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Q8NGQ4

- O10Q1_HUMAN

UniProt

Q8NGQ4 - O10Q1_HUMAN

Protein

Olfactory receptor 10Q1

Gene

OR10Q1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10Q1
    Alternative name(s):
    Olfactory receptor OR11-233
    Gene namesi
    Name:OR10Q1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15134. OR10Q1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31994.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Olfactory receptor 10Q1PRO_0000150714Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi101 ↔ 194PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGQ4.
    PRIDEiQ8NGQ4.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10Q1.
    GenevestigatoriQ8NGQ4.

    Organism-specific databases

    HPAiHPA046968.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000314324.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGQ4.
    SMRiQ8NGQ4. Positions 33-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 588CytoplasmicSequence Analysis
    Topological domaini80 – 10324ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini165 – 20238ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 24220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini264 – 27613ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini298 – 31922CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22220Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40008.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGQ4.
    KOiK04257.
    OMAiTTATEFQ.
    OrthoDBiEOG7G1V6T.
    PhylomeDBiQ8NGQ4.
    TreeFamiTF352734.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVGKLVFNQ SEPTEFVFRA FTTATEFQVL LFLLFLLLYL MILCGNTAII    50
    WVVCTHSTLR TPMYFFLSNL SFLELCYTTV VVPLMLSNIL GAQKPISLAG 100
    CGAQMFFFVT LGSTDCFLLA IMAYDRYVAI CHPLHYTLIM TRELCTQMLG 150
    GALGLALFPS LQLTALIFTL PFCGHHQEIN HFLCDVPPVL RLACADIRVH 200
    QAVLYVVSIL VLTIPFLLIC VSYVFITCAI LSIRSAEGRR RAFSTCSFHL 250
    TVVLLQYGCC SLVYLRPRSS TSEDEDSQIA LVYTFVTPLL NPLLYSLRNK 300
    DVKGALRSAI IRKAASDAN 319
    Length:319
    Mass (Da):35,602
    Last modified:October 1, 2002 - v1
    Checksum:iFC7D971B8D29834E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121E → D.
    Corresponds to variant rs4245219 [ dbSNP | Ensembl ].
    VAR_024129
    Natural varianti191 – 1911R → C.
    Corresponds to variant rs11229301 [ dbSNP | Ensembl ].
    VAR_062065

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065735 Genomic DNA. Translation: BAC05956.1.
    CH471076 Genomic DNA. Translation: EAW73801.1.
    BK004298 Genomic DNA. Translation: DAA04696.1.
    CCDSiCCDS31547.1.
    RefSeqiNP_001004471.1. NM_001004471.2.
    UniGeneiHs.553646.

    Genome annotation databases

    EnsembliENST00000316770; ENSP00000314324; ENSG00000180475.
    GeneIDi219960.
    KEGGihsa:219960.
    UCSCiuc010rkd.2. human.

    Polymorphism databases

    DMDMi38372748.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065735 Genomic DNA. Translation: BAC05956.1 .
    CH471076 Genomic DNA. Translation: EAW73801.1 .
    BK004298 Genomic DNA. Translation: DAA04696.1 .
    CCDSi CCDS31547.1.
    RefSeqi NP_001004471.1. NM_001004471.2.
    UniGenei Hs.553646.

    3D structure databases

    ProteinModelPortali Q8NGQ4.
    SMRi Q8NGQ4. Positions 33-223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000314324.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372748.

    Proteomic databases

    PaxDbi Q8NGQ4.
    PRIDEi Q8NGQ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316770 ; ENSP00000314324 ; ENSG00000180475 .
    GeneIDi 219960.
    KEGGi hsa:219960.
    UCSCi uc010rkd.2. human.

    Organism-specific databases

    CTDi 219960.
    GeneCardsi GC11M057995.
    HGNCi HGNC:15134. OR10Q1.
    HPAi HPA046968.
    neXtProti NX_Q8NGQ4.
    PharmGKBi PA31994.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40008.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGQ4.
    KOi K04257.
    OMAi TTATEFQ.
    OrthoDBi EOG7G1V6T.
    PhylomeDBi Q8NGQ4.
    TreeFami TF352734.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10Q1.
    GenomeRNAii 219960.
    NextBioi 90890.
    PROi Q8NGQ4.

    Gene expression databases

    CleanExi HS_OR10Q1.
    Genevestigatori Q8NGQ4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10Q1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGQ4
    Secondary accession number(s): Q6IFG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3