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Protein

Olfactory receptor 1S2

Gene

OR1S2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1S2
Alternative name(s):
Olfactory receptor OR11-231
Gene namesi
Name:OR1S2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15141. OR1S2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Transmembranei39 – 6224Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini63 – 708CytoplasmicSequence Analysis
Transmembranei71 – 9222Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini93 – 11321ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13320Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini134 – 15219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei153 – 17119Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini172 – 20837ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 23224Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini233 – 24917CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei250 – 27223Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini273 – 28513ExtracellularSequence AnalysisAdd
BLAST
Transmembranei286 – 30520Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini306 – 32520CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32099.

Polymorphism and mutation databases

BioMutaiOR1S2.
DMDMi223590115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Olfactory receptor 1S2PRO_0000150452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi110 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGQ3.

Expressioni

Gene expression databases

CleanExiHS_OR1S2.

Organism-specific databases

HPAiHPA049304.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305469.

Structurei

3D structure databases

ProteinModelPortaliQ8NGQ3.
SMRiQ8NGQ3. Positions 35-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG80114.
GeneTreeiENSGT00760000118845.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGQ3.
KOiK04257.
OMAiNQAEHQN.
OrthoDBiEOG73JKW4.
PhylomeDBiQ8NGQ3.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLCSFLQI SRNMHQENQT TITEFILLGL SNQAEHQNLL FVLFLSMYVV
60 70 80 90 100
TVVGNGLIIV AISLDIYLHT PMYLFLAYLS FADISSISNS VPKMLVNIQT
110 120 130 140 150
NSQSISYESC ITQMYFSIVF VVTDNLLLGT MAFDHFVAIC HPLNYTTFMR
160 170 180 190 200
ARFGTLLTVI SWFLSNIIAL THTLLLIQLL FCDHNTLPHF FCDLAPLLKL
210 220 230 240 250
SCSDTMINEL VLFIVGLSVI IFPFVLIFFS YVCIIRAVLG VSSTQGKWKA
260 270 280 290 300
FSTCGSHLTI ALLFYGTTVG VYFFPSSTHP EDTDKIGAVL FTVVTPMMNP
310 320
FIYSLRNKDM KGALRKLINR KISSL
Length:325
Mass (Da):36,579
Last modified:February 10, 2009 - v2
Checksum:iC76BB6A38929EBB1
GO

Sequence cautioni

The sequence BAC05957.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591I → T.
Corresponds to variant rs11229281 [ dbSNP | Ensembl ].
VAR_062013
Natural varianti225 – 2251V → A.
Corresponds to variant rs11229277 [ dbSNP | Ensembl ].
VAR_059980
Natural varianti225 – 2251V → I.
Corresponds to variant rs11229278 [ dbSNP | Ensembl ].
VAR_059981

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065736 Genomic DNA. Translation: BAC05957.1. Different initiation.
AF399557 Genomic DNA. Translation: AAK95042.1.
BK004297 Genomic DNA. Translation: DAA04695.1.
CCDSiCCDS31545.1.
RefSeqiNP_001004459.1. NM_001004459.1.
UniGeneiHs.553644.

Genome annotation databases

EnsembliENST00000302592; ENSP00000305469; ENSG00000197887.
GeneIDi219958.
KEGGihsa:219958.
UCSCiuc010rkb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065736 Genomic DNA. Translation: BAC05957.1. Different initiation.
AF399557 Genomic DNA. Translation: AAK95042.1.
BK004297 Genomic DNA. Translation: DAA04695.1.
CCDSiCCDS31545.1.
RefSeqiNP_001004459.1. NM_001004459.1.
UniGeneiHs.553644.

3D structure databases

ProteinModelPortaliQ8NGQ3.
SMRiQ8NGQ3. Positions 35-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000305469.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR1S2.
DMDMi223590115.

Proteomic databases

PRIDEiQ8NGQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302592; ENSP00000305469; ENSG00000197887.
GeneIDi219958.
KEGGihsa:219958.
UCSCiuc010rkb.2. human.

Organism-specific databases

CTDi219958.
GeneCardsiGC11M057970.
HGNCiHGNC:15141. OR1S2.
HPAiHPA049304.
neXtProtiNX_Q8NGQ3.
PharmGKBiPA32099.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG80114.
GeneTreeiENSGT00760000118845.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGQ3.
KOiK04257.
OMAiNQAEHQN.
OrthoDBiEOG73JKW4.
PhylomeDBiQ8NGQ3.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1S2.
GenomeRNAii219958.
NextBioi90882.
PROiQ8NGQ3.

Gene expression databases

CleanExiHS_OR1S2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-296.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1S2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGQ3
Secondary accession number(s): Q6IFG5, Q96R85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: February 10, 2009
Last modified: June 24, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.