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Q8NGM9

- OR8D4_HUMAN

UniProt

Q8NGM9 - OR8D4_HUMAN

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Protein
Olfactory receptor 8D4
Gene
OR8D4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8D4
Alternative name(s):
Olfactory receptor OR11-275
Gene namesi
Name:OR8D4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14840. OR8D4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed prediction
Add
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini47 – 548Cytoplasmic Reviewed prediction
Transmembranei55 – 7521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini76 – 9924Extracellular Reviewed prediction
Add
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini161 – 19737Extracellular Reviewed prediction
Add
BLAST
Transmembranei198 – 21720Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini218 – 23720Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini259 – 27113Extracellular Reviewed prediction
Add
BLAST
Transmembranei272 – 29221Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini293 – 31422Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32762.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 8D4
PRO_0000150661Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGM9.

PTM databases

PhosphoSiteiQ8NGM9.

Expressioni

Gene expression databases

BgeeiQ8NGM9.
CleanExiHS_OR8D4.
GenevestigatoriQ8NGM9.

Interactioni

Protein-protein interaction databases

BioGridi130777. 1 interaction.
STRINGi9606.ENSP00000325381.

Structurei

3D structure databases

ProteinModelPortaliQ8NGM9.
SMRiQ8NGM9. Positions 32-184.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG123563.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGM9.
KOiK04257.
OMAiVCVISEC.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGM9.
TreeFamiTF352753.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGM9-1 [UniParc]FASTAAdd to Basket

« Hide

MGVKNHSTVT EFLLSGLTEQ AELQLPLFCL FLGIYTVTVV GNLSMISIIR    50
LNRQLHTPMY YFLSSLSFLD FCYSSVITPK MLSGFLCRDR SISYSGCMIQ 100
LFFFCVCVIS ECYMLAAMAC DRYVAICSPL LYRVIMSPRV CSLLVAAVFS 150
VGFTDAVIHG GCILRLSFCG SNIIKHYFCD IVPLIKLSCS STYIDELLIF 200
VIGGFNMVAT SLTIIISYAF ILTSILRIHS KKGRCKAFST CSSHLTAVLM 250
FYGSLMSMYL KPASSSSLTQ EKVSSVFYTT VILMLNPLIY SLRNNEVRNA 300
LMKLLRRKIS LSPG 314
Length:314
Mass (Da):35,019
Last modified:October 1, 2002 - v1
Checksum:i7D9AB003A8D3B0DA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551L → R.
Corresponds to variant rs17127947 [ dbSNP | Ensembl ].
VAR_034257
Natural varianti92 – 921I → V.
Corresponds to variant rs17127950 [ dbSNP | Ensembl ].
VAR_034258
Natural varianti120 – 1201C → Y.
Corresponds to variant rs10750250 [ dbSNP | Ensembl ].
VAR_053245
Natural varianti133 – 1331R → K.
Corresponds to variant rs7926767 [ dbSNP | Ensembl ].
VAR_024118
Natural varianti200 – 2001F → L.
Corresponds to variant rs10790610 [ dbSNP | Ensembl ].
VAR_024119
Natural varianti205 – 2051F → S.
Corresponds to variant rs12270203 [ dbSNP | Ensembl ].
VAR_034259
Natural varianti283 – 2831L → P.
Corresponds to variant rs7942047 [ dbSNP | Ensembl ].
VAR_024120
Natural varianti298 – 2981R → K.
Corresponds to variant rs7927385 [ dbSNP | Ensembl ].
VAR_024121

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065761 Genomic DNA. Translation: BAC05981.1.
BC137180 mRNA. Translation: AAI37181.1.
BC137206 mRNA. Translation: AAI37207.1.
BK004313 Genomic DNA. Translation: DAA04711.1.
CCDSiCCDS31698.1.
RefSeqiNP_001005197.1. NM_001005197.1.
UniGeneiHs.449688.

Genome annotation databases

EnsembliENST00000321355; ENSP00000325381; ENSG00000181518.
GeneIDi338662.
KEGGihsa:338662.
UCSCiuc010saa.2. human.

Polymorphism databases

DMDMi38372729.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065761 Genomic DNA. Translation: BAC05981.1 .
BC137180 mRNA. Translation: AAI37181.1 .
BC137206 mRNA. Translation: AAI37207.1 .
BK004313 Genomic DNA. Translation: DAA04711.1 .
CCDSi CCDS31698.1.
RefSeqi NP_001005197.1. NM_001005197.1.
UniGenei Hs.449688.

3D structure databases

ProteinModelPortali Q8NGM9.
SMRi Q8NGM9. Positions 32-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130777. 1 interaction.
STRINGi 9606.ENSP00000325381.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGM9.

Polymorphism databases

DMDMi 38372729.

Proteomic databases

PRIDEi Q8NGM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321355 ; ENSP00000325381 ; ENSG00000181518 .
GeneIDi 338662.
KEGGi hsa:338662.
UCSCi uc010saa.2. human.

Organism-specific databases

CTDi 338662.
GeneCardsi GC11P123777.
HGNCi HGNC:14840. OR8D4.
neXtProti NX_Q8NGM9.
PharmGKBi PA32762.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG123563.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGM9.
KOi K04257.
OMAi VCVISEC.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGM9.
TreeFami TF352753.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR8D4.
GenomeRNAii 338662.
NextBioi 97086.
PROi Q8NGM9.

Gene expression databases

Bgeei Q8NGM9.
CleanExi HS_OR8D4.
Genevestigatori Q8NGM9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR8D4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGM9
Secondary accession number(s): Q6IFE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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