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Protein

Olfactory receptor 6Q1

Gene

OR6Q1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6Q1
Alternative name(s):
Olfactory receptor OR11-226
Gene namesi
Name:OR6Q1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172381.4
HGNCiHGNC:15302 OR6Q1
neXtProtiNX_Q8NGQ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 103ExtracellularSequence analysisAdd BLAST26
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 143CytoplasmicSequence analysisAdd BLAST19
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 201ExtracellularSequence analysisAdd BLAST37
Transmembranei202 – 221Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini222 – 241CytoplasmicSequence analysisAdd BLAST20
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 275ExtracellularSequence analysisAdd BLAST13
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 317CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32602

Polymorphism and mutation databases

BioMutaiOR6Q1
DMDMi296439254

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506361 – 317Olfactory receptor 6Q1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGQ2
PRIDEiQ8NGQ2

PTM databases

iPTMnetiQ8NGQ2
PhosphoSitePlusiQ8NGQ2

Expressioni

Gene expression databases

CleanExiHS_OR6Q1
ExpressionAtlasiQ8NGQ2 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307734

Structurei

3D structure databases

ProteinModelPortaliQ8NGQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJNN Eukaryota
ENOG4111998 LUCA
GeneTreeiENSGT00800000124041
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGQ2
KOiK04257
OMAiTHLSCLE
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGQ2
TreeFamiTF337475

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPYTKNWTQ VTEFVMMGFA GIHEAHLLFF ILFLTMYLFT LVENLAIILV
60 70 80 90 100
VGLDHRLRRP MYFFLTHLSC LEIWYTSVTV PKMLAGFIGV DGGKNISYAD
110 120 130 140 150
CLSQLFIFTF LGATECFLLA AMAYDRYVAI CMPLHYGAFV SWGTCIRLAA
160 170 180 190 200
ACWLVGFLTP ILPIYLLSQL TFYGPNVIDH FSCDASPLLA LSCSDVTWKE
210 220 230 240 250
TVDFLVSLAV LLASSMVIAV SYGNIVWTLL HIRSAAERWK AFSTCAAHLT
260 270 280 290 300
VVSLFYGTLF FMYVQTKVTS SINFNKVVSV FYSVVTPMLN PLIYSLRNKE
310
VKGALGRVFS LNFWKGQ
Length:317
Mass (Da):35,736
Last modified:May 18, 2010 - v2
Checksum:i1312FAA42BC80E58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100D → G in BAC05958 (Ref. 1) Curated1
Sequence conflicti100D → G in AAI51148 (PubMed:15489334).Curated1
Sequence conflicti100D → G in AAK95094 (PubMed:12213199).Curated1
Sequence conflicti173Y → C in BAC05958 (Ref. 1) Curated1
Sequence conflicti173Y → C in AAI51148 (PubMed:15489334).Curated1
Sequence conflicti173Y → C in AAK95094 (PubMed:12213199).Curated1

Polymorphismi

A single nucleotide deletion at position Leu-229 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The deletion is more frequent in African-Americans than in non-Africans.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064742172F → I Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_057561316G → A. Corresponds to variant dbSNP:rs1374570Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065737 Genomic DNA Translation: BAC05958.1
AP003401 Genomic DNA No translation available.
BC151147 mRNA Translation: AAI51148.1
AF399609 Genomic DNA Translation: AAK95094.1
BK004291 Genomic DNA Translation: DAA04689.1
CCDSiCCDS31541.1
RefSeqiNP_001005186.2, NM_001005186.2
UniGeneiHs.690432

Genome annotation databases

EnsembliENST00000302622; ENSP00000307734; ENSG00000279051
GeneIDi219952
KEGGihsa:219952
UCSCiuc010rjz.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR6Q1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGQ2
Secondary accession number(s): B9EKW1, Q6IFH1, Q96R34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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