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Q8NGN6 (O10G7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10G7
Alternative name(s):
Olfactory receptor OR11-283
Gene names
Name:OR10G7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Olfactory receptor 10G7
PRO_0000150699

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4421Helical; Name=1; Potential
Topological domain45 – 528Cytoplasmic Potential
Transmembrane53 – 7321Helical; Name=2; Potential
Topological domain74 – 9825Extracellular Potential
Transmembrane99 – 11921Helical; Name=3; Potential
Topological domain120 – 13819Cytoplasmic Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 19637Extracellular Potential
Transmembrane197 – 21620Helical; Name=5; Potential
Topological domain217 – 23620Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 26811Extracellular Potential
Transmembrane269 – 28921Helical; Name=7; Potential
Topological domain290 – 31122Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 188 By similarity

Natural variations

Natural variant51T → S.
Corresponds to variant rs3894197 [ dbSNP | Ensembl ].
VAR_024126
Natural variant131T → M.
Corresponds to variant rs11827843 [ dbSNP | Ensembl ].
VAR_048060
Natural variant181A → V.
Corresponds to variant rs3894198 [ dbSNP | Ensembl ].
VAR_048061
Natural variant201G → A.
Corresponds to variant rs3894199 [ dbSNP | Ensembl ].
VAR_048062
Natural variant281I → V.
Corresponds to variant rs11219420 [ dbSNP | Ensembl ].
VAR_048063
Natural variant901T → A.
Corresponds to variant rs470208 [ dbSNP | Ensembl ].
VAR_048064
Natural variant1361T → S.
Corresponds to variant rs513591 [ dbSNP | Ensembl ].
VAR_034285

Sequences

Sequence LengthMass (Da)Tools
Q8NGN6 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: D507B511CF7B1D22

FASTA31134,517
        10         20         30         40         50         60 
MSNATLLTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF 

        70         80         90        100        110        120 
LTNLSFIDMW FSTVTVPKML MTLVSPSGRT ISFHSCVAQL YFFHFLGSTE CFLYTVMSYD 

       130        140        150        160        170        180 
RYLAISYPLR YTNMMTGRSC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA 

       190        200        210        220        230        240 
PPILKLACAD TSANEMVIFV NIGLVASGCF VLIVLSYVSI VCSILRIRTS EGRHRAFQTC 

       250        260        270        280        290        300 
ASHCIVVLCF FGPGLFIYLR PGSRDALHGV VAVFYTTLTP LFNPVVYTLR NKEVKKALLK 

       310 
LKNGSVFAQG E 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065754 Genomic DNA. Translation: BAC05974.1.
CH471065 Genomic DNA. Translation: EAW67568.1.
BK004314 Genomic DNA. Translation: DAA04712.1.
RefSeqNP_001004463.1. NM_001004463.1.
UniGeneHs.553761.

3D structure databases

ProteinModelPortalQ8NGN6.
SMRQ8NGN6. Positions 30-183, 275-303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000329689.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGN6.

Polymorphism databases

DMDM38372736.

Proteomic databases

PRIDEQ8NGN6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330487; ENSP00000329689; ENSG00000182634.
GeneID390265.
KEGGhsa:390265.
UCSCuc001pzq.1. human.

Organism-specific databases

CTD390265.
GeneCardsGC11M123908.
HGNCHGNC:14842. OR10G7.
neXtProtNX_Q8NGN6.
PharmGKBPA31974.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41301.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGN6.
KOK04257.
OMALRICTSE.
OrthoDBEOG7288RS.
PhylomeDBQ8NGN6.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8NGN6.
CleanExHS_OR10G7.
GenevestigatorQ8NGN6.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10G7.
NextBio103606.
PROQ8NGN6.

Entry information

Entry nameO10G7_HUMAN
AccessionPrimary (citable) accession number: Q8NGN6
Secondary accession number(s): Q6IFE8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries