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Protein

Olfactory receptor 4D5

Gene

OR4D5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4D5
Alternative name(s):
Olfactory receptor OR11-276
Gene namesi
Name:OR4D5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14852. OR4D5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23516CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence AnalysisAdd
BLAST
Transmembranei270 – 28920Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 31829CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32272.

Polymorphism and mutation databases

BioMutaiOR4D5.
DMDMi38372730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 4D5PRO_0000150539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN0.
PRIDEiQ8NGN0.

PTM databases

PhosphoSiteiQ8NGN0.

Expressioni

Gene expression databases

CleanExiHS_OR4D5.

Organism-specific databases

HPAiHPA045005.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305970.

Structurei

3D structure databases

ProteinModelPortaliQ8NGN0.
SMRiQ8NGN0. Positions 30-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147236.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN0.
KOiK04257.
OMAiDPHLHTT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGN0.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPANHSQVA GFVLLGLSQV WELRFVFFTV FSAVYFMTVV GNLLIVVIVT
60 70 80 90 100
SDPHLHTTMY FLLGNLSFLD FCYSSITAPR MLVDLLSGNP TISFGGCLTQ
110 120 130 140 150
LFFFHFIGGI KIFLLTVMAY DRYIAISQPL HYTLIMNQTV CALLMAASWV
160 170 180 190 200
GGFIHSIVQI ALTIQLPFCG PDKLDNFYCD VPQLIKLACT DTFVLELLMV
210 220 230 240 250
SNNGLVTLMC FLVLLGSYTA LLVMLRSHSR EGRSKALSTC ASHIAVVTLI
260 270 280 290 300
FVPCIYVYTR PFRTFPMDKA VSVLYTIVTP MLNPAIYTLR NKEVIMAMKK
310
LWRRKKDPIG PLEHRPLH
Length:318
Mass (Da):35,771
Last modified:October 1, 2002 - v1
Checksum:i587D3AF60FF8B135
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065760 Genomic DNA. Translation: BAC05980.1.
CH471065 Genomic DNA. Translation: EAW67561.1.
BC136943 mRNA. Translation: AAI36944.1.
BC136945 mRNA. Translation: AAI36946.1.
BK004316 Genomic DNA. Translation: DAA04714.1.
CCDSiCCDS31699.1.
RefSeqiNP_001001965.1. NM_001001965.1.
UniGeneiHs.553639.

Genome annotation databases

EnsembliENST00000307033; ENSP00000305970; ENSG00000171014.
GeneIDi219875.
KEGGihsa:219875.
UCSCiuc001pzk.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065760 Genomic DNA. Translation: BAC05980.1.
CH471065 Genomic DNA. Translation: EAW67561.1.
BC136943 mRNA. Translation: AAI36944.1.
BC136945 mRNA. Translation: AAI36946.1.
BK004316 Genomic DNA. Translation: DAA04714.1.
CCDSiCCDS31699.1.
RefSeqiNP_001001965.1. NM_001001965.1.
UniGeneiHs.553639.

3D structure databases

ProteinModelPortaliQ8NGN0.
SMRiQ8NGN0. Positions 30-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000305970.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGN0.

Polymorphism and mutation databases

BioMutaiOR4D5.
DMDMi38372730.

Proteomic databases

PaxDbiQ8NGN0.
PRIDEiQ8NGN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307033; ENSP00000305970; ENSG00000171014.
GeneIDi219875.
KEGGihsa:219875.
UCSCiuc001pzk.1. human.

Organism-specific databases

CTDi219875.
GeneCardsiGC11P123810.
HGNCiHGNC:14852. OR4D5.
HPAiHPA045005.
neXtProtiNX_Q8NGN0.
PharmGKBiPA32272.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147236.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN0.
KOiK04257.
OMAiDPHLHTT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGN0.
TreeFamiTF352732.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4D5.
GenomeRNAii219875.
NextBioi90834.
PROiQ8NGN0.

Gene expression databases

CleanExiHS_OR4D5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4D5_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN0
Secondary accession number(s): B9EGZ4, Q6IFE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.