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Q8NGQ4 (O10Q1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10Q1
Alternative name(s):
Olfactory receptor OR11-233
Gene names
Name:OR10Q1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Olfactory receptor 10Q1
PRO_0000150714

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 5021Helical; Name=1; Potential
Topological domain51 – 588Cytoplasmic Potential
Transmembrane59 – 7921Helical; Name=2; Potential
Topological domain80 – 10324Extracellular Potential
Transmembrane104 – 12421Helical; Name=3; Potential
Topological domain125 – 14319Cytoplasmic Potential
Transmembrane144 – 16421Helical; Name=4; Potential
Topological domain165 – 20238Extracellular Potential
Transmembrane203 – 22220Helical; Name=5; Potential
Topological domain223 – 24220Cytoplasmic Potential
Transmembrane243 – 26321Helical; Name=6; Potential
Topological domain264 – 27613Extracellular Potential
Transmembrane277 – 29721Helical; Name=7; Potential
Topological domain298 – 31922Cytoplasmic Potential

Amino acid modifications

Glycosylation91N-linked (GlcNAc...) Potential
Disulfide bond101 ↔ 194 By similarity

Natural variations

Natural variant121E → D.
Corresponds to variant rs4245219 [ dbSNP | Ensembl ].
VAR_024129
Natural variant1911R → C.
Corresponds to variant rs11229301 [ dbSNP | Ensembl ].
VAR_062065

Sequences

Sequence LengthMass (Da)Tools
Q8NGQ4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: FC7D971B8D29834E

FASTA31935,602
        10         20         30         40         50         60 
MPVGKLVFNQ SEPTEFVFRA FTTATEFQVL LFLLFLLLYL MILCGNTAII WVVCTHSTLR 

        70         80         90        100        110        120 
TPMYFFLSNL SFLELCYTTV VVPLMLSNIL GAQKPISLAG CGAQMFFFVT LGSTDCFLLA 

       130        140        150        160        170        180 
IMAYDRYVAI CHPLHYTLIM TRELCTQMLG GALGLALFPS LQLTALIFTL PFCGHHQEIN 

       190        200        210        220        230        240 
HFLCDVPPVL RLACADIRVH QAVLYVVSIL VLTIPFLLIC VSYVFITCAI LSIRSAEGRR 

       250        260        270        280        290        300 
RAFSTCSFHL TVVLLQYGCC SLVYLRPRSS TSEDEDSQIA LVYTFVTPLL NPLLYSLRNK 

       310 
DVKGALRSAI IRKAASDAN 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065735 Genomic DNA. Translation: BAC05956.1.
CH471076 Genomic DNA. Translation: EAW73801.1.
BK004298 Genomic DNA. Translation: DAA04696.1.
RefSeqNP_001004471.1. NM_001004471.2.
UniGeneHs.553646.

3D structure databases

ProteinModelPortalQ8NGQ4.
SMRQ8NGQ4. Positions 33-223, 282-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000314324.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372748.

Proteomic databases

PaxDbQ8NGQ4.
PRIDEQ8NGQ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316770; ENSP00000314324; ENSG00000180475.
GeneID219960.
KEGGhsa:219960.
UCSCuc010rkd.2. human.

Organism-specific databases

CTD219960.
GeneCardsGC11M057995.
HGNCHGNC:15134. OR10Q1.
HPAHPA046968.
neXtProtNX_Q8NGQ4.
PharmGKBPA31994.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40008.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGQ4.
KOK04257.
OMATTATEFQ.
OrthoDBEOG7G1V6T.
PhylomeDBQ8NGQ4.
TreeFamTF352734.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10Q1.
GenevestigatorQ8NGQ4.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10Q1.
GenomeRNAi219960.
NextBio90890.
PROQ8NGQ4.

Entry information

Entry nameO10Q1_HUMAN
AccessionPrimary (citable) accession number: Q8NGQ4
Secondary accession number(s): Q6IFG4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries