Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NGN5

- O10G8_HUMAN

UniProt

Q8NGN5 - O10G8_HUMAN

Protein

Olfactory receptor 10G8

Gene

OR10G8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10G8
    Alternative name(s):
    Olfactory receptor OR11-282
    Gene namesi
    Name:OR10G8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14845. OR10G8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31975.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 10G8PRO_0000150700Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGN5.
    PRIDEiQ8NGN5.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10G8.
    GenevestigatoriQ8NGN5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000325076.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGN5.
    SMRiQ8NGN5. Positions 18-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 528CytoplasmicSequence Analysis
    Topological domaini74 – 9825ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 26811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31122CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG271559.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    KOiK04257.
    OMAiMTGRSCT.
    OrthoDBiEOG7288RS.
    PhylomeDBiQ8NGN5.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGN5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNASLLTAF ILMGLPHAPA LDAPLFGVFL VVYVLTVLGN LLILLVIRVD    50
    SHLHTTMYYF LTNLSFIDMW FSTVTVPKLL MTLVFPSGRA ISFHSCMAQL 100
    YFFHFLGGTE CFLYRVMSCD RYLAISYPLR YTSMMTGRSC TLLATSTWLS 150
    GSLHSAVQAI LTFHLPYCGP NWIQHYLCDA PPILKLACAD TSAIETVIFV 200
    TVGIVASGCF VLIVLSYVSI VCSILRIRTS EGKHRAFQTC ASHCIVVLCF 250
    FGPGLFIYLR PGSRKAVDGV VAVFYTVLTP LLNPVVYTLR NKEVKKALLK 300
    LKDKVAHSQS K 311
    Length:311
    Mass (Da):34,519
    Last modified:October 1, 2002 - v1
    Checksum:i1F3214FD463A7CFD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065755 Genomic DNA. Translation: BAC05975.1.
    CH471065 Genomic DNA. Translation: EAW67567.1.
    BC136917 mRNA. Translation: AAI36918.1.
    BC136920 mRNA. Translation: AAI36921.1.
    BK004510 Genomic DNA. Translation: DAA04908.1.
    CCDSiCCDS31704.1.
    RefSeqiNP_001004464.1. NM_001004464.1.
    UniGeneiHs.553635.

    Genome annotation databases

    EnsembliENST00000431524; ENSP00000389072; ENSG00000234560.
    GeneIDi219869.
    KEGGihsa:219869.
    UCSCiuc001pzp.1. human.

    Polymorphism databases

    DMDMi38372735.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065755 Genomic DNA. Translation: BAC05975.1 .
    CH471065 Genomic DNA. Translation: EAW67567.1 .
    BC136917 mRNA. Translation: AAI36918.1 .
    BC136920 mRNA. Translation: AAI36921.1 .
    BK004510 Genomic DNA. Translation: DAA04908.1 .
    CCDSi CCDS31704.1.
    RefSeqi NP_001004464.1. NM_001004464.1.
    UniGenei Hs.553635.

    3D structure databases

    ProteinModelPortali Q8NGN5.
    SMRi Q8NGN5. Positions 18-152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000325076.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372735.

    Proteomic databases

    PaxDbi Q8NGN5.
    PRIDEi Q8NGN5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000431524 ; ENSP00000389072 ; ENSG00000234560 .
    GeneIDi 219869.
    KEGGi hsa:219869.
    UCSCi uc001pzp.1. human.

    Organism-specific databases

    CTDi 219869.
    GeneCardsi GC11P123900.
    HGNCi HGNC:14845. OR10G8.
    neXtProti NX_Q8NGN5.
    PharmGKBi PA31975.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271559.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    KOi K04257.
    OMAi MTGRSCT.
    OrthoDBi EOG7288RS.
    PhylomeDBi Q8NGN5.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10G8.
    GenomeRNAii 219869.
    NextBioi 90818.
    PROi Q8NGN5.

    Gene expression databases

    CleanExi HS_OR10G8.
    Genevestigatori Q8NGN5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10G8_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGN5
    Secondary accession number(s): B2RNJ3, Q6IEV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3