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Protein

Olfactory receptor 6Q1

Gene

OR6Q1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6Q1
Alternative name(s):
Olfactory receptor OR11-226
Gene namesi
Name:OR6Q1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15302. OR6Q1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 10326ExtracellularSequence analysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 14319CytoplasmicSequence analysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini165 – 20137ExtracellularSequence analysisAdd
BLAST
Transmembranei202 – 22120Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini222 – 24120CytoplasmicSequence analysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini263 – 27513ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini297 – 31721CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32602.

Polymorphism and mutation databases

BioMutaiOR6Q1.
DMDMi296439254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Olfactory receptor 6Q1PRO_0000150636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence analysis
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGQ2.
PRIDEiQ8NGQ2.

PTM databases

iPTMnetiQ8NGQ2.
PhosphoSiteiQ8NGQ2.

Expressioni

Gene expression databases

CleanExiHS_OR6Q1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307734.

Structurei

3D structure databases

ProteinModelPortaliQ8NGQ2.
SMRiQ8NGQ2. Positions 28-162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJNN. Eukaryota.
ENOG4111998. LUCA.
GeneTreeiENSGT00800000124041.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGQ2.
KOiK04257.
OMAiTHLSCLE.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGQ2.
TreeFamiTF337475.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPYTKNWTQ VTEFVMMGFA GIHEAHLLFF ILFLTMYLFT LVENLAIILV
60 70 80 90 100
VGLDHRLRRP MYFFLTHLSC LEIWYTSVTV PKMLAGFIGV DGGKNISYAD
110 120 130 140 150
CLSQLFIFTF LGATECFLLA AMAYDRYVAI CMPLHYGAFV SWGTCIRLAA
160 170 180 190 200
ACWLVGFLTP ILPIYLLSQL TFYGPNVIDH FSCDASPLLA LSCSDVTWKE
210 220 230 240 250
TVDFLVSLAV LLASSMVIAV SYGNIVWTLL HIRSAAERWK AFSTCAAHLT
260 270 280 290 300
VVSLFYGTLF FMYVQTKVTS SINFNKVVSV FYSVVTPMLN PLIYSLRNKE
310
VKGALGRVFS LNFWKGQ
Length:317
Mass (Da):35,736
Last modified:May 18, 2010 - v2
Checksum:i1312FAA42BC80E58
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001D → G in BAC05958 (Ref. 1) Curated
Sequence conflicti100 – 1001D → G in AAI51148 (PubMed:15489334).Curated
Sequence conflicti100 – 1001D → G in AAK95094 (PubMed:12213199).Curated
Sequence conflicti173 – 1731Y → C in BAC05958 (Ref. 1) Curated
Sequence conflicti173 – 1731Y → C in AAI51148 (PubMed:15489334).Curated
Sequence conflicti173 – 1731Y → C in AAK95094 (PubMed:12213199).Curated

Polymorphismi

A single nucleotide deletion at position Leu-229 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The deletion is more frequent in African-Americans than in non-Africans.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti172 – 1721F → I Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064742
Natural varianti316 – 3161G → A.
Corresponds to variant rs1374570 [ dbSNP | Ensembl ].
VAR_057561

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065737 Genomic DNA. Translation: BAC05958.1.
AP003401 Genomic DNA. No translation available.
BC151147 mRNA. Translation: AAI51148.1.
AF399609 Genomic DNA. Translation: AAK95094.1.
BK004291 Genomic DNA. Translation: DAA04689.1.
CCDSiCCDS31541.1.
RefSeqiNP_001005186.2. NM_001005186.2.
UniGeneiHs.690432.

Genome annotation databases

EnsembliENST00000623976; ENSP00000485678; ENSG00000172381.
GeneIDi219952.
KEGGihsa:219952.
UCSCiuc010rjz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065737 Genomic DNA. Translation: BAC05958.1.
AP003401 Genomic DNA. No translation available.
BC151147 mRNA. Translation: AAI51148.1.
AF399609 Genomic DNA. Translation: AAK95094.1.
BK004291 Genomic DNA. Translation: DAA04689.1.
CCDSiCCDS31541.1.
RefSeqiNP_001005186.2. NM_001005186.2.
UniGeneiHs.690432.

3D structure databases

ProteinModelPortaliQ8NGQ2.
SMRiQ8NGQ2. Positions 28-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000307734.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGQ2.
PhosphoSiteiQ8NGQ2.

Polymorphism and mutation databases

BioMutaiOR6Q1.
DMDMi296439254.

Proteomic databases

PaxDbiQ8NGQ2.
PRIDEiQ8NGQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000623976; ENSP00000485678; ENSG00000172381.
GeneIDi219952.
KEGGihsa:219952.
UCSCiuc010rjz.2. human.

Organism-specific databases

CTDi219952.
GeneCardsiOR6Q1.
H-InvDBHIX0036067.
HGNCiHGNC:15302. OR6Q1.
neXtProtiNX_Q8NGQ2.
PharmGKBiPA32602.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJNN. Eukaryota.
ENOG4111998. LUCA.
GeneTreeiENSGT00800000124041.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGQ2.
KOiK04257.
OMAiTHLSCLE.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGQ2.
TreeFamiTF337475.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR6Q1.
GenomeRNAii219952.
NextBioi90866.
PROiQ8NGQ2.

Gene expression databases

CleanExiHS_OR6Q1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-287.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  7. Cited for: POLYMORPHISM.
  8. Cited for: VARIANT ILE-172.

Entry informationi

Entry nameiOR6Q1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGQ2
Secondary accession number(s): B9EKW1, Q6IFH1, Q96R34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: February 17, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.