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Protein

Olfactory receptor 6M1

Gene

OR6M1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6M1
Alternative name(s):
Olfactory receptor OR11-271
Gene namesi
Name:OR6M1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14711. OR6M1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence Analysis
Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini74 – 9724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19436ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21420Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini215 – 23420CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini256 – 26813ExtracellularSequence AnalysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 31324CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32596.

Polymorphism and mutation databases

BioMutaiOR6M1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 6M1PRO_0000150632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 186PROSITE-ProRule annotation
Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGM8.
PRIDEiQ8NGM8.

Expressioni

Gene expression databases

CleanExiHS_OR6M1.

Organism-specific databases

HPAiHPA048674.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311038.

Structurei

3D structure databases

ProteinModelPortaliQ8NGM8.
SMRiQ8NGM8. Positions 23-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG133881.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGM8.
KOiK04257.
OMAiCRKEINH.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGM8.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNWSTVTEI TLIAFPALLE IRISLFVVLV VTYTLTATGN ITIISLIWID
60 70 80 90 100
HRLQTPMYFF LSNLSFLDIL YTTVITPKLL ACLLGEEKTI SFAGCMIQTY
110 120 130 140 150
FYFFLGTVEF ILLAVMSFDR YMAICDPLHY TVIMNSRACL LLVLGCWVGA
160 170 180 190 200
FLSVLFPTIV VTRLPYCRKE INHFFCDIAP LLQVACINTH LIEKINFLLS
210 220 230 240 250
ALVILSSLAF TTGSYVYIIS TILRIPSTQG RQKAFSTCAS HITVVSIAHG
260 270 280 290 300
SNIFVYVRPN QNSSLDYDKV AAVLITVVTP LLNPFIYSLR NEKVQEVLRE
310
TVNRIMTLIQ RKT
Length:313
Mass (Da):35,328
Last modified:October 1, 2002 - v1
Checksum:i52794CB2134202CF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti276 – 2761T → K.
Corresponds to variant rs4936845 [ dbSNP | Ensembl ].
VAR_053222

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065762 Genomic DNA. Translation: BAC05982.1.
CH471065 Genomic DNA. Translation: EAW67556.1.
BC136929 mRNA. Translation: AAI36930.1.
BC136931 mRNA. Translation: AAI36932.1.
AF399606 Genomic DNA. Translation: AAK95091.1.
BK004493 Genomic DNA. Translation: DAA04891.1.
CCDSiCCDS31696.1.
RefSeqiNP_001005325.1. NM_001005325.1.
UniGeneiHs.557924.

Genome annotation databases

EnsembliENST00000309154; ENSP00000311038; ENSG00000196099.
GeneIDi390261.
KEGGihsa:390261.
UCSCiuc010rzz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065762 Genomic DNA. Translation: BAC05982.1.
CH471065 Genomic DNA. Translation: EAW67556.1.
BC136929 mRNA. Translation: AAI36930.1.
BC136931 mRNA. Translation: AAI36932.1.
AF399606 Genomic DNA. Translation: AAK95091.1.
BK004493 Genomic DNA. Translation: DAA04891.1.
CCDSiCCDS31696.1.
RefSeqiNP_001005325.1. NM_001005325.1.
UniGeneiHs.557924.

3D structure databases

ProteinModelPortaliQ8NGM8.
SMRiQ8NGM8. Positions 23-302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311038.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR6M1.

Proteomic databases

PaxDbiQ8NGM8.
PRIDEiQ8NGM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309154; ENSP00000311038; ENSG00000196099.
GeneIDi390261.
KEGGihsa:390261.
UCSCiuc010rzz.2. human.

Organism-specific databases

CTDi390261.
GeneCardsiGC11M123676.
HGNCiHGNC:14711. OR6M1.
HPAiHPA048674.
neXtProtiNX_Q8NGM8.
PharmGKBiPA32596.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG133881.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGM8.
KOiK04257.
OMAiCRKEINH.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGM8.
TreeFamiTF336833.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR6M1.
GenomeRNAii390261.
NextBioi103598.
PROiQ8NGM8.

Gene expression databases

CleanExiHS_OR6M1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR6M1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGM8
Secondary accession number(s): B2RNK0, Q6IEW9, Q96R37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.