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Protein

Olfactory receptor 5C1

Gene

OR5C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5C1
Alternative name(s):
Olfactory receptor 5C2
Olfactory receptor 9-F
Short name:
OR9-F
Gene namesi
Name:OR5C1
Synonyms:OR5C2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8331. OR5C1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence analysisAdd
BLAST
Transmembranei30 – 5021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini51 – 588CytoplasmicSequence analysis
Transmembranei59 – 7921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10324ExtracellularSequence analysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 14319CytoplasmicSequence analysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini165 – 20036ExtracellularSequence analysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini222 – 24120CytoplasmicSequence analysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini263 – 27513ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini297 – 32024CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32511.

Polymorphism and mutation databases

BioMutaiOR5C1.
DMDMi38372754.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 5C1PRO_0000150590Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR4.
PRIDEiQ8NGR4.

Expressioni

Gene expression databases

CleanExiHS_OR5C1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362784.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR4.
SMRiQ8NGR4. Positions 113-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JATY. Eukaryota.
ENOG4111ATB. LUCA.
GeneTreeiENSGT00760000118942.
HOVERGENiHBG017625.
InParanoidiQ8NGR4.
KOiK04257.
OMAiASTCCSH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGR4.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSENLTRAA VAPAEFVLLG ITNRWDLRVA LFLTCLPVYL VSLLGNMGMA
60 70 80 90 100
LLIRMDARLH TPMYFFLANL SLLDACYSSA IGPKMLVDLL LPRATIPYTA
110 120 130 140 150
CALQMFVFAG LADTECCLLA AMAYDRYVAI RNPLLYTTAM SQRLCLALLG
160 170 180 190 200
ASGLGGAVSA FVHTTLTFRL SFCRSRKINS FFCDIPPLLA ISCSDTSLNE
210 220 230 240 250
LLLFAICGFI QTATVLAITV SYGFIAGAVI HMRSVEGSRR AASTGGSHLT
260 270 280 290 300
AVAMMYGTLI FMYLRPSSSY ALDTDKMASV FYTLVIPSLN PLIYSLRNKE
310 320
VKEALRQTWS RFHCPGQGSQ
Length:320
Mass (Da):34,991
Last modified:October 1, 2002 - v1
Checksum:iBFEFBCE40A988BD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065725 Genomic DNA. Translation: BAC05946.1.
BC136700 mRNA. Translation: AAI36701.1.
BC136701 mRNA. Translation: AAI36702.1.
AF399514 Genomic DNA. Translation: AAK94999.1.
CCDSiCCDS35131.1.
RefSeqiNP_001001923.1. NM_001001923.1.
UniGeneiHs.534761.

Genome annotation databases

EnsembliENST00000373680; ENSP00000362784; ENSG00000148215.
GeneIDi392391.
KEGGihsa:392391.
UCSCiuc011lzd.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065725 Genomic DNA. Translation: BAC05946.1.
BC136700 mRNA. Translation: AAI36701.1.
BC136701 mRNA. Translation: AAI36702.1.
AF399514 Genomic DNA. Translation: AAK94999.1.
CCDSiCCDS35131.1.
RefSeqiNP_001001923.1. NM_001001923.1.
UniGeneiHs.534761.

3D structure databases

ProteinModelPortaliQ8NGR4.
SMRiQ8NGR4. Positions 113-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362784.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5C1.
DMDMi38372754.

Proteomic databases

PaxDbiQ8NGR4.
PRIDEiQ8NGR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373680; ENSP00000362784; ENSG00000148215.
GeneIDi392391.
KEGGihsa:392391.
UCSCiuc011lzd.2. human.

Organism-specific databases

CTDi392391.
GeneCardsiOR5C1.
HGNCiHGNC:8331. OR5C1.
neXtProtiNX_Q8NGR4.
PharmGKBiPA32511.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JATY. Eukaryota.
ENOG4111ATB. LUCA.
GeneTreeiENSGT00760000118942.
HOVERGENiHBG017625.
InParanoidiQ8NGR4.
KOiK04257.
OMAiASTCCSH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGR4.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5C1.
GenomeRNAii392391.
PROiQ8NGR4.

Gene expression databases

CleanExiHS_OR5C1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5C1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR4
Secondary accession number(s): B2RN54, B9EGT0, Q96RC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.