ID   O10Q1_HUMAN             Reviewed;         319 AA.
AC   Q8NGQ4; B9EIL7; Q6IFG4;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 149.
DE   RecName: Full=Olfactory receptor 10Q1;
DE   AltName: Full=Olfactory receptor OR11-233;
GN   Name=OR10Q1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASP-12 AND CYS-191.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10Q1";
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DR   EMBL; AB065735; BAC05956.1; -; Genomic_DNA.
DR   EMBL; CH471076; EAW73801.1; -; Genomic_DNA.
DR   EMBL; BC140731; AAI40732.1; -; mRNA.
DR   EMBL; BK004298; DAA04696.1; -; Genomic_DNA.
DR   CCDS; CCDS31547.1; -.
DR   RefSeq; NP_001004471.1; NM_001004471.2.
DR   AlphaFoldDB; Q8NGQ4; -.
DR   SMR; Q8NGQ4; -.
DR   STRING; 9606.ENSP00000314324; -.
DR   GlyCosmos; Q8NGQ4; 1 site, No reported glycans.
DR   GlyGen; Q8NGQ4; 1 site.
DR   iPTMnet; Q8NGQ4; -.
DR   PhosphoSitePlus; Q8NGQ4; -.
DR   BioMuta; OR10Q1; -.
DR   DMDM; 38372748; -.
DR   MassIVE; Q8NGQ4; -.
DR   PaxDb; 9606-ENSP00000314324; -.
DR   PeptideAtlas; Q8NGQ4; -.
DR   Antibodypedia; 62821; 18 antibodies from 13 providers.
DR   DNASU; 219960; -.
DR   Ensembl; ENST00000316770.2; ENSP00000314324.2; ENSG00000180475.4.
DR   GeneID; 219960; -.
DR   KEGG; hsa:219960; -.
DR   MANE-Select; ENST00000316770.2; ENSP00000314324.2; NM_001004471.2; NP_001004471.1.
DR   UCSC; uc010rkd.2; human.
DR   AGR; HGNC:15134; -.
DR   CTD; 219960; -.
DR   GeneCards; OR10Q1; -.
DR   HGNC; HGNC:15134; OR10Q1.
DR   HPA; ENSG00000180475; Not detected.
DR   neXtProt; NX_Q8NGQ4; -.
DR   PharmGKB; PA31994; -.
DR   VEuPathDB; HostDB:ENSG00000180475; -.
DR   eggNOG; ENOG502RKK8; Eukaryota.
DR   GeneTree; ENSGT01060000248581; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; Q8NGQ4; -.
DR   OMA; LCTQMLG; -.
DR   OrthoDB; 5258140at2759; -.
DR   PhylomeDB; Q8NGQ4; -.
DR   TreeFam; TF352734; -.
DR   PathwayCommons; Q8NGQ4; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 219960; 11 hits in 742 CRISPR screens.
DR   GeneWiki; OR10Q1; -.
DR   GenomeRNAi; 219960; -.
DR   Pharos; Q8NGQ4; Tdark.
DR   PRO; PR:Q8NGQ4; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGQ4; Protein.
DR   Bgee; ENSG00000180475; Expressed in stromal cell of endometrium and 16 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF570; OLFACTORY RECEPTOR; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..319
FT                   /note="Olfactory receptor 10Q1"
FT                   /id="PRO_0000150714"
FT   TOPO_DOM        1..29
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..58
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..103
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..202
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..222
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..242
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        264..276
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..319
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        9
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        101..194
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         12
FT                   /note="E -> D (in dbSNP:rs4245219)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_024129"
FT   VARIANT         191
FT                   /note="R -> C (in dbSNP:rs11229301)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_062065"
SQ   SEQUENCE   319 AA;  35602 MW;  FC7D971B8D29834E CRC64;
     MPVGKLVFNQ SEPTEFVFRA FTTATEFQVL LFLLFLLLYL MILCGNTAII WVVCTHSTLR
     TPMYFFLSNL SFLELCYTTV VVPLMLSNIL GAQKPISLAG CGAQMFFFVT LGSTDCFLLA
     IMAYDRYVAI CHPLHYTLIM TRELCTQMLG GALGLALFPS LQLTALIFTL PFCGHHQEIN
     HFLCDVPPVL RLACADIRVH QAVLYVVSIL VLTIPFLLIC VSYVFITCAI LSIRSAEGRR
     RAFSTCSFHL TVVLLQYGCC SLVYLRPRSS TSEDEDSQIA LVYTFVTPLL NPLLYSLRNK
     DVKGALRSAI IRKAASDAN
//