Q8NGN5 (O10G8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10G8

Alternative name(s):
Olfactory receptor OR11-282

Gene names

Name:

OR10G8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Olfactory receptor 10G8		PRO_0000150700
Regions
	Topological domain	1 – 23	23	Extracellular Potential
	Transmembrane	24 – 44	21	Helical; Name=1; Potential
	Topological domain	45 – 52	8	Cytoplasmic Potential
	Transmembrane	53 – 73	21	Helical; Name=2; Potential
	Topological domain	74 – 98	25	Extracellular Potential
	Transmembrane	99 – 119	21	Helical; Name=3; Potential
	Topological domain	120 – 138	19	Cytoplasmic Potential
	Transmembrane	139 – 159	21	Helical; Name=4; Potential
	Topological domain	160 – 196	37	Extracellular Potential
	Transmembrane	197 – 216	20	Helical; Name=5; Potential
	Topological domain	217 – 236	20	Cytoplasmic Potential
	Transmembrane	237 – 257	21	Helical; Name=6; Potential
	Topological domain	258 – 268	11	Extracellular Potential
	Transmembrane	269 – 289	21	Helical; Name=7; Potential
	Topological domain	290 – 311	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Disulfide bond	96 ↔ 188		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NGN5 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 1F3214FD463A7CFD	FASTA	311	34,519
	10 20 30 40 50 60 MSNASLLTAF ILMGLPHAPA LDAPLFGVFL VVYVLTVLGN LLILLVIRVD SHLHTTMYYF 70 80 90 100 110 120 LTNLSFIDMW FSTVTVPKLL MTLVFPSGRA ISFHSCMAQL YFFHFLGGTE CFLYRVMSCD 130 140 150 160 170 180 RYLAISYPLR YTSMMTGRSC TLLATSTWLS GSLHSAVQAI LTFHLPYCGP NWIQHYLCDA 190 200 210 220 230 240 PPILKLACAD TSAIETVIFV TVGIVASGCF VLIVLSYVSI VCSILRIRTS EGKHRAFQTC 250 260 270 280 290 300 ASHCIVVLCF FGPGLFIYLR PGSRKAVDGV VAVFYTVLTP LLNPVVYTLR NKEVKKALLK 310 LKDKVAHSQS K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065755 Genomic DNA. Translation: BAC05975.1. CH471065 Genomic DNA. Translation: EAW67567.1. BC136917 mRNA. Translation: AAI36918.1. BC136920 mRNA. Translation: AAI36921.1. BK004510 Genomic DNA. Translation: DAA04908.1.
IPI	IPI00303556.
RefSeq	NP_001004464.1. NM_001004464.1.
UniGene	Hs.553635.
3D structure databases
ProteinModelPortal	Q8NGN5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000325076.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38372735.
Proteomic databases
PaxDb	Q8NGN5.
PRIDE	Q8NGN5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000431524; ENSP00000389072; ENSG00000234560.
GeneID	219869.
KEGG	hsa:219869.
UCSC	uc001pzp.1. human.
Organism-specific databases
CTD	219869.
GeneCards	GC11P123900.
HGNC	HGNC:14845. OR10G8.
neXtProt	NX_Q8NGN5.
PharmGKB	PA31975.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG271559.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
KO	K04257.
OMA	EIVIFVT.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR10G8.
Genevestigator	Q8NGN5.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	219869.
NextBio	90818.

Entry information

Entry name

O10G8_HUMAN

Accession

Primary (citable) accession number: Q8NGN5
Secondary accession number(s): B2RNJ3, Q6IEV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.