SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8NGN2

- O10S1_HUMAN

UniProt

Q8NGN2 - O10S1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Olfactory receptor 10S1
Gene
OR10S1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10S1
    Alternative name(s):
    Olfactory receptor OR11-279
    Gene namesi
    Name:OR10S1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14807. OR10S1.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei39 – 5921Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini60 – 678Cytoplasmic Reviewed prediction
    Transmembranei68 – 8821Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini89 – 11325Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei114 – 13421Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini135 – 15319Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei154 – 17421Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini175 – 21137Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei212 – 23120Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini232 – 25120Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei252 – 27221Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini273 – 28311Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei284 – 30421Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini305 – 33127Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31999.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331Olfactory receptor 10S1
    PRO_0000150716Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi111 ↔ 203 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGN2.
    PRIDEiQ8NGN2.

    PTM databases

    PhosphoSiteiQ8NGN2.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10S1.
    GenevestigatoriQ8NGN2.

    Organism-specific databases

    HPAiHPA019038.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000353947.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGN2.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74082.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGN2.
    KOiK04257.
    OMAiTWATGAI.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGN2.
    TreeFamiTF352732.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGN2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSRSVCEKM TMTTENPNQT VVSHFFLEGL RYTAKHSSLF FLLFLLIYSI    50
    TVAGNLLILL TVGSDSHLSL PMYHFLGHLS FLDACLSTVT VPKVMAGLLT 100
    LDGKVISFEG CAVQLYCFHF LASTECFLYT VMAYDRYLAI CQPLHYPVAM 150
    NRRMCAEMAG ITWAIGATHA AIHTSLTFRL LYCGPCHIAY FFCDIPPVLK 200
    LACTDTTINE LVMLASIGIV AAGCLILIVI SYIFIVAAVL RIRTAQGRQR 250
    AFSPCTAQLT GVLLYYVPPV CIYLQPRSSE AGAGAPAVFY TIVTPMLNPF 300
    IYTLRNKEVK HALQRLLCSS FRESTAGSPP P 331
    Length:331
    Mass (Da):36,501
    Last modified:February 10, 2009 - v2
    Checksum:i50DA45E36CA595D6
    GO

    Sequence cautioni

    The sequence BAC05978.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti63 – 631G → S.
    Corresponds to variant rs17759513 [ dbSNP | Ensembl ].
    VAR_054358
    Natural varianti93 – 931K → R.
    Corresponds to variant rs17686210 [ dbSNP | Ensembl ].
    VAR_054359
    Natural varianti112 – 1121A → V.
    Corresponds to variant rs17759447 [ dbSNP | Ensembl ].
    VAR_054360

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065758 Genomic DNA. Translation: BAC05978.1. Different initiation.
    AP001884 Genomic DNA. No translation available.
    BC137037 mRNA. Translation: AAI37038.1.
    BC137038 mRNA. Translation: AAI37039.1.
    AF399565 Genomic DNA. Translation: AAK95050.1.
    BK004509 Genomic DNA. Translation: DAA04907.1.
    CCDSiCCDS31701.1.
    RefSeqiNP_001004474.1. NM_001004474.1.
    UniGeneiHs.553637.

    Genome annotation databases

    EnsembliENST00000531945; ENSP00000431914; ENSG00000196248.
    GeneIDi219873.
    KEGGihsa:219873.
    UCSCiuc001pzm.1. human.

    Polymorphism databases

    DMDMi223590111.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065758 Genomic DNA. Translation: BAC05978.1 . Different initiation.
    AP001884 Genomic DNA. No translation available.
    BC137037 mRNA. Translation: AAI37038.1 .
    BC137038 mRNA. Translation: AAI37039.1 .
    AF399565 Genomic DNA. Translation: AAK95050.1 .
    BK004509 Genomic DNA. Translation: DAA04907.1 .
    CCDSi CCDS31701.1.
    RefSeqi NP_001004474.1. NM_001004474.1.
    UniGenei Hs.553637.

    3D structure databases

    ProteinModelPortali Q8NGN2.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000353947.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGN2.

    Polymorphism databases

    DMDMi 223590111.

    Proteomic databases

    PaxDbi Q8NGN2.
    PRIDEi Q8NGN2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000531945 ; ENSP00000431914 ; ENSG00000196248 .
    GeneIDi 219873.
    KEGGi hsa:219873.
    UCSCi uc001pzm.1. human.

    Organism-specific databases

    CTDi 219873.
    GeneCardsi GC11M123849.
    HGNCi HGNC:14807. OR10S1.
    HPAi HPA019038.
    neXtProti NX_Q8NGN2.
    PharmGKBi PA31999.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74082.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGN2.
    KOi K04257.
    OMAi TWATGAI.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGN2.
    TreeFami TF352732.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10S1.
    GenomeRNAii 219873.
    NextBioi 90826.
    PROi Q8NGN2.

    Gene expression databases

    CleanExi HS_OR10S1.
    Genevestigatori Q8NGN2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-295.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10S1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGN2
    Secondary accession number(s): B9EH43, Q6IEV3, Q96R78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: February 10, 2009
    Last modified: September 3, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-10 is the initiator.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi