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Q8NGQ1

- OR9G4_HUMAN

UniProt

Q8NGQ1 - OR9G4_HUMAN

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Protein

Olfactory receptor 9G4

Gene

OR9G4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9G4
Alternative name(s):
Olfactory receptor OR11-216
Gene namesi
Name:OR9G4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15322. OR9G4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini65 – 717CytoplasmicSequence Analysis
Transmembranei72 – 9221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini93 – 11321ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini135 – 15218CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei153 – 17321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini174 – 21239ExtracellularSequence AnalysisAdd
BLAST
Transmembranei213 – 23321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini234 – 25219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini274 – 28613ExtracellularSequence AnalysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini308 – 32720CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Olfactory receptor 9G4PRO_0000150679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGQ1.
PRIDEiQ8NGQ1.

Expressioni

Gene expression databases

CleanExiHS_OR9G4.
GenevestigatoriQ8NGQ1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307515.

Structurei

3D structure databases

ProteinModelPortaliQ8NGQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43438.
GeneTreeiENSGT00770000120519.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGQ1.
KOiK04257.
OMAiRKATQTI.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGQ1.
TreeFamiTF352735.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIFPSHDSQA FTSVDMEVGN CTILTEFILL GFSADSQWQP ILFGVFLMLY
60 70 80 90 100
LITLSGNMTL VILIRTDSHL HTPMYFFIGN LSFLDFWYTS VYTPKILASC
110 120 130 140 150
VSEDKRISLA GCGAQLFFSC VVAYTECYLL AAMAYDRHAA ICNPLLYSGT
160 170 180 190 200
MSTALCTGLV AGSYIGGFLN AIAHTANTFR LHFCGKNIID HFFCDAPPLV
210 220 230 240 250
KMSCTNTRVY EKVLLGVVGF TVLSSILAIL ISYVNILLAI LRIHSASGRH
260 270 280 290 300
KAFSTCASHL ISVMLFYGSL LFMYSRPSST YSLERDKVAA LFYTVINPLL
310 320
NPLIYSLRNK DIKEAFRKAT QTIQPQT
Length:327
Mass (Da):36,344
Last modified:November 4, 2008 - v2
Checksum:i4607F3C763DD97D9
GO

Sequence cautioni

The sequence BAC05959.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431F → S.
Corresponds to variant rs11228763 [ dbSNP | Ensembl ].
VAR_053257
Natural varianti206 – 2061N → D.
Corresponds to variant rs577576 [ dbSNP | Ensembl ].
VAR_053258
Natural varianti222 – 2221V → A.
Corresponds to variant rs513873 [ dbSNP | Ensembl ].
VAR_053259

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065738 Genomic DNA. Translation: BAC05959.1. Different initiation.
AP001803 Genomic DNA. No translation available.
AF399530 Genomic DNA. Translation: AAK95015.1.
BK004400 Genomic DNA. Translation: DAA04798.1.
CCDSiCCDS31537.1.
RefSeqiNP_001005284.1. NM_001005284.1.
UniGeneiHs.554521.

Genome annotation databases

EnsembliENST00000302957; ENSP00000307515; ENSG00000172457.
ENST00000575017; ENSP00000459325; ENSG00000262647.
GeneIDi283189.
KEGGihsa:283189.
UCSCiuc010rjo.2. human.

Polymorphism databases

DMDMi212276456.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065738 Genomic DNA. Translation: BAC05959.1 . Different initiation.
AP001803 Genomic DNA. No translation available.
AF399530 Genomic DNA. Translation: AAK95015.1 .
BK004400 Genomic DNA. Translation: DAA04798.1 .
CCDSi CCDS31537.1.
RefSeqi NP_001005284.1. NM_001005284.1.
UniGenei Hs.554521.

3D structure databases

ProteinModelPortali Q8NGQ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000307515.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 212276456.

Proteomic databases

PaxDbi Q8NGQ1.
PRIDEi Q8NGQ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302957 ; ENSP00000307515 ; ENSG00000172457 .
ENST00000575017 ; ENSP00000459325 ; ENSG00000262647 .
GeneIDi 283189.
KEGGi hsa:283189.
UCSCi uc010rjo.2. human.

Organism-specific databases

CTDi 283189.
GeneCardsi GC11M056510.
HGNCi HGNC:15322. OR9G4.
neXtProti NX_Q8NGQ1.
PharmGKBi PA32791.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43438.
GeneTreei ENSGT00770000120519.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGQ1.
KOi K04257.
OMAi RKATQTI.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGQ1.
TreeFami TF352735.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR9G4.
GenomeRNAii 283189.
NextBioi 93701.
PROi Q8NGQ1.

Gene expression databases

CleanExi HS_OR9G4.
Genevestigatori Q8NGQ1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-299.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR9G4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGQ1
Secondary accession number(s): Q6IF62, Q96RA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: November 26, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3