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Protein

Olfactory receptor 1L6

Gene

OR1L6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1L6
Alternative name(s):
Olfactory receptor 1L7
Olfactory receptor OR9-30
Gene namesi
Name:OR1L6
Synonyms:OR1L7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8218. OR1L6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262ExtracellularSequence AnalysisAdd
BLAST
Transmembranei63 – 8624Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini87 – 948CytoplasmicSequence Analysis
Transmembranei95 – 11622Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini117 – 13721ExtracellularSequence AnalysisAdd
BLAST
Transmembranei138 – 15720Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini158 – 17619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei177 – 19519Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini196 – 23338ExtracellularSequence AnalysisAdd
BLAST
Transmembranei234 – 25623Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini257 – 27317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei274 – 29623Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini297 – 30913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei310 – 32920Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini330 – 34718CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32087.

Polymorphism and mutation databases

DMDMi229462929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Olfactory receptor 1L6PRO_0000150445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi134 ↔ 226PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR2.
PRIDEiQ8NGR2.

PTM databases

PhosphoSiteiQ8NGR2.

Expressioni

Gene expression databases

CleanExiHS_OR1L6.
GenevestigatoriQ8NGR2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362788.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR2.
SMRiQ8NGR2. Positions 59-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44632.
GeneTreeiENSGT00760000119207.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR2.
KOiK04257.
OMAiDMEIKNY.
OrthoDBiEOG7D85WJ.
PhylomeDBiQ8NGR2.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYFYRLKLM KEAVLVKLPF TSLPLLLQTL SRKSRDMEIK NYSSSTSGFI
60 70 80 90 100
LLGLSSNPQL QKPLFAIFLI MYLLAAVGNV LIIPAIYSDP RLHTPMYFFL
110 120 130 140 150
SNLSFMDICF TTVIVPKMLV NFLSETKVIS YVGCLAQMYF FMAFGNTDSY
160 170 180 190 200
LLASMAIDRL VAICNPLHYD VVMKPRHCLL MLLGSCSISH LHSLFRVLLM
210 220 230 240 250
SRLSFCASHI IKHFFCDTQP VLKLSCSDTS SSQMVVMTET LAVIVTPFLC
260 270 280 290 300
IIFSYLRIMV TVLRIPSAAG KWKAFSTCGS HLTAVALFYG SIIYVYFRPL
310 320 330 340
SMYSVVRDRV ATVMYTVVTP MLNPFIYSLR NKDMKRGLKK LQDRIYR
Length:347
Mass (Da):39,515
Last modified:May 5, 2009 - v2
Checksum:i12DBD2BBC6CD3270
GO

Sequence cautioni

The sequence BAC05948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591Q → K.
Corresponds to variant rs10760252 [ dbSNP | Ensembl ].
VAR_055056
Natural varianti186 – 1861C → Y.
Corresponds to variant rs4838012 [ dbSNP | Ensembl ].
VAR_055057
Natural varianti251 – 2511I → T.
Corresponds to variant rs10985760 [ dbSNP | Ensembl ].
VAR_055058
Natural varianti259 – 2591M → I.
Corresponds to variant rs10818741 [ dbSNP | Ensembl ].
VAR_055059

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065727 Genomic DNA. Translation: BAC05948.1. Different initiation.
AC006313 Genomic DNA. No translation available.
AF399563 Genomic DNA. Translation: AAK95048.1.
BK004234 Genomic DNA. Translation: DAA04632.1.
RefSeqiNP_001004453.2. NM_001004453.2.
UniGeneiHs.553790.

Genome annotation databases

EnsembliENST00000373684; ENSP00000362788; ENSG00000171459.
GeneIDi392390.
KEGGihsa:392390.
UCSCiuc022bna.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065727 Genomic DNA. Translation: BAC05948.1. Different initiation.
AC006313 Genomic DNA. No translation available.
AF399563 Genomic DNA. Translation: AAK95048.1.
BK004234 Genomic DNA. Translation: DAA04632.1.
RefSeqiNP_001004453.2. NM_001004453.2.
UniGeneiHs.553790.

3D structure databases

ProteinModelPortaliQ8NGR2.
SMRiQ8NGR2. Positions 59-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362788.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGR2.

Polymorphism and mutation databases

DMDMi229462929.

Proteomic databases

PaxDbiQ8NGR2.
PRIDEiQ8NGR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373684; ENSP00000362788; ENSG00000171459.
GeneIDi392390.
KEGGihsa:392390.
UCSCiuc022bna.1. human.

Organism-specific databases

CTDi392390.
GeneCardsiGC09P125512.
HGNCiHGNC:8218. OR1L6.
neXtProtiNX_Q8NGR2.
PharmGKBiPA32087.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44632.
GeneTreeiENSGT00760000119207.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR2.
KOiK04257.
OMAiDMEIKNY.
OrthoDBiEOG7D85WJ.
PhylomeDBiQ8NGR2.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1L6.
GenomeRNAii392390.
NextBioi105142.
PROiQ8NGR2.

Gene expression databases

CleanExiHS_OR1L6.
GenevestigatoriQ8NGR2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 105-319.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1L6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR2
Secondary accession number(s): Q6IFM8, Q96R80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: April 29, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-37 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.