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Q8NGM9

- OR8D4_HUMAN

UniProt

Q8NGM9 - OR8D4_HUMAN

Protein

Olfactory receptor 8D4

Gene

OR8D4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 8D4
    Alternative name(s):
    Olfactory receptor OR11-275
    Gene namesi
    Name:OR8D4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14840. OR8D4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32762.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 8D4PRO_0000150661Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGM9.

    PTM databases

    PhosphoSiteiQ8NGM9.

    Expressioni

    Gene expression databases

    BgeeiQ8NGM9.
    CleanExiHS_OR8D4.
    GenevestigatoriQ8NGM9.

    Interactioni

    Protein-protein interaction databases

    BioGridi130777. 1 interaction.
    STRINGi9606.ENSP00000325381.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGM9.
    SMRiQ8NGM9. Positions 32-184.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG123563.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGM9.
    KOiK04257.
    OMAiVCVISEC.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGM9.
    TreeFamiTF352753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVKNHSTVT EFLLSGLTEQ AELQLPLFCL FLGIYTVTVV GNLSMISIIR    50
    LNRQLHTPMY YFLSSLSFLD FCYSSVITPK MLSGFLCRDR SISYSGCMIQ 100
    LFFFCVCVIS ECYMLAAMAC DRYVAICSPL LYRVIMSPRV CSLLVAAVFS 150
    VGFTDAVIHG GCILRLSFCG SNIIKHYFCD IVPLIKLSCS STYIDELLIF 200
    VIGGFNMVAT SLTIIISYAF ILTSILRIHS KKGRCKAFST CSSHLTAVLM 250
    FYGSLMSMYL KPASSSSLTQ EKVSSVFYTT VILMLNPLIY SLRNNEVRNA 300
    LMKLLRRKIS LSPG 314
    Length:314
    Mass (Da):35,019
    Last modified:October 1, 2002 - v1
    Checksum:i7D9AB003A8D3B0DA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551L → R.
    Corresponds to variant rs17127947 [ dbSNP | Ensembl ].
    VAR_034257
    Natural varianti92 – 921I → V.
    Corresponds to variant rs17127950 [ dbSNP | Ensembl ].
    VAR_034258
    Natural varianti120 – 1201C → Y.
    Corresponds to variant rs10750250 [ dbSNP | Ensembl ].
    VAR_053245
    Natural varianti133 – 1331R → K.
    Corresponds to variant rs7926767 [ dbSNP | Ensembl ].
    VAR_024118
    Natural varianti200 – 2001F → L.
    Corresponds to variant rs10790610 [ dbSNP | Ensembl ].
    VAR_024119
    Natural varianti205 – 2051F → S.
    Corresponds to variant rs12270203 [ dbSNP | Ensembl ].
    VAR_034259
    Natural varianti283 – 2831L → P.
    Corresponds to variant rs7942047 [ dbSNP | Ensembl ].
    VAR_024120
    Natural varianti298 – 2981R → K.
    Corresponds to variant rs7927385 [ dbSNP | Ensembl ].
    VAR_024121

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065761 Genomic DNA. Translation: BAC05981.1.
    BC137180 mRNA. Translation: AAI37181.1.
    BC137206 mRNA. Translation: AAI37207.1.
    BK004313 Genomic DNA. Translation: DAA04711.1.
    CCDSiCCDS31698.1.
    RefSeqiNP_001005197.1. NM_001005197.1.
    UniGeneiHs.449688.

    Genome annotation databases

    EnsembliENST00000321355; ENSP00000325381; ENSG00000181518.
    GeneIDi338662.
    KEGGihsa:338662.
    UCSCiuc010saa.2. human.

    Polymorphism databases

    DMDMi38372729.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065761 Genomic DNA. Translation: BAC05981.1 .
    BC137180 mRNA. Translation: AAI37181.1 .
    BC137206 mRNA. Translation: AAI37207.1 .
    BK004313 Genomic DNA. Translation: DAA04711.1 .
    CCDSi CCDS31698.1.
    RefSeqi NP_001005197.1. NM_001005197.1.
    UniGenei Hs.449688.

    3D structure databases

    ProteinModelPortali Q8NGM9.
    SMRi Q8NGM9. Positions 32-184.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130777. 1 interaction.
    STRINGi 9606.ENSP00000325381.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGM9.

    Polymorphism databases

    DMDMi 38372729.

    Proteomic databases

    PRIDEi Q8NGM9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321355 ; ENSP00000325381 ; ENSG00000181518 .
    GeneIDi 338662.
    KEGGi hsa:338662.
    UCSCi uc010saa.2. human.

    Organism-specific databases

    CTDi 338662.
    GeneCardsi GC11P123777.
    HGNCi HGNC:14840. OR8D4.
    neXtProti NX_Q8NGM9.
    PharmGKBi PA32762.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG123563.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGM9.
    KOi K04257.
    OMAi VCVISEC.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGM9.
    TreeFami TF352753.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR8D4.
    GenomeRNAii 338662.
    NextBioi 97086.
    PROi Q8NGM9.

    Gene expression databases

    Bgeei Q8NGM9.
    CleanExi HS_OR8D4.
    Genevestigatori Q8NGM9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR8D4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGM9
    Secondary accession number(s): Q6IFE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3