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Q8NGN0

- OR4D5_HUMAN

UniProt

Q8NGN0 - OR4D5_HUMAN

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Protein

Olfactory receptor 4D5

Gene

OR4D5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4D5
Alternative name(s):
Olfactory receptor OR11-276
Gene namesi
Name:OR4D5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14852. OR4D5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32272.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 4D5PRO_0000150539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN0.
PRIDEiQ8NGN0.

PTM databases

PhosphoSiteiQ8NGN0.

Expressioni

Gene expression databases

CleanExiHS_OR4D5.
GenevestigatoriQ8NGN0.

Organism-specific databases

HPAiHPA045005.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305970.

Structurei

3D structure databases

ProteinModelPortaliQ8NGN0.
SMRiQ8NGN0. Positions 30-154.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Topological domaini220 – 23516CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence AnalysisAdd
BLAST
Topological domaini290 – 31829CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei270 – 28920Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147236.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN0.
KOiK04257.
OMAiGLTIQLP.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGN0.
TreeFamiTF352732.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGN0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPANHSQVA GFVLLGLSQV WELRFVFFTV FSAVYFMTVV GNLLIVVIVT
60 70 80 90 100
SDPHLHTTMY FLLGNLSFLD FCYSSITAPR MLVDLLSGNP TISFGGCLTQ
110 120 130 140 150
LFFFHFIGGI KIFLLTVMAY DRYIAISQPL HYTLIMNQTV CALLMAASWV
160 170 180 190 200
GGFIHSIVQI ALTIQLPFCG PDKLDNFYCD VPQLIKLACT DTFVLELLMV
210 220 230 240 250
SNNGLVTLMC FLVLLGSYTA LLVMLRSHSR EGRSKALSTC ASHIAVVTLI
260 270 280 290 300
FVPCIYVYTR PFRTFPMDKA VSVLYTIVTP MLNPAIYTLR NKEVIMAMKK
310
LWRRKKDPIG PLEHRPLH
Length:318
Mass (Da):35,771
Last modified:October 1, 2002 - v1
Checksum:i587D3AF60FF8B135
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065760 Genomic DNA. Translation: BAC05980.1.
CH471065 Genomic DNA. Translation: EAW67561.1.
BC136943 mRNA. Translation: AAI36944.1.
BC136945 mRNA. Translation: AAI36946.1.
BK004316 Genomic DNA. Translation: DAA04714.1.
CCDSiCCDS31699.1.
RefSeqiNP_001001965.1. NM_001001965.1.
UniGeneiHs.553639.

Genome annotation databases

EnsembliENST00000307033; ENSP00000305970; ENSG00000171014.
GeneIDi219875.
KEGGihsa:219875.
UCSCiuc001pzk.1. human.

Polymorphism databases

DMDMi38372730.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065760 Genomic DNA. Translation: BAC05980.1 .
CH471065 Genomic DNA. Translation: EAW67561.1 .
BC136943 mRNA. Translation: AAI36944.1 .
BC136945 mRNA. Translation: AAI36946.1 .
BK004316 Genomic DNA. Translation: DAA04714.1 .
CCDSi CCDS31699.1.
RefSeqi NP_001001965.1. NM_001001965.1.
UniGenei Hs.553639.

3D structure databases

ProteinModelPortali Q8NGN0.
SMRi Q8NGN0. Positions 30-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000305970.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGN0.

Polymorphism databases

DMDMi 38372730.

Proteomic databases

PaxDbi Q8NGN0.
PRIDEi Q8NGN0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307033 ; ENSP00000305970 ; ENSG00000171014 .
GeneIDi 219875.
KEGGi hsa:219875.
UCSCi uc001pzk.1. human.

Organism-specific databases

CTDi 219875.
GeneCardsi GC11P123810.
HGNCi HGNC:14852. OR4D5.
HPAi HPA045005.
neXtProti NX_Q8NGN0.
PharmGKBi PA32272.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147236.
GeneTreei ENSGT00760000119104.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGN0.
KOi K04257.
OMAi GLTIQLP.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGN0.
TreeFami TF352732.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR4D5.
GenomeRNAii 219875.
NextBioi 90834.
PROi Q8NGN0.

Gene expression databases

CleanExi HS_OR4D5.
Genevestigatori Q8NGN0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4D5_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN0
Secondary accession number(s): B9EGZ4, Q6IFE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3