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Protein

Olfactory receptor 1L6

Gene

OR1L6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1L6
Alternative name(s):
Olfactory receptor 1L7
Olfactory receptor OR9-30
Gene namesi
Name:OR1L6
Synonyms:OR1L7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000171459.3.
HGNCiHGNC:8218. OR1L6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62ExtracellularSequence analysisAdd BLAST62
Transmembranei63 – 86Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini87 – 94CytoplasmicSequence analysis8
Transmembranei95 – 116Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini117 – 137ExtracellularSequence analysisAdd BLAST21
Transmembranei138 – 157Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini158 – 176CytoplasmicSequence analysisAdd BLAST19
Transmembranei177 – 195Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini196 – 233ExtracellularSequence analysisAdd BLAST38
Transmembranei234 – 256Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini257 – 273CytoplasmicSequence analysisAdd BLAST17
Transmembranei274 – 296Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini297 – 309ExtracellularSequence analysisAdd BLAST13
Transmembranei310 – 329Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini330 – 347CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32087.

Polymorphism and mutation databases

DMDMi229462929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504451 – 347Olfactory receptor 1L6Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi134 ↔ 226PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR2.
PeptideAtlasiQ8NGR2.
PRIDEiQ8NGR2.

PTM databases

iPTMnetiQ8NGR2.
PhosphoSitePlusiQ8NGR2.

Expressioni

Gene expression databases

BgeeiENSG00000171459.
CleanExiHS_OR1L6.
ExpressionAtlasiQ8NGR2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304235.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFXJ. Eukaryota.
ENOG41114P7. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR2.
KOiK04257.
OMAiMSYFYRL.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NGR2.
TreeFamiTF337210.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NGR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYFYRLKLM KEAVLVKLPF TSLPLLLQTL SRKSRDMEIK NYSSSTSGFI
60 70 80 90 100
LLGLSSNPQL QKPLFAIFLI MYLLAAVGNV LIIPAIYSDP RLHTPMYFFL
110 120 130 140 150
SNLSFMDICF TTVIVPKMLV NFLSETKVIS YVGCLAQMYF FMAFGNTDSY
160 170 180 190 200
LLASMAIDRL VAICNPLHYD VVMKPRHCLL MLLGSCSISH LHSLFRVLLM
210 220 230 240 250
SRLSFCASHI IKHFFCDTQP VLKLSCSDTS SSQMVVMTET LAVIVTPFLC
260 270 280 290 300
IIFSYLRIMV TVLRIPSAAG KWKAFSTCGS HLTAVALFYG SIIYVYFRPL
310 320 330 340
SMYSVVRDRV ATVMYTVVTP MLNPFIYSLR NKDMKRGLKK LQDRIYR
Length:347
Mass (Da):39,515
Last modified:May 5, 2009 - v2
Checksum:i12DBD2BBC6CD3270
GO

Sequence cautioni

The sequence BAC05948 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05505659Q → K. Corresponds to variant dbSNP:rs10760252Ensembl.1
Natural variantiVAR_055057186C → Y. Corresponds to variant dbSNP:rs4838012Ensembl.1
Natural variantiVAR_055058251I → T. Corresponds to variant dbSNP:rs10985760Ensembl.1
Natural variantiVAR_055059259M → I. Corresponds to variant dbSNP:rs10818741Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065727 Genomic DNA. Translation: BAC05948.1. Different initiation.
AC006313 Genomic DNA. No translation available.
AF399563 Genomic DNA. Translation: AAK95048.1.
BK004234 Genomic DNA. Translation: DAA04632.1.
RefSeqiNP_001004453.2. NM_001004453.2.
UniGeneiHs.553790.

Genome annotation databases

EnsembliENST00000373684; ENSP00000362788; ENSG00000171459.
GeneIDi392390.
KEGGihsa:392390.
UCSCiuc022bna.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR1L6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR2
Secondary accession number(s): Q6IFM8, Q96R80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: September 27, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-37 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families