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Q8NGR1

- O13A1_HUMAN

UniProt

Q8NGR1 - O13A1_HUMAN

Protein

Olfactory receptor 13A1

Gene

OR13A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 13A1
    Alternative name(s):
    Olfactory receptor OR10-3
    Gene namesi
    Name:OR13A1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:14772. OR13A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32030.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Olfactory receptor 13A1PRO_0000150730Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi115 ↔ 207PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGR1.
    PRIDEiQ8NGR1.

    Expressioni

    Gene expression databases

    CleanExiHS_OR13A1.
    GenevestigatoriQ8NGR1.

    Organism-specific databases

    HPAiHPA057237.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000311379.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGR1.
    SMRiQ8NGR1. Positions 56-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini65 – 728CytoplasmicSequence Analysis
    Topological domaini94 – 11724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini139 – 15719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 21537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 25520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini277 – 28913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini311 – 32818CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 23520Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45616.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGR1.
    KOiK04257.
    OMAiMESHLIV.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGR1.
    TreeFamiTF337579.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGR1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLWMESHLI VPETRPSPRM MSNQTLVTEF ILQGFSEHPE YRVFLFSCFL    50
    FLYSGALTGN VLITLAITFN PGLHAPMYFF LLNLATMDII CTSSIMPKAL 100
    ASLVSEESSI SYGGCMAQLY FLTWAASSEL LLLTVMAYDR YAAICHPLHY 150
    SSMMSKVFCS GLATAVWLLC AVNTAIHTGL MLRLDFCGPN VIIHFFCEVP 200
    PLLLLSCSST YVNGVMIVLA DAFYGIVNFL MTIASYGFIV SSILKVKTAW 250
    GRQKAFSTCS SHLTVVCMYY TAVFYAYISP VSGYSAGKSK LAGLLYTVLS 300
    PTLNPLIYTL RNKEVKAALR KLFPFFRN 328
    Length:328
    Mass (Da):36,494
    Last modified:May 5, 2009 - v2
    Checksum:i809F36DB7592902E
    GO

    Sequence cautioni

    The sequence BAC05949.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAH73801.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065728 Genomic DNA. Translation: BAC05949.1. Different initiation.
    AK131555 mRNA. Translation: BAD18689.1.
    AL512324 Genomic DNA. Translation: CAH73801.1. Different initiation.
    CH471160 Genomic DNA. Translation: EAW86641.1.
    BC104853 mRNA. Translation: AAI04854.1.
    BC104855 mRNA. Translation: AAI04856.1.
    BC143622 mRNA. Translation: AAI43623.1.
    BK004287 Genomic DNA. Translation: DAA04685.1.
    CCDSiCCDS31188.1.
    RefSeqiNP_001004297.2. NM_001004297.2.
    UniGeneiHs.532435.

    Genome annotation databases

    EnsembliENST00000374401; ENSP00000363522; ENSG00000256574.
    ENST00000536058; ENSP00000438657; ENSG00000256574.
    ENST00000553795; ENSP00000451950; ENSG00000256574.
    GeneIDi79290.
    KEGGihsa:79290.
    UCSCiuc001jcc.1. human.

    Polymorphism databases

    DMDMi229462928.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065728 Genomic DNA. Translation: BAC05949.1 . Different initiation.
    AK131555 mRNA. Translation: BAD18689.1 .
    AL512324 Genomic DNA. Translation: CAH73801.1 . Different initiation.
    CH471160 Genomic DNA. Translation: EAW86641.1 .
    BC104853 mRNA. Translation: AAI04854.1 .
    BC104855 mRNA. Translation: AAI04856.1 .
    BC143622 mRNA. Translation: AAI43623.1 .
    BK004287 Genomic DNA. Translation: DAA04685.1 .
    CCDSi CCDS31188.1.
    RefSeqi NP_001004297.2. NM_001004297.2.
    UniGenei Hs.532435.

    3D structure databases

    ProteinModelPortali Q8NGR1.
    SMRi Q8NGR1. Positions 56-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000311379.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 229462928.

    Proteomic databases

    PaxDbi Q8NGR1.
    PRIDEi Q8NGR1.

    Protocols and materials databases

    DNASUi 79290.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374401 ; ENSP00000363522 ; ENSG00000256574 .
    ENST00000536058 ; ENSP00000438657 ; ENSG00000256574 .
    ENST00000553795 ; ENSP00000451950 ; ENSG00000256574 .
    GeneIDi 79290.
    KEGGi hsa:79290.
    UCSCi uc001jcc.1. human.

    Organism-specific databases

    CTDi 79290.
    GeneCardsi GC10M045798.
    HGNCi HGNC:14772. OR13A1.
    HPAi HPA057237.
    neXtProti NX_Q8NGR1.
    PharmGKBi PA32030.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45616.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGR1.
    KOi K04257.
    OMAi MESHLIV.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGR1.
    TreeFami TF337579.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR13A1.
    GenomeRNAii 79290.
    NextBioi 68244.
    PROi Q8NGR1.

    Gene expression databases

    CleanExi HS_OR13A1.
    Genevestigatori Q8NGR1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.
    6. Cited for: IDENTIFICATION.
    7. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO13A1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGR1
    Secondary accession number(s): Q2M3M4
    , Q5VV57, Q6IFH5, Q6ZMN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-20 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3