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Q8NGN6

- O10G7_HUMAN

UniProt

Q8NGN6 - O10G7_HUMAN

Protein

Olfactory receptor 10G7

Gene

OR10G7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10G7
    Alternative name(s):
    Olfactory receptor OR11-283
    Gene namesi
    Name:OR10G7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14842. OR10G7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31974.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 10G7PRO_0000150699Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGN6.

    PTM databases

    PhosphoSiteiQ8NGN6.

    Expressioni

    Gene expression databases

    BgeeiQ8NGN6.
    CleanExiHS_OR10G7.
    GenevestigatoriQ8NGN6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000329689.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGN6.
    SMRiQ8NGN6. Positions 30-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 528CytoplasmicSequence Analysis
    Topological domaini74 – 9825ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 26811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31122CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41301.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGN6.
    KOiK04257.
    OMAiCVSHCIV.
    OrthoDBiEOG7288RS.
    PhylomeDBiQ8NGN6.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNATLLTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD    50
    SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRT ISFHSCVAQL 100
    YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTNMMTGRSC ALLATGTWLS 150
    GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANEMVIFV 200
    NIGLVASGCF VLIVLSYVSI VCSILRIRTS EGRHRAFQTC ASHCIVVLCF 250
    FGPGLFIYLR PGSRDALHGV VAVFYTTLTP LFNPVVYTLR NKEVKKALLK 300
    LKNGSVFAQG E 311
    Length:311
    Mass (Da):34,517
    Last modified:October 1, 2002 - v1
    Checksum:iD507B511CF7B1D22
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51T → S.
    Corresponds to variant rs3894197 [ dbSNP | Ensembl ].
    VAR_024126
    Natural varianti13 – 131T → M.
    Corresponds to variant rs11827843 [ dbSNP | Ensembl ].
    VAR_048060
    Natural varianti18 – 181A → V.
    Corresponds to variant rs3894198 [ dbSNP | Ensembl ].
    VAR_048061
    Natural varianti20 – 201G → A.
    Corresponds to variant rs3894199 [ dbSNP | Ensembl ].
    VAR_048062
    Natural varianti28 – 281I → V.
    Corresponds to variant rs11219420 [ dbSNP | Ensembl ].
    VAR_048063
    Natural varianti90 – 901T → A.
    Corresponds to variant rs470208 [ dbSNP | Ensembl ].
    VAR_048064
    Natural varianti136 – 1361T → S.
    Corresponds to variant rs513591 [ dbSNP | Ensembl ].
    VAR_034285

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065754 Genomic DNA. Translation: BAC05974.1.
    CH471065 Genomic DNA. Translation: EAW67568.1.
    BK004314 Genomic DNA. Translation: DAA04712.1.
    CCDSiCCDS31705.1.
    RefSeqiNP_001004463.1. NM_001004463.1.
    UniGeneiHs.553761.

    Genome annotation databases

    EnsembliENST00000330487; ENSP00000329689; ENSG00000182634.
    GeneIDi390265.
    KEGGihsa:390265.
    UCSCiuc001pzq.1. human.

    Polymorphism databases

    DMDMi38372736.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065754 Genomic DNA. Translation: BAC05974.1 .
    CH471065 Genomic DNA. Translation: EAW67568.1 .
    BK004314 Genomic DNA. Translation: DAA04712.1 .
    CCDSi CCDS31705.1.
    RefSeqi NP_001004463.1. NM_001004463.1.
    UniGenei Hs.553761.

    3D structure databases

    ProteinModelPortali Q8NGN6.
    SMRi Q8NGN6. Positions 30-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000329689.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGN6.

    Polymorphism databases

    DMDMi 38372736.

    Proteomic databases

    PRIDEi Q8NGN6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330487 ; ENSP00000329689 ; ENSG00000182634 .
    GeneIDi 390265.
    KEGGi hsa:390265.
    UCSCi uc001pzq.1. human.

    Organism-specific databases

    CTDi 390265.
    GeneCardsi GC11M123908.
    HGNCi HGNC:14842. OR10G7.
    neXtProti NX_Q8NGN6.
    PharmGKBi PA31974.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41301.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGN6.
    KOi K04257.
    OMAi CVSHCIV.
    OrthoDBi EOG7288RS.
    PhylomeDBi Q8NGN6.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10G7.
    NextBioi 103606.
    PROi Q8NGN6.

    Gene expression databases

    Bgeei Q8NGN6.
    CleanExi HS_OR10G7.
    Genevestigatori Q8NGN6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10G7_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGN6
    Secondary accession number(s): Q6IFE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3