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Protein

Olfactory receptor 5M3

Gene

OR5M3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174937-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5M3
Alternative name(s):
Olfactory receptor OR11-191
Gene namesi
Name:OR5M3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14806. OR5M3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 194ExtracellularSequence analysisAdd BLAST36
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 269ExtracellularSequence analysisAdd BLAST13
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 307CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174937.
PharmGKBiPA32553.

Polymorphism and mutation databases

BioMutaiOR5M3.
DMDMi116242692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506051 – 307Olfactory receptor 5M3Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGP4.
PRIDEiQ8NGP4.

PTM databases

iPTMnetiQ8NGP4.
PhosphoSitePlusiQ8NGP4.

Expressioni

Gene expression databases

CleanExiHS_OR5M3.

Organism-specific databases

HPAiCAB009941.
CAB015457.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312208.

Structurei

3D structure databases

ProteinModelPortaliQ8NGP4.
SMRiQ8NGP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8Q5. Eukaryota.
ENOG41118IZ. LUCA.
GeneTreeiENSGT00810000125401.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGP4.
KOiK04257.
OMAiTSRREWQ.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGP4.
TreeFamiTF352751.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNFTDVTEF ILLGLTSRRE WQVLFFIIFL VVYIITMVGN IGMMVLIKVS
60 70 80 90 100
PQLNNPMYFF LSHLSFVDVW FSSNVTPKML ENLLSDKKTI TYAGCLVQCF
110 120 130 140 150
FFIALVHVEI FILAAMAFDR YMAIGNPLLY GSKMSRVVCI RLITFPYIYG
160 170 180 190 200
FLTSLAATLW TYGLYFCGKI EINHFYCADP PLIKMACAGT FVKEYTMIIL
210 220 230 240 250
AGINFTYSLT VIIISYLFIL IAILRMRSAE GRQKAFSTCG SHLTAVIIFY
260 270 280 290 300
GTLIFMYLRR PTEESVEQGK MVAVFYTTVI PMLNPMIYSL RNKDVKKAMM

KVISRSC
Length:307
Mass (Da):35,156
Last modified:October 17, 2006 - v2
Checksum:i2A81FDBC464AEDFA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05754984L → F.1 PublicationCorresponds to variant rs605734dbSNPEnsembl.1
Natural variantiVAR_057550163G → S.Corresponds to variant rs17150664dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065746 Genomic DNA. Translation: BAC05966.1.
CH471076 Genomic DNA. Translation: EAW73715.1.
BC136982 mRNA. Translation: AAI36983.1.
BC136983 mRNA. Translation: AAI36984.1.
AF399518 Genomic DNA. Translation: AAK95003.1.
BK004498 Genomic DNA. Translation: DAA04896.1.
CCDSiCCDS31532.1.
RefSeqiNP_001004742.2. NM_001004742.2.
UniGeneiHs.553631.

Genome annotation databases

EnsembliENST00000312240; ENSP00000312208; ENSG00000174937.
GeneIDi219482.
KEGGihsa:219482.
UCSCiuc010rjk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065746 Genomic DNA. Translation: BAC05966.1.
CH471076 Genomic DNA. Translation: EAW73715.1.
BC136982 mRNA. Translation: AAI36983.1.
BC136983 mRNA. Translation: AAI36984.1.
AF399518 Genomic DNA. Translation: AAK95003.1.
BK004498 Genomic DNA. Translation: DAA04896.1.
CCDSiCCDS31532.1.
RefSeqiNP_001004742.2. NM_001004742.2.
UniGeneiHs.553631.

3D structure databases

ProteinModelPortaliQ8NGP4.
SMRiQ8NGP4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312208.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGP4.
PhosphoSitePlusiQ8NGP4.

Polymorphism and mutation databases

BioMutaiOR5M3.
DMDMi116242692.

Proteomic databases

PaxDbiQ8NGP4.
PRIDEiQ8NGP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312240; ENSP00000312208; ENSG00000174937.
GeneIDi219482.
KEGGihsa:219482.
UCSCiuc010rjk.3. human.

Organism-specific databases

CTDi219482.
GeneCardsiOR5M3.
HGNCiHGNC:14806. OR5M3.
HPAiCAB009941.
CAB015457.
neXtProtiNX_Q8NGP4.
OpenTargetsiENSG00000174937.
PharmGKBiPA32553.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8Q5. Eukaryota.
ENOG41118IZ. LUCA.
GeneTreeiENSGT00810000125401.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGP4.
KOiK04257.
OMAiTSRREWQ.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGP4.
TreeFamiTF352751.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174937-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5M3.
GenomeRNAii219482.
PROiQ8NGP4.

Gene expression databases

CleanExiHS_OR5M3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5M3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGP4
Secondary accession number(s): B2RNM7, Q6IEW4, Q96RC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.