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Q8NGN0 (OR4D5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 4D5
Alternative name(s):
Olfactory receptor OR11-276
Gene names
Name:OR4D5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Olfactory receptor 4D5
PRO_0000150539

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21924Helical; Name=5; Potential
Topological domain220 – 23516Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 26911Extracellular Potential
Transmembrane270 – 28920Helical; Name=7; Potential
Topological domain290 – 31829Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NGN0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 587D3AF60FF8B135

FASTA31835,771
        10         20         30         40         50         60 
MNPANHSQVA GFVLLGLSQV WELRFVFFTV FSAVYFMTVV GNLLIVVIVT SDPHLHTTMY 

        70         80         90        100        110        120 
FLLGNLSFLD FCYSSITAPR MLVDLLSGNP TISFGGCLTQ LFFFHFIGGI KIFLLTVMAY 

       130        140        150        160        170        180 
DRYIAISQPL HYTLIMNQTV CALLMAASWV GGFIHSIVQI ALTIQLPFCG PDKLDNFYCD 

       190        200        210        220        230        240 
VPQLIKLACT DTFVLELLMV SNNGLVTLMC FLVLLGSYTA LLVMLRSHSR EGRSKALSTC 

       250        260        270        280        290        300 
ASHIAVVTLI FVPCIYVYTR PFRTFPMDKA VSVLYTIVTP MLNPAIYTLR NKEVIMAMKK 

       310 
LWRRKKDPIG PLEHRPLH 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065760 Genomic DNA. Translation: BAC05980.1.
CH471065 Genomic DNA. Translation: EAW67561.1.
BC136943 mRNA. Translation: AAI36944.1.
BC136945 mRNA. Translation: AAI36946.1.
BK004316 Genomic DNA. Translation: DAA04714.1.
RefSeqNP_001001965.1. NM_001001965.1.
UniGeneHs.553639.

3D structure databases

ProteinModelPortalQ8NGN0.
SMRQ8NGN0. Positions 30-154, 275-304.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000305970.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGN0.

Polymorphism databases

DMDM38372730.

Proteomic databases

PaxDbQ8NGN0.
PRIDEQ8NGN0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307033; ENSP00000305970; ENSG00000171014.
GeneID219875.
KEGGhsa:219875.
UCSCuc001pzk.1. human.

Organism-specific databases

CTD219875.
GeneCardsGC11P123810.
HGNCHGNC:14852. OR4D5.
HPAHPA045005.
neXtProtNX_Q8NGN0.
PharmGKBPA32272.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG147236.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGN0.
KOK04257.
OMADPHLHTT.
OrthoDBEOG71K63J.
PhylomeDBQ8NGN0.
TreeFamTF352732.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR4D5.
GenevestigatorQ8NGN0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR4D5.
GenomeRNAi219875.
NextBio90834.
PROQ8NGN0.

Entry information

Entry nameOR4D5_HUMAN
AccessionPrimary (citable) accession number: Q8NGN0
Secondary accession number(s): B9EGZ4, Q6IFE6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries