ID   OR1S2_HUMAN             Reviewed;         325 AA.
AC   Q8NGQ3; Q6IFG5; Q96R85;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   24-JAN-2024, entry version 157.
DE   RecName: Full=Olfactory receptor 1S2;
DE   AltName: Full=Olfactory receptor OR11-231;
GN   Name=OR1S2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-296.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-14 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC05957.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1S2";
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DR   EMBL; AB065736; BAC05957.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AF399557; AAK95042.1; -; Genomic_DNA.
DR   EMBL; BK004297; DAA04695.1; -; Genomic_DNA.
DR   RefSeq; NP_001004459.1; NM_001004459.1.
DR   AlphaFoldDB; Q8NGQ3; -.
DR   SMR; Q8NGQ3; -.
DR   STRING; 9606.ENSP00000305469; -.
DR   GlyCosmos; Q8NGQ3; 1 site, No reported glycans.
DR   GlyGen; Q8NGQ3; 1 site.
DR   iPTMnet; Q8NGQ3; -.
DR   PhosphoSitePlus; Q8NGQ3; -.
DR   BioMuta; OR1S2; -.
DR   DMDM; 223590115; -.
DR   PaxDb; 9606-ENSP00000305469; -.
DR   ProteomicsDB; 73575; -.
DR   Antibodypedia; 58756; 79 antibodies from 21 providers.
DR   DNASU; 219958; -.
DR   GeneID; 219958; -.
DR   KEGG; hsa:219958; -.
DR   UCSC; uc010rkb.3; human.
DR   AGR; HGNC:15141; -.
DR   CTD; 219958; -.
DR   GeneCards; OR1S2; -.
DR   HGNC; HGNC:15141; OR1S2.
DR   neXtProt; NX_Q8NGQ3; -.
DR   PharmGKB; PA32099; -.
DR   VEuPathDB; HostDB:ENSG00000197887; -.
DR   eggNOG; ENOG502RQAM; Eukaryota.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q8NGQ3; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NGQ3; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; Q8NGQ3; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 219958; 4 hits in 686 CRISPR screens.
DR   GeneWiki; OR1S2; -.
DR   GenomeRNAi; 219958; -.
DR   Pharos; Q8NGQ3; Tdark.
DR   PRO; PR:Q8NGQ3; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGQ3; Protein.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd15918; 7tmA_OR1_7-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48001:SF115; OLFACTORY RECEPTOR 1S1-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..325
FT                   /note="Olfactory receptor 1S2"
FT                   /id="PRO_0000150452"
FT   TOPO_DOM        1..38
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..62
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..70
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..92
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..113
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..133
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        134..152
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..171
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..208
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..232
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        233..249
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..272
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273..285
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..305
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        306..325
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        110..202
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         59
FT                   /note="I -> T (in dbSNP:rs11229281)"
FT                   /id="VAR_062013"
FT   VARIANT         225
FT                   /note="V -> A (in dbSNP:rs11229277)"
FT                   /id="VAR_059980"
FT   VARIANT         225
FT                   /note="V -> I (in dbSNP:rs11229278)"
FT                   /id="VAR_059981"
SQ   SEQUENCE   325 AA;  36579 MW;  C76BB6A38929EBB1 CRC64;
     MKTLCSFLQI SRNMHQENQT TITEFILLGL SNQAEHQNLL FVLFLSMYVV TVVGNGLIIV
     AISLDIYLHT PMYLFLAYLS FADISSISNS VPKMLVNIQT NSQSISYESC ITQMYFSIVF
     VVTDNLLLGT MAFDHFVAIC HPLNYTTFMR ARFGTLLTVI SWFLSNIIAL THTLLLIQLL
     FCDHNTLPHF FCDLAPLLKL SCSDTMINEL VLFIVGLSVI IFPFVLIFFS YVCIIRAVLG
     VSSTQGKWKA FSTCGSHLTI ALLFYGTTVG VYFFPSSTHP EDTDKIGAVL FTVVTPMMNP
     FIYSLRNKDM KGALRKLINR KISSL
//