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Q8NGR2 (OR1L6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1L6
Alternative name(s):
Olfactory receptor 1L7
Olfactory receptor OR9-30
Gene names
Name:OR1L6
Synonyms:OR1L7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-37 is the initiator.

Sequence caution

The sequence BAC05948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Olfactory receptor 1L6
PRO_0000150445

Regions

Topological domain1 – 6262Extracellular Potential
Transmembrane63 – 8624Helical; Name=1; Potential
Topological domain87 – 948Cytoplasmic Potential
Transmembrane95 – 11622Helical; Name=2; Potential
Topological domain117 – 13721Extracellular Potential
Transmembrane138 – 15720Helical; Name=3; Potential
Topological domain158 – 17619Cytoplasmic Potential
Transmembrane177 – 19519Helical; Name=4; Potential
Topological domain196 – 23338Extracellular Potential
Transmembrane234 – 25623Helical; Name=5; Potential
Topological domain257 – 27317Cytoplasmic Potential
Transmembrane274 – 29623Helical; Name=6; Potential
Topological domain297 – 30913Extracellular Potential
Transmembrane310 – 32920Helical; Name=7; Potential
Topological domain330 – 34718Cytoplasmic Potential

Amino acid modifications

Glycosylation411N-linked (GlcNAc...) Potential
Disulfide bond134 ↔ 226 By similarity

Natural variations

Natural variant591Q → K.
Corresponds to variant rs10760252 [ dbSNP | Ensembl ].
VAR_055056
Natural variant1861C → Y.
Corresponds to variant rs4838012 [ dbSNP | Ensembl ].
VAR_055057
Natural variant2511I → T.
Corresponds to variant rs10985760 [ dbSNP | Ensembl ].
VAR_055058
Natural variant2591M → I.
Corresponds to variant rs10818741 [ dbSNP | Ensembl ].
VAR_055059

Sequences

Sequence LengthMass (Da)Tools
Q8NGR2 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 12DBD2BBC6CD3270

FASTA34739,515
        10         20         30         40         50         60 
MSYFYRLKLM KEAVLVKLPF TSLPLLLQTL SRKSRDMEIK NYSSSTSGFI LLGLSSNPQL 

        70         80         90        100        110        120 
QKPLFAIFLI MYLLAAVGNV LIIPAIYSDP RLHTPMYFFL SNLSFMDICF TTVIVPKMLV 

       130        140        150        160        170        180 
NFLSETKVIS YVGCLAQMYF FMAFGNTDSY LLASMAIDRL VAICNPLHYD VVMKPRHCLL 

       190        200        210        220        230        240 
MLLGSCSISH LHSLFRVLLM SRLSFCASHI IKHFFCDTQP VLKLSCSDTS SSQMVVMTET 

       250        260        270        280        290        300 
LAVIVTPFLC IIFSYLRIMV TVLRIPSAAG KWKAFSTCGS HLTAVALFYG SIIYVYFRPL 

       310        320        330        340 
SMYSVVRDRV ATVMYTVVTP MLNPFIYSLR NKDMKRGLKK LQDRIYR 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 105-319.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065727 Genomic DNA. Translation: BAC05948.1. Different initiation.
AC006313 Genomic DNA. No translation available.
AF399563 Genomic DNA. Translation: AAK95048.1.
BK004234 Genomic DNA. Translation: DAA04632.1.
RefSeqNP_001004453.2. NM_001004453.2.
UniGeneHs.553790.

3D structure databases

ProteinModelPortalQ8NGR2.
SMRQ8NGR2. Positions 59-341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000362788.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGR2.

Polymorphism databases

DMDM229462929.

Proteomic databases

PaxDbQ8NGR2.
PRIDEQ8NGR2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304720; ENSP00000304235; ENSG00000171459.
ENST00000373684; ENSP00000362788; ENSG00000171459.
GeneID392390.
KEGGhsa:392390.
UCSCuc022bna.1. human.

Organism-specific databases

CTD392390.
GeneCardsGC09P125512.
HGNCHGNC:8218. OR1L6.
neXtProtNX_Q8NGR2.
PharmGKBPA32087.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44632.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGR2.
KOK04257.
OMADMEIKNY.
OrthoDBEOG7D85WJ.
PhylomeDBQ8NGR2.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR1L6.
GenevestigatorQ8NGR2.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1L6.
GenomeRNAi392390.
NextBio105142.
PROQ8NGR2.

Entry information

Entry nameOR1L6_HUMAN
AccessionPrimary (citable) accession number: Q8NGR2
Secondary accession number(s): Q6IFM8, Q96R80
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: June 11, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries