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Protein

Olfactory receptor 1K1

Gene

OR1K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1K1
Gene namesi
Name:OR1K1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8212. OR1K1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence analysisAdd
BLAST
Transmembranei27 – 5024Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini51 – 588CytoplasmicSequence analysis
Transmembranei59 – 8022Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 10121ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12120Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 15919Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini160 – 19738ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 22023Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini221 – 23717CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 26023Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27313ExtracellularSequence analysisAdd
BLAST
Transmembranei274 – 29320Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini294 – 31623CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32083.

Polymorphism and mutation databases

BioMutaiOR1K1.
DMDMi38372753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 1K1PRO_0000150441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR3.
PeptideAtlasiQ8NGR3.
PRIDEiQ8NGR3.
TopDownProteomicsiQ8NGR3.

PTM databases

iPTMnetiQ8NGR3.
PhosphoSiteiQ8NGR3.

Expressioni

Gene expression databases

BgeeiQ8NGR3.
CleanExiHS_OR1K1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277309.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR3.
SMRiQ8NGR3. Positions 13-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEJ3. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00810000125381.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGR3.
KOiK04257.
OMAiSDTRHIQ.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGR3.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAANESSEG ISFVLLGLTT SPGQQRPLFV LFLLLYVASL LGNGLIVAAI
60 70 80 90 100
QASPALHAPM YFLLAHLSFA DLCFASVTVP KMLANLLAHD HSISLAGCLT
110 120 130 140 150
QMYFFFALGV TDSCLLAAMA YDCYVAIRHP LPYATRMSRA MCAALVGMAW
160 170 180 190 200
LVSHVHSLLY ILLMARLSFC ASHQVPHFFC DHQPLLRLSC SDTHHIQLLI
210 220 230 240 250
FTEGAAVVVT PFLLILASYG AIAAAVLQLP SASGRLRAVS TCGSHLAVVS
260 270 280 290 300
LFYGTVIAVY FQATSRREAE WGRVATVMYT VVTPMLNPII YSLWNRDVQG
310
ALRALLIGRR ISASDS
Length:316
Mass (Da):34,268
Last modified:October 1, 2002 - v1
Checksum:i8FF1AFABF955971A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti271 – 2711W → R.
Corresponds to variant rs7046603 [ dbSNP | Ensembl ].
VAR_034168

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065726 Genomic DNA. Translation: BAC05947.1.
AL359512 Genomic DNA. Translation: CAI94957.1.
CH471090 Genomic DNA. Translation: EAW87545.1.
BC137033 mRNA. Translation: AAI37034.1.
BC137034 mRNA. Translation: AAI37035.1.
AF399622 Genomic DNA. Translation: AAK95107.1.
CCDSiCCDS35132.1.
RefSeqiNP_543135.1. NM_080859.1.
UniGeneiHs.632681.

Genome annotation databases

EnsembliENST00000277309; ENSP00000277309; ENSG00000165204.
GeneIDi392392.
KEGGihsa:392392.
UCSCiuc011lze.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065726 Genomic DNA. Translation: BAC05947.1.
AL359512 Genomic DNA. Translation: CAI94957.1.
CH471090 Genomic DNA. Translation: EAW87545.1.
BC137033 mRNA. Translation: AAI37034.1.
BC137034 mRNA. Translation: AAI37035.1.
AF399622 Genomic DNA. Translation: AAK95107.1.
CCDSiCCDS35132.1.
RefSeqiNP_543135.1. NM_080859.1.
UniGeneiHs.632681.

3D structure databases

ProteinModelPortaliQ8NGR3.
SMRiQ8NGR3. Positions 13-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000277309.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGR3.
PhosphoSiteiQ8NGR3.

Polymorphism and mutation databases

BioMutaiOR1K1.
DMDMi38372753.

Proteomic databases

PaxDbiQ8NGR3.
PeptideAtlasiQ8NGR3.
PRIDEiQ8NGR3.
TopDownProteomicsiQ8NGR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277309; ENSP00000277309; ENSG00000165204.
GeneIDi392392.
KEGGihsa:392392.
UCSCiuc011lze.2. human.

Organism-specific databases

CTDi392392.
GeneCardsiOR1K1.
H-InvDBHIX0169374.
HGNCiHGNC:8212. OR1K1.
neXtProtiNX_Q8NGR3.
PharmGKBiPA32083.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEJ3. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00810000125381.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGR3.
KOiK04257.
OMAiSDTRHIQ.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGR3.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1K1.
GenomeRNAii392392.
PROiQ8NGR3.

Gene expression databases

BgeeiQ8NGR3.
CleanExiHS_OR1K1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.

Entry informationi

Entry nameiOR1K1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR3
Secondary accession number(s): B9EH41, Q4VXB7, Q96R23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.