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Q8NGR1

- O13A1_HUMAN

UniProt

Q8NGR1 - O13A1_HUMAN

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Protein

Olfactory receptor 13A1

Gene

OR13A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13A1
Alternative name(s):
Olfactory receptor OR10-3
Gene namesi
Name:OR13A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:14772. OR13A1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Olfactory receptor 13A1PRO_0000150730Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR1.
PRIDEiQ8NGR1.

Expressioni

Gene expression databases

CleanExiHS_OR13A1.
GenevestigatoriQ8NGR1.

Organism-specific databases

HPAiHPA057237.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311379.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR1.
SMRiQ8NGR1. Positions 56-188.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
BLAST
Topological domaini65 – 728CytoplasmicSequence Analysis
Topological domaini94 – 11724ExtracellularSequence AnalysisAdd
BLAST
Topological domaini139 – 15719CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini179 – 21537ExtracellularSequence AnalysisAdd
BLAST
Topological domaini236 – 25520CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini277 – 28913ExtracellularSequence AnalysisAdd
BLAST
Topological domaini311 – 32818CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei118 – 13821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei216 – 23520Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei290 – 31021Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45616.
GeneTreeiENSGT00440000034500.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR1.
KOiK04257.
OMAiMESHLIV.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGR1.
TreeFamiTF337579.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLWMESHLI VPETRPSPRM MSNQTLVTEF ILQGFSEHPE YRVFLFSCFL
60 70 80 90 100
FLYSGALTGN VLITLAITFN PGLHAPMYFF LLNLATMDII CTSSIMPKAL
110 120 130 140 150
ASLVSEESSI SYGGCMAQLY FLTWAASSEL LLLTVMAYDR YAAICHPLHY
160 170 180 190 200
SSMMSKVFCS GLATAVWLLC AVNTAIHTGL MLRLDFCGPN VIIHFFCEVP
210 220 230 240 250
PLLLLSCSST YVNGVMIVLA DAFYGIVNFL MTIASYGFIV SSILKVKTAW
260 270 280 290 300
GRQKAFSTCS SHLTVVCMYY TAVFYAYISP VSGYSAGKSK LAGLLYTVLS
310 320
PTLNPLIYTL RNKEVKAALR KLFPFFRN
Length:328
Mass (Da):36,494
Last modified:May 5, 2009 - v2
Checksum:i809F36DB7592902E
GO

Sequence cautioni

The sequence BAC05949.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAH73801.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065728 Genomic DNA. Translation: BAC05949.1. Different initiation.
AK131555 mRNA. Translation: BAD18689.1.
AL512324 Genomic DNA. Translation: CAH73801.1. Different initiation.
CH471160 Genomic DNA. Translation: EAW86641.1.
BC104853 mRNA. Translation: AAI04854.1.
BC104855 mRNA. Translation: AAI04856.1.
BC143622 mRNA. Translation: AAI43623.1.
BK004287 Genomic DNA. Translation: DAA04685.1.
CCDSiCCDS31188.1.
RefSeqiNP_001004297.2. NM_001004297.2.
UniGeneiHs.532435.

Genome annotation databases

EnsembliENST00000374401; ENSP00000363522; ENSG00000256574.
ENST00000536058; ENSP00000438657; ENSG00000256574.
ENST00000553795; ENSP00000451950; ENSG00000256574.
ENST00000612185; ENSP00000484353; ENSG00000277495.
ENST00000615770; ENSP00000480319; ENSG00000277495.
ENST00000616267; ENSP00000483252; ENSG00000277495.
GeneIDi79290.
KEGGihsa:79290.
UCSCiuc001jcc.1. human.

Polymorphism databases

DMDMi229462928.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065728 Genomic DNA. Translation: BAC05949.1 . Different initiation.
AK131555 mRNA. Translation: BAD18689.1 .
AL512324 Genomic DNA. Translation: CAH73801.1 . Different initiation.
CH471160 Genomic DNA. Translation: EAW86641.1 .
BC104853 mRNA. Translation: AAI04854.1 .
BC104855 mRNA. Translation: AAI04856.1 .
BC143622 mRNA. Translation: AAI43623.1 .
BK004287 Genomic DNA. Translation: DAA04685.1 .
CCDSi CCDS31188.1.
RefSeqi NP_001004297.2. NM_001004297.2.
UniGenei Hs.532435.

3D structure databases

ProteinModelPortali Q8NGR1.
SMRi Q8NGR1. Positions 56-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000311379.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 229462928.

Proteomic databases

PaxDbi Q8NGR1.
PRIDEi Q8NGR1.

Protocols and materials databases

DNASUi 79290.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374401 ; ENSP00000363522 ; ENSG00000256574 .
ENST00000536058 ; ENSP00000438657 ; ENSG00000256574 .
ENST00000553795 ; ENSP00000451950 ; ENSG00000256574 .
ENST00000612185 ; ENSP00000484353 ; ENSG00000277495 .
ENST00000615770 ; ENSP00000480319 ; ENSG00000277495 .
ENST00000616267 ; ENSP00000483252 ; ENSG00000277495 .
GeneIDi 79290.
KEGGi hsa:79290.
UCSCi uc001jcc.1. human.

Organism-specific databases

CTDi 79290.
GeneCardsi GC10M045798.
HGNCi HGNC:14772. OR13A1.
HPAi HPA057237.
neXtProti NX_Q8NGR1.
PharmGKBi PA32030.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45616.
GeneTreei ENSGT00440000034500.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGR1.
KOi K04257.
OMAi MESHLIV.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGR1.
TreeFami TF337579.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR13A1.
GenomeRNAii 79290.
NextBioi 68244.
PROi Q8NGR1.

Gene expression databases

CleanExi HS_OR13A1.
Genevestigatori Q8NGR1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO13A1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR1
Secondary accession number(s): Q2M3M4
, Q5VV57, Q6IFH5, Q6ZMN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-20 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3