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Q8NGQ3

- OR1S2_HUMAN

UniProt

Q8NGQ3 - OR1S2_HUMAN

Protein

Olfactory receptor 1S2

Gene

OR1S2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1S2
    Alternative name(s):
    Olfactory receptor OR11-231
    Gene namesi
    Name:OR1S2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15141. OR1S2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32099.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Olfactory receptor 1S2PRO_0000150452Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi110 ↔ 202PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGQ3.

    Expressioni

    Gene expression databases

    CleanExiHS_OR1S2.
    GenevestigatoriQ8NGQ3.

    Organism-specific databases

    HPAiHPA049304.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000305469.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGQ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 708CytoplasmicSequence Analysis
    Topological domaini93 – 11321ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 20837ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini233 – 24917CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 28513ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini306 – 32520CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 6224Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei71 – 9222Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13320Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei153 – 17119Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 23224Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei250 – 27223Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30520Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG80114.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGQ3.
    KOiK04257.
    OMAiTIMKPRI.
    OrthoDBiEOG73JKW4.
    PhylomeDBiQ8NGQ3.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTLCSFLQI SRNMHQENQT TITEFILLGL SNQAEHQNLL FVLFLSMYVV    50
    TVVGNGLIIV AISLDIYLHT PMYLFLAYLS FADISSISNS VPKMLVNIQT 100
    NSQSISYESC ITQMYFSIVF VVTDNLLLGT MAFDHFVAIC HPLNYTTFMR 150
    ARFGTLLTVI SWFLSNIIAL THTLLLIQLL FCDHNTLPHF FCDLAPLLKL 200
    SCSDTMINEL VLFIVGLSVI IFPFVLIFFS YVCIIRAVLG VSSTQGKWKA 250
    FSTCGSHLTI ALLFYGTTVG VYFFPSSTHP EDTDKIGAVL FTVVTPMMNP 300
    FIYSLRNKDM KGALRKLINR KISSL 325
    Length:325
    Mass (Da):36,579
    Last modified:February 10, 2009 - v2
    Checksum:iC76BB6A38929EBB1
    GO

    Sequence cautioni

    The sequence BAC05957.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591I → T.
    Corresponds to variant rs11229281 [ dbSNP | Ensembl ].
    VAR_062013
    Natural varianti225 – 2251V → A.
    Corresponds to variant rs11229277 [ dbSNP | Ensembl ].
    VAR_059980
    Natural varianti225 – 2251V → I.
    Corresponds to variant rs11229278 [ dbSNP | Ensembl ].
    VAR_059981

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065736 Genomic DNA. Translation: BAC05957.1. Different initiation.
    AF399557 Genomic DNA. Translation: AAK95042.1.
    BK004297 Genomic DNA. Translation: DAA04695.1.
    CCDSiCCDS31545.1.
    RefSeqiNP_001004459.1. NM_001004459.1.
    UniGeneiHs.553644.

    Genome annotation databases

    EnsembliENST00000302592; ENSP00000305469; ENSG00000197887.
    GeneIDi219958.
    KEGGihsa:219958.
    UCSCiuc010rkb.2. human.

    Polymorphism databases

    DMDMi223590115.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065736 Genomic DNA. Translation: BAC05957.1 . Different initiation.
    AF399557 Genomic DNA. Translation: AAK95042.1 .
    BK004297 Genomic DNA. Translation: DAA04695.1 .
    CCDSi CCDS31545.1.
    RefSeqi NP_001004459.1. NM_001004459.1.
    UniGenei Hs.553644.

    3D structure databases

    ProteinModelPortali Q8NGQ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000305469.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 223590115.

    Proteomic databases

    PRIDEi Q8NGQ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302592 ; ENSP00000305469 ; ENSG00000197887 .
    GeneIDi 219958.
    KEGGi hsa:219958.
    UCSCi uc010rkb.2. human.

    Organism-specific databases

    CTDi 219958.
    GeneCardsi GC11M057970.
    HGNCi HGNC:15141. OR1S2.
    HPAi HPA049304.
    neXtProti NX_Q8NGQ3.
    PharmGKBi PA32099.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG80114.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGQ3.
    KOi K04257.
    OMAi TIMKPRI.
    OrthoDBi EOG73JKW4.
    PhylomeDBi Q8NGQ3.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1S2.
    GenomeRNAii 219958.
    NextBioi 90882.
    PROi Q8NGQ3.

    Gene expression databases

    CleanExi HS_OR1S2.
    Genevestigatori Q8NGQ3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-296.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR1S2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGQ3
    Secondary accession number(s): Q6IFG5, Q96R85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-14 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3