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Q8NGQ4

- O10Q1_HUMAN

UniProt

Q8NGQ4 - O10Q1_HUMAN

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Protein

Olfactory receptor 10Q1

Gene

OR10Q1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10Q1
Alternative name(s):
Olfactory receptor OR11-233
Gene namesi
Name:OR10Q1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15134. OR10Q1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 588CytoplasmicSequence Analysis
Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10324ExtracellularSequence AnalysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 14319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini165 – 20238ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22220Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini223 – 24220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei243 – 26321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini264 – 27613ExtracellularSequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini298 – 31922CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31994.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Olfactory receptor 10Q1PRO_0000150714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi101 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGQ4.
PRIDEiQ8NGQ4.

Expressioni

Gene expression databases

CleanExiHS_OR10Q1.
GenevestigatoriQ8NGQ4.

Organism-specific databases

HPAiHPA046968.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000314324.

Structurei

3D structure databases

ProteinModelPortaliQ8NGQ4.
SMRiQ8NGQ4. Positions 33-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40008.
GeneTreeiENSGT00710000106401.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGQ4.
KOiK04257.
OMAiTTATEFQ.
OrthoDBiEOG7G1V6T.
PhylomeDBiQ8NGQ4.
TreeFamiTF352734.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGQ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVGKLVFNQ SEPTEFVFRA FTTATEFQVL LFLLFLLLYL MILCGNTAII
60 70 80 90 100
WVVCTHSTLR TPMYFFLSNL SFLELCYTTV VVPLMLSNIL GAQKPISLAG
110 120 130 140 150
CGAQMFFFVT LGSTDCFLLA IMAYDRYVAI CHPLHYTLIM TRELCTQMLG
160 170 180 190 200
GALGLALFPS LQLTALIFTL PFCGHHQEIN HFLCDVPPVL RLACADIRVH
210 220 230 240 250
QAVLYVVSIL VLTIPFLLIC VSYVFITCAI LSIRSAEGRR RAFSTCSFHL
260 270 280 290 300
TVVLLQYGCC SLVYLRPRSS TSEDEDSQIA LVYTFVTPLL NPLLYSLRNK
310
DVKGALRSAI IRKAASDAN
Length:319
Mass (Da):35,602
Last modified:October 1, 2002 - v1
Checksum:iFC7D971B8D29834E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121E → D.
Corresponds to variant rs4245219 [ dbSNP | Ensembl ].
VAR_024129
Natural varianti191 – 1911R → C.
Corresponds to variant rs11229301 [ dbSNP | Ensembl ].
VAR_062065

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065735 Genomic DNA. Translation: BAC05956.1.
CH471076 Genomic DNA. Translation: EAW73801.1.
BK004298 Genomic DNA. Translation: DAA04696.1.
CCDSiCCDS31547.1.
RefSeqiNP_001004471.1. NM_001004471.2.
UniGeneiHs.553646.

Genome annotation databases

EnsembliENST00000316770; ENSP00000314324; ENSG00000180475.
GeneIDi219960.
KEGGihsa:219960.
UCSCiuc010rkd.2. human.

Polymorphism databases

DMDMi38372748.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065735 Genomic DNA. Translation: BAC05956.1 .
CH471076 Genomic DNA. Translation: EAW73801.1 .
BK004298 Genomic DNA. Translation: DAA04696.1 .
CCDSi CCDS31547.1.
RefSeqi NP_001004471.1. NM_001004471.2.
UniGenei Hs.553646.

3D structure databases

ProteinModelPortali Q8NGQ4.
SMRi Q8NGQ4. Positions 33-223.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000314324.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372748.

Proteomic databases

PaxDbi Q8NGQ4.
PRIDEi Q8NGQ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316770 ; ENSP00000314324 ; ENSG00000180475 .
GeneIDi 219960.
KEGGi hsa:219960.
UCSCi uc010rkd.2. human.

Organism-specific databases

CTDi 219960.
GeneCardsi GC11M057995.
HGNCi HGNC:15134. OR10Q1.
HPAi HPA046968.
neXtProti NX_Q8NGQ4.
PharmGKBi PA31994.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40008.
GeneTreei ENSGT00710000106401.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGQ4.
KOi K04257.
OMAi TTATEFQ.
OrthoDBi EOG7G1V6T.
PhylomeDBi Q8NGQ4.
TreeFami TF352734.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10Q1.
GenomeRNAii 219960.
NextBioi 90890.
PROi Q8NGQ4.

Gene expression databases

CleanExi HS_OR10Q1.
Genevestigatori Q8NGQ4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10Q1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGQ4
Secondary accession number(s): Q6IFG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3