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Q8NGM9 (OR8D4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 8D4
Alternative name(s):
Olfactory receptor OR11-275
Gene names
Name:OR8D4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Olfactory receptor 8D4
PRO_0000150661

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31422Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant551L → R.
Corresponds to variant rs17127947 [ dbSNP | Ensembl ].
VAR_034257
Natural variant921I → V.
Corresponds to variant rs17127950 [ dbSNP | Ensembl ].
VAR_034258
Natural variant1201C → Y.
Corresponds to variant rs10750250 [ dbSNP | Ensembl ].
VAR_053245
Natural variant1331R → K.
Corresponds to variant rs7926767 [ dbSNP | Ensembl ].
VAR_024118
Natural variant2001F → L.
Corresponds to variant rs10790610 [ dbSNP | Ensembl ].
VAR_024119
Natural variant2051F → S.
Corresponds to variant rs12270203 [ dbSNP | Ensembl ].
VAR_034259
Natural variant2831L → P.
Corresponds to variant rs7942047 [ dbSNP | Ensembl ].
VAR_024120
Natural variant2981R → K.
Corresponds to variant rs7927385 [ dbSNP | Ensembl ].
VAR_024121

Sequences

Sequence LengthMass (Da)Tools
Q8NGM9 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 7D9AB003A8D3B0DA

FASTA31435,019
        10         20         30         40         50         60 
MGVKNHSTVT EFLLSGLTEQ AELQLPLFCL FLGIYTVTVV GNLSMISIIR LNRQLHTPMY 

        70         80         90        100        110        120 
YFLSSLSFLD FCYSSVITPK MLSGFLCRDR SISYSGCMIQ LFFFCVCVIS ECYMLAAMAC 

       130        140        150        160        170        180 
DRYVAICSPL LYRVIMSPRV CSLLVAAVFS VGFTDAVIHG GCILRLSFCG SNIIKHYFCD 

       190        200        210        220        230        240 
IVPLIKLSCS STYIDELLIF VIGGFNMVAT SLTIIISYAF ILTSILRIHS KKGRCKAFST 

       250        260        270        280        290        300 
CSSHLTAVLM FYGSLMSMYL KPASSSSLTQ EKVSSVFYTT VILMLNPLIY SLRNNEVRNA 

       310 
LMKLLRRKIS LSPG 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065761 Genomic DNA. Translation: BAC05981.1.
BC137180 mRNA. Translation: AAI37181.1.
BC137206 mRNA. Translation: AAI37207.1.
BK004313 Genomic DNA. Translation: DAA04711.1.
CCDSCCDS31698.1.
RefSeqNP_001005197.1. NM_001005197.1.
UniGeneHs.449688.

3D structure databases

ProteinModelPortalQ8NGM9.
SMRQ8NGM9. Positions 32-184.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130777. 1 interaction.
STRING9606.ENSP00000325381.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGM9.

Polymorphism databases

DMDM38372729.

Proteomic databases

PRIDEQ8NGM9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000321355; ENSP00000325381; ENSG00000181518.
GeneID338662.
KEGGhsa:338662.
UCSCuc010saa.2. human.

Organism-specific databases

CTD338662.
GeneCardsGC11P123777.
HGNCHGNC:14840. OR8D4.
neXtProtNX_Q8NGM9.
PharmGKBPA32762.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG123563.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGM9.
KOK04257.
OMAVCVISEC.
OrthoDBEOG71K63J.
PhylomeDBQ8NGM9.
TreeFamTF352753.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8NGM9.
CleanExHS_OR8D4.
GenevestigatorQ8NGM9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR8D4.
GenomeRNAi338662.
NextBio97086.
PROQ8NGM9.

Entry information

Entry nameOR8D4_HUMAN
AccessionPrimary (citable) accession number: Q8NGM9
Secondary accession number(s): Q6IFE9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries