ID   O10S1_HUMAN             Reviewed;         331 AA.
AC   Q8NGN2; B9EH43; Q6IEV3; Q96R78;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   24-JAN-2024, entry version 158.
DE   RecName: Full=Olfactory receptor 10S1;
DE   AltName: Full=Olfactory receptor OR11-279;
GN   Name=OR10S1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-295.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-10 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC05978.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10S1";
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DR   EMBL; AB065758; BAC05978.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AP001884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC137037; AAI37038.1; -; mRNA.
DR   EMBL; BC137038; AAI37039.1; -; mRNA.
DR   EMBL; AF399565; AAK95050.1; -; Genomic_DNA.
DR   EMBL; BK004509; DAA04907.1; -; Genomic_DNA.
DR   RefSeq; NP_001004474.1; NM_001004474.1.
DR   AlphaFoldDB; Q8NGN2; -.
DR   SMR; Q8NGN2; -.
DR   BioGRID; 128589; 10.
DR   STRING; 9606.ENSP00000431914; -.
DR   GlyCosmos; Q8NGN2; 1 site, No reported glycans.
DR   GlyGen; Q8NGN2; 1 site.
DR   iPTMnet; Q8NGN2; -.
DR   PhosphoSitePlus; Q8NGN2; -.
DR   BioMuta; OR10S1; -.
DR   DMDM; 223590111; -.
DR   MassIVE; Q8NGN2; -.
DR   PaxDb; 9606-ENSP00000431914; -.
DR   PeptideAtlas; Q8NGN2; -.
DR   Antibodypedia; 18962; 124 antibodies from 24 providers.
DR   DNASU; 219873; -.
DR   GeneID; 219873; -.
DR   KEGG; hsa:219873; -.
DR   UCSC; uc001pzm.2; human.
DR   AGR; HGNC:14807; -.
DR   CTD; 219873; -.
DR   GeneCards; OR10S1; -.
DR   HGNC; HGNC:14807; OR10S1.
DR   neXtProt; NX_Q8NGN2; -.
DR   PharmGKB; PA31999; -.
DR   VEuPathDB; HostDB:ENSG00000196248; -.
DR   eggNOG; ENOG502SI4A; Eukaryota.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGN2; -.
DR   OrthoDB; 4632440at2759; -.
DR   PhylomeDB; Q8NGN2; -.
DR   TreeFam; TF352732; -.
DR   PathwayCommons; Q8NGN2; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 219873; 5 hits in 740 CRISPR screens.
DR   GeneWiki; OR10S1; -.
DR   GenomeRNAi; 219873; -.
DR   Pharos; Q8NGN2; Tdark.
DR   PRO; PR:Q8NGN2; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGN2; Protein.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF205; OLFACTORY RECEPTOR 10S1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..331
FT                   /note="Olfactory receptor 10S1"
FT                   /id="PRO_0000150716"
FT   TOPO_DOM        1..38
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..67
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..113
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        175..211
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..231
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        232..251
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273..283
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        305..331
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        111..203
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         63
FT                   /note="G -> S (in dbSNP:rs17759513)"
FT                   /id="VAR_054358"
FT   VARIANT         93
FT                   /note="K -> R (in dbSNP:rs17686210)"
FT                   /id="VAR_054359"
FT   VARIANT         112
FT                   /note="A -> V (in dbSNP:rs17759447)"
FT                   /id="VAR_054360"
SQ   SEQUENCE   331 AA;  36501 MW;  50DA45E36CA595D6 CRC64;
     MTSRSVCEKM TMTTENPNQT VVSHFFLEGL RYTAKHSSLF FLLFLLIYSI TVAGNLLILL
     TVGSDSHLSL PMYHFLGHLS FLDACLSTVT VPKVMAGLLT LDGKVISFEG CAVQLYCFHF
     LASTECFLYT VMAYDRYLAI CQPLHYPVAM NRRMCAEMAG ITWAIGATHA AIHTSLTFRL
     LYCGPCHIAY FFCDIPPVLK LACTDTTINE LVMLASIGIV AAGCLILIVI SYIFIVAAVL
     RIRTAQGRQR AFSPCTAQLT GVLLYYVPPV CIYLQPRSSE AGAGAPAVFY TIVTPMLNPF
     IYTLRNKEVK HALQRLLCSS FRESTAGSPP P
//