAii 347169.
NextBioi 99059.
PROi Q8NGR6.

Gene expression databases

CleanExi HS_OR1B1.
Genevestigatori Q8NGR6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  5. Cited for: POLYMORPHISM.

Entry informationi

Entry nameiOR1B1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR6
Secondary accession number(s): Q6IFN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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