Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NGQ3 (OR1S2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1S2
Alternative name(s):
Olfactory receptor OR11-231
Gene names
Name:OR1S2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.

Sequence caution

The sequence BAC05957.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Olfactory receptor 1S2
PRO_0000150452

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 6224Helical; Name=1; Potential
Topological domain63 – 708Cytoplasmic Potential
Transmembrane71 – 9222Helical; Name=2; Potential
Topological domain93 – 11321Extracellular Potential
Transmembrane114 – 13320Helical; Name=3; Potential
Topological domain134 – 15219Cytoplasmic Potential
Transmembrane153 – 17119Helical; Name=4; Potential
Topological domain172 – 20837Extracellular Potential
Transmembrane209 – 23224Helical; Name=5; Potential
Topological domain233 – 24917Cytoplasmic Potential
Transmembrane250 – 27223Helical; Name=6; Potential
Topological domain273 – 28513Extracellular Potential
Transmembrane286 – 30520Helical; Name=7; Potential
Topological domain306 – 32520Cytoplasmic Potential

Amino acid modifications

Glycosylation181N-linked (GlcNAc...) Potential
Disulfide bond110 ↔ 202 By similarity

Natural variations

Natural variant591I → T.
Corresponds to variant rs11229281 [ dbSNP | Ensembl ].
VAR_062013
Natural variant2251V → A.
Corresponds to variant rs11229277 [ dbSNP | Ensembl ].
VAR_059980
Natural variant2251V → I.
Corresponds to variant rs11229278 [ dbSNP | Ensembl ].
VAR_059981

Sequences

Sequence LengthMass (Da)Tools
Q8NGQ3 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: C76BB6A38929EBB1

FASTA32536,579
        10         20         30         40         50         60 
MKTLCSFLQI SRNMHQENQT TITEFILLGL SNQAEHQNLL FVLFLSMYVV TVVGNGLIIV 

        70         80         90        100        110        120 
AISLDIYLHT PMYLFLAYLS FADISSISNS VPKMLVNIQT NSQSISYESC ITQMYFSIVF 

       130        140        150        160        170        180 
VVTDNLLLGT MAFDHFVAIC HPLNYTTFMR ARFGTLLTVI SWFLSNIIAL THTLLLIQLL 

       190        200        210        220        230        240 
FCDHNTLPHF FCDLAPLLKL SCSDTMINEL VLFIVGLSVI IFPFVLIFFS YVCIIRAVLG 

       250        260        270        280        290        300 
VSSTQGKWKA FSTCGSHLTI ALLFYGTTVG VYFFPSSTHP EDTDKIGAVL FTVVTPMMNP 

       310        320 
FIYSLRNKDM KGALRKLINR KISSL 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-296.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065736 Genomic DNA. Translation: BAC05957.1. Different initiation.
AF399557 Genomic DNA. Translation: AAK95042.1.
BK004297 Genomic DNA. Translation: DAA04695.1.
RefSeqNP_001004459.1. NM_001004459.1.
UniGeneHs.553644.

3D structure databases

ProteinModelPortalQ8NGQ3.
SMRQ8NGQ3. Positions 37-239, 291-320.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000305469.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM223590115.

Proteomic databases

PRIDEQ8NGQ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302592; ENSP00000305469; ENSG00000197887.
GeneID219958.
KEGGhsa:219958.
UCSCuc010rkb.2. human.

Organism-specific databases

CTD219958.
GeneCardsGC11M057970.
HGNCHGNC:15141. OR1S2.
HPAHPA049304.
neXtProtNX_Q8NGQ3.
PharmGKBPA32099.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG80114.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGQ3.
KOK04257.
OMAAMINNIV.
OrthoDBEOG73JKW4.
PhylomeDBQ8NGQ3.
TreeFamTF337210.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR1S2.
GenevestigatorQ8NGQ3.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1S2.
GenomeRNAi219958.
NextBio90882.
PROQ8NGQ3.

Entry information

Entry nameOR1S2_HUMAN
AccessionPrimary (citable) accession number: Q8NGQ3
Secondary accession number(s): Q6IFG5, Q96R85
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: February 10, 2009
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries