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Protein

Olfactory receptor 9Q1

Gene

OR9Q1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9Q1
Gene namesi
Name:OR9Q1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14724. OR9Q1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23619CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence analysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 31019CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32805.

Polymorphism and mutation databases

BioMutaiOR9Q1.
DMDMi38372749.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 9Q1PRO_0000150683Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGQ5.
PRIDEiQ8NGQ5.

Expressioni

Gene expression databases

CleanExiHS_OR9Q1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334934.

Structurei

3D structure databases

ProteinModelPortaliQ8NGQ5.
SMRiQ8NGQ5. Positions 19-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9HE. Eukaryota.
ENOG4111D5I. LUCA.
GeneTreeiENSGT00810000125445.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGQ5.
KOiK04257.
OMAiNLEMIIL.
OrthoDBiEOG7MPRF7.
PhylomeDBiQ8NGQ5.
TreeFamiTF337111.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEMNLTLVT EFLLIAFTEY PEWALPLFLL FLFMYLITVL GNLEMIILIL
60 70 80 90 100
MDHQLHAPMY FLLSHLAFMD VCYSSITVPQ MLAVLLEHGA ALSYTRCAAQ
110 120 130 140 150
FFLFTFFGSI DCYLLALMAY DRYLAVCQPL LYVTILTQQA RLSLVAGAYV
160 170 180 190 200
AGLISALVRT VSAFTLSFCG TSEIDFIFCD LPPLLKLTCG ESYTQEVLII
210 220 230 240 250
MFAIFVIPAS MVVILVSYLF IIVAIMGIPA GSQAKTFSTC TSHLTAVSLF
260 270 280 290 300
FGTLIFMYLR GNSDQSSEKN RVVSVLYTEV IPMLNPLIYS LRNKEVKEAL
310
RKILNRAKLS
Length:310
Mass (Da):34,757
Last modified:October 1, 2002 - v1
Checksum:i6C27C347AE8FD741
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti159 – 1591R → L.
Corresponds to variant rs12420738 [ dbSNP | Ensembl ].
VAR_053260

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065734 Genomic DNA. Translation: BAC05955.1.
AF399532 Genomic DNA. Translation: AAK95017.1.
BC110819 mRNA. Translation: AAI10820.1.
CCDSiCCDS31543.1.
RefSeqiNP_001005212.1. NM_001005212.3.
UniGeneiHs.689841.

Genome annotation databases

EnsembliENST00000335397; ENSP00000334934; ENSG00000186509.
ENST00000612174; ENSP00000479549; ENSG00000186509.
GeneIDi219956.
KEGGihsa:219956.
UCSCiuc001nmj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065734 Genomic DNA. Translation: BAC05955.1.
AF399532 Genomic DNA. Translation: AAK95017.1.
BC110819 mRNA. Translation: AAI10820.1.
CCDSiCCDS31543.1.
RefSeqiNP_001005212.1. NM_001005212.3.
UniGeneiHs.689841.

3D structure databases

ProteinModelPortaliQ8NGQ5.
SMRiQ8NGQ5. Positions 19-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334934.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR9Q1.
DMDMi38372749.

Proteomic databases

PaxDbiQ8NGQ5.
PRIDEiQ8NGQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335397; ENSP00000334934; ENSG00000186509.
ENST00000612174; ENSP00000479549; ENSG00000186509.
GeneIDi219956.
KEGGihsa:219956.
UCSCiuc001nmj.4. human.

Organism-specific databases

CTDi219956.
GeneCardsiOR9Q1.
HGNCiHGNC:14724. OR9Q1.
neXtProtiNX_Q8NGQ5.
PharmGKBiPA32805.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9HE. Eukaryota.
ENOG4111D5I. LUCA.
GeneTreeiENSGT00810000125445.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGQ5.
KOiK04257.
OMAiNLEMIIL.
OrthoDBiEOG7MPRF7.
PhylomeDBiQ8NGQ5.
TreeFamiTF337111.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR9Q1.
GenomeRNAii219956.
NextBioi90874.
PROiQ8NGQ5.

Gene expression databases

CleanExiHS_OR9Q1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiOR9Q1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGQ5
Secondary accession number(s): Q2TAN3, Q96RA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.