ID   OR9G4_HUMAN             Reviewed;         327 AA.
AC   Q8NGQ1; Q6IF62; Q96RA9;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 2.
DT   08-NOV-2023, entry version 158.
DE   RecName: Full=Olfactory receptor 9G4;
DE   AltName: Full=Olfactory receptor OR11-216;
GN   Name=OR9G4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-299.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-16 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC05959.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR9G4";
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DR   EMBL; AB065738; BAC05959.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AP001803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF399530; AAK95015.1; -; Genomic_DNA.
DR   EMBL; BK004400; DAA04798.1; -; Genomic_DNA.
DR   RefSeq; NP_001005284.1; NM_001005284.1.
DR   AlphaFoldDB; Q8NGQ1; -.
DR   SMR; Q8NGQ1; -.
DR   STRING; 9606.ENSP00000307515; -.
DR   GlyCosmos; Q8NGQ1; 1 site, No reported glycans.
DR   GlyGen; Q8NGQ1; 1 site.
DR   BioMuta; OR9G4; -.
DR   DMDM; 212276456; -.
DR   EPD; Q8NGQ1; -.
DR   MassIVE; Q8NGQ1; -.
DR   PaxDb; 9606-ENSP00000307515; -.
DR   DNASU; 283189; -.
DR   Ensembl; ENST00000575017.3; ENSP00000459325.1; ENSG00000262647.3.
DR   GeneID; 283189; -.
DR   KEGG; hsa:283189; -.
DR   UCSC; uc010rjo.3; human.
DR   AGR; HGNC:15322; -.
DR   CTD; 283189; -.
DR   GeneCards; OR9G4; -.
DR   HGNC; HGNC:15322; OR9G4.
DR   neXtProt; NX_Q8NGQ1; -.
DR   PharmGKB; PA32791; -.
DR   eggNOG; ENOG502SIHB; Eukaryota.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGQ1; -.
DR   OrthoDB; 4657152at2759; -.
DR   PhylomeDB; Q8NGQ1; -.
DR   TreeFam; TF352735; -.
DR   PathwayCommons; Q8NGQ1; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 283189; 4 hits in 738 CRISPR screens.
DR   GeneWiki; OR9G4; -.
DR   GenomeRNAi; 283189; -.
DR   Pharos; Q8NGQ1; Tdark.
DR   PRO; PR:Q8NGQ1; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q8NGQ1; Protein.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15418; 7tmA_OR9G-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48018:SF129; OLFACTORY RECEPTOR 9G4; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..327
FT                   /note="Olfactory receptor 9G4"
FT                   /id="PRO_0000150679"
FT   TOPO_DOM        1..43
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..71
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..113
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..152
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..212
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..252
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        274..286
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        308..327
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        20
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        112..194
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         43
FT                   /note="F -> S (in dbSNP:rs11228763)"
FT                   /id="VAR_053257"
FT   VARIANT         206
FT                   /note="N -> D (in dbSNP:rs577576)"
FT                   /id="VAR_053258"
FT   VARIANT         222
FT                   /note="V -> A (in dbSNP:rs513873)"
FT                   /id="VAR_053259"
SQ   SEQUENCE   327 AA;  36344 MW;  4607F3C763DD97D9 CRC64;
     MIFPSHDSQA FTSVDMEVGN CTILTEFILL GFSADSQWQP ILFGVFLMLY LITLSGNMTL
     VILIRTDSHL HTPMYFFIGN LSFLDFWYTS VYTPKILASC VSEDKRISLA GCGAQLFFSC
     VVAYTECYLL AAMAYDRHAA ICNPLLYSGT MSTALCTGLV AGSYIGGFLN AIAHTANTFR
     LHFCGKNIID HFFCDAPPLV KMSCTNTRVY EKVLLGVVGF TVLSSILAIL ISYVNILLAI
     LRIHSASGRH KAFSTCASHL ISVMLFYGSL LFMYSRPSST YSLERDKVAA LFYTVINPLL
     NPLIYSLRNK DIKEAFRKAT QTIQPQT
//