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Q8NGQ3

- OR1S2_HUMAN

UniProt

Q8NGQ3 - OR1S2_HUMAN

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Protein
Olfactory receptor 1S2
Gene
OR1S2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1S2
Alternative name(s):
Olfactory receptor OR11-231
Gene namesi
Name:OR1S2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15141. OR1S2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838Extracellular Reviewed prediction
Add
BLAST
Transmembranei39 – 6224Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini63 – 708Cytoplasmic Reviewed prediction
Transmembranei71 – 9222Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini93 – 11321Extracellular Reviewed prediction
Add
BLAST
Transmembranei114 – 13320Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini134 – 15219Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei153 – 17119Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini172 – 20837Extracellular Reviewed prediction
Add
BLAST
Transmembranei209 – 23224Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini233 – 24917Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei250 – 27223Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini273 – 28513Extracellular Reviewed prediction
Add
BLAST
Transmembranei286 – 30520Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini306 – 32520Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32099.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Olfactory receptor 1S2
PRO_0000150452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi110 ↔ 202 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGQ3.

Expressioni

Gene expression databases

CleanExiHS_OR1S2.
GenevestigatoriQ8NGQ3.

Organism-specific databases

HPAiHPA049304.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305469.

Structurei

3D structure databases

ProteinModelPortaliQ8NGQ3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG80114.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGQ3.
KOiK04257.
OMAiTIMKPRI.
OrthoDBiEOG73JKW4.
PhylomeDBiQ8NGQ3.
TreeFamiTF337210.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGQ3-1 [UniParc]FASTAAdd to Basket

« Hide

MKTLCSFLQI SRNMHQENQT TITEFILLGL SNQAEHQNLL FVLFLSMYVV    50
TVVGNGLIIV AISLDIYLHT PMYLFLAYLS FADISSISNS VPKMLVNIQT 100
NSQSISYESC ITQMYFSIVF VVTDNLLLGT MAFDHFVAIC HPLNYTTFMR 150
ARFGTLLTVI SWFLSNIIAL THTLLLIQLL FCDHNTLPHF FCDLAPLLKL 200
SCSDTMINEL VLFIVGLSVI IFPFVLIFFS YVCIIRAVLG VSSTQGKWKA 250
FSTCGSHLTI ALLFYGTTVG VYFFPSSTHP EDTDKIGAVL FTVVTPMMNP 300
FIYSLRNKDM KGALRKLINR KISSL 325
Length:325
Mass (Da):36,579
Last modified:February 10, 2009 - v2
Checksum:iC76BB6A38929EBB1
GO

Sequence cautioni

The sequence BAC05957.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591I → T.
Corresponds to variant rs11229281 [ dbSNP | Ensembl ].
VAR_062013
Natural varianti225 – 2251V → A.
Corresponds to variant rs11229277 [ dbSNP | Ensembl ].
VAR_059980
Natural varianti225 – 2251V → I.
Corresponds to variant rs11229278 [ dbSNP | Ensembl ].
VAR_059981

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065736 Genomic DNA. Translation: BAC05957.1. Different initiation.
AF399557 Genomic DNA. Translation: AAK95042.1.
BK004297 Genomic DNA. Translation: DAA04695.1.
CCDSiCCDS31545.1.
RefSeqiNP_001004459.1. NM_001004459.1.
UniGeneiHs.553644.

Genome annotation databases

EnsembliENST00000302592; ENSP00000305469; ENSG00000197887.
GeneIDi219958.
KEGGihsa:219958.
UCSCiuc010rkb.2. human.

Polymorphism databases

DMDMi223590115.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065736 Genomic DNA. Translation: BAC05957.1 . Different initiation.
AF399557 Genomic DNA. Translation: AAK95042.1 .
BK004297 Genomic DNA. Translation: DAA04695.1 .
CCDSi CCDS31545.1.
RefSeqi NP_001004459.1. NM_001004459.1.
UniGenei Hs.553644.

3D structure databases

ProteinModelPortali Q8NGQ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000305469.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 223590115.

Proteomic databases

PRIDEi Q8NGQ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302592 ; ENSP00000305469 ; ENSG00000197887 .
GeneIDi 219958.
KEGGi hsa:219958.
UCSCi uc010rkb.2. human.

Organism-specific databases

CTDi 219958.
GeneCardsi GC11M057970.
HGNCi HGNC:15141. OR1S2.
HPAi HPA049304.
neXtProti NX_Q8NGQ3.
PharmGKBi PA32099.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG80114.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGQ3.
KOi K04257.
OMAi TIMKPRI.
OrthoDBi EOG73JKW4.
PhylomeDBi Q8NGQ3.
TreeFami TF337210.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1S2.
GenomeRNAii 219958.
NextBioi 90882.
PROi Q8NGQ3.

Gene expression databases

CleanExi HS_OR1S2.
Genevestigatori Q8NGQ3.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-296.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1S2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGQ3
Secondary accession number(s): Q6IFG5, Q96R85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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