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Q8NGN3

- O10G4_HUMAN

UniProt

Q8NGN3 - O10G4_HUMAN

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Protein
Olfactory receptor 10G4
Gene
OR10G4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10G4
    Alternative name(s):
    Olfactory receptor OR11-278
    Gene namesi
    Name:OR10G4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14809. OR10G4.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei24 – 4421Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini45 – 528Cytoplasmic Reviewed prediction
    Transmembranei53 – 7321Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini74 – 9825Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei99 – 11921Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini120 – 13819Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei139 – 15921Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini160 – 19637Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei197 – 21620Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini217 – 23620Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei237 – 25721Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini258 – 26811Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei269 – 28921Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini290 – 31122Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31971.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 10G4
    PRO_0000150697Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi96 ↔ 188 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGN3.
    PRIDEiQ8NGN3.

    PTM databases

    PhosphoSiteiQ8NGN3.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10G4.
    GenevestigatoriQ8NGN3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGN3.
    SMRiQ8NGN3. Positions 18-183.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG271559.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    KOiK04257.
    OMAiIFVDIGI.
    OrthoDBiEOG7288RS.
    PhylomeDBiQ8NGN3.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGN3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNASLVTAF ILTGLPHAPG LDALLFGIFL VVYVLTVLGN LLILLVIRVD    50
    SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL 100
    YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTSMMSGSRC ALLATGTWLS 150
    GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANVMVIFV 200
    DIGIVASGCF VLIVLSYVSI VCSILRIRTS DGRRRAFQTC ASHCIVVLCF 250
    FVPCVVIYLR PGSMDAMDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK 300
    LRDKVAHPQR K 311
    Length:311
    Mass (Da):34,569
    Last modified:October 1, 2002 - v1
    Checksum:iA46CBCE6EF461752
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241L → P.
    Corresponds to variant rs547068 [ dbSNP | Ensembl ].
    VAR_053275
    Natural varianti101 – 1011Y → C.
    Corresponds to variant rs4474449 [ dbSNP | Ensembl ].
    VAR_060025
    Natural varianti134 – 1341M → V.
    Corresponds to variant rs1893766 [ dbSNP | Ensembl ].
    VAR_053276
    Natural varianti146 – 1461G → C.
    Corresponds to variant rs503223 [ dbSNP | Ensembl ].
    VAR_060026
    Natural varianti146 – 1461G → R.
    Corresponds to variant rs503223 [ dbSNP | Ensembl ].
    VAR_060027
    Natural varianti146 – 1461G → S.
    Corresponds to variant rs503223 [ dbSNP | Ensembl ].
    VAR_060028
    Natural varianti181 – 1811P → S.
    Corresponds to variant rs1893764 [ dbSNP | Ensembl ].
    VAR_053277
    Natural varianti195 – 1951V → E.
    Corresponds to variant rs4084209 [ dbSNP | Ensembl ].
    VAR_034283
    Natural varianti226 – 2261R → Q.
    Corresponds to variant rs11219408 [ dbSNP | Ensembl ].
    VAR_053278
    Natural varianti235 – 2351R → G.
    Corresponds to variant rs4936880 [ dbSNP | Ensembl ].
    VAR_034284
    Natural varianti295 – 2951K → Q.
    Corresponds to variant rs4936881 [ dbSNP | Ensembl ].
    VAR_053279

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065757 Genomic DNA. Translation: BAC05977.1.
    BK004502 Genomic DNA. Translation: DAA04900.1.
    CCDSiCCDS31702.1.
    RefSeqiNP_001004462.1. NM_001004462.1.
    UniGeneiHs.553760.

    Genome annotation databases

    EnsembliENST00000320891; ENSP00000325076; ENSG00000254737.
    GeneIDi390264.
    KEGGihsa:390264.
    UCSCiuc010sac.2. human.

    Polymorphism databases

    DMDMi38372733.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065757 Genomic DNA. Translation: BAC05977.1 .
    BK004502 Genomic DNA. Translation: DAA04900.1 .
    CCDSi CCDS31702.1.
    RefSeqi NP_001004462.1. NM_001004462.1.
    UniGenei Hs.553760.

    3D structure databases

    ProteinModelPortali Q8NGN3.
    SMRi Q8NGN3. Positions 18-183.
    ModBasei Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGN3.

    Polymorphism databases

    DMDMi 38372733.

    Proteomic databases

    PaxDbi Q8NGN3.
    PRIDEi Q8NGN3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320891 ; ENSP00000325076 ; ENSG00000254737 .
    GeneIDi 390264.
    KEGGi hsa:390264.
    UCSCi uc010sac.2. human.

    Organism-specific databases

    CTDi 390264.
    GeneCardsi GC11P123886.
    HGNCi HGNC:14809. OR10G4.
    neXtProti NX_Q8NGN3.
    PharmGKBi PA31971.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271559.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    KOi K04257.
    OMAi IFVDIGI.
    OrthoDBi EOG7288RS.
    PhylomeDBi Q8NGN3.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10G4.
    NextBioi 103602.
    PROi Q8NGN3.

    Gene expression databases

    CleanExi HS_OR10G4.
    Genevestigatori Q8NGN3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10G4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGN3
    Secondary accession number(s): Q6IEW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: September 3, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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