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Protein

Olfactory receptor 6T1

Gene

OR6T1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6T1
Alternative name(s):
Olfactory receptor OR11-277
Gene namesi
Name:OR6T1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14848. OR6T1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 32331CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32605.

Polymorphism and mutation databases

BioMutaiOR6T1.
DMDMi38372731.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Olfactory receptor 6T1PRO_0000150638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN1.
PRIDEiQ8NGN1.

PTM databases

iPTMnetiQ8NGN1.
PhosphoSiteiQ8NGN1.

Expressioni

Gene expression databases

CleanExiHS_OR6T1.

Organism-specific databases

HPAiHPA060893.

Interactioni

Protein-protein interaction databases

BioGridi128590. 1 interaction.
STRINGi9606.ENSP00000325203.

Structurei

3D structure databases

ProteinModelPortaliQ8NGN1.
SMRiQ8NGN1. Positions 25-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIHK. Eukaryota.
ENOG41116C7. LUCA.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGN1.
KOiK04257.
OMAiPKMLVVI.
OrthoDBiEOG7QVM38.
PhylomeDBiQ8NGN1.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPENWTQVT SFVLLGFPSS HLIQFLVFLG LMVTYIVTAT GKLLIIVLSW
60 70 80 90 100
IDQRLHIQMY FFLRNFSFLE LLLVTVVVPK MLVVILTGDH TISFVSCIIQ
110 120 130 140 150
SYLYFFLGTT DFFLLAVMSL DRYLAICRPL RYETLMNGHV CSQLVLASWL
160 170 180 190 200
AGFLWVLCPT VLMASLPFCG PNGIDHFFRD SWPLLRLSCG DTHLLKLVAF
210 220 230 240 250
MLSTLVLLGS LALTSVSYAC ILATVLRAPT AAERRKAFST CASHLTVVVI
260 270 280 290 300
IYGSSIFLYI RMSEAQSKLL NKGASVLSCI ITPLLNPFIF TLRNDKVQQA
310 320
LREALGWPRL TAVMKLRVTS QRK
Length:323
Mass (Da):36,348
Last modified:October 1, 2002 - v1
Checksum:i115EA0F3A5BE91E4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231I → T.
Corresponds to variant rs6590022 [ dbSNP | Ensembl ].
VAR_048049
Natural varianti64 – 641R → W.
Corresponds to variant rs6590021 [ dbSNP | Ensembl ].
VAR_048050
Natural varianti251 – 2511I → V.
Corresponds to variant rs7937317 [ dbSNP | Ensembl ].
VAR_048051

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065759 Genomic DNA. Translation: BAC05979.1.
CH471065 Genomic DNA. Translation: EAW67562.1.
BC136906 mRNA. Translation: AAI36907.1.
BK004315 Genomic DNA. Translation: DAA04713.1.
CCDSiCCDS31700.1.
RefSeqiNP_001005187.1. NM_001005187.1.
UniGeneiHs.553638.

Genome annotation databases

EnsembliENST00000321252; ENSP00000325203; ENSG00000181499.
GeneIDi219874.
KEGGihsa:219874.
UCSCiuc010sab.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065759 Genomic DNA. Translation: BAC05979.1.
CH471065 Genomic DNA. Translation: EAW67562.1.
BC136906 mRNA. Translation: AAI36907.1.
BK004315 Genomic DNA. Translation: DAA04713.1.
CCDSiCCDS31700.1.
RefSeqiNP_001005187.1. NM_001005187.1.
UniGeneiHs.553638.

3D structure databases

ProteinModelPortaliQ8NGN1.
SMRiQ8NGN1. Positions 25-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128590. 1 interaction.
STRINGi9606.ENSP00000325203.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGN1.
PhosphoSiteiQ8NGN1.

Polymorphism and mutation databases

BioMutaiOR6T1.
DMDMi38372731.

Proteomic databases

PaxDbiQ8NGN1.
PRIDEiQ8NGN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321252; ENSP00000325203; ENSG00000181499.
GeneIDi219874.
KEGGihsa:219874.
UCSCiuc010sab.3. human.

Organism-specific databases

CTDi219874.
GeneCardsiOR6T1.
HGNCiHGNC:14848. OR6T1.
HPAiHPA060893.
neXtProtiNX_Q8NGN1.
PharmGKBiPA32605.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIHK. Eukaryota.
ENOG41116C7. LUCA.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGN1.
KOiK04257.
OMAiPKMLVVI.
OrthoDBiEOG7QVM38.
PhylomeDBiQ8NGN1.
TreeFamiTF336833.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR6T1.
GenomeRNAii219874.
PROiQ8NGN1.

Gene expression databases

CleanExiHS_OR6T1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR6T1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN1
Secondary accession number(s): Q6IFE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.