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Q8NGR2

- OR1L6_HUMAN

UniProt

Q8NGR2 - OR1L6_HUMAN

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Protein

Olfactory receptor 1L6

Gene

OR1L6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1L6
Alternative name(s):
Olfactory receptor 1L7
Olfactory receptor OR9-30
Gene namesi
Name:OR1L6
Synonyms:OR1L7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:8218. OR1L6.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32087.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Olfactory receptor 1L6PRO_0000150445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi134 ↔ 226PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR2.
PRIDEiQ8NGR2.

PTM databases

PhosphoSiteiQ8NGR2.

Expressioni

Gene expression databases

CleanExiHS_OR1L6.
GenevestigatoriQ8NGR2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362788.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR2.
SMRiQ8NGR2. Positions 59-341.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262ExtracellularSequence AnalysisAdd
BLAST
Topological domaini87 – 948CytoplasmicSequence Analysis
Topological domaini117 – 13721ExtracellularSequence AnalysisAdd
BLAST
Topological domaini158 – 17619CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini196 – 23338ExtracellularSequence AnalysisAdd
BLAST
Topological domaini257 – 27317CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini297 – 30913ExtracellularSequence AnalysisAdd
BLAST
Topological domaini330 – 34718CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei63 – 8624Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei95 – 11622Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei138 – 15720Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei177 – 19519Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei234 – 25623Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei274 – 29623Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei310 – 32920Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44632.
GeneTreeiENSGT00760000119207.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR2.
KOiK04257.
OMAiDMEIKNY.
OrthoDBiEOG7D85WJ.
PhylomeDBiQ8NGR2.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYFYRLKLM KEAVLVKLPF TSLPLLLQTL SRKSRDMEIK NYSSSTSGFI
60 70 80 90 100
LLGLSSNPQL QKPLFAIFLI MYLLAAVGNV LIIPAIYSDP RLHTPMYFFL
110 120 130 140 150
SNLSFMDICF TTVIVPKMLV NFLSETKVIS YVGCLAQMYF FMAFGNTDSY
160 170 180 190 200
LLASMAIDRL VAICNPLHYD VVMKPRHCLL MLLGSCSISH LHSLFRVLLM
210 220 230 240 250
SRLSFCASHI IKHFFCDTQP VLKLSCSDTS SSQMVVMTET LAVIVTPFLC
260 270 280 290 300
IIFSYLRIMV TVLRIPSAAG KWKAFSTCGS HLTAVALFYG SIIYVYFRPL
310 320 330 340
SMYSVVRDRV ATVMYTVVTP MLNPFIYSLR NKDMKRGLKK LQDRIYR
Length:347
Mass (Da):39,515
Last modified:May 5, 2009 - v2
Checksum:i12DBD2BBC6CD3270
GO

Sequence cautioni

The sequence BAC05948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591Q → K.
Corresponds to variant rs10760252 [ dbSNP | Ensembl ].
VAR_055056
Natural varianti186 – 1861C → Y.
Corresponds to variant rs4838012 [ dbSNP | Ensembl ].
VAR_055057
Natural varianti251 – 2511I → T.
Corresponds to variant rs10985760 [ dbSNP | Ensembl ].
VAR_055058
Natural varianti259 – 2591M → I.
Corresponds to variant rs10818741 [ dbSNP | Ensembl ].
VAR_055059

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065727 Genomic DNA. Translation: BAC05948.1. Different initiation.
AC006313 Genomic DNA. No translation available.
AF399563 Genomic DNA. Translation: AAK95048.1.
BK004234 Genomic DNA. Translation: DAA04632.1.
RefSeqiNP_001004453.2. NM_001004453.2.
UniGeneiHs.553790.

Genome annotation databases

EnsembliENST00000304720; ENSP00000304235; ENSG00000171459.
ENST00000373684; ENSP00000362788; ENSG00000171459.
GeneIDi392390.
KEGGihsa:392390.
UCSCiuc022bna.1. human.

Polymorphism databases

DMDMi229462929.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065727 Genomic DNA. Translation: BAC05948.1 . Different initiation.
AC006313 Genomic DNA. No translation available.
AF399563 Genomic DNA. Translation: AAK95048.1 .
BK004234 Genomic DNA. Translation: DAA04632.1 .
RefSeqi NP_001004453.2. NM_001004453.2.
UniGenei Hs.553790.

3D structure databases

ProteinModelPortali Q8NGR2.
SMRi Q8NGR2. Positions 59-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000362788.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGR2.

Polymorphism databases

DMDMi 229462929.

Proteomic databases

PaxDbi Q8NGR2.
PRIDEi Q8NGR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304720 ; ENSP00000304235 ; ENSG00000171459 .
ENST00000373684 ; ENSP00000362788 ; ENSG00000171459 .
GeneIDi 392390.
KEGGi hsa:392390.
UCSCi uc022bna.1. human.

Organism-specific databases

CTDi 392390.
GeneCardsi GC09P125512.
HGNCi HGNC:8218. OR1L6.
neXtProti NX_Q8NGR2.
PharmGKBi PA32087.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44632.
GeneTreei ENSGT00760000119207.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGR2.
KOi K04257.
OMAi DMEIKNY.
OrthoDBi EOG7D85WJ.
PhylomeDBi Q8NGR2.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1L6.
GenomeRNAii 392390.
NextBioi 105142.
PROi Q8NGR2.

Gene expression databases

CleanExi HS_OR1L6.
Genevestigatori Q8NGR2.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 105-319.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1L6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR2
Secondary accession number(s): Q6IFM8, Q96R80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-37 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3