Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NGQ1 (OR9G4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 9G4
Alternative name(s):
Olfactory receptor OR11-216
Gene names
Name:OR9G4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.

Sequence caution

The sequence BAC05959.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Olfactory receptor 9G4
PRO_0000150679

Regions

Topological domain1 – 4343Extracellular Potential
Transmembrane44 – 6421Helical; Name=1; Potential
Topological domain65 – 717Cytoplasmic Potential
Transmembrane72 – 9221Helical; Name=2; Potential
Topological domain93 – 11321Extracellular Potential
Transmembrane114 – 13421Helical; Name=3; Potential
Topological domain135 – 15218Cytoplasmic Potential
Transmembrane153 – 17321Helical; Name=4; Potential
Topological domain174 – 21239Extracellular Potential
Transmembrane213 – 23321Helical; Name=5; Potential
Topological domain234 – 25219Cytoplasmic Potential
Transmembrane253 – 27321Helical; Name=6; Potential
Topological domain274 – 28613Extracellular Potential
Transmembrane287 – 30721Helical; Name=7; Potential
Topological domain308 – 32720Cytoplasmic Potential

Amino acid modifications

Glycosylation201N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 194 By similarity

Natural variations

Natural variant431F → S.
Corresponds to variant rs11228763 [ dbSNP | Ensembl ].
VAR_053257
Natural variant2061N → D.
Corresponds to variant rs577576 [ dbSNP | Ensembl ].
VAR_053258
Natural variant2221V → A.
Corresponds to variant rs513873 [ dbSNP | Ensembl ].
VAR_053259

Sequences

Sequence LengthMass (Da)Tools
Q8NGQ1 [UniParc].

Last modified November 4, 2008. Version 2.
Checksum: 4607F3C763DD97D9

FASTA32736,344
        10         20         30         40         50         60 
MIFPSHDSQA FTSVDMEVGN CTILTEFILL GFSADSQWQP ILFGVFLMLY LITLSGNMTL 

        70         80         90        100        110        120 
VILIRTDSHL HTPMYFFIGN LSFLDFWYTS VYTPKILASC VSEDKRISLA GCGAQLFFSC 

       130        140        150        160        170        180 
VVAYTECYLL AAMAYDRHAA ICNPLLYSGT MSTALCTGLV AGSYIGGFLN AIAHTANTFR 

       190        200        210        220        230        240 
LHFCGKNIID HFFCDAPPLV KMSCTNTRVY EKVLLGVVGF TVLSSILAIL ISYVNILLAI 

       250        260        270        280        290        300 
LRIHSASGRH KAFSTCASHL ISVMLFYGSL LFMYSRPSST YSLERDKVAA LFYTVINPLL 

       310        320 
NPLIYSLRNK DIKEAFRKAT QTIQPQT 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-299.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065738 Genomic DNA. Translation: BAC05959.1. Different initiation.
AP001803 Genomic DNA. No translation available.
AF399530 Genomic DNA. Translation: AAK95015.1.
BK004400 Genomic DNA. Translation: DAA04798.1.
RefSeqNP_001005284.1. NM_001005284.1.
UniGeneHs.554521.

3D structure databases

ProteinModelPortalQ8NGQ1.
SMRQ8NGQ1. Positions 291-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000307515.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM212276456.

Proteomic databases

PaxDbQ8NGQ1.
PRIDEQ8NGQ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302957; ENSP00000307515; ENSG00000172457.
ENST00000575017; ENSP00000459325; ENSG00000262647.
GeneID283189.
KEGGhsa:283189.
UCSCuc010rjo.2. human.

Organism-specific databases

CTD283189.
GeneCardsGC11M056510.
HGNCHGNC:15322. OR9G4.
neXtProtNX_Q8NGQ1.
PharmGKBPA32791.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43438.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGQ1.
KOK04257.
OMARKATQTI.
OrthoDBEOG71K63J.
PhylomeDBQ8NGQ1.
TreeFamTF352735.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR9G4.
GenevestigatorQ8NGQ1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR9G4.
GenomeRNAi283189.
NextBio93701.
PROQ8NGQ1.

Entry information

Entry nameOR9G4_HUMAN
AccessionPrimary (citable) accession number: Q8NGQ1
Secondary accession number(s): Q6IF62, Q96RA9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries