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Protein

Olfactory receptor 10S1

Gene

OR10S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10S1
Alternative name(s):
Olfactory receptor OR11-279
Gene namesi
Name:OR10S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14807. OR10S1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Transmembranei39 – 5921Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini60 – 678CytoplasmicSequence Analysis
Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini89 – 11325ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini135 – 15319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei154 – 17421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini175 – 21137ExtracellularSequence AnalysisAdd
BLAST
Transmembranei212 – 23120Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini232 – 25120CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini273 – 28311ExtracellularSequence AnalysisAdd
BLAST
Transmembranei284 – 30421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini305 – 33127CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Olfactory receptor 10S1PRO_0000150716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi111 ↔ 203PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN2.
PRIDEiQ8NGN2.

PTM databases

PhosphoSiteiQ8NGN2.

Expressioni

Gene expression databases

CleanExiHS_OR10S1.
GenevestigatoriQ8NGN2.

Organism-specific databases

HPAiHPA019038.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353947.

Structurei

3D structure databases

ProteinModelPortaliQ8NGN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74082.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN2.
KOiK04257.
OMAiTWATGAI.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGN2.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRSVCEKM TMTTENPNQT VVSHFFLEGL RYTAKHSSLF FLLFLLIYSI
60 70 80 90 100
TVAGNLLILL TVGSDSHLSL PMYHFLGHLS FLDACLSTVT VPKVMAGLLT
110 120 130 140 150
LDGKVISFEG CAVQLYCFHF LASTECFLYT VMAYDRYLAI CQPLHYPVAM
160 170 180 190 200
NRRMCAEMAG ITWAIGATHA AIHTSLTFRL LYCGPCHIAY FFCDIPPVLK
210 220 230 240 250
LACTDTTINE LVMLASIGIV AAGCLILIVI SYIFIVAAVL RIRTAQGRQR
260 270 280 290 300
AFSPCTAQLT GVLLYYVPPV CIYLQPRSSE AGAGAPAVFY TIVTPMLNPF
310 320 330
IYTLRNKEVK HALQRLLCSS FRESTAGSPP P
Length:331
Mass (Da):36,501
Last modified:February 10, 2009 - v2
Checksum:i50DA45E36CA595D6
GO

Sequence cautioni

The sequence BAC05978.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631G → S.
Corresponds to variant rs17759513 [ dbSNP | Ensembl ].
VAR_054358
Natural varianti93 – 931K → R.
Corresponds to variant rs17686210 [ dbSNP | Ensembl ].
VAR_054359
Natural varianti112 – 1121A → V.
Corresponds to variant rs17759447 [ dbSNP | Ensembl ].
VAR_054360

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065758 Genomic DNA. Translation: BAC05978.1. Different initiation.
AP001884 Genomic DNA. No translation available.
BC137037 mRNA. Translation: AAI37038.1.
BC137038 mRNA. Translation: AAI37039.1.
AF399565 Genomic DNA. Translation: AAK95050.1.
BK004509 Genomic DNA. Translation: DAA04907.1.
CCDSiCCDS31701.1.
RefSeqiNP_001004474.1. NM_001004474.1.
UniGeneiHs.553637.

Genome annotation databases

EnsembliENST00000531945; ENSP00000431914; ENSG00000196248.
GeneIDi219873.
KEGGihsa:219873.
UCSCiuc001pzm.1. human.

Polymorphism databases

DMDMi223590111.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065758 Genomic DNA. Translation: BAC05978.1. Different initiation.
AP001884 Genomic DNA. No translation available.
BC137037 mRNA. Translation: AAI37038.1.
BC137038 mRNA. Translation: AAI37039.1.
AF399565 Genomic DNA. Translation: AAK95050.1.
BK004509 Genomic DNA. Translation: DAA04907.1.
CCDSiCCDS31701.1.
RefSeqiNP_001004474.1. NM_001004474.1.
UniGeneiHs.553637.

3D structure databases

ProteinModelPortaliQ8NGN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353947.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGN2.

Polymorphism databases

DMDMi223590111.

Proteomic databases

PaxDbiQ8NGN2.
PRIDEiQ8NGN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000531945; ENSP00000431914; ENSG00000196248.
GeneIDi219873.
KEGGihsa:219873.
UCSCiuc001pzm.1. human.

Organism-specific databases

CTDi219873.
GeneCardsiGC11M123849.
HGNCiHGNC:14807. OR10S1.
HPAiHPA019038.
neXtProtiNX_Q8NGN2.
PharmGKBiPA31999.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG74082.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN2.
KOiK04257.
OMAiTWATGAI.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGN2.
TreeFamiTF352732.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10S1.
GenomeRNAii219873.
NextBioi90826.
PROiQ8NGN2.

Gene expression databases

CleanExiHS_OR10S1.
GenevestigatoriQ8NGN2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-295.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiO10S1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN2
Secondary accession number(s): B9EH43, Q6IEV3, Q96R78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: January 7, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.