Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NGN4

- O10G9_HUMAN

UniProt

Q8NGN4 - O10G9_HUMAN

Protein

Olfactory receptor 10G9

Gene

OR10G9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10G9
    Alternative name(s):
    Olfactory receptor 10G10
    Gene namesi
    Name:OR10G9
    Synonyms:OR10G10P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15129. OR10G9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31976.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 10G9PRO_0000150701Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ8NGN4.

    PTM databases

    PhosphoSiteiQ8NGN4.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10G9.
    GenevestigatoriQ8NGN4.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000364164.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGN4.
    SMRiQ8NGN4. Positions 18-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 528CytoplasmicSequence Analysis
    Topological domaini74 – 9825ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 26811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31122CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    KOiK04257.
    OMAiHAPELDI.
    OrthoDBiEOG7288RS.
    PhylomeDBiQ8NGN4.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKTSLVTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD    50
    SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL 100
    YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTSMMSGSRC ALLATSTWLS 150
    GSLHSAVQTI LTFHLPYCGP NQIQHYLCDA PPILKLACAD TSANEMVIFV 200
    DIGLVASGCF LLIVLSYVSI VCSILRIHTS EGRHRAFQTC ASHCIVVLCF 250
    FVPCVFIYLR PGSRDVVDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK 300
    LRDKVAHSQG E 311
    Length:311
    Mass (Da):34,574
    Last modified:October 1, 2002 - v1
    Checksum:i03031B6522DB92AE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti134 – 1341M → V.
    Corresponds to variant rs12366219 [ dbSNP | Ensembl ].
    VAR_053280
    Natural varianti136 – 1361S → T.
    Corresponds to variant rs17128190 [ dbSNP | Ensembl ].
    VAR_034286
    Natural varianti172 – 1721Q → R.
    Corresponds to variant rs11219413 [ dbSNP | Ensembl ].
    VAR_034287
    Natural varianti228 – 2281H → R.
    Corresponds to variant rs12221656 [ dbSNP | Ensembl ].
    VAR_060029

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065756 Genomic DNA. Translation: BAC05976.1.
    CCDSiCCDS31703.1.
    RefSeqiNP_001001953.1. NM_001001953.1.
    UniGeneiHs.553636.

    Genome annotation databases

    EnsembliENST00000375024; ENSP00000364164; ENSG00000236981.
    GeneIDi219870.
    KEGGihsa:219870.
    UCSCiuc010sad.2. human.

    Polymorphism databases

    DMDMi38372734.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065756 Genomic DNA. Translation: BAC05976.1 .
    CCDSi CCDS31703.1.
    RefSeqi NP_001001953.1. NM_001001953.1.
    UniGenei Hs.553636.

    3D structure databases

    ProteinModelPortali Q8NGN4.
    SMRi Q8NGN4. Positions 18-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000364164.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGN4.

    Polymorphism databases

    DMDMi 38372734.

    Proteomic databases

    PRIDEi Q8NGN4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375024 ; ENSP00000364164 ; ENSG00000236981 .
    GeneIDi 219870.
    KEGGi hsa:219870.
    UCSCi uc010sad.2. human.

    Organism-specific databases

    CTDi 219870.
    GeneCardsi GC11P123893.
    HGNCi HGNC:15129. OR10G9.
    neXtProti NX_Q8NGN4.
    PharmGKBi PA31976.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    KOi K04257.
    OMAi HAPELDI.
    OrthoDBi EOG7288RS.
    PhylomeDBi Q8NGN4.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10G9.
    NextBioi 90822.
    PROi Q8NGN4.

    Gene expression databases

    CleanExi HS_OR10G9.
    Genevestigatori Q8NGN4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiO10G9_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3