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Q8NGQ1

- OR9G4_HUMAN

UniProt

Q8NGQ1 - OR9G4_HUMAN

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Protein
Olfactory receptor 9G4
Gene
OR9G4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 9G4
    Alternative name(s):
    Olfactory receptor OR11-216
    Gene namesi
    Name:OR9G4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15322. OR9G4.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei44 – 6421Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini65 – 717Cytoplasmic Reviewed prediction
    Transmembranei72 – 9221Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini93 – 11321Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei114 – 13421Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini135 – 15218Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei153 – 17321Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini174 – 21239Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei213 – 23321Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini234 – 25219Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei253 – 27321Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini274 – 28613Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei287 – 30721Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini308 – 32720Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32791.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Olfactory receptor 9G4
    PRO_0000150679Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi20 – 201N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi112 ↔ 194 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGQ1.
    PRIDEiQ8NGQ1.

    Expressioni

    Gene expression databases

    CleanExiHS_OR9G4.
    GenevestigatoriQ8NGQ1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000307515.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGQ1.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43438.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGQ1.
    KOiK04257.
    OMAiRKATQTI.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGQ1.
    TreeFamiTF352735.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGQ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIFPSHDSQA FTSVDMEVGN CTILTEFILL GFSADSQWQP ILFGVFLMLY    50
    LITLSGNMTL VILIRTDSHL HTPMYFFIGN LSFLDFWYTS VYTPKILASC 100
    VSEDKRISLA GCGAQLFFSC VVAYTECYLL AAMAYDRHAA ICNPLLYSGT 150
    MSTALCTGLV AGSYIGGFLN AIAHTANTFR LHFCGKNIID HFFCDAPPLV 200
    KMSCTNTRVY EKVLLGVVGF TVLSSILAIL ISYVNILLAI LRIHSASGRH 250
    KAFSTCASHL ISVMLFYGSL LFMYSRPSST YSLERDKVAA LFYTVINPLL 300
    NPLIYSLRNK DIKEAFRKAT QTIQPQT 327
    Length:327
    Mass (Da):36,344
    Last modified:November 4, 2008 - v2
    Checksum:i4607F3C763DD97D9
    GO

    Sequence cautioni

    The sequence BAC05959.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431F → S.
    Corresponds to variant rs11228763 [ dbSNP | Ensembl ].
    VAR_053257
    Natural varianti206 – 2061N → D.
    Corresponds to variant rs577576 [ dbSNP | Ensembl ].
    VAR_053258
    Natural varianti222 – 2221V → A.
    Corresponds to variant rs513873 [ dbSNP | Ensembl ].
    VAR_053259

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065738 Genomic DNA. Translation: BAC05959.1. Different initiation.
    AP001803 Genomic DNA. No translation available.
    AF399530 Genomic DNA. Translation: AAK95015.1.
    BK004400 Genomic DNA. Translation: DAA04798.1.
    CCDSiCCDS31537.1.
    RefSeqiNP_001005284.1. NM_001005284.1.
    UniGeneiHs.554521.

    Genome annotation databases

    EnsembliENST00000302957; ENSP00000307515; ENSG00000172457.
    ENST00000575017; ENSP00000459325; ENSG00000262647.
    GeneIDi283189.
    KEGGihsa:283189.
    UCSCiuc010rjo.2. human.

    Polymorphism databases

    DMDMi212276456.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065738 Genomic DNA. Translation: BAC05959.1 . Different initiation.
    AP001803 Genomic DNA. No translation available.
    AF399530 Genomic DNA. Translation: AAK95015.1 .
    BK004400 Genomic DNA. Translation: DAA04798.1 .
    CCDSi CCDS31537.1.
    RefSeqi NP_001005284.1. NM_001005284.1.
    UniGenei Hs.554521.

    3D structure databases

    ProteinModelPortali Q8NGQ1.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000307515.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 212276456.

    Proteomic databases

    PaxDbi Q8NGQ1.
    PRIDEi Q8NGQ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302957 ; ENSP00000307515 ; ENSG00000172457 .
    ENST00000575017 ; ENSP00000459325 ; ENSG00000262647 .
    GeneIDi 283189.
    KEGGi hsa:283189.
    UCSCi uc010rjo.2. human.

    Organism-specific databases

    CTDi 283189.
    GeneCardsi GC11M056510.
    HGNCi HGNC:15322. OR9G4.
    neXtProti NX_Q8NGQ1.
    PharmGKBi PA32791.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43438.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGQ1.
    KOi K04257.
    OMAi RKATQTI.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGQ1.
    TreeFami TF352735.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR9G4.
    GenomeRNAii 283189.
    NextBioi 93701.
    PROi Q8NGQ1.

    Gene expression databases

    CleanExi HS_OR9G4.
    Genevestigatori Q8NGQ1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 83-299.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR9G4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGQ1
    Secondary accession number(s): Q6IF62, Q96RA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: November 4, 2008
    Last modified: September 3, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-16 is the initiator.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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