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Protein

Olfactory receptor 5M9

Gene

OR5M9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5M9
Alternative name(s):
Olfactory receptor OR11-190
Gene namesi
Name:OR5M9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15294. OR5M9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence Analysis
Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini74 – 9724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19436ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini216 – 23520CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini257 – 26913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini291 – 31020CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32559.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 5M9PRO_0000150607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGP3.
PRIDEiQ8NGP3.

Expressioni

Gene expression databases

CleanExiHS_OR5M9.
GenevestigatoriQ8NGP3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000279791.

Structurei

3D structure databases

ProteinModelPortaliQ8NGP3.
SMRiQ8NGP3. Positions 24-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77483.
GeneTreeiENSGT00760000118826.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGP3.
KOiK04257.
OMAiEITMIVI.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGP3.
TreeFamiTF352751.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNFTDVTEF TLLGLTCRQE LQVLFFVVFL AVYMITLLGN IGMIILISIS
60 70 80 90 100
PQLQSPMYFF LSHLSFADVC FSSNVTPKML ENLLSETKTI SYVGCLVQCY
110 120 130 140 150
FFIAVVHVEV YILAVMAFDR YMAGCNPLLY GSKMSRTVCV RLISVPYVYG
160 170 180 190 200
FSVSLICTLW TYGLYFCGNF EINHFYCADP PLIQIACGRV HIKEITMIVI
210 220 230 240 250
AGINFTYSLS VVLISYTLIV VAVLRMRSAD GRRKAFSTCG SHLTAVSMFY
260 270 280 290 300
GTPIFMYLRR PTEESVEQGK MVAVFYTTVI PMLNPMIYSL RNKDVKEAVN
310
KAITKTYVRQ
Length:310
Mass (Da):35,093
Last modified:October 1, 2002 - v1
Checksum:i6D938CD1D4B7E7D1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti270 – 2701K → R.
Corresponds to variant rs1945237 [ dbSNP | Ensembl ].
VAR_034230

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065747 Genomic DNA. Translation: BAC05967.1.
AF399519 Genomic DNA. Translation: AAK95004.1.
BK004497 Genomic DNA. Translation: DAA04895.1.
CCDSiCCDS31531.1.
RefSeqiNP_001004743.1. NM_001004743.1.
UniGeneiHs.553749.

Genome annotation databases

EnsembliENST00000279791; ENSP00000279791; ENSG00000150269.
GeneIDi390162.
KEGGihsa:390162.
UCSCiuc010rjj.2. human.

Polymorphism databases

DMDMi38372741.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065747 Genomic DNA. Translation: BAC05967.1.
AF399519 Genomic DNA. Translation: AAK95004.1.
BK004497 Genomic DNA. Translation: DAA04895.1.
CCDSiCCDS31531.1.
RefSeqiNP_001004743.1. NM_001004743.1.
UniGeneiHs.553749.

3D structure databases

ProteinModelPortaliQ8NGP3.
SMRiQ8NGP3. Positions 24-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000279791.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi38372741.

Proteomic databases

PaxDbiQ8NGP3.
PRIDEiQ8NGP3.

Protocols and materials databases

DNASUi390162.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279791; ENSP00000279791; ENSG00000150269.
GeneIDi390162.
KEGGihsa:390162.
UCSCiuc010rjj.2. human.

Organism-specific databases

CTDi390162.
GeneCardsiGC11M056230.
HGNCiHGNC:15294. OR5M9.
neXtProtiNX_Q8NGP3.
PharmGKBiPA32559.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG77483.
GeneTreeiENSGT00760000118826.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGP3.
KOiK04257.
OMAiEITMIVI.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGP3.
TreeFamiTF352751.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5M9.
GenomeRNAii390162.
NextBioi103468.
PROiQ8NGP3.

Gene expression databases

CleanExiHS_OR5M9.
GenevestigatoriQ8NGP3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiOR5M9_HUMAN
AccessioniPrimary (citable) accession number: Q8NGP3
Secondary accession number(s): Q6IEW5, Q96RB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.