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Q8NGN4 (O10G9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10G9
Alternative name(s):
Olfactory receptor 10G10
Gene names
Name:OR10G9
Synonyms:OR10G10P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Olfactory receptor 10G9
PRO_0000150701

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4421Helical; Name=1; Potential
Topological domain45 – 528Cytoplasmic Potential
Transmembrane53 – 7321Helical; Name=2; Potential
Topological domain74 – 9825Extracellular Potential
Transmembrane99 – 11921Helical; Name=3; Potential
Topological domain120 – 13819Cytoplasmic Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 19637Extracellular Potential
Transmembrane197 – 21620Helical; Name=5; Potential
Topological domain217 – 23620Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 26811Extracellular Potential
Transmembrane269 – 28921Helical; Name=7; Potential
Topological domain290 – 31122Cytoplasmic Potential

Amino acid modifications

Disulfide bond96 ↔ 188 By similarity

Natural variations

Natural variant1341M → V.
Corresponds to variant rs12366219 [ dbSNP | Ensembl ].
VAR_053280
Natural variant1361S → T.
Corresponds to variant rs17128190 [ dbSNP | Ensembl ].
VAR_034286
Natural variant1721Q → R.
Corresponds to variant rs11219413 [ dbSNP | Ensembl ].
VAR_034287
Natural variant2281H → R.
Corresponds to variant rs12221656 [ dbSNP | Ensembl ].
VAR_060029

Sequences

Sequence LengthMass (Da)Tools
Q8NGN4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 03031B6522DB92AE

FASTA31134,574
        10         20         30         40         50         60 
MSKTSLVTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF 

        70         80         90        100        110        120 
LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL YFFHFLGSTE CFLYTVMSYD 

       130        140        150        160        170        180 
RYLAISYPLR YTSMMSGSRC ALLATSTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYLCDA 

       190        200        210        220        230        240 
PPILKLACAD TSANEMVIFV DIGLVASGCF LLIVLSYVSI VCSILRIHTS EGRHRAFQTC 

       250        260        270        280        290        300 
ASHCIVVLCF FVPCVFIYLR PGSRDVVDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK 

       310 
LRDKVAHSQG E 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065756 Genomic DNA. Translation: BAC05976.1.
RefSeqNP_001001953.1. NM_001001953.1.
UniGeneHs.553636.

3D structure databases

ProteinModelPortalQ8NGN4.
SMRQ8NGN4. Positions 18-183, 275-304.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000364164.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGN4.

Polymorphism databases

DMDM38372734.

Proteomic databases

PRIDEQ8NGN4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375024; ENSP00000364164; ENSG00000236981.
GeneID219870.
KEGGhsa:219870.
UCSCuc010sad.2. human.

Organism-specific databases

CTD219870.
GeneCardsGC11P123893.
HGNCHGNC:15129. OR10G9.
neXtProtNX_Q8NGN4.
PharmGKBPA31976.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000041362.
HOVERGENHBG017625.
KOK04257.
OMAHAPELDI.
OrthoDBEOG7288RS.
PhylomeDBQ8NGN4.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10G9.
GenevestigatorQ8NGN4.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10G9.
NextBio90822.
PROQ8NGN4.

Entry information

Entry nameO10G9_HUMAN
AccessionPrimary (citable) accession number: Q8NGN4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries