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Q8NGN5 (O10G8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10G8
Alternative name(s):
Olfactory receptor OR11-282
Gene names
Name:OR10G8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Olfactory receptor 10G8
PRO_0000150700

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4421Helical; Name=1; Potential
Topological domain45 – 528Cytoplasmic Potential
Transmembrane53 – 7321Helical; Name=2; Potential
Topological domain74 – 9825Extracellular Potential
Transmembrane99 – 11921Helical; Name=3; Potential
Topological domain120 – 13819Cytoplasmic Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 19637Extracellular Potential
Transmembrane197 – 21620Helical; Name=5; Potential
Topological domain217 – 23620Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 26811Extracellular Potential
Transmembrane269 – 28921Helical; Name=7; Potential
Topological domain290 – 31122Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 188 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NGN5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 1F3214FD463A7CFD

FASTA31134,519
        10         20         30         40         50         60 
MSNASLLTAF ILMGLPHAPA LDAPLFGVFL VVYVLTVLGN LLILLVIRVD SHLHTTMYYF 

        70         80         90        100        110        120 
LTNLSFIDMW FSTVTVPKLL MTLVFPSGRA ISFHSCMAQL YFFHFLGGTE CFLYRVMSCD 

       130        140        150        160        170        180 
RYLAISYPLR YTSMMTGRSC TLLATSTWLS GSLHSAVQAI LTFHLPYCGP NWIQHYLCDA 

       190        200        210        220        230        240 
PPILKLACAD TSAIETVIFV TVGIVASGCF VLIVLSYVSI VCSILRIRTS EGKHRAFQTC 

       250        260        270        280        290        300 
ASHCIVVLCF FGPGLFIYLR PGSRKAVDGV VAVFYTVLTP LLNPVVYTLR NKEVKKALLK 

       310 
LKDKVAHSQS K 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065755 Genomic DNA. Translation: BAC05975.1.
CH471065 Genomic DNA. Translation: EAW67567.1.
BC136917 mRNA. Translation: AAI36918.1.
BC136920 mRNA. Translation: AAI36921.1.
BK004510 Genomic DNA. Translation: DAA04908.1.
RefSeqNP_001004464.1. NM_001004464.1.
UniGeneHs.553635.

3D structure databases

ProteinModelPortalQ8NGN5.
SMRQ8NGN5. Positions 18-152, 274-303.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000325076.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372735.

Proteomic databases

PaxDbQ8NGN5.
PRIDEQ8NGN5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000431524; ENSP00000389072; ENSG00000234560.
GeneID219869.
KEGGhsa:219869.
UCSCuc001pzp.1. human.

Organism-specific databases

CTD219869.
GeneCardsGC11P123900.
HGNCHGNC:14845. OR10G8.
neXtProtNX_Q8NGN5.
PharmGKBPA31975.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG271559.
HOGENOMHOG000041362.
HOVERGENHBG017625.
KOK04257.
OMAMTGRSCT.
OrthoDBEOG7288RS.
PhylomeDBQ8NGN5.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10G8.
GenevestigatorQ8NGN5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10G8.
GenomeRNAi219869.
NextBio90818.
PROQ8NGN5.

Entry information

Entry nameO10G8_HUMAN
AccessionPrimary (citable) accession number: Q8NGN5
Secondary accession number(s): B2RNJ3, Q6IEV2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries