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Protein

Olfactory receptor 1K1

Gene

OR1K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165204-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1K1
Gene namesi
Name:OR1K1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8212. OR1K1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 50Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 101ExtracellularSequence analysisAdd BLAST21
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 159Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini160 – 197ExtracellularSequence analysisAdd BLAST38
Transmembranei198 – 220Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini221 – 237CytoplasmicSequence analysisAdd BLAST17
Transmembranei238 – 260Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini261 – 273ExtracellularSequence analysisAdd BLAST13
Transmembranei274 – 293Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini294 – 316CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi392392.
OpenTargetsiENSG00000165204.
PharmGKBiPA32083.

Polymorphism and mutation databases

BioMutaiOR1K1.
DMDMi38372753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504411 – 316Olfactory receptor 1K1Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR3.
PRIDEiQ8NGR3.
TopDownProteomicsiQ8NGR3.

PTM databases

iPTMnetiQ8NGR3.
PhosphoSitePlusiQ8NGR3.

Expressioni

Gene expression databases

CleanExiHS_OR1K1.
ExpressionAtlasiQ8NGR3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277309.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR3.
SMRiQ8NGR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEJ3. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGR3.
KOiK04257.
OMAiSDTRHIQ.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NGR3.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAANESSEG ISFVLLGLTT SPGQQRPLFV LFLLLYVASL LGNGLIVAAI
60 70 80 90 100
QASPALHAPM YFLLAHLSFA DLCFASVTVP KMLANLLAHD HSISLAGCLT
110 120 130 140 150
QMYFFFALGV TDSCLLAAMA YDCYVAIRHP LPYATRMSRA MCAALVGMAW
160 170 180 190 200
LVSHVHSLLY ILLMARLSFC ASHQVPHFFC DHQPLLRLSC SDTHHIQLLI
210 220 230 240 250
FTEGAAVVVT PFLLILASYG AIAAAVLQLP SASGRLRAVS TCGSHLAVVS
260 270 280 290 300
LFYGTVIAVY FQATSRREAE WGRVATVMYT VVTPMLNPII YSLWNRDVQG
310
ALRALLIGRR ISASDS
Length:316
Mass (Da):34,268
Last modified:October 1, 2002 - v1
Checksum:i8FF1AFABF955971A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034168271W → R.Corresponds to variant rs7046603dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065726 Genomic DNA. Translation: BAC05947.1.
AL359512 Genomic DNA. Translation: CAI94957.1.
CH471090 Genomic DNA. Translation: EAW87545.1.
BC137033 mRNA. Translation: AAI37034.1.
BC137034 mRNA. Translation: AAI37035.1.
AF399622 Genomic DNA. Translation: AAK95107.1.
CCDSiCCDS35132.1.
RefSeqiNP_543135.1. NM_080859.1.
UniGeneiHs.632681.

Genome annotation databases

EnsembliENST00000277309; ENSP00000277309; ENSG00000165204.
GeneIDi392392.
KEGGihsa:392392.
UCSCiuc011lze.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065726 Genomic DNA. Translation: BAC05947.1.
AL359512 Genomic DNA. Translation: CAI94957.1.
CH471090 Genomic DNA. Translation: EAW87545.1.
BC137033 mRNA. Translation: AAI37034.1.
BC137034 mRNA. Translation: AAI37035.1.
AF399622 Genomic DNA. Translation: AAK95107.1.
CCDSiCCDS35132.1.
RefSeqiNP_543135.1. NM_080859.1.
UniGeneiHs.632681.

3D structure databases

ProteinModelPortaliQ8NGR3.
SMRiQ8NGR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000277309.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGR3.
PhosphoSitePlusiQ8NGR3.

Polymorphism and mutation databases

BioMutaiOR1K1.
DMDMi38372753.

Proteomic databases

PaxDbiQ8NGR3.
PRIDEiQ8NGR3.
TopDownProteomicsiQ8NGR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277309; ENSP00000277309; ENSG00000165204.
GeneIDi392392.
KEGGihsa:392392.
UCSCiuc011lze.2. human.

Organism-specific databases

CTDi392392.
DisGeNETi392392.
GeneCardsiOR1K1.
H-InvDBHIX0169374.
HGNCiHGNC:8212. OR1K1.
neXtProtiNX_Q8NGR3.
OpenTargetsiENSG00000165204.
PharmGKBiPA32083.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEJ3. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGR3.
KOiK04257.
OMAiSDTRHIQ.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NGR3.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165204-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1K1.
GenomeRNAii392392.
PROiQ8NGR3.

Gene expression databases

CleanExiHS_OR1K1.
ExpressionAtlasiQ8NGR3. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1K1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR3
Secondary accession number(s): B9EH41, Q4VXB7, Q96R23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.