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Protein

Olfactory receptor 4D5

Gene

OR4D5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171014-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4D5
Alternative name(s):
Olfactory receptor OR11-276
Gene namesi
Name:OR4D5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14852. OR4D5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 318CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171014.
PharmGKBiPA32272.

Polymorphism and mutation databases

BioMutaiOR4D5.
DMDMi38372730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505391 – 318Olfactory receptor 4D5Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGN0.
PRIDEiQ8NGN0.

PTM databases

iPTMnetiQ8NGN0.
PhosphoSitePlusiQ8NGN0.

Expressioni

Gene expression databases

CleanExiHS_OR4D5.
ExpressionAtlasiQ8NGN0. baseline and differential.

Organism-specific databases

HPAiHPA045005.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305970.

Structurei

3D structure databases

ProteinModelPortaliQ8NGN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEFX. Eukaryota.
ENOG41119VH. LUCA.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN0.
KOiK04257.
OMAiDPHLHTT.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGN0.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPANHSQVA GFVLLGLSQV WELRFVFFTV FSAVYFMTVV GNLLIVVIVT
60 70 80 90 100
SDPHLHTTMY FLLGNLSFLD FCYSSITAPR MLVDLLSGNP TISFGGCLTQ
110 120 130 140 150
LFFFHFIGGI KIFLLTVMAY DRYIAISQPL HYTLIMNQTV CALLMAASWV
160 170 180 190 200
GGFIHSIVQI ALTIQLPFCG PDKLDNFYCD VPQLIKLACT DTFVLELLMV
210 220 230 240 250
SNNGLVTLMC FLVLLGSYTA LLVMLRSHSR EGRSKALSTC ASHIAVVTLI
260 270 280 290 300
FVPCIYVYTR PFRTFPMDKA VSVLYTIVTP MLNPAIYTLR NKEVIMAMKK
310
LWRRKKDPIG PLEHRPLH
Length:318
Mass (Da):35,771
Last modified:October 1, 2002 - v1
Checksum:i587D3AF60FF8B135
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065760 Genomic DNA. Translation: BAC05980.1.
CH471065 Genomic DNA. Translation: EAW67561.1.
BC136943 mRNA. Translation: AAI36944.1.
BC136945 mRNA. Translation: AAI36946.1.
BK004316 Genomic DNA. Translation: DAA04714.1.
CCDSiCCDS31699.1.
RefSeqiNP_001001965.1. NM_001001965.1.
UniGeneiHs.553639.

Genome annotation databases

EnsembliENST00000307033; ENSP00000305970; ENSG00000171014.
GeneIDi219875.
KEGGihsa:219875.
UCSCiuc001pzk.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065760 Genomic DNA. Translation: BAC05980.1.
CH471065 Genomic DNA. Translation: EAW67561.1.
BC136943 mRNA. Translation: AAI36944.1.
BC136945 mRNA. Translation: AAI36946.1.
BK004316 Genomic DNA. Translation: DAA04714.1.
CCDSiCCDS31699.1.
RefSeqiNP_001001965.1. NM_001001965.1.
UniGeneiHs.553639.

3D structure databases

ProteinModelPortaliQ8NGN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000305970.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGN0.
PhosphoSitePlusiQ8NGN0.

Polymorphism and mutation databases

BioMutaiOR4D5.
DMDMi38372730.

Proteomic databases

PaxDbiQ8NGN0.
PRIDEiQ8NGN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307033; ENSP00000305970; ENSG00000171014.
GeneIDi219875.
KEGGihsa:219875.
UCSCiuc001pzk.2. human.

Organism-specific databases

CTDi219875.
GeneCardsiOR4D5.
HGNCiHGNC:14852. OR4D5.
HPAiHPA045005.
neXtProtiNX_Q8NGN0.
OpenTargetsiENSG00000171014.
PharmGKBiPA32272.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEFX. Eukaryota.
ENOG41119VH. LUCA.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGN0.
KOiK04257.
OMAiDPHLHTT.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGN0.
TreeFamiTF352732.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171014-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4D5.
GenomeRNAii219875.
PROiQ8NGN0.

Gene expression databases

CleanExiHS_OR4D5.
ExpressionAtlasiQ8NGN0. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4D5_HUMAN
AccessioniPrimary (citable) accession number: Q8NGN0
Secondary accession number(s): B9EGZ4, Q6IFE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.