ID O10G8_HUMAN Reviewed; 311 AA. AC Q8NGN5; B2RNJ3; Q6IEV2; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 24-JAN-2024, entry version 158. DE RecName: Full=Olfactory receptor 10G8; DE AltName: Full=Olfactory receptor OR11-282; GN Name=OR10G8; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [5] RP ERRATUM OF PUBMED:14983052. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10G8"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065755; BAC05975.1; -; Genomic_DNA. DR EMBL; CH471065; EAW67567.1; -; Genomic_DNA. DR EMBL; BC136917; AAI36918.1; -; mRNA. DR EMBL; BC136920; AAI36921.1; -; mRNA. DR EMBL; BK004510; DAA04908.1; -; Genomic_DNA. DR CCDS; CCDS31704.1; -. DR RefSeq; NP_001004464.1; NM_001004464.1. DR AlphaFoldDB; Q8NGN5; -. DR SMR; Q8NGN5; -. DR BioGRID; 128587; 15. DR STRING; 9606.ENSP00000389072; -. DR GlyCosmos; Q8NGN5; 1 site, No reported glycans. DR GlyGen; Q8NGN5; 1 site. DR iPTMnet; Q8NGN5; -. DR PhosphoSitePlus; Q8NGN5; -. DR BioMuta; OR10G8; -. DR DMDM; 38372735; -. DR MassIVE; Q8NGN5; -. DR PaxDb; 9606-ENSP00000389072; -. DR PeptideAtlas; Q8NGN5; -. DR Antibodypedia; 67320; 63 antibodies from 17 providers. DR DNASU; 219869; -. DR Ensembl; ENST00000431524.1; ENSP00000389072.1; ENSG00000234560.5. DR Ensembl; ENST00000641224.2; ENSP00000493087.1; ENSG00000234560.5. DR GeneID; 219869; -. DR KEGG; hsa:219869; -. DR MANE-Select; ENST00000641224.2; ENSP00000493087.1; NM_001004464.2; NP_001004464.1. DR UCSC; uc001pzp.2; human. DR AGR; HGNC:14845; -. DR CTD; 219869; -. DR GeneCards; OR10G8; -. DR HGNC; HGNC:14845; OR10G8. DR HPA; ENSG00000234560; Not detected. DR neXtProt; NX_Q8NGN5; -. DR PharmGKB; PA31975; -. DR VEuPathDB; HostDB:ENSG00000234560; -. DR eggNOG; ENOG502SI4A; Eukaryota. DR GeneTree; ENSGT01050000244869; -. DR HOGENOM; CLU_012526_8_1_1; -. DR InParanoid; Q8NGN5; -. DR OMA; TSMMSGC; -. DR OrthoDB; 4338559at2759; -. DR PhylomeDB; Q8NGN5; -. DR TreeFam; TF337251; -. DR PathwayCommons; Q8NGN5; -. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR BioGRID-ORCS; 219869; 7 hits in 736 CRISPR screens. DR GeneWiki; OR10G8; -. DR GenomeRNAi; 219869; -. DR Pharos; Q8NGN5; Tdark. DR PRO; PR:Q8NGN5; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q8NGN5; Protein. DR Bgee; ENSG00000234560; Expressed in primordial germ cell in gonad and 1 other cell type or tissue. DR ExpressionAtlas; Q8NGN5; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR26453:SF682; OLFACTORY RECEPTOR 10G8; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..311 FT /note="Olfactory receptor 10G8" FT /id="PRO_0000150700" FT TOPO_DOM 1..23 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 24..44 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 45..52 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 53..73 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 74..98 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 99..119 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 120..138 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 139..159 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 160..196 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 197..216 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 217..236 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 237..257 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 258..268 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 269..289 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 290..311 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 3 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 96..188 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" SQ SEQUENCE 311 AA; 34519 MW; 1F3214FD463A7CFD CRC64; MSNASLLTAF ILMGLPHAPA LDAPLFGVFL VVYVLTVLGN LLILLVIRVD SHLHTTMYYF LTNLSFIDMW FSTVTVPKLL MTLVFPSGRA ISFHSCMAQL YFFHFLGGTE CFLYRVMSCD RYLAISYPLR YTSMMTGRSC TLLATSTWLS GSLHSAVQAI LTFHLPYCGP NWIQHYLCDA PPILKLACAD TSAIETVIFV TVGIVASGCF VLIVLSYVSI VCSILRIRTS EGKHRAFQTC ASHCIVVLCF FGPGLFIYLR PGSRKAVDGV VAVFYTVLTP LLNPVVYTLR NKEVKKALLK LKDKVAHSQS K //