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Q8NGN2 (O10S1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10S1
Alternative name(s):
Olfactory receptor OR11-279
Gene names
Name:OR10S1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.

Sequence caution

The sequence BAC05978.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Olfactory receptor 10S1
PRO_0000150716

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 5921Helical; Name=1; Potential
Topological domain60 – 678Cytoplasmic Potential
Transmembrane68 – 8821Helical; Name=2; Potential
Topological domain89 – 11325Extracellular Potential
Transmembrane114 – 13421Helical; Name=3; Potential
Topological domain135 – 15319Cytoplasmic Potential
Transmembrane154 – 17421Helical; Name=4; Potential
Topological domain175 – 21137Extracellular Potential
Transmembrane212 – 23120Helical; Name=5; Potential
Topological domain232 – 25120Cytoplasmic Potential
Transmembrane252 – 27221Helical; Name=6; Potential
Topological domain273 – 28311Extracellular Potential
Transmembrane284 – 30421Helical; Name=7; Potential
Topological domain305 – 33127Cytoplasmic Potential

Amino acid modifications

Glycosylation181N-linked (GlcNAc...) Potential
Disulfide bond111 ↔ 203 By similarity

Natural variations

Natural variant631G → S.
Corresponds to variant rs17759513 [ dbSNP | Ensembl ].
VAR_054358
Natural variant931K → R.
Corresponds to variant rs17686210 [ dbSNP | Ensembl ].
VAR_054359
Natural variant1121A → V.
Corresponds to variant rs17759447 [ dbSNP | Ensembl ].
VAR_054360

Sequences

Sequence LengthMass (Da)Tools
Q8NGN2 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: 50DA45E36CA595D6

FASTA33136,501
        10         20         30         40         50         60 
MTSRSVCEKM TMTTENPNQT VVSHFFLEGL RYTAKHSSLF FLLFLLIYSI TVAGNLLILL 

        70         80         90        100        110        120 
TVGSDSHLSL PMYHFLGHLS FLDACLSTVT VPKVMAGLLT LDGKVISFEG CAVQLYCFHF 

       130        140        150        160        170        180 
LASTECFLYT VMAYDRYLAI CQPLHYPVAM NRRMCAEMAG ITWAIGATHA AIHTSLTFRL 

       190        200        210        220        230        240 
LYCGPCHIAY FFCDIPPVLK LACTDTTINE LVMLASIGIV AAGCLILIVI SYIFIVAAVL 

       250        260        270        280        290        300 
RIRTAQGRQR AFSPCTAQLT GVLLYYVPPV CIYLQPRSSE AGAGAPAVFY TIVTPMLNPF 

       310        320        330 
IYTLRNKEVK HALQRLLCSS FRESTAGSPP P 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-295.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065758 Genomic DNA. Translation: BAC05978.1. Different initiation.
AP001884 Genomic DNA. No translation available.
BC137037 mRNA. Translation: AAI37038.1.
BC137038 mRNA. Translation: AAI37039.1.
AF399565 Genomic DNA. Translation: AAK95050.1.
BK004509 Genomic DNA. Translation: DAA04907.1.
CCDSCCDS31701.1.
RefSeqNP_001004474.1. NM_001004474.1.
UniGeneHs.553637.

3D structure databases

ProteinModelPortalQ8NGN2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000353947.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGN2.

Polymorphism databases

DMDM223590111.

Proteomic databases

PaxDbQ8NGN2.
PRIDEQ8NGN2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000531945; ENSP00000431914; ENSG00000196248.
GeneID219873.
KEGGhsa:219873.
UCSCuc001pzm.1. human.

Organism-specific databases

CTD219873.
GeneCardsGC11M123849.
HGNCHGNC:14807. OR10S1.
HPAHPA019038.
neXtProtNX_Q8NGN2.
PharmGKBPA31999.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG74082.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGN2.
KOK04257.
OMATWATGAI.
OrthoDBEOG71K63J.
PhylomeDBQ8NGN2.
TreeFamTF352732.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10S1.
GenevestigatorQ8NGN2.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10S1.
GenomeRNAi219873.
NextBio90826.
PROQ8NGN2.

Entry information

Entry nameO10S1_HUMAN
AccessionPrimary (citable) accession number: Q8NGN2
Secondary accession number(s): B9EH43, Q6IEV3, Q96R78
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries