Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 4C13

Gene

OR4C13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C13
Alternative name(s):
Olfactory receptor OR11-260
Gene namesi
Name:OR4C13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000258817.1
HGNCiHGNC:15169 OR4C13
neXtProtiNX_Q8NGP0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 233CytoplasmicSequence analysisAdd BLAST16
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 287Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini288 – 309CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283092
PharmGKBiPA32255

Polymorphism and mutation databases

BioMutaiOR4C13
DMDMi212276453

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505341 – 309Olfactory receptor 4C13Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGP0
PeptideAtlasiQ8NGP0
PRIDEiQ8NGP0

PTM databases

iPTMnetiQ8NGP0
PhosphoSitePlusiQ8NGP0

Expressioni

Gene expression databases

CleanExiHS_OR4C13

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000452277

Structurei

3D structure databases

ProteinModelPortaliQ8NGP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KC9W Eukaryota
ENOG4110P6N LUCA
GeneTreeiENSGT00910000144032
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGP0
KOiK04257
OMAiCTNTHTL
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NGP0
TreeFamiTF352732

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANRNNVTEF ILLGLTENPK MQKIIFVVFS VIYINAMIGN VLIVVTITAS
60 70 80 90 100
PSLRSPMYFF LAYLSFIDAC YSSVNTPKLI TDSLYENKTI LFNGCMTQVF
110 120 130 140 150
GEHFFRGVEV ILLTVMAYDH YVAICKPLHY TTVMKQHVCS LLVGVSWVGG
160 170 180 190 200
FLHATIQILF ICQLPFCGPN VIDHFMCDLY TLINLACTNT HTLGLFIAAN
210 220 230 240 250
SGFICLLNCL LLLVSCVVIL YSLKTHSLEA RHEALSTCVS HITVVILSFI
260 270 280 290 300
PCIFVYMRPP ATLPIDKAVA VFYTMITSML NPLIYTLRNA QMKNAIRKLC

SRKAISSVK
Length:309
Mass (Da):34,582
Last modified:November 4, 2008 - v2
Checksum:i3EAD1271181FBFF2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0674402A → V. Corresponds to variant dbSNP:rs28378220Ensembl.1
Natural variantiVAR_067441133V → I3 PublicationsCorresponds to variant dbSNP:rs28662375Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065750 Genomic DNA Translation: BAC05970.1
AP006587 Genomic DNA No translation available.
AC073113 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW67853.1
BC137005 mRNA Translation: AAI37006.1
AF399575 Genomic DNA Translation: AAK95060.1
BK004414 Genomic DNA Translation: DAA04812.1
CCDSiCCDS31495.1
RefSeqiNP_001001955.2, NM_001001955.2
UniGeneiHs.553668

Genome annotation databases

EnsembliENST00000555099; ENSP00000452277; ENSG00000258817
GeneIDi283092
KEGGihsa:283092
UCSCiuc010rhz.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4CD_HUMAN
AccessioniPrimary (citable) accession number: Q8NGP0
Secondary accession number(s): A6NJJ3
, B9EH30, Q6IF48, Q96R68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: February 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome