Q8NGQ1 (OR9G4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 9G4

Alternative name(s):
Olfactory receptor OR11-216

Gene names

Name:

OR9G4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	It is uncertain whether Met-1 or Met-16 is the initiator.
Sequence caution	The sequence BAC05959.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Olfactory receptor 9G4		PRO_0000150679
Regions
	Topological domain	1 – 43	43	Extracellular Potential
	Transmembrane	44 – 64	21	Helical; Name=1; Potential
	Topological domain	65 – 71	7	Cytoplasmic Potential
	Transmembrane	72 – 92	21	Helical; Name=2; Potential
	Topological domain	93 – 113	21	Extracellular Potential
	Transmembrane	114 – 134	21	Helical; Name=3; Potential
	Topological domain	135 – 152	18	Cytoplasmic Potential
	Transmembrane	153 – 173	21	Helical; Name=4; Potential
	Topological domain	174 – 212	39	Extracellular Potential
	Transmembrane	213 – 233	21	Helical; Name=5; Potential
	Topological domain	234 – 252	19	Cytoplasmic Potential
	Transmembrane	253 – 273	21	Helical; Name=6; Potential
	Topological domain	274 – 286	13	Extracellular Potential
	Transmembrane	287 – 307	21	Helical; Name=7; Potential
	Topological domain	308 – 327	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	20	1	N-linked (GlcNAc...) Potential
	Disulfide bond	112 ↔ 194		By similarity
Natural variations
	Natural variant	43	1	F → S. Corresponds to variant rs11228763 [ dbSNP | Ensembl ].		VAR_053257
	Natural variant	206	1	N → D. Corresponds to variant rs577576 [ dbSNP | Ensembl ].		VAR_053258
	Natural variant	222	1	V → A. Corresponds to variant rs513873 [ dbSNP | Ensembl ].		VAR_053259

Sequences

	Sequence		Length	Mass (Da)
	Q8NGQ1 [UniParc]. Last modified November 4, 2008. Version 2. Checksum: 4607F3C763DD97D9	FASTA	327	36,344
	10 20 30 40 50 60 MIFPSHDSQA FTSVDMEVGN CTILTEFILL GFSADSQWQP ILFGVFLMLY LITLSGNMTL 70 80 90 100 110 120 VILIRTDSHL HTPMYFFIGN LSFLDFWYTS VYTPKILASC VSEDKRISLA GCGAQLFFSC 130 140 150 160 170 180 VVAYTECYLL AAMAYDRHAA ICNPLLYSGT MSTALCTGLV AGSYIGGFLN AIAHTANTFR 190 200 210 220 230 240 LHFCGKNIID HFFCDAPPLV KMSCTNTRVY EKVLLGVVGF TVLSSILAIL ISYVNILLAI 250 260 270 280 290 300 LRIHSASGRH KAFSTCASHL ISVMLFYGSL LFMYSRPSST YSLERDKVAA LFYTVINPLL 310 320 NPLIYSLRNK DIKEAFRKAT QTIQPQT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-299.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065738 Genomic DNA. Translation: BAC05959.1. Different initiation. AP001803 Genomic DNA. No translation available. AF399530 Genomic DNA. Translation: AAK95015.1. BK004400 Genomic DNA. Translation: DAA04798.1.
IPI	IPI00169082.
RefSeq	NP_001005284.1. NM_001005284.1.
UniGene	Hs.554521.
3D structure databases
ProteinModelPortal	Q8NGQ1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000307515.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	212276456.
Proteomic databases
PaxDb	Q8NGQ1.
PRIDE	Q8NGQ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302957; ENSP00000307515; ENSG00000172457. ENST00000575017; ENSP00000459325; ENSG00000262647.
GeneID	283189.
KEGG	hsa:283189.
UCSC	uc010rjo.2. human.
Organism-specific databases
CTD	283189.
GeneCards	GC11M056510.
HGNC	HGNC:15322. OR9G4.
neXtProt	NX_Q8NGQ1.
PharmGKB	PA32791.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43438.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q8NGQ1.
KO	K04257.
OMA	RKATQTI.
OrthoDB	EOG4M91RW.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR9G4.
Genevestigator	Q8NGQ1.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	283189.
NextBio	93701.

Entry information

Entry name

OR9G4_HUMAN

Accession

Primary (citable) accession number: Q8NGQ1
Secondary accession number(s): Q6IF62, Q96RA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	November 4, 2008
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.