Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NGP3

- OR5M9_HUMAN

UniProt

Q8NGP3 - OR5M9_HUMAN

Protein

Olfactory receptor 5M9

Gene

OR5M9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5M9
    Alternative name(s):
    Olfactory receptor OR11-190
    Gene namesi
    Name:OR5M9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15294. OR5M9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32559.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Olfactory receptor 5M9PRO_0000150607Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGP3.
    PRIDEiQ8NGP3.

    Expressioni

    Gene expression databases

    CleanExiHS_OR5M9.
    GenevestigatoriQ8NGP3.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000279791.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGP3.
    SMRiQ8NGP3. Positions 24-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 528CytoplasmicSequence Analysis
    Topological domaini74 – 9724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19436ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 23520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 26913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini291 – 31020CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77483.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGP3.
    KOiK04257.
    OMAiEITMIVI.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGP3.
    TreeFamiTF352751.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNFTDVTEF TLLGLTCRQE LQVLFFVVFL AVYMITLLGN IGMIILISIS    50
    PQLQSPMYFF LSHLSFADVC FSSNVTPKML ENLLSETKTI SYVGCLVQCY 100
    FFIAVVHVEV YILAVMAFDR YMAGCNPLLY GSKMSRTVCV RLISVPYVYG 150
    FSVSLICTLW TYGLYFCGNF EINHFYCADP PLIQIACGRV HIKEITMIVI 200
    AGINFTYSLS VVLISYTLIV VAVLRMRSAD GRRKAFSTCG SHLTAVSMFY 250
    GTPIFMYLRR PTEESVEQGK MVAVFYTTVI PMLNPMIYSL RNKDVKEAVN 300
    KAITKTYVRQ 310
    Length:310
    Mass (Da):35,093
    Last modified:October 1, 2002 - v1
    Checksum:i6D938CD1D4B7E7D1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti270 – 2701K → R.
    Corresponds to variant rs1945237 [ dbSNP | Ensembl ].
    VAR_034230

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065747 Genomic DNA. Translation: BAC05967.1.
    AF399519 Genomic DNA. Translation: AAK95004.1.
    BK004497 Genomic DNA. Translation: DAA04895.1.
    CCDSiCCDS31531.1.
    RefSeqiNP_001004743.1. NM_001004743.1.
    UniGeneiHs.553749.

    Genome annotation databases

    EnsembliENST00000279791; ENSP00000279791; ENSG00000150269.
    GeneIDi390162.
    KEGGihsa:390162.
    UCSCiuc010rjj.2. human.

    Polymorphism databases

    DMDMi38372741.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065747 Genomic DNA. Translation: BAC05967.1 .
    AF399519 Genomic DNA. Translation: AAK95004.1 .
    BK004497 Genomic DNA. Translation: DAA04895.1 .
    CCDSi CCDS31531.1.
    RefSeqi NP_001004743.1. NM_001004743.1.
    UniGenei Hs.553749.

    3D structure databases

    ProteinModelPortali Q8NGP3.
    SMRi Q8NGP3. Positions 24-155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000279791.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372741.

    Proteomic databases

    PaxDbi Q8NGP3.
    PRIDEi Q8NGP3.

    Protocols and materials databases

    DNASUi 390162.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000279791 ; ENSP00000279791 ; ENSG00000150269 .
    GeneIDi 390162.
    KEGGi hsa:390162.
    UCSCi uc010rjj.2. human.

    Organism-specific databases

    CTDi 390162.
    GeneCardsi GC11M056230.
    HGNCi HGNC:15294. OR5M9.
    neXtProti NX_Q8NGP3.
    PharmGKBi PA32559.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77483.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGP3.
    KOi K04257.
    OMAi EITMIVI.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGP3.
    TreeFami TF352751.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR5M9.
    GenomeRNAii 390162.
    NextBioi 103468.
    PROi Q8NGP3.

    Gene expression databases

    CleanExi HS_OR5M9.
    Genevestigatori Q8NGP3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR5M9_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGP3
    Secondary accession number(s): Q6IEW5, Q96RB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3