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Q8NGN2

- O10S1_HUMAN

UniProt

Q8NGN2 - O10S1_HUMAN

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Protein
Olfactory receptor 10S1
Gene
OR10S1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10S1
Alternative name(s):
Olfactory receptor OR11-279
Gene namesi
Name:OR10S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14807. OR10S1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838Extracellular Reviewed prediction
Add
BLAST
Transmembranei39 – 5921Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini60 – 678Cytoplasmic Reviewed prediction
Transmembranei68 – 8821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini89 – 11325Extracellular Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini135 – 15319Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei154 – 17421Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini175 – 21137Extracellular Reviewed prediction
Add
BLAST
Transmembranei212 – 23120Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini232 – 25120Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei252 – 27221Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini273 – 28311Extracellular Reviewed prediction
Add
BLAST
Transmembranei284 – 30421Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini305 – 33127Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Olfactory receptor 10S1
PRO_0000150716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi111 ↔ 203 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN2.
PRIDEiQ8NGN2.

PTM databases

PhosphoSiteiQ8NGN2.

Expressioni

Gene expression databases

CleanExiHS_OR10S1.
GenevestigatoriQ8NGN2.

Organism-specific databases

HPAiHPA019038.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353947.

Structurei

3D structure databases

ProteinModelPortaliQ8NGN2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74082.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN2.
KOiK04257.
OMAiTWATGAI.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGN2.
TreeFamiTF352732.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGN2-1 [UniParc]FASTAAdd to Basket

« Hide

MTSRSVCEKM TMTTENPNQT VVSHFFLEGL RYTAKHSSLF FLLFLLIYSI    50
TVAGNLLILL TVGSDSHLSL PMYHFLGHLS FLDACLSTVT VPKVMAGLLT 100
LDGKVISFEG CAVQLYCFHF LASTECFLYT VMAYDRYLAI CQPLHYPVAM 150
NRRMCAEMAG ITWAIGATHA AIHTSLTFRL LYCGPCHIAY FFCDIPPVLK 200
LACTDTTINE LVMLASIGIV AAGCLILIVI SYIFIVAAVL RIRTAQGRQR 250
AFSPCTAQLT GVLLYYVPPV CIYLQPRSSE AGAGAPAVFY TIVTPMLNPF 300
IYTLRNKEVK HALQRLLCSS FRESTAGSPP P 331
Length:331
Mass (Da):36,501
Last modified:February 10, 2009 - v2
Checksum:i50DA45E36CA595D6
GO

Sequence cautioni

The sequence BAC05978.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631G → S.
Corresponds to variant rs17759513 [ dbSNP | Ensembl ].
VAR_054358
Natural varianti93 – 931K → R.
Corresponds to variant rs17686210 [ dbSNP | Ensembl ].
VAR_054359
Natural varianti112 – 1121A → V.
Corresponds to variant rs17759447 [ dbSNP | Ensembl ].
VAR_054360

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065758 Genomic DNA. Translation: BAC05978.1. Different initiation.
AP001884 Genomic DNA. No translation available.
BC137037 mRNA. Translation: AAI37038.1.
BC137038 mRNA. Translation: AAI37039.1.
AF399565 Genomic DNA. Translation: AAK95050.1.
BK004509 Genomic DNA. Translation: DAA04907.1.
CCDSiCCDS31701.1.
RefSeqiNP_001004474.1. NM_001004474.1.
UniGeneiHs.553637.

Genome annotation databases

EnsembliENST00000531945; ENSP00000431914; ENSG00000196248.
GeneIDi219873.
KEGGihsa:219873.
UCSCiuc001pzm.1. human.

Polymorphism databases

DMDMi223590111.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065758 Genomic DNA. Translation: BAC05978.1 . Different initiation.
AP001884 Genomic DNA. No translation available.
BC137037 mRNA. Translation: AAI37038.1 .
BC137038 mRNA. Translation: AAI37039.1 .
AF399565 Genomic DNA. Translation: AAK95050.1 .
BK004509 Genomic DNA. Translation: DAA04907.1 .
CCDSi CCDS31701.1.
RefSeqi NP_001004474.1. NM_001004474.1.
UniGenei Hs.553637.

3D structure databases

ProteinModelPortali Q8NGN2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000353947.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGN2.

Polymorphism databases

DMDMi 223590111.

Proteomic databases

PaxDbi Q8NGN2.
PRIDEi Q8NGN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000531945 ; ENSP00000431914 ; ENSG00000196248 .
GeneIDi 219873.
KEGGi hsa:219873.
UCSCi uc001pzm.1. human.

Organism-specific databases

CTDi 219873.
GeneCardsi GC11M123849.
HGNCi HGNC:14807. OR10S1.
HPAi HPA019038.
neXtProti NX_Q8NGN2.
PharmGKBi PA31999.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG74082.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGN2.
KOi K04257.
OMAi TWATGAI.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGN2.
TreeFami TF352732.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10S1.
GenomeRNAii 219873.
NextBioi 90826.
PROi Q8NGN2.

Gene expression databases

CleanExi HS_OR10S1.
Genevestigatori Q8NGN2.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-295.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10S1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN2
Secondary accession number(s): B9EH43, Q6IEV3, Q96R78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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