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Protein

Olfactory receptor 13A1

Gene

OR13A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13A1
Alternative name(s):
Olfactory receptor OR10-3
Gene namesi
Name:OR13A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:14772. OR13A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini65 – 728CytoplasmicSequence Analysis
Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini94 – 11724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei118 – 13821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini139 – 15719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini179 – 21537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 23520Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini236 – 25520CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini277 – 28913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei290 – 31021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini311 – 32818CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32030.

Polymorphism and mutation databases

BioMutaiOR13A1.
DMDMi229462928.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Olfactory receptor 13A1PRO_0000150730Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGR1.
PRIDEiQ8NGR1.

Expressioni

Gene expression databases

CleanExiHS_OR13A1.

Organism-specific databases

HPAiHPA057237.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363522.

Structurei

3D structure databases

ProteinModelPortaliQ8NGR1.
SMRiQ8NGR1. Positions 40-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45616.
GeneTreeiENSGT00440000034500.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR1.
KOiK04257.
OMAiFYGIVNF.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGR1.
TreeFamiTF337579.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLWMESHLI VPETRPSPRM MSNQTLVTEF ILQGFSEHPE YRVFLFSCFL
60 70 80 90 100
FLYSGALTGN VLITLAITFN PGLHAPMYFF LLNLATMDII CTSSIMPKAL
110 120 130 140 150
ASLVSEESSI SYGGCMAQLY FLTWAASSEL LLLTVMAYDR YAAICHPLHY
160 170 180 190 200
SSMMSKVFCS GLATAVWLLC AVNTAIHTGL MLRLDFCGPN VIIHFFCEVP
210 220 230 240 250
PLLLLSCSST YVNGVMIVLA DAFYGIVNFL MTIASYGFIV SSILKVKTAW
260 270 280 290 300
GRQKAFSTCS SHLTVVCMYY TAVFYAYISP VSGYSAGKSK LAGLLYTVLS
310 320
PTLNPLIYTL RNKEVKAALR KLFPFFRN
Length:328
Mass (Da):36,494
Last modified:May 5, 2009 - v2
Checksum:i809F36DB7592902E
GO

Sequence cautioni

The sequence BAC05949.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAH73801.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065728 Genomic DNA. Translation: BAC05949.1. Different initiation.
AK131555 mRNA. Translation: BAD18689.1.
AL512324 Genomic DNA. Translation: CAH73801.1. Different initiation.
CH471160 Genomic DNA. Translation: EAW86641.1.
BC104853 mRNA. Translation: AAI04854.1.
BC104855 mRNA. Translation: AAI04856.1.
BC143622 mRNA. Translation: AAI43623.1.
BK004287 Genomic DNA. Translation: DAA04685.1.
CCDSiCCDS31188.1.
RefSeqiNP_001004297.2. NM_001004297.2.
XP_011538447.1. XM_011540145.1.
XP_011538448.1. XM_011540146.1.
XP_011538449.1. XM_011540147.1.
XP_011538450.1. XM_011540148.1.
XP_011538451.1. XM_011540149.1.
XP_011538452.1. XM_011540150.1.
XP_011545284.1. XM_011546982.1.
XP_011545285.1. XM_011546983.1.
XP_011545286.1. XM_011546984.1.
XP_011545287.1. XM_011546985.1.
XP_011545288.1. XM_011546986.1.
XP_011545289.1. XM_011546987.1.
UniGeneiHs.532435.

Genome annotation databases

EnsembliENST00000374401; ENSP00000363522; ENSG00000256574.
ENST00000536058; ENSP00000438657; ENSG00000256574.
ENST00000553795; ENSP00000451950; ENSG00000256574.
ENST00000612185; ENSP00000484353; ENSG00000277495.
ENST00000615770; ENSP00000480319; ENSG00000277495.
ENST00000616267; ENSP00000483252; ENSG00000277495.
GeneIDi79290.
KEGGihsa:79290.
UCSCiuc001jcc.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065728 Genomic DNA. Translation: BAC05949.1. Different initiation.
AK131555 mRNA. Translation: BAD18689.1.
AL512324 Genomic DNA. Translation: CAH73801.1. Different initiation.
CH471160 Genomic DNA. Translation: EAW86641.1.
BC104853 mRNA. Translation: AAI04854.1.
BC104855 mRNA. Translation: AAI04856.1.
BC143622 mRNA. Translation: AAI43623.1.
BK004287 Genomic DNA. Translation: DAA04685.1.
CCDSiCCDS31188.1.
RefSeqiNP_001004297.2. NM_001004297.2.
XP_011538447.1. XM_011540145.1.
XP_011538448.1. XM_011540146.1.
XP_011538449.1. XM_011540147.1.
XP_011538450.1. XM_011540148.1.
XP_011538451.1. XM_011540149.1.
XP_011538452.1. XM_011540150.1.
XP_011545284.1. XM_011546982.1.
XP_011545285.1. XM_011546983.1.
XP_011545286.1. XM_011546984.1.
XP_011545287.1. XM_011546985.1.
XP_011545288.1. XM_011546986.1.
XP_011545289.1. XM_011546987.1.
UniGeneiHs.532435.

3D structure databases

ProteinModelPortaliQ8NGR1.
SMRiQ8NGR1. Positions 40-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363522.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR13A1.
DMDMi229462928.

Proteomic databases

PaxDbiQ8NGR1.
PRIDEiQ8NGR1.

Protocols and materials databases

DNASUi79290.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374401; ENSP00000363522; ENSG00000256574.
ENST00000536058; ENSP00000438657; ENSG00000256574.
ENST00000553795; ENSP00000451950; ENSG00000256574.
ENST00000612185; ENSP00000484353; ENSG00000277495.
ENST00000615770; ENSP00000480319; ENSG00000277495.
ENST00000616267; ENSP00000483252; ENSG00000277495.
GeneIDi79290.
KEGGihsa:79290.
UCSCiuc001jcc.1. human.

Organism-specific databases

CTDi79290.
GeneCardsiGC10M045798.
HGNCiHGNC:14772. OR13A1.
HPAiHPA057237.
neXtProtiNX_Q8NGR1.
PharmGKBiPA32030.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45616.
GeneTreeiENSGT00440000034500.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGR1.
KOiK04257.
OMAiFYGIVNF.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGR1.
TreeFamiTF337579.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR13A1.
GenomeRNAii79290.
NextBioi68244.
PROiQ8NGR1.

Gene expression databases

CleanExiHS_OR13A1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO13A1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGR1
Secondary accession number(s): Q2M3M4
, Q5VV57, Q6IFH5, Q6ZMN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: July 22, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-20 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.