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Protein

Olfactory receptor 1K1

Gene

OR1K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1K1
Gene namesi
Name:OR1K1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000165204.3
HGNCiHGNC:8212 OR1K1
neXtProtiNX_Q8NGR3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 50Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 101ExtracellularSequence analysisAdd BLAST21
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 159Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini160 – 197ExtracellularSequence analysisAdd BLAST38
Transmembranei198 – 220Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini221 – 237CytoplasmicSequence analysisAdd BLAST17
Transmembranei238 – 260Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini261 – 273ExtracellularSequence analysisAdd BLAST13
Transmembranei274 – 293Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini294 – 316CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi392392
PharmGKBiPA32083

Polymorphism and mutation databases

BioMutaiOR1K1
DMDMi38372753

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504411 – 316Olfactory receptor 1K1Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR3
PRIDEiQ8NGR3
TopDownProteomicsiQ8NGR3

PTM databases

iPTMnetiQ8NGR3
PhosphoSitePlusiQ8NGR3

Expressioni

Gene expression databases

BgeeiENSG00000165204
CleanExiHS_OR1K1
ExpressionAtlasiQ8NGR3 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277309

Structurei

3D structure databases

ProteinModelPortaliQ8NGR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEJ3 Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00910000144098
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NGR3
KOiK04257
OMAiSDTRHIQ
OrthoDBiEOG091G0B53
PhylomeDBiQ8NGR3
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAANESSEG ISFVLLGLTT SPGQQRPLFV LFLLLYVASL LGNGLIVAAI
60 70 80 90 100
QASPALHAPM YFLLAHLSFA DLCFASVTVP KMLANLLAHD HSISLAGCLT
110 120 130 140 150
QMYFFFALGV TDSCLLAAMA YDCYVAIRHP LPYATRMSRA MCAALVGMAW
160 170 180 190 200
LVSHVHSLLY ILLMARLSFC ASHQVPHFFC DHQPLLRLSC SDTHHIQLLI
210 220 230 240 250
FTEGAAVVVT PFLLILASYG AIAAAVLQLP SASGRLRAVS TCGSHLAVVS
260 270 280 290 300
LFYGTVIAVY FQATSRREAE WGRVATVMYT VVTPMLNPII YSLWNRDVQG
310
ALRALLIGRR ISASDS
Length:316
Mass (Da):34,268
Last modified:October 1, 2002 - v1
Checksum:i8FF1AFABF955971A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034168271W → R. Corresponds to variant dbSNP:rs7046603Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065726 Genomic DNA Translation: BAC05947.1
AL359512 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87545.1
BC137033 mRNA Translation: AAI37034.1
BC137034 mRNA Translation: AAI37035.1
AF399622 Genomic DNA Translation: AAK95107.1
CCDSiCCDS35132.1
RefSeqiNP_543135.1, NM_080859.1
UniGeneiHs.632681

Genome annotation databases

EnsembliENST00000277309; ENSP00000277309; ENSG00000165204
GeneIDi392392
KEGGihsa:392392
UCSCiuc011lze.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR1K1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR3
Secondary accession number(s): B9EH41, Q4VXB7, Q96R23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome