Q8NGM9 (OR8D4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 8D4

Alternative name(s):
Olfactory receptor OR11-275

Gene names

Name:

OR8D4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Olfactory receptor 8D4		PRO_0000150661
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 217	20	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 314	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	55	1	L → R. Corresponds to variant rs17127947 [ dbSNP | Ensembl ].		VAR_034257
	Natural variant	92	1	I → V. Corresponds to variant rs17127950 [ dbSNP | Ensembl ].		VAR_034258
	Natural variant	120	1	C → Y. Corresponds to variant rs10750250 [ dbSNP | Ensembl ].		VAR_053245
	Natural variant	133	1	R → K. Corresponds to variant rs7926767 [ dbSNP | Ensembl ].		VAR_024118
	Natural variant	200	1	F → L. Corresponds to variant rs10790610 [ dbSNP | Ensembl ].		VAR_024119
	Natural variant	205	1	F → S. Corresponds to variant rs12270203 [ dbSNP | Ensembl ].		VAR_034259
	Natural variant	283	1	L → P. Corresponds to variant rs7942047 [ dbSNP | Ensembl ].		VAR_024120
	Natural variant	298	1	R → K. Corresponds to variant rs7927385 [ dbSNP | Ensembl ].		VAR_024121

Sequences

	Sequence		Length	Mass (Da)
	Q8NGM9 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 7D9AB003A8D3B0DA	FASTA	314	35,019
	10 20 30 40 50 60 MGVKNHSTVT EFLLSGLTEQ AELQLPLFCL FLGIYTVTVV GNLSMISIIR LNRQLHTPMY 70 80 90 100 110 120 YFLSSLSFLD FCYSSVITPK MLSGFLCRDR SISYSGCMIQ LFFFCVCVIS ECYMLAAMAC 130 140 150 160 170 180 DRYVAICSPL LYRVIMSPRV CSLLVAAVFS VGFTDAVIHG GCILRLSFCG SNIIKHYFCD 190 200 210 220 230 240 IVPLIKLSCS STYIDELLIF VIGGFNMVAT SLTIIISYAF ILTSILRIHS KKGRCKAFST 250 260 270 280 290 300 CSSHLTAVLM FYGSLMSMYL KPASSSSLTQ EKVSSVFYTT VILMLNPLIY SLRNNEVRNA 310 LMKLLRRKIS LSPG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065761 Genomic DNA. Translation: BAC05981.1. BC137180 mRNA. Translation: AAI37181.1. BC137206 mRNA. Translation: AAI37207.1. BK004313 Genomic DNA. Translation: DAA04711.1.
IPI	IPI00169064.
RefSeq	NP_001005197.1. NM_001005197.1.
UniGene	Hs.449688.
3D structure databases
ProteinModelPortal	Q8NGM9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000325381.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NGM9.
Polymorphism databases
DMDM	38372729.
Proteomic databases
PRIDE	Q8NGM9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321355; ENSP00000325381; ENSG00000181518.
GeneID	338662.
KEGG	hsa:338662.
UCSC	uc010saa.2. human.
Organism-specific databases
CTD	338662.
GeneCards	GC11P123777.
HGNC	HGNC:14840. OR8D4.
neXtProt	NX_Q8NGM9.
PharmGKB	PA32762.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG123563.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q8NGM9.
KO	K04257.
OMA	VCVISEC.
OrthoDB	EOG4MGS80.
PhylomeDB	Q8NGM9.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q8NGM9.
CleanEx	HS_OR8D4.
Genevestigator	Q8NGM9.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	338662.
NextBio	97086.

Entry information

Entry name

OR8D4_HUMAN

Accession

Primary (citable) accession number: Q8NGM9
Secondary accession number(s): Q6IFE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.