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Q8NGN3 (O10G4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10G4
Alternative name(s):
Olfactory receptor OR11-278
Gene names
Name:OR10G4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Olfactory receptor 10G4
PRO_0000150697

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4421Helical; Name=1; Potential
Topological domain45 – 528Cytoplasmic Potential
Transmembrane53 – 7321Helical; Name=2; Potential
Topological domain74 – 9825Extracellular Potential
Transmembrane99 – 11921Helical; Name=3; Potential
Topological domain120 – 13819Cytoplasmic Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 19637Extracellular Potential
Transmembrane197 – 21620Helical; Name=5; Potential
Topological domain217 – 23620Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 26811Extracellular Potential
Transmembrane269 – 28921Helical; Name=7; Potential
Topological domain290 – 31122Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 188 By similarity

Natural variations

Natural variant241L → P.
Corresponds to variant rs547068 [ dbSNP | Ensembl ].
VAR_053275
Natural variant1011Y → C.
Corresponds to variant rs4474449 [ dbSNP | Ensembl ].
VAR_060025
Natural variant1341M → V.
Corresponds to variant rs1893766 [ dbSNP | Ensembl ].
VAR_053276
Natural variant1461G → C.
Corresponds to variant rs503223 [ dbSNP | Ensembl ].
VAR_060026
Natural variant1461G → R.
Corresponds to variant rs503223 [ dbSNP | Ensembl ].
VAR_060027
Natural variant1461G → S.
Corresponds to variant rs503223 [ dbSNP | Ensembl ].
VAR_060028
Natural variant1811P → S.
Corresponds to variant rs1893764 [ dbSNP | Ensembl ].
VAR_053277
Natural variant1951V → E.
Corresponds to variant rs4084209 [ dbSNP | Ensembl ].
VAR_034283
Natural variant2261R → Q.
Corresponds to variant rs11219408 [ dbSNP | Ensembl ].
VAR_053278
Natural variant2351R → G.
Corresponds to variant rs4936880 [ dbSNP | Ensembl ].
VAR_034284
Natural variant2951K → Q.
Corresponds to variant rs4936881 [ dbSNP | Ensembl ].
VAR_053279

Sequences

Sequence LengthMass (Da)Tools
Q8NGN3 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: A46CBCE6EF461752

FASTA31134,569
        10         20         30         40         50         60 
MSNASLVTAF ILTGLPHAPG LDALLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF 

        70         80         90        100        110        120 
LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL YFFHFLGSTE CFLYTVMSYD 

       130        140        150        160        170        180 
RYLAISYPLR YTSMMSGSRC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA 

       190        200        210        220        230        240 
PPILKLACAD TSANVMVIFV DIGIVASGCF VLIVLSYVSI VCSILRIRTS DGRRRAFQTC 

       250        260        270        280        290        300 
ASHCIVVLCF FVPCVVIYLR PGSMDAMDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK 

       310 
LRDKVAHPQR K 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065757 Genomic DNA. Translation: BAC05977.1.
BK004502 Genomic DNA. Translation: DAA04900.1.
CCDSCCDS31702.1.
RefSeqNP_001004462.1. NM_001004462.1.
UniGeneHs.553760.

3D structure databases

ProteinModelPortalQ8NGN3.
SMRQ8NGN3. Positions 18-183.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGN3.

Polymorphism databases

DMDM38372733.

Proteomic databases

PaxDbQ8NGN3.
PRIDEQ8NGN3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320891; ENSP00000325076; ENSG00000254737.
GeneID390264.
KEGGhsa:390264.
UCSCuc010sac.2. human.

Organism-specific databases

CTD390264.
GeneCardsGC11P123886.
HGNCHGNC:14809. OR10G4.
neXtProtNX_Q8NGN3.
PharmGKBPA31971.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG271559.
HOGENOMHOG000041362.
HOVERGENHBG017625.
KOK04257.
OMAIFVDIGI.
OrthoDBEOG7288RS.
PhylomeDBQ8NGN3.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10G4.
GenevestigatorQ8NGN3.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10G4.
NextBio103602.
PROQ8NGN3.

Entry information

Entry nameO10G4_HUMAN
AccessionPrimary (citable) accession number: Q8NGN3
Secondary accession number(s): Q6IEW0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries