Q8NGN2 (O10S1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10S1

Alternative name(s):
Olfactory receptor OR11-279

Gene names

Name:

OR10S1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	It is uncertain whether Met-1 or Met-10 is the initiator.
Sequence caution	The sequence BAC05978.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Olfactory receptor 10S1		PRO_0000150716
Regions
	Topological domain	1 – 38	38	Extracellular Potential
	Transmembrane	39 – 59	21	Helical; Name=1; Potential
	Topological domain	60 – 67	8	Cytoplasmic Potential
	Transmembrane	68 – 88	21	Helical; Name=2; Potential
	Topological domain	89 – 113	25	Extracellular Potential
	Transmembrane	114 – 134	21	Helical; Name=3; Potential
	Topological domain	135 – 153	19	Cytoplasmic Potential
	Transmembrane	154 – 174	21	Helical; Name=4; Potential
	Topological domain	175 – 211	37	Extracellular Potential
	Transmembrane	212 – 231	20	Helical; Name=5; Potential
	Topological domain	232 – 251	20	Cytoplasmic Potential
	Transmembrane	252 – 272	21	Helical; Name=6; Potential
	Topological domain	273 – 283	11	Extracellular Potential
	Transmembrane	284 – 304	21	Helical; Name=7; Potential
	Topological domain	305 – 331	27	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Disulfide bond	111 ↔ 203		By similarity
Natural variations
	Natural variant	63	1	G → S. Corresponds to variant rs17759513 [ dbSNP | Ensembl ].		VAR_054358
	Natural variant	93	1	K → R. Corresponds to variant rs17686210 [ dbSNP | Ensembl ].		VAR_054359
	Natural variant	112	1	A → V. Corresponds to variant rs17759447 [ dbSNP | Ensembl ].		VAR_054360

Sequences

	Sequence		Length	Mass (Da)
	Q8NGN2 [UniParc]. Last modified February 10, 2009. Version 2. Checksum: 50DA45E36CA595D6	FASTA	331	36,501
	10 20 30 40 50 60 MTSRSVCEKM TMTTENPNQT VVSHFFLEGL RYTAKHSSLF FLLFLLIYSI TVAGNLLILL 70 80 90 100 110 120 TVGSDSHLSL PMYHFLGHLS FLDACLSTVT VPKVMAGLLT LDGKVISFEG CAVQLYCFHF 130 140 150 160 170 180 LASTECFLYT VMAYDRYLAI CQPLHYPVAM NRRMCAEMAG ITWAIGATHA AIHTSLTFRL 190 200 210 220 230 240 LYCGPCHIAY FFCDIPPVLK LACTDTTINE LVMLASIGIV AAGCLILIVI SYIFIVAAVL 250 260 270 280 290 300 RIRTAQGRQR AFSPCTAQLT GVLLYYVPPV CIYLQPRSSE AGAGAPAVFY TIVTPMLNPF 310 320 330 IYTLRNKEVK HALQRLLCSS FRESTAGSPP P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-295.
[5]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065758 Genomic DNA. Translation: BAC05978.1. Different initiation. AP001884 Genomic DNA. No translation available. BC137037 mRNA. Translation: AAI37038.1. BC137038 mRNA. Translation: AAI37039.1. AF399565 Genomic DNA. Translation: AAK95050.1. BK004509 Genomic DNA. Translation: DAA04907.1.
IPI	IPI00979843.
RefSeq	NP_001004474.1. NM_001004474.1.
UniGene	Hs.553637.
3D structure databases
ProteinModelPortal	Q8NGN2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000353947.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NGN2.
Polymorphism databases
DMDM	223590111.
Proteomic databases
PaxDb	Q8NGN2.
PRIDE	Q8NGN2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000531945; ENSP00000431914; ENSG00000196248.
GeneID	219873.
KEGG	hsa:219873.
UCSC	uc001pzm.1. human.
Organism-specific databases
CTD	219873.
GeneCards	GC11M123849.
HGNC	HGNC:14807. OR10S1.
HPA	HPA019038.
neXtProt	NX_Q8NGN2.
PharmGKB	PA31999.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG74082.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	Q8NGN2.
KO	K04257.
OMA	AGATWAT.
OrthoDB	EOG4H72C4.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR10S1.
Genevestigator	Q8NGN2.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	219873.
NextBio	90826.

Entry information

Entry name

O10S1_HUMAN

Accession

Primary (citable) accession number: Q8NGN2
Secondary accession number(s): B9EH43, Q6IEV3, Q96R78

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.