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Protein

Olfactory receptor 9G4

Gene

OR9G4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172457-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9G4
Alternative name(s):
Olfactory receptor OR11-216
Gene namesi
Name:OR9G4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15322. OR9G4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 71CytoplasmicSequence analysis7
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 113ExtracellularSequence analysisAdd BLAST21
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini135 – 152CytoplasmicSequence analysisAdd BLAST18
Transmembranei153 – 173Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini174 – 212ExtracellularSequence analysisAdd BLAST39
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini234 – 252CytoplasmicSequence analysisAdd BLAST19
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 286ExtracellularSequence analysisAdd BLAST13
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 327CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172457.
ENSG00000262647.
PharmGKBiPA32791.

Polymorphism and mutation databases

BioMutaiOR9G4.
DMDMi212276456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506791 – 327Olfactory receptor 9G4Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi112 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGQ1.
PRIDEiQ8NGQ1.

Expressioni

Gene expression databases

CleanExiHS_OR9G4.

Structurei

3D structure databases

ProteinModelPortaliQ8NGQ1.
SMRiQ8NGQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR6F. Eukaryota.
ENOG4111BIZ. LUCA.
GeneTreeiENSGT00800000124117.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGQ1.
KOiK04257.
OMAiPKILASC.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGQ1.
TreeFamiTF352735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFPSHDSQA FTSVDMEVGN CTILTEFILL GFSADSQWQP ILFGVFLMLY
60 70 80 90 100
LITLSGNMTL VILIRTDSHL HTPMYFFIGN LSFLDFWYTS VYTPKILASC
110 120 130 140 150
VSEDKRISLA GCGAQLFFSC VVAYTECYLL AAMAYDRHAA ICNPLLYSGT
160 170 180 190 200
MSTALCTGLV AGSYIGGFLN AIAHTANTFR LHFCGKNIID HFFCDAPPLV
210 220 230 240 250
KMSCTNTRVY EKVLLGVVGF TVLSSILAIL ISYVNILLAI LRIHSASGRH
260 270 280 290 300
KAFSTCASHL ISVMLFYGSL LFMYSRPSST YSLERDKVAA LFYTVINPLL
310 320
NPLIYSLRNK DIKEAFRKAT QTIQPQT
Length:327
Mass (Da):36,344
Last modified:November 4, 2008 - v2
Checksum:i4607F3C763DD97D9
GO

Sequence cautioni

The sequence BAC05959 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05325743F → S.Corresponds to variant rs11228763dbSNPEnsembl.1
Natural variantiVAR_053258206N → D.Corresponds to variant rs577576dbSNPEnsembl.1
Natural variantiVAR_053259222V → A.Corresponds to variant rs513873dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065738 Genomic DNA. Translation: BAC05959.1. Different initiation.
AP001803 Genomic DNA. No translation available.
AF399530 Genomic DNA. Translation: AAK95015.1.
BK004400 Genomic DNA. Translation: DAA04798.1.
CCDSiCCDS31537.1.
RefSeqiNP_001005284.1. NM_001005284.1.
UniGeneiHs.554521.

Genome annotation databases

EnsembliENST00000302957; ENSP00000307515; ENSG00000172457.
ENST00000575017; ENSP00000459325; ENSG00000262647.
GeneIDi283189.
KEGGihsa:283189.
UCSCiuc010rjo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065738 Genomic DNA. Translation: BAC05959.1. Different initiation.
AP001803 Genomic DNA. No translation available.
AF399530 Genomic DNA. Translation: AAK95015.1.
BK004400 Genomic DNA. Translation: DAA04798.1.
CCDSiCCDS31537.1.
RefSeqiNP_001005284.1. NM_001005284.1.
UniGeneiHs.554521.

3D structure databases

ProteinModelPortaliQ8NGQ1.
SMRiQ8NGQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR9G4.
DMDMi212276456.

Proteomic databases

PaxDbiQ8NGQ1.
PRIDEiQ8NGQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302957; ENSP00000307515; ENSG00000172457.
ENST00000575017; ENSP00000459325; ENSG00000262647.
GeneIDi283189.
KEGGihsa:283189.
UCSCiuc010rjo.3. human.

Organism-specific databases

CTDi283189.
GeneCardsiOR9G4.
HGNCiHGNC:15322. OR9G4.
neXtProtiNX_Q8NGQ1.
OpenTargetsiENSG00000172457.
ENSG00000262647.
PharmGKBiPA32791.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR6F. Eukaryota.
ENOG4111BIZ. LUCA.
GeneTreeiENSGT00800000124117.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGQ1.
KOiK04257.
OMAiPKILASC.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGQ1.
TreeFamiTF352735.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172457-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR9G4.
GenomeRNAii283189.
PROiQ8NGQ1.

Gene expression databases

CleanExiHS_OR9G4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR9G4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGQ1
Secondary accession number(s): Q6IF62, Q96RA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.