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Q8NGR2

- OR1L6_HUMAN

UniProt

Q8NGR2 - OR1L6_HUMAN

Protein

Olfactory receptor 1L6

Gene

OR1L6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1L6
    Alternative name(s):
    Olfactory receptor 1L7
    Olfactory receptor OR9-30
    Gene namesi
    Name:OR1L6
    Synonyms:OR1L7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:8218. OR1L6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32087.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Olfactory receptor 1L6PRO_0000150445Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi134 ↔ 226PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGR2.
    PRIDEiQ8NGR2.

    PTM databases

    PhosphoSiteiQ8NGR2.

    Expressioni

    Gene expression databases

    CleanExiHS_OR1L6.
    GenevestigatoriQ8NGR2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000362788.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGR2.
    SMRiQ8NGR2. Positions 59-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6262ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini87 – 948CytoplasmicSequence Analysis
    Topological domaini117 – 13721ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini158 – 17619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini196 – 23338ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini257 – 27317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini297 – 30913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini330 – 34718CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei63 – 8624Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei95 – 11622Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15720Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei177 – 19519Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25623Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29623Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei310 – 32920Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44632.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGR2.
    KOiK04257.
    OMAiDMEIKNY.
    OrthoDBiEOG7D85WJ.
    PhylomeDBiQ8NGR2.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYFYRLKLM KEAVLVKLPF TSLPLLLQTL SRKSRDMEIK NYSSSTSGFI    50
    LLGLSSNPQL QKPLFAIFLI MYLLAAVGNV LIIPAIYSDP RLHTPMYFFL 100
    SNLSFMDICF TTVIVPKMLV NFLSETKVIS YVGCLAQMYF FMAFGNTDSY 150
    LLASMAIDRL VAICNPLHYD VVMKPRHCLL MLLGSCSISH LHSLFRVLLM 200
    SRLSFCASHI IKHFFCDTQP VLKLSCSDTS SSQMVVMTET LAVIVTPFLC 250
    IIFSYLRIMV TVLRIPSAAG KWKAFSTCGS HLTAVALFYG SIIYVYFRPL 300
    SMYSVVRDRV ATVMYTVVTP MLNPFIYSLR NKDMKRGLKK LQDRIYR 347
    Length:347
    Mass (Da):39,515
    Last modified:May 5, 2009 - v2
    Checksum:i12DBD2BBC6CD3270
    GO

    Sequence cautioni

    The sequence BAC05948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591Q → K.
    Corresponds to variant rs10760252 [ dbSNP | Ensembl ].
    VAR_055056
    Natural varianti186 – 1861C → Y.
    Corresponds to variant rs4838012 [ dbSNP | Ensembl ].
    VAR_055057
    Natural varianti251 – 2511I → T.
    Corresponds to variant rs10985760 [ dbSNP | Ensembl ].
    VAR_055058
    Natural varianti259 – 2591M → I.
    Corresponds to variant rs10818741 [ dbSNP | Ensembl ].
    VAR_055059

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065727 Genomic DNA. Translation: BAC05948.1. Different initiation.
    AC006313 Genomic DNA. No translation available.
    AF399563 Genomic DNA. Translation: AAK95048.1.
    BK004234 Genomic DNA. Translation: DAA04632.1.
    RefSeqiNP_001004453.2. NM_001004453.2.
    UniGeneiHs.553790.

    Genome annotation databases

    EnsembliENST00000304720; ENSP00000304235; ENSG00000171459.
    ENST00000373684; ENSP00000362788; ENSG00000171459.
    GeneIDi392390.
    KEGGihsa:392390.
    UCSCiuc022bna.1. human.

    Polymorphism databases

    DMDMi229462929.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065727 Genomic DNA. Translation: BAC05948.1 . Different initiation.
    AC006313 Genomic DNA. No translation available.
    AF399563 Genomic DNA. Translation: AAK95048.1 .
    BK004234 Genomic DNA. Translation: DAA04632.1 .
    RefSeqi NP_001004453.2. NM_001004453.2.
    UniGenei Hs.553790.

    3D structure databases

    ProteinModelPortali Q8NGR2.
    SMRi Q8NGR2. Positions 59-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000362788.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGR2.

    Polymorphism databases

    DMDMi 229462929.

    Proteomic databases

    PaxDbi Q8NGR2.
    PRIDEi Q8NGR2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304720 ; ENSP00000304235 ; ENSG00000171459 .
    ENST00000373684 ; ENSP00000362788 ; ENSG00000171459 .
    GeneIDi 392390.
    KEGGi hsa:392390.
    UCSCi uc022bna.1. human.

    Organism-specific databases

    CTDi 392390.
    GeneCardsi GC09P125512.
    HGNCi HGNC:8218. OR1L6.
    neXtProti NX_Q8NGR2.
    PharmGKBi PA32087.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44632.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGR2.
    KOi K04257.
    OMAi DMEIKNY.
    OrthoDBi EOG7D85WJ.
    PhylomeDBi Q8NGR2.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1L6.
    GenomeRNAii 392390.
    NextBioi 105142.
    PROi Q8NGR2.

    Gene expression databases

    CleanExi HS_OR1L6.
    Genevestigatori Q8NGR2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 105-319.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR1L6_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGR2
    Secondary accession number(s): Q6IFM8, Q96R80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-37 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3