ID   OR8D4_HUMAN             Reviewed;         314 AA.
AC   Q8NGM9; Q6IFE9;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 159.
DE   RecName: Full=Olfactory receptor 8D4;
DE   AltName: Full=Olfactory receptor OR11-275;
GN   Name=OR8D4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8D4";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB065761; BAC05981.1; -; Genomic_DNA.
DR   EMBL; BC137180; AAI37181.1; -; mRNA.
DR   EMBL; BC137206; AAI37207.1; -; mRNA.
DR   EMBL; BK004313; DAA04711.1; -; Genomic_DNA.
DR   CCDS; CCDS31698.1; -.
DR   RefSeq; NP_001005197.1; NM_001005197.1.
DR   AlphaFoldDB; Q8NGM9; -.
DR   SMR; Q8NGM9; -.
DR   BioGRID; 130777; 1.
DR   STRING; 9606.ENSP00000493391; -.
DR   GlyCosmos; Q8NGM9; 1 site, No reported glycans.
DR   GlyGen; Q8NGM9; 1 site.
DR   iPTMnet; Q8NGM9; -.
DR   PhosphoSitePlus; Q8NGM9; -.
DR   BioMuta; OR8D4; -.
DR   DMDM; 38372729; -.
DR   MassIVE; Q8NGM9; -.
DR   PaxDb; 9606-ENSP00000325381; -.
DR   Antibodypedia; 56775; 77 antibodies from 19 providers.
DR   DNASU; 338662; -.
DR   Ensembl; ENST00000321355.3; ENSP00000325381.2; ENSG00000181518.4.
DR   Ensembl; ENST00000641687.1; ENSP00000493391.1; ENSG00000181518.4.
DR   GeneID; 338662; -.
DR   KEGG; hsa:338662; -.
DR   MANE-Select; ENST00000641687.1; ENSP00000493391.1; NM_001005197.2; NP_001005197.1.
DR   UCSC; uc010saa.3; human.
DR   AGR; HGNC:14840; -.
DR   CTD; 338662; -.
DR   GeneCards; OR8D4; -.
DR   HGNC; HGNC:14840; OR8D4.
DR   HPA; ENSG00000181518; Not detected.
DR   neXtProt; NX_Q8NGM9; -.
DR   PharmGKB; PA32762; -.
DR   VEuPathDB; HostDB:ENSG00000181518; -.
DR   eggNOG; ENOG502SJS1; Eukaryota.
DR   GeneTree; ENSGT01040000240383; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGM9; -.
DR   OMA; CIFIISE; -.
DR   OrthoDB; 5317957at2759; -.
DR   PhylomeDB; Q8NGM9; -.
DR   TreeFam; TF352753; -.
DR   PathwayCommons; Q8NGM9; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 338662; 13 hits in 741 CRISPR screens.
DR   GeneWiki; OR8D4; -.
DR   GenomeRNAi; 338662; -.
DR   Pharos; Q8NGM9; Tdark.
DR   PRO; PR:Q8NGM9; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGM9; Protein.
DR   Bgee; ENSG00000181518; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 1 other cell type or tissue.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15406; 7tmA_OR8D-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48018:SF137; OLFACTORY RECEPTOR 8D4; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Olfactory receptor 8D4"
FT                   /id="PRO_0000150661"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         55
FT                   /note="L -> R (in dbSNP:rs17127947)"
FT                   /id="VAR_034257"
FT   VARIANT         92
FT                   /note="I -> V (in dbSNP:rs17127950)"
FT                   /id="VAR_034258"
FT   VARIANT         120
FT                   /note="C -> Y (in dbSNP:rs10750250)"
FT                   /id="VAR_053245"
FT   VARIANT         133
FT                   /note="R -> K (in dbSNP:rs7926767)"
FT                   /id="VAR_024118"
FT   VARIANT         200
FT                   /note="F -> L (in dbSNP:rs10790610)"
FT                   /id="VAR_024119"
FT   VARIANT         205
FT                   /note="F -> S (in dbSNP:rs12270203)"
FT                   /id="VAR_034259"
FT   VARIANT         283
FT                   /note="L -> P (in dbSNP:rs7942047)"
FT                   /id="VAR_024120"
FT   VARIANT         298
FT                   /note="R -> K (in dbSNP:rs7927385)"
FT                   /id="VAR_024121"
SQ   SEQUENCE   314 AA;  35019 MW;  7D9AB003A8D3B0DA CRC64;
     MGVKNHSTVT EFLLSGLTEQ AELQLPLFCL FLGIYTVTVV GNLSMISIIR LNRQLHTPMY
     YFLSSLSFLD FCYSSVITPK MLSGFLCRDR SISYSGCMIQ LFFFCVCVIS ECYMLAAMAC
     DRYVAICSPL LYRVIMSPRV CSLLVAAVFS VGFTDAVIHG GCILRLSFCG SNIIKHYFCD
     IVPLIKLSCS STYIDELLIF VIGGFNMVAT SLTIIISYAF ILTSILRIHS KKGRCKAFST
     CSSHLTAVLM FYGSLMSMYL KPASSSSLTQ EKVSSVFYTT VILMLNPLIY SLRNNEVRNA
     LMKLLRRKIS LSPG
//