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Q8NGN6

- O10G7_HUMAN

UniProt

Q8NGN6 - O10G7_HUMAN

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Protein
Olfactory receptor 10G7
Gene
OR10G7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G7
Alternative name(s):
Olfactory receptor OR11-283
Gene namesi
Name:OR10G7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14842. OR10G7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Extracellular Reviewed prediction
Add
BLAST
Transmembranei24 – 4421Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini45 – 528Cytoplasmic Reviewed prediction
Transmembranei53 – 7321Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini74 – 9825Extracellular Reviewed prediction
Add
BLAST
Transmembranei99 – 11921Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini120 – 13819Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei139 – 15921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini160 – 19637Extracellular Reviewed prediction
Add
BLAST
Transmembranei197 – 21620Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini217 – 23620Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei237 – 25721Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini258 – 26811Extracellular Reviewed prediction
Add
BLAST
Transmembranei269 – 28921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini290 – 31122Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31974.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 10G7
PRO_0000150699Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi96 ↔ 188 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGN6.

PTM databases

PhosphoSiteiQ8NGN6.

Expressioni

Gene expression databases

BgeeiQ8NGN6.
CleanExiHS_OR10G7.
GenevestigatoriQ8NGN6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329689.

Structurei

3D structure databases

ProteinModelPortaliQ8NGN6.
SMRiQ8NGN6. Positions 30-183.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41301.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN6.
KOiK04257.
OMAiCVSHCIV.
OrthoDBiEOG7288RS.
PhylomeDBiQ8NGN6.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGN6-1 [UniParc]FASTAAdd to Basket

« Hide

MSNATLLTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD    50
SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRT ISFHSCVAQL 100
YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTNMMTGRSC ALLATGTWLS 150
GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANEMVIFV 200
NIGLVASGCF VLIVLSYVSI VCSILRIRTS EGRHRAFQTC ASHCIVVLCF 250
FGPGLFIYLR PGSRDALHGV VAVFYTTLTP LFNPVVYTLR NKEVKKALLK 300
LKNGSVFAQG E 311
Length:311
Mass (Da):34,517
Last modified:October 1, 2002 - v1
Checksum:iD507B511CF7B1D22
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51T → S.
Corresponds to variant rs3894197 [ dbSNP | Ensembl ].
VAR_024126
Natural varianti13 – 131T → M.
Corresponds to variant rs11827843 [ dbSNP | Ensembl ].
VAR_048060
Natural varianti18 – 181A → V.
Corresponds to variant rs3894198 [ dbSNP | Ensembl ].
VAR_048061
Natural varianti20 – 201G → A.
Corresponds to variant rs3894199 [ dbSNP | Ensembl ].
VAR_048062
Natural varianti28 – 281I → V.
Corresponds to variant rs11219420 [ dbSNP | Ensembl ].
VAR_048063
Natural varianti90 – 901T → A.
Corresponds to variant rs470208 [ dbSNP | Ensembl ].
VAR_048064
Natural varianti136 – 1361T → S.
Corresponds to variant rs513591 [ dbSNP | Ensembl ].
VAR_034285

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065754 Genomic DNA. Translation: BAC05974.1.
CH471065 Genomic DNA. Translation: EAW67568.1.
BK004314 Genomic DNA. Translation: DAA04712.1.
CCDSiCCDS31705.1.
RefSeqiNP_001004463.1. NM_001004463.1.
UniGeneiHs.553761.

Genome annotation databases

EnsembliENST00000330487; ENSP00000329689; ENSG00000182634.
GeneIDi390265.
KEGGihsa:390265.
UCSCiuc001pzq.1. human.

Polymorphism databases

DMDMi38372736.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065754 Genomic DNA. Translation: BAC05974.1 .
CH471065 Genomic DNA. Translation: EAW67568.1 .
BK004314 Genomic DNA. Translation: DAA04712.1 .
CCDSi CCDS31705.1.
RefSeqi NP_001004463.1. NM_001004463.1.
UniGenei Hs.553761.

3D structure databases

ProteinModelPortali Q8NGN6.
SMRi Q8NGN6. Positions 30-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000329689.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGN6.

Polymorphism databases

DMDMi 38372736.

Proteomic databases

PRIDEi Q8NGN6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330487 ; ENSP00000329689 ; ENSG00000182634 .
GeneIDi 390265.
KEGGi hsa:390265.
UCSCi uc001pzq.1. human.

Organism-specific databases

CTDi 390265.
GeneCardsi GC11M123908.
HGNCi HGNC:14842. OR10G7.
neXtProti NX_Q8NGN6.
PharmGKBi PA31974.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41301.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGN6.
KOi K04257.
OMAi CVSHCIV.
OrthoDBi EOG7288RS.
PhylomeDBi Q8NGN6.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10G7.
NextBioi 103606.
PROi Q8NGN6.

Gene expression databases

Bgeei Q8NGN6.
CleanExi HS_OR10G7.
Genevestigatori Q8NGN6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10G7_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN6
Secondary accession number(s): Q6IFE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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