ID   O10G9_HUMAN             Reviewed;         311 AA.
AC   Q8NGN4;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 150.
DE   RecName: Full=Olfactory receptor 10G9;
DE   AltName: Full=Olfactory receptor 10G10;
GN   Name=OR10G9; Synonyms=OR10G10P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10G9";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB065756; BAC05976.1; -; Genomic_DNA.
DR   CCDS; CCDS31703.1; -.
DR   RefSeq; NP_001001953.1; NM_001001953.1.
DR   AlphaFoldDB; Q8NGN4; -.
DR   SMR; Q8NGN4; -.
DR   STRING; 9606.ENSP00000364164; -.
DR   iPTMnet; Q8NGN4; -.
DR   PhosphoSitePlus; Q8NGN4; -.
DR   BioMuta; OR10G9; -.
DR   DMDM; 38372734; -.
DR   PaxDb; 9606-ENSP00000364164; -.
DR   PeptideAtlas; Q8NGN4; -.
DR   Antibodypedia; 56782; 128 antibodies from 21 providers.
DR   DNASU; 219870; -.
DR   Ensembl; ENST00000375024.1; ENSP00000364164.1; ENSG00000236981.1.
DR   GeneID; 219870; -.
DR   KEGG; hsa:219870; -.
DR   MANE-Select; ENST00000375024.1; ENSP00000364164.1; NM_001001953.1; NP_001001953.1.
DR   UCSC; uc010sad.2; human.
DR   AGR; HGNC:15129; -.
DR   CTD; 219870; -.
DR   GeneCards; OR10G9; -.
DR   HGNC; HGNC:15129; OR10G9.
DR   HPA; ENSG00000236981; Not detected.
DR   neXtProt; NX_Q8NGN4; -.
DR   PharmGKB; PA31976; -.
DR   VEuPathDB; HostDB:ENSG00000236981; -.
DR   eggNOG; ENOG502SI4A; Eukaryota.
DR   GeneTree; ENSGT01050000244869; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q8NGN4; -.
DR   OMA; VCSIFKI; -.
DR   OrthoDB; 4338559at2759; -.
DR   PhylomeDB; Q8NGN4; -.
DR   TreeFam; TF337251; -.
DR   PathwayCommons; Q8NGN4; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 219870; 6 hits in 650 CRISPR screens.
DR   GeneWiki; OR10G9; -.
DR   GenomeRNAi; 219870; -.
DR   Pharos; Q8NGN4; Tdark.
DR   PRO; PR:Q8NGN4; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGN4; Protein.
DR   Bgee; ENSG00000236981; Expressed in primordial germ cell in gonad.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15916; 7tmA_OR10G-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF6; OLFACTORY RECEPTOR 10G4-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..311
FT                   /note="Olfactory receptor 10G9"
FT                   /id="PRO_0000150701"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..216
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..268
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         134
FT                   /note="M -> V (in dbSNP:rs12366219)"
FT                   /id="VAR_053280"
FT   VARIANT         136
FT                   /note="S -> T (in dbSNP:rs17128190)"
FT                   /id="VAR_034286"
FT   VARIANT         172
FT                   /note="Q -> R (in dbSNP:rs11219413)"
FT                   /id="VAR_034287"
FT   VARIANT         228
FT                   /note="H -> R (in dbSNP:rs12221656)"
FT                   /id="VAR_060029"
SQ   SEQUENCE   311 AA;  34574 MW;  03031B6522DB92AE CRC64;
     MSKTSLVTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF
     LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL YFFHFLGSTE CFLYTVMSYD
     RYLAISYPLR YTSMMSGSRC ALLATSTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYLCDA
     PPILKLACAD TSANEMVIFV DIGLVASGCF LLIVLSYVSI VCSILRIHTS EGRHRAFQTC
     ASHCIVVLCF FVPCVFIYLR PGSRDVVDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK
     LRDKVAHSQG E
//