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Protein

Olfactory receptor 9G4

Gene

OR9G4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GO_Central
  2. odorant binding Source: GO_Central
  3. olfactory receptor activity Source: GO_Central

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. G-protein coupled receptor signaling pathway Source: GO_Central
  3. sensory perception of smell Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9G4
Alternative name(s):
Olfactory receptor OR11-216
Gene namesi
Name:OR9G4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 11, Unplaced

Organism-specific databases

HGNCiHGNC:15322. OR9G4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini65 – 717CytoplasmicSequence Analysis
Transmembranei72 – 9221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini93 – 11321ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini135 – 15218CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei153 – 17321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini174 – 21239ExtracellularSequence AnalysisAdd
BLAST
Transmembranei213 – 23321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini234 – 25219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini274 – 28613ExtracellularSequence AnalysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini308 – 32720CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32791.

Polymorphism and mutation databases

BioMutaiOR9G4.
DMDMi212276456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Olfactory receptor 9G4PRO_0000150679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGQ1.
PRIDEiQ8NGQ1.

Expressioni

Gene expression databases

CleanExiHS_OR9G4.
GenevestigatoriQ8NGQ1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307515.

Structurei

3D structure databases

ProteinModelPortaliQ8NGQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43438.
GeneTreeiENSGT00780000121966.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGQ1.
KOiK04257.
OMAiFRKATQT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGQ1.
TreeFamiTF352735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFPSHDSQA FTSVDMEVGN CTILTEFILL GFSADSQWQP ILFGVFLMLY
60 70 80 90 100
LITLSGNMTL VILIRTDSHL HTPMYFFIGN LSFLDFWYTS VYTPKILASC
110 120 130 140 150
VSEDKRISLA GCGAQLFFSC VVAYTECYLL AAMAYDRHAA ICNPLLYSGT
160 170 180 190 200
MSTALCTGLV AGSYIGGFLN AIAHTANTFR LHFCGKNIID HFFCDAPPLV
210 220 230 240 250
KMSCTNTRVY EKVLLGVVGF TVLSSILAIL ISYVNILLAI LRIHSASGRH
260 270 280 290 300
KAFSTCASHL ISVMLFYGSL LFMYSRPSST YSLERDKVAA LFYTVINPLL
310 320
NPLIYSLRNK DIKEAFRKAT QTIQPQT
Length:327
Mass (Da):36,344
Last modified:November 4, 2008 - v2
Checksum:i4607F3C763DD97D9
GO

Sequence cautioni

The sequence BAC05959.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431F → S.
Corresponds to variant rs11228763 [ dbSNP | Ensembl ].
VAR_053257
Natural varianti206 – 2061N → D.
Corresponds to variant rs577576 [ dbSNP | Ensembl ].
VAR_053258
Natural varianti222 – 2221V → A.
Corresponds to variant rs513873 [ dbSNP | Ensembl ].
VAR_053259

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065738 Genomic DNA. Translation: BAC05959.1. Different initiation.
AP001803 Genomic DNA. No translation available.
AF399530 Genomic DNA. Translation: AAK95015.1.
BK004400 Genomic DNA. Translation: DAA04798.1.
CCDSiCCDS31537.1.
RefSeqiNP_001005284.1. NM_001005284.1.
UniGeneiHs.554521.

Genome annotation databases

EnsembliENST00000302957; ENSP00000307515; ENSG00000172457.
ENST00000575017; ENSP00000459325; ENSG00000262647.
GeneIDi283189.
KEGGihsa:283189.
UCSCiuc010rjo.2. human.

Polymorphism and mutation databases

BioMutaiOR9G4.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065738 Genomic DNA. Translation: BAC05959.1. Different initiation.
AP001803 Genomic DNA. No translation available.
AF399530 Genomic DNA. Translation: AAK95015.1.
BK004400 Genomic DNA. Translation: DAA04798.1.
CCDSiCCDS31537.1.
RefSeqiNP_001005284.1. NM_001005284.1.
UniGeneiHs.554521.

3D structure databases

ProteinModelPortaliQ8NGQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000307515.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR9G4.
DMDMi212276456.

Proteomic databases

PaxDbiQ8NGQ1.
PRIDEiQ8NGQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302957; ENSP00000307515; ENSG00000172457.
ENST00000575017; ENSP00000459325; ENSG00000262647.
GeneIDi283189.
KEGGihsa:283189.
UCSCiuc010rjo.2. human.

Organism-specific databases

CTDi283189.
GeneCardsiGC11M056510.
HGNCiHGNC:15322. OR9G4.
neXtProtiNX_Q8NGQ1.
PharmGKBiPA32791.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43438.
GeneTreeiENSGT00780000121966.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGQ1.
KOiK04257.
OMAiFRKATQT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGQ1.
TreeFamiTF352735.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR9G4.
GenomeRNAii283189.
NextBioi93701.
PROiQ8NGQ1.

Gene expression databases

CleanExiHS_OR9G4.
GenevestigatoriQ8NGQ1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-299.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR9G4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGQ1
Secondary accession number(s): Q6IF62, Q96RA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: April 29, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.