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Q8NGN3

- O10G4_HUMAN

UniProt

Q8NGN3 - O10G4_HUMAN

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Protein

Olfactory receptor 10G4

Gene

OR10G4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10G4
Alternative name(s):
Olfactory receptor OR11-278
Gene namesi
Name:OR10G4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14809. OR10G4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence Analysis
Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini74 – 9825ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 23620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 26811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 31122CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31971.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 10G4PRO_0000150697Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN3.
PRIDEiQ8NGN3.

PTM databases

PhosphoSiteiQ8NGN3.

Expressioni

Gene expression databases

CleanExiHS_OR10G4.
GenevestigatoriQ8NGN3.

Structurei

3D structure databases

ProteinModelPortaliQ8NGN3.
SMRiQ8NGN3. Positions 18-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271559.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN3.
KOiK04257.
OMAiIFVDIGI.
OrthoDBiEOG7288RS.
PhylomeDBiQ8NGN3.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNASLVTAF ILTGLPHAPG LDALLFGIFL VVYVLTVLGN LLILLVIRVD
60 70 80 90 100
SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL
110 120 130 140 150
YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTSMMSGSRC ALLATGTWLS
160 170 180 190 200
GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANVMVIFV
210 220 230 240 250
DIGIVASGCF VLIVLSYVSI VCSILRIRTS DGRRRAFQTC ASHCIVVLCF
260 270 280 290 300
FVPCVVIYLR PGSMDAMDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK
310
LRDKVAHPQR K
Length:311
Mass (Da):34,569
Last modified:October 1, 2002 - v1
Checksum:iA46CBCE6EF461752
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241L → P.
Corresponds to variant rs547068 [ dbSNP | Ensembl ].
VAR_053275
Natural varianti101 – 1011Y → C.
Corresponds to variant rs4474449 [ dbSNP | Ensembl ].
VAR_060025
Natural varianti134 – 1341M → V.
Corresponds to variant rs1893766 [ dbSNP | Ensembl ].
VAR_053276
Natural varianti146 – 1461G → C.
Corresponds to variant rs503223 [ dbSNP | Ensembl ].
VAR_060026
Natural varianti146 – 1461G → R.
Corresponds to variant rs503223 [ dbSNP | Ensembl ].
VAR_060027
Natural varianti146 – 1461G → S.
Corresponds to variant rs503223 [ dbSNP | Ensembl ].
VAR_060028
Natural varianti181 – 1811P → S.
Corresponds to variant rs1893764 [ dbSNP | Ensembl ].
VAR_053277
Natural varianti195 – 1951V → E.
Corresponds to variant rs4084209 [ dbSNP | Ensembl ].
VAR_034283
Natural varianti226 – 2261R → Q.
Corresponds to variant rs11219408 [ dbSNP | Ensembl ].
VAR_053278
Natural varianti235 – 2351R → G.
Corresponds to variant rs4936880 [ dbSNP | Ensembl ].
VAR_034284
Natural varianti295 – 2951K → Q.
Corresponds to variant rs4936881 [ dbSNP | Ensembl ].
VAR_053279

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065757 Genomic DNA. Translation: BAC05977.1.
BK004502 Genomic DNA. Translation: DAA04900.1.
CCDSiCCDS31702.1.
RefSeqiNP_001004462.1. NM_001004462.1.
UniGeneiHs.553760.

Genome annotation databases

EnsembliENST00000320891; ENSP00000325076; ENSG00000254737.
GeneIDi390264.
KEGGihsa:390264.
UCSCiuc010sac.2. human.

Polymorphism databases

DMDMi38372733.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065757 Genomic DNA. Translation: BAC05977.1 .
BK004502 Genomic DNA. Translation: DAA04900.1 .
CCDSi CCDS31702.1.
RefSeqi NP_001004462.1. NM_001004462.1.
UniGenei Hs.553760.

3D structure databases

ProteinModelPortali Q8NGN3.
SMRi Q8NGN3. Positions 18-183.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGN3.

Polymorphism databases

DMDMi 38372733.

Proteomic databases

PaxDbi Q8NGN3.
PRIDEi Q8NGN3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320891 ; ENSP00000325076 ; ENSG00000254737 .
GeneIDi 390264.
KEGGi hsa:390264.
UCSCi uc010sac.2. human.

Organism-specific databases

CTDi 390264.
GeneCardsi GC11P123886.
HGNCi HGNC:14809. OR10G4.
neXtProti NX_Q8NGN3.
PharmGKBi PA31971.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271559.
GeneTreei ENSGT00760000119161.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGN3.
KOi K04257.
OMAi IFVDIGI.
OrthoDBi EOG7288RS.
PhylomeDBi Q8NGN3.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10G4.
GenomeRNAii 390264.
NextBioi 103602.
PROi Q8NGN3.

Gene expression databases

CleanExi HS_OR10G4.
Genevestigatori Q8NGN3.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10G4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN3
Secondary accession number(s): Q6IEW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3