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Protein

Olfactory receptor 10G7

Gene

OR10G7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G7
Alternative name(s):
Olfactory receptor OR11-283
Gene namesi
Name:OR10G7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14842. OR10G7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence Analysis
Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini74 – 9825ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 23620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 26811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 31122CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31974.

Polymorphism and mutation databases

BioMutaiOR10G7.
DMDMi38372736.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 10G7PRO_0000150699Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGN6.

PTM databases

PhosphoSiteiQ8NGN6.

Expressioni

Gene expression databases

BgeeiQ8NGN6.
CleanExiHS_OR10G7.
GenevestigatoriQ8NGN6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329689.

Structurei

3D structure databases

ProteinModelPortaliQ8NGN6.
SMRiQ8NGN6. Positions 30-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41301.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN6.
KOiK04257.
OMAiLMSERTC.
OrthoDBiEOG7288RS.
PhylomeDBiQ8NGN6.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
IPR030779. OR10G7.
[Graphical view]
PANTHERiPTHR26453:SF7. PTHR26453:SF7. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNATLLTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD
60 70 80 90 100
SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRT ISFHSCVAQL
110 120 130 140 150
YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTNMMTGRSC ALLATGTWLS
160 170 180 190 200
GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANEMVIFV
210 220 230 240 250
NIGLVASGCF VLIVLSYVSI VCSILRIRTS EGRHRAFQTC ASHCIVVLCF
260 270 280 290 300
FGPGLFIYLR PGSRDALHGV VAVFYTTLTP LFNPVVYTLR NKEVKKALLK
310
LKNGSVFAQG E
Length:311
Mass (Da):34,517
Last modified:October 1, 2002 - v1
Checksum:iD507B511CF7B1D22
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51T → S.
Corresponds to variant rs3894197 [ dbSNP | Ensembl ].
VAR_024126
Natural varianti13 – 131T → M.
Corresponds to variant rs11827843 [ dbSNP | Ensembl ].
VAR_048060
Natural varianti18 – 181A → V.
Corresponds to variant rs3894198 [ dbSNP | Ensembl ].
VAR_048061
Natural varianti20 – 201G → A.
Corresponds to variant rs3894199 [ dbSNP | Ensembl ].
VAR_048062
Natural varianti28 – 281I → V.
Corresponds to variant rs11219420 [ dbSNP | Ensembl ].
VAR_048063
Natural varianti90 – 901T → A.
Corresponds to variant rs470208 [ dbSNP | Ensembl ].
VAR_048064
Natural varianti136 – 1361T → S.
Corresponds to variant rs513591 [ dbSNP | Ensembl ].
VAR_034285

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065754 Genomic DNA. Translation: BAC05974.1.
CH471065 Genomic DNA. Translation: EAW67568.1.
BK004314 Genomic DNA. Translation: DAA04712.1.
CCDSiCCDS31705.1.
RefSeqiNP_001004463.1. NM_001004463.1.
UniGeneiHs.553761.

Genome annotation databases

EnsembliENST00000330487; ENSP00000329689; ENSG00000182634.
GeneIDi390265.
KEGGihsa:390265.
UCSCiuc001pzq.1. human.

Polymorphism and mutation databases

BioMutaiOR10G7.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065754 Genomic DNA. Translation: BAC05974.1.
CH471065 Genomic DNA. Translation: EAW67568.1.
BK004314 Genomic DNA. Translation: DAA04712.1.
CCDSiCCDS31705.1.
RefSeqiNP_001004463.1. NM_001004463.1.
UniGeneiHs.553761.

3D structure databases

ProteinModelPortaliQ8NGN6.
SMRiQ8NGN6. Positions 30-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000329689.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGN6.

Polymorphism and mutation databases

BioMutaiOR10G7.
DMDMi38372736.

Proteomic databases

PRIDEiQ8NGN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330487; ENSP00000329689; ENSG00000182634.
GeneIDi390265.
KEGGihsa:390265.
UCSCiuc001pzq.1. human.

Organism-specific databases

CTDi390265.
GeneCardsiGC11M123908.
HGNCiHGNC:14842. OR10G7.
neXtProtiNX_Q8NGN6.
PharmGKBiPA31974.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41301.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN6.
KOiK04257.
OMAiLMSERTC.
OrthoDBiEOG7288RS.
PhylomeDBiQ8NGN6.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10G7.
GenomeRNAii390265.
NextBioi103606.
PROiQ8NGN6.

Gene expression databases

BgeeiQ8NGN6.
CleanExiHS_OR10G7.
GenevestigatoriQ8NGN6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
IPR030779. OR10G7.
[Graphical view]
PANTHERiPTHR26453:SF7. PTHR26453:SF7. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10G7_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN6
Secondary accession number(s): Q6IFE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.