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Protein

Olfactory receptor 4C13

Gene

OR4C13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C13
Alternative name(s):
Olfactory receptor OR11-260
Gene namesi
Name:OR4C13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15169. OR4C13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4724Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence analysis
Transmembranei56 – 7722Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence analysisAdd
BLAST
Transmembranei99 – 11820Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15619Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini157 – 19337ExtracellularSequence analysisAdd
BLAST
Transmembranei194 – 21724Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23316CytoplasmicSequence analysisAdd
BLAST
Transmembranei234 – 25623Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini257 – 26711ExtracellularSequence analysisAdd
BLAST
Transmembranei268 – 28720Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini288 – 30922CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32255.

Polymorphism and mutation databases

BioMutaiOR4C13.
DMDMi212276453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 4C13PRO_0000150534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGP0.
PRIDEiQ8NGP0.

PTM databases

iPTMnetiQ8NGP0.
PhosphoSiteiQ8NGP0.

Expressioni

Gene expression databases

CleanExiHS_OR4C13.

Structurei

3D structure databases

ProteinModelPortaliQ8NGP0.
SMRiQ8NGP0. Positions 23-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KC9W. Eukaryota.
ENOG4110P6N. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGP0.
KOiK04257.
OMAiCTNTHTL.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NGP0.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANRNNVTEF ILLGLTENPK MQKIIFVVFS VIYINAMIGN VLIVVTITAS
60 70 80 90 100
PSLRSPMYFF LAYLSFIDAC YSSVNTPKLI TDSLYENKTI LFNGCMTQVF
110 120 130 140 150
GEHFFRGVEV ILLTVMAYDH YVAICKPLHY TTVMKQHVCS LLVGVSWVGG
160 170 180 190 200
FLHATIQILF ICQLPFCGPN VIDHFMCDLY TLINLACTNT HTLGLFIAAN
210 220 230 240 250
SGFICLLNCL LLLVSCVVIL YSLKTHSLEA RHEALSTCVS HITVVILSFI
260 270 280 290 300
PCIFVYMRPP ATLPIDKAVA VFYTMITSML NPLIYTLRNA QMKNAIRKLC

SRKAISSVK
Length:309
Mass (Da):34,582
Last modified:November 4, 2008 - v2
Checksum:i3EAD1271181FBFF2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21A → V.
Corresponds to variant rs28378220 [ dbSNP | Ensembl ].
VAR_067440
Natural varianti133 – 1331V → I.3 Publications
Corresponds to variant rs28662375 [ dbSNP | Ensembl ].
VAR_067441

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065750 Genomic DNA. Translation: BAC05970.1.
AP006587 Genomic DNA. No translation available.
AC073113 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67853.1.
BC137005 mRNA. Translation: AAI37006.1.
AF399575 Genomic DNA. Translation: AAK95060.1.
BK004414 Genomic DNA. Translation: DAA04812.1.
CCDSiCCDS31495.1.
RefSeqiNP_001001955.2. NM_001001955.2.
UniGeneiHs.553668.

Genome annotation databases

EnsembliENST00000555099; ENSP00000452277; ENSG00000258817.
GeneIDi283092.
KEGGihsa:283092.
UCSCiuc010rhz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065750 Genomic DNA. Translation: BAC05970.1.
AP006587 Genomic DNA. No translation available.
AC073113 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67853.1.
BC137005 mRNA. Translation: AAI37006.1.
AF399575 Genomic DNA. Translation: AAK95060.1.
BK004414 Genomic DNA. Translation: DAA04812.1.
CCDSiCCDS31495.1.
RefSeqiNP_001001955.2. NM_001001955.2.
UniGeneiHs.553668.

3D structure databases

ProteinModelPortaliQ8NGP0.
SMRiQ8NGP0. Positions 23-160.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGP0.
PhosphoSiteiQ8NGP0.

Polymorphism and mutation databases

BioMutaiOR4C13.
DMDMi212276453.

Proteomic databases

PaxDbiQ8NGP0.
PRIDEiQ8NGP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000555099; ENSP00000452277; ENSG00000258817.
GeneIDi283092.
KEGGihsa:283092.
UCSCiuc010rhz.2. human.

Organism-specific databases

CTDi283092.
GeneCardsiOR4C13.
H-InvDBHIX0036112.
HIX0171371.
HGNCiHGNC:15169. OR4C13.
neXtProtiNX_Q8NGP0.
PharmGKBiPA32255.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC9W. Eukaryota.
ENOG4110P6N. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGP0.
KOiK04257.
OMAiCTNTHTL.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NGP0.
TreeFamiTF352732.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4C13.
GenomeRNAii283092.
NextBioi93606.
PROiQ8NGP0.

Gene expression databases

CleanExiHS_OR4C13.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-133.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-133.
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-278, VARIANT ILE-133.
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4CD_HUMAN
AccessioniPrimary (citable) accession number: Q8NGP0
Secondary accession number(s): A6NJJ3
, B9EH30, Q6IF48, Q96R68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: May 11, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.