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Q8NGP3 (OR5M9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5M9
Alternative name(s):
Olfactory receptor OR11-190
Gene names
Name:OR5M9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Olfactory receptor 5M9
PRO_0000150607

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4421Helical; Name=1; Potential
Topological domain45 – 528Cytoplasmic Potential
Transmembrane53 – 7321Helical; Name=2; Potential
Topological domain74 – 9724Extracellular Potential
Transmembrane98 – 11821Helical; Name=3; Potential
Topological domain119 – 13719Cytoplasmic Potential
Transmembrane138 – 15821Helical; Name=4; Potential
Topological domain159 – 19436Extracellular Potential
Transmembrane195 – 21521Helical; Name=5; Potential
Topological domain216 – 23520Cytoplasmic Potential
Transmembrane236 – 25621Helical; Name=6; Potential
Topological domain257 – 26913Extracellular Potential
Transmembrane270 – 29021Helical; Name=7; Potential
Topological domain291 – 31020Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 187 By similarity

Natural variations

Natural variant2701K → R.
Corresponds to variant rs1945237 [ dbSNP | Ensembl ].
VAR_034230

Sequences

Sequence LengthMass (Da)Tools
Q8NGP3 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 6D938CD1D4B7E7D1

FASTA31035,093
        10         20         30         40         50         60 
MPNFTDVTEF TLLGLTCRQE LQVLFFVVFL AVYMITLLGN IGMIILISIS PQLQSPMYFF 

        70         80         90        100        110        120 
LSHLSFADVC FSSNVTPKML ENLLSETKTI SYVGCLVQCY FFIAVVHVEV YILAVMAFDR 

       130        140        150        160        170        180 
YMAGCNPLLY GSKMSRTVCV RLISVPYVYG FSVSLICTLW TYGLYFCGNF EINHFYCADP 

       190        200        210        220        230        240 
PLIQIACGRV HIKEITMIVI AGINFTYSLS VVLISYTLIV VAVLRMRSAD GRRKAFSTCG 

       250        260        270        280        290        300 
SHLTAVSMFY GTPIFMYLRR PTEESVEQGK MVAVFYTTVI PMLNPMIYSL RNKDVKEAVN 

       310 
KAITKTYVRQ 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065747 Genomic DNA. Translation: BAC05967.1.
AF399519 Genomic DNA. Translation: AAK95004.1.
BK004497 Genomic DNA. Translation: DAA04895.1.
CCDSCCDS31531.1.
RefSeqNP_001004743.1. NM_001004743.1.
UniGeneHs.553749.

3D structure databases

ProteinModelPortalQ8NGP3.
SMRQ8NGP3. Positions 24-155.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000279791.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372741.

Proteomic databases

PaxDbQ8NGP3.
PRIDEQ8NGP3.

Protocols and materials databases

DNASU390162.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000279791; ENSP00000279791; ENSG00000150269.
GeneID390162.
KEGGhsa:390162.
UCSCuc010rjj.2. human.

Organism-specific databases

CTD390162.
GeneCardsGC11M056230.
HGNCHGNC:15294. OR5M9.
neXtProtNX_Q8NGP3.
PharmGKBPA32559.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG77483.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGP3.
KOK04257.
OMAEITMIVI.
OrthoDBEOG71K63J.
PhylomeDBQ8NGP3.
TreeFamTF352751.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR5M9.
GenevestigatorQ8NGP3.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR5M9.
GenomeRNAi390162.
NextBio103468.
PROQ8NGP3.

Entry information

Entry nameOR5M9_HUMAN
AccessionPrimary (citable) accession number: Q8NGP3
Secondary accession number(s): Q6IEW5, Q96RB9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries