Q8NGN3 (O10G4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10G4

Alternative name(s):
Olfactory receptor OR11-278

Gene names

Name:

OR10G4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Olfactory receptor 10G4		PRO_0000150697
Regions
	Topological domain	1 – 23	23	Extracellular Potential
	Transmembrane	24 – 44	21	Helical; Name=1; Potential
	Topological domain	45 – 52	8	Cytoplasmic Potential
	Transmembrane	53 – 73	21	Helical; Name=2; Potential
	Topological domain	74 – 98	25	Extracellular Potential
	Transmembrane	99 – 119	21	Helical; Name=3; Potential
	Topological domain	120 – 138	19	Cytoplasmic Potential
	Transmembrane	139 – 159	21	Helical; Name=4; Potential
	Topological domain	160 – 196	37	Extracellular Potential
	Transmembrane	197 – 216	20	Helical; Name=5; Potential
	Topological domain	217 – 236	20	Cytoplasmic Potential
	Transmembrane	237 – 257	21	Helical; Name=6; Potential
	Topological domain	258 – 268	11	Extracellular Potential
	Transmembrane	269 – 289	21	Helical; Name=7; Potential
	Topological domain	290 – 311	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Disulfide bond	96 ↔ 188		By similarity
Natural variations
	Natural variant	24	1	L → P. Corresponds to variant rs547068 [ dbSNP | Ensembl ].		VAR_053275
	Natural variant	101	1	Y → C. Corresponds to variant rs4474449 [ dbSNP | Ensembl ].		VAR_060025
	Natural variant	134	1	M → V. Corresponds to variant rs1893766 [ dbSNP | Ensembl ].		VAR_053276
	Natural variant	146	1	G → C. Corresponds to variant rs503223 [ dbSNP | Ensembl ].		VAR_060026
	Natural variant	146	1	G → R. Corresponds to variant rs503223 [ dbSNP | Ensembl ].		VAR_060027
	Natural variant	146	1	G → S. Corresponds to variant rs503223 [ dbSNP | Ensembl ].		VAR_060028
	Natural variant	181	1	P → S. Corresponds to variant rs1893764 [ dbSNP | Ensembl ].		VAR_053277
	Natural variant	195	1	V → E. Corresponds to variant rs4084209 [ dbSNP | Ensembl ].		VAR_034283
	Natural variant	226	1	R → Q. Corresponds to variant rs11219408 [ dbSNP | Ensembl ].		VAR_053278
	Natural variant	235	1	R → G. Corresponds to variant rs4936880 [ dbSNP | Ensembl ].		VAR_034284
	Natural variant	295	1	K → Q. Corresponds to variant rs4936881 [ dbSNP | Ensembl ].		VAR_053279

Sequences

	Sequence		Length	Mass (Da)
	Q8NGN3 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: A46CBCE6EF461752	FASTA	311	34,569
	10 20 30 40 50 60 MSNASLVTAF ILTGLPHAPG LDALLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF 70 80 90 100 110 120 LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL YFFHFLGSTE CFLYTVMSYD 130 140 150 160 170 180 RYLAISYPLR YTSMMSGSRC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA 190 200 210 220 230 240 PPILKLACAD TSANVMVIFV DIGIVASGCF VLIVLSYVSI VCSILRIRTS DGRRRAFQTC 250 260 270 280 290 300 ASHCIVVLCF FVPCVVIYLR PGSMDAMDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK 310 LRDKVAHPQR K

References

[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[3]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065757 Genomic DNA. Translation: BAC05977.1. BK004502 Genomic DNA. Translation: DAA04900.1.
IPI	IPI00169067.
RefSeq	NP_001004462.1. NM_001004462.1.
UniGene	Hs.553760.
3D structure databases
ProteinModelPortal	Q8NGN3.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NGN3.
Polymorphism databases
DMDM	38372733.
Proteomic databases
PaxDb	Q8NGN3.
PRIDE	Q8NGN3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320891; ENSP00000325076; ENSG00000254737.
GeneID	390264.
KEGG	hsa:390264.
UCSC	uc010sac.2. human.
Organism-specific databases
CTD	390264.
GeneCards	GC11P123886.
HGNC	HGNC:14809. OR10G4.
neXtProt	NX_Q8NGN3.
PharmGKB	PA31971.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG271559.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
KO	K04257.
OMA	IFVDIGI.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR10G4.
Genevestigator	Q8NGN3.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	103602.

Entry information

Entry name

O10G4_HUMAN

Accession

Primary (citable) accession number: Q8NGN3
Secondary accession number(s): Q6IEW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.