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Protein

Olfactory receptor 1L4

Gene

OR1L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1L4
Alternative name(s):
OST046
Olfactory receptor 1L5
Olfactory receptor 9-E
Short name:
OR9-E
Olfactory receptor OR9-29
Gene namesi
Name:OR1L4
Synonyms:OR1L5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136939.1
HGNCiHGNC:8216 OR1L4
neXtProtiNX_Q8NGR5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 50Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 101ExtracellularSequence analysisAdd BLAST21
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 159Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini160 – 197ExtracellularSequence analysisAdd BLAST38
Transmembranei198 – 220Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini221 – 237CytoplasmicSequence analysisAdd BLAST17
Transmembranei238 – 260Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini261 – 273ExtracellularSequence analysisAdd BLAST13
Transmembranei274 – 293Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini294 – 311CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136939
PharmGKBiPA32086

Polymorphism and mutation databases

BioMutaiOR1L4
DMDMi38372755

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504441 – 311Olfactory receptor 1L4Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR5
PeptideAtlasiQ8NGR5
PRIDEiQ8NGR5

PTM databases

iPTMnetiQ8NGR5
PhosphoSitePlusiQ8NGR5

Expressioni

Gene expression databases

BgeeiENSG00000136939
CleanExiHS_OR1L4

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000259466

Structurei

3D structure databases

ProteinModelPortaliQ8NGR5
SMRiQ8NGR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFXJ Eukaryota
ENOG41114P7 LUCA
GeneTreeiENSGT00910000144098
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGR5
KOiK04257
OMAiFFMALAN
OrthoDBiEOG091G0B53
PhylomeDBiQ8NGR5
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METKNYSSST SGFILLGLSS NPKLQKPLFA IFLIMYLLTA VGNVLIILAI
60 70 80 90 100
YSDPRLHTPM YFFLSNLSFM DICFTTVIVP KMLVNFLSET KIISYVGCLI
110 120 130 140 150
QMYFFMAFGN TDSYLLASMA IDRLVAICNP LHYDVVMKPW HCLLMLLGSC
160 170 180 190 200
SISHLHSLFR VLLMSRLSFC ASHIIKHFFC DTQPVLKLSC SDTSSSQMVV
210 220 230 240 250
MTETLAVIVT PFLCTIFSYL QIIVTVLRIP SAAGKWKAFS TCGSHLTVVV
260 270 280 290 300
LFYGSVIYVY FRPLSMYSVM KGRVATVMYT VVTPMLNPFI YSLRNKDMKR
310
GLKKLRHRIY S
Length:311
Mass (Da):35,277
Last modified:October 1, 2002 - v1
Checksum:i2CF7C78F0D435399
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053124234G → R1 PublicationCorresponds to variant dbSNP:rs2215530Ensembl.1
Natural variantiVAR_053125310Y → H. Corresponds to variant dbSNP:rs12341025Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065724 Genomic DNA Translation: BAC05945.1
AF399562 Genomic DNA Translation: AAK95047.1
BK004232 Genomic DNA Translation: DAA04630.1
CCDSiCCDS35129.1
RefSeqiNP_001005235.1, NM_001005235.1
UniGeneiHs.626838

Genome annotation databases

EnsembliENST00000259466; ENSP00000259466; ENSG00000136939
GeneIDi254973
KEGGihsa:254973
UCSCiuc004bmu.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR1L4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR5
Secondary accession number(s): Q6IFN0, Q96R81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome