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Protein

Olfactory receptor 5AR1

Gene

OR5AR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172459-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5AR1
Alternative name(s):
Olfactory receptor OR11-209
Gene namesi
Name:OR5AR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15260. OR5AR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 58CytoplasmicSequence analysis9
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 205ExtracellularSequence analysisAdd BLAST45
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 239CytoplasmicSequence analysisAdd BLAST13
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 271ExtracellularSequence analysisAdd BLAST11
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 310CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172459.
PharmGKBiPA32471.

Polymorphism and mutation databases

BioMutaiOR5AR1.
DMDMi37081363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505791 – 310Olfactory receptor 5AR1Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGP9.
PRIDEiQ8NGP9.

PTM databases

iPTMnetiQ8NGP9.
PhosphoSitePlusiQ8NGP9.

Expressioni

Gene expression databases

CleanExiHS_OR5AR1.
ExpressionAtlasiQ8NGP9. differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302639.

Structurei

3D structure databases

ProteinModelPortaliQ8NGP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIU6. Eukaryota.
ENOG4111BJM. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGP9.
KOiK04257.
OMAiITQDPQM.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGP9.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKENSSMVT EFIFMGITQD PQMEIIFFVV FLIVYLVNVV GNIGMIILIT
60 70 80 90 100
TDTQLHTPMY FFLCNLSFVD LGYSSAIAPR MLADFLTNHK VISFSSCATQ
110 120 130 140 150
FAFFVGFVDA ECYVLAAMAY GRFVAICRPL HYSTFMSKQV CLALMLGSYL
160 170 180 190 200
AGLVSLVAHT TLTFSLSYCG SNIINHFFCE IPPLLALSCS DTYISEILLF
210 220 230 240 250
SLCGFIEFST ILIIFISYTF ILVAIIRMRS AEGRLKAFST CGSHLTGITL
260 270 280 290 300
FYGTVMFMYL RPTSSYSLDQ DKWASVFYTV IIPMLNPLIY SLRNKDVKAA
310
FKKLIGKKSQ
Length:310
Mass (Da):34,815
Last modified:October 1, 2002 - v1
Checksum:i660D5C566B330E47
GO

Polymorphismi

A stop codon in the gene coding for this protein at position Gln-19 is responsible for functional diversity thus producing a pseudogene.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062038225I → V.Corresponds to variant rs56067375dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065740 Genomic DNA. Translation: BAC05961.1.
BK004401 Genomic DNA. Translation: DAA04799.1.
RefSeqiNP_001004730.1. NM_001004730.1.
UniGeneiHs.553633.

Genome annotation databases

EnsembliENST00000624596; ENSP00000485240; ENSG00000172459.
GeneIDi219493.
KEGGihsa:219493.
UCSCiuc010rjm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065740 Genomic DNA. Translation: BAC05961.1.
BK004401 Genomic DNA. Translation: DAA04799.1.
RefSeqiNP_001004730.1. NM_001004730.1.
UniGeneiHs.553633.

3D structure databases

ProteinModelPortaliQ8NGP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302639.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGP9.
PhosphoSitePlusiQ8NGP9.

Polymorphism and mutation databases

BioMutaiOR5AR1.
DMDMi37081363.

Proteomic databases

PaxDbiQ8NGP9.
PRIDEiQ8NGP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624596; ENSP00000485240; ENSG00000172459.
GeneIDi219493.
KEGGihsa:219493.
UCSCiuc010rjm.2. human.

Organism-specific databases

CTDi219493.
GeneCardsiOR5AR1.
HGNCiHGNC:15260. OR5AR1.
neXtProtiNX_Q8NGP9.
OpenTargetsiENSG00000172459.
PharmGKBiPA32471.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIU6. Eukaryota.
ENOG4111BJM. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGP9.
KOiK04257.
OMAiITQDPQM.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGP9.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172459-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5AR1.
GenomeRNAii219493.
PROiQ8NGP9.

Gene expression databases

CleanExiHS_OR5AR1.
ExpressionAtlasiQ8NGP9. differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO5AR1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGP9
Secondary accession number(s): Q6IF61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.