ID   O10G7_HUMAN             Reviewed;         311 AA.
AC   Q8NGN6; Q6IFE8;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 160.
DE   RecName: Full=Olfactory receptor 10G7;
DE   AltName: Full=Olfactory receptor OR11-283;
GN   Name=OR10G7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10G7";
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DR   EMBL; AB065754; BAC05974.1; -; Genomic_DNA.
DR   EMBL; CH471065; EAW67568.1; -; Genomic_DNA.
DR   EMBL; BK004314; DAA04712.1; -; Genomic_DNA.
DR   CCDS; CCDS31705.1; -.
DR   RefSeq; NP_001004463.1; NM_001004463.1.
DR   AlphaFoldDB; Q8NGN6; -.
DR   SMR; Q8NGN6; -.
DR   STRING; 9606.ENSP00000492905; -.
DR   GlyCosmos; Q8NGN6; 1 site, No reported glycans.
DR   GlyGen; Q8NGN6; 1 site.
DR   iPTMnet; Q8NGN6; -.
DR   PhosphoSitePlus; Q8NGN6; -.
DR   BioMuta; OR10G7; -.
DR   DMDM; 38372736; -.
DR   PaxDb; 9606-ENSP00000329689; -.
DR   PeptideAtlas; Q8NGN6; -.
DR   Antibodypedia; 56785; 48 antibodies from 15 providers.
DR   DNASU; 390265; -.
DR   Ensembl; ENST00000641585.1; ENSP00000492905.1; ENSG00000182634.9.
DR   GeneID; 390265; -.
DR   KEGG; hsa:390265; -.
DR   MANE-Select; ENST00000641585.1; ENSP00000492905.1; NM_001004463.2; NP_001004463.1.
DR   UCSC; uc001pzq.2; human.
DR   AGR; HGNC:14842; -.
DR   CTD; 390265; -.
DR   GeneCards; OR10G7; -.
DR   HGNC; HGNC:14842; OR10G7.
DR   HPA; ENSG00000182634; Not detected.
DR   neXtProt; NX_Q8NGN6; -.
DR   OpenTargets; ENSG00000182634; -.
DR   PharmGKB; PA31974; -.
DR   VEuPathDB; HostDB:ENSG00000182634; -.
DR   eggNOG; ENOG502SI4A; Eukaryota.
DR   GeneTree; ENSGT01050000244869; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q8NGN6; -.
DR   OMA; MTGRSCA; -.
DR   OrthoDB; 4338559at2759; -.
DR   PhylomeDB; Q8NGN6; -.
DR   TreeFam; TF337251; -.
DR   PathwayCommons; Q8NGN6; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390265; 8 hits in 689 CRISPR screens.
DR   GeneWiki; OR10G7; -.
DR   GenomeRNAi; 390265; -.
DR   Pharos; Q8NGN6; Tdark.
DR   PRO; PR:Q8NGN6; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGN6; Protein.
DR   ExpressionAtlas; Q8NGN6; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15916; 7tmA_OR10G-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF7; OLFACTORY RECEPTOR 10G7; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..311
FT                   /note="Olfactory receptor 10G7"
FT                   /id="PRO_0000150699"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..216
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..268
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         5
FT                   /note="T -> S (in dbSNP:rs3894197)"
FT                   /id="VAR_024126"
FT   VARIANT         13
FT                   /note="T -> M (in dbSNP:rs11827843)"
FT                   /id="VAR_048060"
FT   VARIANT         18
FT                   /note="A -> V (in dbSNP:rs3894198)"
FT                   /id="VAR_048061"
FT   VARIANT         20
FT                   /note="G -> A (in dbSNP:rs3894199)"
FT                   /id="VAR_048062"
FT   VARIANT         28
FT                   /note="I -> V (in dbSNP:rs11219420)"
FT                   /id="VAR_048063"
FT   VARIANT         90
FT                   /note="T -> A (in dbSNP:rs470208)"
FT                   /id="VAR_048064"
FT   VARIANT         136
FT                   /note="T -> S (in dbSNP:rs513591)"
FT                   /id="VAR_034285"
SQ   SEQUENCE   311 AA;  34517 MW;  D507B511CF7B1D22 CRC64;
     MSNATLLTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF
     LTNLSFIDMW FSTVTVPKML MTLVSPSGRT ISFHSCVAQL YFFHFLGSTE CFLYTVMSYD
     RYLAISYPLR YTNMMTGRSC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA
     PPILKLACAD TSANEMVIFV NIGLVASGCF VLIVLSYVSI VCSILRIRTS EGRHRAFQTC
     ASHCIVVLCF FGPGLFIYLR PGSRDALHGV VAVFYTTLTP LFNPVVYTLR NKEVKKALLK
     LKNGSVFAQG E
//