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Protein

Olfactory receptor 10G8

Gene

OR10G8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181457-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G8
Alternative name(s):
Olfactory receptor OR11-282
Gene namesi
Name:OR10G8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14845. OR10G8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 98ExtracellularSequence analysisAdd BLAST25
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 196ExtracellularSequence analysisAdd BLAST37
Transmembranei197 – 216Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 268ExtracellularSequence analysisAdd BLAST11
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 311CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000234560.
PharmGKBiPA31975.

Polymorphism and mutation databases

BioMutaiOR10G8.
DMDMi38372735.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507001 – 311Olfactory receptor 10G8Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN5.
PRIDEiQ8NGN5.

PTM databases

iPTMnetiQ8NGN5.
PhosphoSitePlusiQ8NGN5.

Expressioni

Gene expression databases

CleanExiHS_OR10G8.
ExpressionAtlasiQ8NGN5. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000389072.

Structurei

3D structure databases

ProteinModelPortaliQ8NGN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN5.
KOiK04257.
OMAiMTGRSCT.
OrthoDBiEOG091G0DMR.
PhylomeDBiQ8NGN5.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNASLLTAF ILMGLPHAPA LDAPLFGVFL VVYVLTVLGN LLILLVIRVD
60 70 80 90 100
SHLHTTMYYF LTNLSFIDMW FSTVTVPKLL MTLVFPSGRA ISFHSCMAQL
110 120 130 140 150
YFFHFLGGTE CFLYRVMSCD RYLAISYPLR YTSMMTGRSC TLLATSTWLS
160 170 180 190 200
GSLHSAVQAI LTFHLPYCGP NWIQHYLCDA PPILKLACAD TSAIETVIFV
210 220 230 240 250
TVGIVASGCF VLIVLSYVSI VCSILRIRTS EGKHRAFQTC ASHCIVVLCF
260 270 280 290 300
FGPGLFIYLR PGSRKAVDGV VAVFYTVLTP LLNPVVYTLR NKEVKKALLK
310
LKDKVAHSQS K
Length:311
Mass (Da):34,519
Last modified:October 1, 2002 - v1
Checksum:i1F3214FD463A7CFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065755 Genomic DNA. Translation: BAC05975.1.
CH471065 Genomic DNA. Translation: EAW67567.1.
BC136917 mRNA. Translation: AAI36918.1.
BC136920 mRNA. Translation: AAI36921.1.
BK004510 Genomic DNA. Translation: DAA04908.1.
CCDSiCCDS31704.1.
RefSeqiNP_001004464.1. NM_001004464.1.
UniGeneiHs.553635.

Genome annotation databases

EnsembliENST00000431524; ENSP00000389072; ENSG00000234560.
GeneIDi219869.
KEGGihsa:219869.
UCSCiuc001pzp.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065755 Genomic DNA. Translation: BAC05975.1.
CH471065 Genomic DNA. Translation: EAW67567.1.
BC136917 mRNA. Translation: AAI36918.1.
BC136920 mRNA. Translation: AAI36921.1.
BK004510 Genomic DNA. Translation: DAA04908.1.
CCDSiCCDS31704.1.
RefSeqiNP_001004464.1. NM_001004464.1.
UniGeneiHs.553635.

3D structure databases

ProteinModelPortaliQ8NGN5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000389072.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGN5.
PhosphoSitePlusiQ8NGN5.

Polymorphism and mutation databases

BioMutaiOR10G8.
DMDMi38372735.

Proteomic databases

PaxDbiQ8NGN5.
PRIDEiQ8NGN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431524; ENSP00000389072; ENSG00000234560.
GeneIDi219869.
KEGGihsa:219869.
UCSCiuc001pzp.2. human.

Organism-specific databases

CTDi219869.
GeneCardsiOR10G8.
HGNCiHGNC:14845. OR10G8.
neXtProtiNX_Q8NGN5.
OpenTargetsiENSG00000234560.
PharmGKBiPA31975.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN5.
KOiK04257.
OMAiMTGRSCT.
OrthoDBiEOG091G0DMR.
PhylomeDBiQ8NGN5.
TreeFamiTF337251.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181457-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10G8.
GenomeRNAii219869.
PROiQ8NGN5.

Gene expression databases

CleanExiHS_OR10G8.
ExpressionAtlasiQ8NGN5. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10G8_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN5
Secondary accession number(s): B2RNJ3, Q6IEV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.