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Q8NGN4

- O10G9_HUMAN

UniProt

Q8NGN4 - O10G9_HUMAN

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Protein

Olfactory receptor 10G9

Gene
OR10G9, OR10G10P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G9
Alternative name(s):
Olfactory receptor 10G10
Gene namesi
Name:OR10G9
Synonyms:OR10G10P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15129. OR10G9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Extracellular Reviewed predictionAdd
BLAST
Transmembranei24 – 4421Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini45 – 528Cytoplasmic Reviewed prediction
Transmembranei53 – 7321Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini74 – 9825Extracellular Reviewed predictionAdd
BLAST
Transmembranei99 – 11921Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini120 – 13819Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei139 – 15921Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini160 – 19637Extracellular Reviewed predictionAdd
BLAST
Transmembranei197 – 21620Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini217 – 23620Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei237 – 25721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini258 – 26811Extracellular Reviewed predictionAdd
BLAST
Transmembranei269 – 28921Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini290 – 31122Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 10G9PRO_0000150701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi96 ↔ 188 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8NGN4.

PTM databases

PhosphoSiteiQ8NGN4.

Expressioni

Gene expression databases

CleanExiHS_OR10G9.
GenevestigatoriQ8NGN4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364164.

Structurei

3D structure databases

ProteinModelPortaliQ8NGN4.
SMRiQ8NGN4. Positions 18-183.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000041362.
HOVERGENiHBG017625.
KOiK04257.
OMAiHAPELDI.
OrthoDBiEOG7288RS.
PhylomeDBiQ8NGN4.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGN4-1 [UniParc]FASTAAdd to Basket

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MSKTSLVTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD    50
SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL 100
YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTSMMSGSRC ALLATSTWLS 150
GSLHSAVQTI LTFHLPYCGP NQIQHYLCDA PPILKLACAD TSANEMVIFV 200
DIGLVASGCF LLIVLSYVSI VCSILRIHTS EGRHRAFQTC ASHCIVVLCF 250
FVPCVFIYLR PGSRDVVDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK 300
LRDKVAHSQG E 311
Length:311
Mass (Da):34,574
Last modified:October 1, 2002 - v1
Checksum:i03031B6522DB92AE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti134 – 1341M → V.
Corresponds to variant rs12366219 [ dbSNP | Ensembl ].
VAR_053280
Natural varianti136 – 1361S → T.
Corresponds to variant rs17128190 [ dbSNP | Ensembl ].
VAR_034286
Natural varianti172 – 1721Q → R.
Corresponds to variant rs11219413 [ dbSNP | Ensembl ].
VAR_034287
Natural varianti228 – 2281H → R.
Corresponds to variant rs12221656 [ dbSNP | Ensembl ].
VAR_060029

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065756 Genomic DNA. Translation: BAC05976.1.
CCDSiCCDS31703.1.
RefSeqiNP_001001953.1. NM_001001953.1.
UniGeneiHs.553636.

Genome annotation databases

EnsembliENST00000375024; ENSP00000364164; ENSG00000236981.
GeneIDi219870.
KEGGihsa:219870.
UCSCiuc010sad.2. human.

Polymorphism databases

DMDMi38372734.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065756 Genomic DNA. Translation: BAC05976.1 .
CCDSi CCDS31703.1.
RefSeqi NP_001001953.1. NM_001001953.1.
UniGenei Hs.553636.

3D structure databases

ProteinModelPortali Q8NGN4.
SMRi Q8NGN4. Positions 18-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000364164.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGN4.

Polymorphism databases

DMDMi 38372734.

Proteomic databases

PRIDEi Q8NGN4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375024 ; ENSP00000364164 ; ENSG00000236981 .
GeneIDi 219870.
KEGGi hsa:219870.
UCSCi uc010sad.2. human.

Organism-specific databases

CTDi 219870.
GeneCardsi GC11P123893.
HGNCi HGNC:15129. OR10G9.
neXtProti NX_Q8NGN4.
PharmGKBi PA31976.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000041362.
HOVERGENi HBG017625.
KOi K04257.
OMAi HAPELDI.
OrthoDBi EOG7288RS.
PhylomeDBi Q8NGN4.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10G9.
NextBioi 90822.
PROi Q8NGN4.

Gene expression databases

CleanExi HS_OR10G9.
Genevestigatori Q8NGN4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiO10G9_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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