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Protein

Olfactory receptor 10S1

Gene

OR10S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33582-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10S1
Alternative name(s):
Olfactory receptor OR11-279
Gene namesi
Name:OR10S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14807. OR10S1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 59Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini60 – 67CytoplasmicSequence analysis8
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 113ExtracellularSequence analysisAdd BLAST25
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini135 – 153CytoplasmicSequence analysisAdd BLAST19
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 211ExtracellularSequence analysisAdd BLAST37
Transmembranei212 – 231Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini232 – 251CytoplasmicSequence analysisAdd BLAST20
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 283ExtracellularSequence analysisAdd BLAST11
Transmembranei284 – 304Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini305 – 331CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196248.
PharmGKBiPA31999.

Polymorphism and mutation databases

BioMutaiOR10S1.
DMDMi223590111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507161 – 331Olfactory receptor 10S1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 203PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN2.
PeptideAtlasiQ8NGN2.
PRIDEiQ8NGN2.

PTM databases

iPTMnetiQ8NGN2.
PhosphoSitePlusiQ8NGN2.

Expressioni

Gene expression databases

CleanExiHS_OR10S1.

Organism-specific databases

HPAiHPA019038.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000431914.

Structurei

3D structure databases

ProteinModelPortaliQ8NGN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ13. Eukaryota.
ENOG4111DA0. LUCA.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN2.
KOiK04257.
OMAiTWATGAI.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGN2.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRSVCEKM TMTTENPNQT VVSHFFLEGL RYTAKHSSLF FLLFLLIYSI
60 70 80 90 100
TVAGNLLILL TVGSDSHLSL PMYHFLGHLS FLDACLSTVT VPKVMAGLLT
110 120 130 140 150
LDGKVISFEG CAVQLYCFHF LASTECFLYT VMAYDRYLAI CQPLHYPVAM
160 170 180 190 200
NRRMCAEMAG ITWAIGATHA AIHTSLTFRL LYCGPCHIAY FFCDIPPVLK
210 220 230 240 250
LACTDTTINE LVMLASIGIV AAGCLILIVI SYIFIVAAVL RIRTAQGRQR
260 270 280 290 300
AFSPCTAQLT GVLLYYVPPV CIYLQPRSSE AGAGAPAVFY TIVTPMLNPF
310 320 330
IYTLRNKEVK HALQRLLCSS FRESTAGSPP P
Length:331
Mass (Da):36,501
Last modified:February 10, 2009 - v2
Checksum:i50DA45E36CA595D6
GO

Sequence cautioni

The sequence BAC05978 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05435863G → S.Corresponds to variant rs17759513dbSNPEnsembl.1
Natural variantiVAR_05435993K → R.Corresponds to variant rs17686210dbSNPEnsembl.1
Natural variantiVAR_054360112A → V.Corresponds to variant rs17759447dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065758 Genomic DNA. Translation: BAC05978.1. Different initiation.
AP001884 Genomic DNA. No translation available.
BC137037 mRNA. Translation: AAI37038.1.
BC137038 mRNA. Translation: AAI37039.1.
AF399565 Genomic DNA. Translation: AAK95050.1.
BK004509 Genomic DNA. Translation: DAA04907.1.
CCDSiCCDS31701.1.
RefSeqiNP_001004474.1. NM_001004474.1.
UniGeneiHs.553637.

Genome annotation databases

EnsembliENST00000531945; ENSP00000431914; ENSG00000196248.
GeneIDi219873.
KEGGihsa:219873.
UCSCiuc001pzm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065758 Genomic DNA. Translation: BAC05978.1. Different initiation.
AP001884 Genomic DNA. No translation available.
BC137037 mRNA. Translation: AAI37038.1.
BC137038 mRNA. Translation: AAI37039.1.
AF399565 Genomic DNA. Translation: AAK95050.1.
BK004509 Genomic DNA. Translation: DAA04907.1.
CCDSiCCDS31701.1.
RefSeqiNP_001004474.1. NM_001004474.1.
UniGeneiHs.553637.

3D structure databases

ProteinModelPortaliQ8NGN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000431914.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGN2.
PhosphoSitePlusiQ8NGN2.

Polymorphism and mutation databases

BioMutaiOR10S1.
DMDMi223590111.

Proteomic databases

PaxDbiQ8NGN2.
PeptideAtlasiQ8NGN2.
PRIDEiQ8NGN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000531945; ENSP00000431914; ENSG00000196248.
GeneIDi219873.
KEGGihsa:219873.
UCSCiuc001pzm.2. human.

Organism-specific databases

CTDi219873.
GeneCardsiOR10S1.
HGNCiHGNC:14807. OR10S1.
HPAiHPA019038.
neXtProtiNX_Q8NGN2.
OpenTargetsiENSG00000196248.
PharmGKBiPA31999.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ13. Eukaryota.
ENOG4111DA0. LUCA.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN2.
KOiK04257.
OMAiTWATGAI.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGN2.
TreeFamiTF352732.

Enzyme and pathway databases

BioCyciZFISH:G66-33582-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10S1.
GenomeRNAii219873.
PROiQ8NGN2.

Gene expression databases

CleanExiHS_OR10S1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10S1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN2
Secondary accession number(s): B9EH43, Q6IEV3, Q96R78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.