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Protein

Olfactory receptor 6M1

Gene

OR6M1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32704-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6M1
Alternative name(s):
Olfactory receptor OR11-271
Gene namesi
Name:OR6M1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14711. OR6M1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 194ExtracellularSequence analysisAdd BLAST36
Transmembranei195 – 214Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini215 – 234CytoplasmicSequence analysisAdd BLAST20
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 268ExtracellularSequence analysisAdd BLAST13
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 313CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196099.
PharmGKBiPA32596.

Polymorphism and mutation databases

BioMutaiOR6M1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506321 – 313Olfactory receptor 6M1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 186PROSITE-ProRule annotation
Glycosylationi262N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGM8.
PRIDEiQ8NGM8.

Expressioni

Gene expression databases

CleanExiHS_OR6M1.
ExpressionAtlasiQ8NGM8. baseline and differential.

Organism-specific databases

HPAiHPA048674.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311038.

Structurei

3D structure databases

ProteinModelPortaliQ8NGM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJE. Eukaryota.
ENOG4111AZU. LUCA.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGM8.
KOiK04257.
OMAiCRKEINH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGM8.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNWSTVTEI TLIAFPALLE IRISLFVVLV VTYTLTATGN ITIISLIWID
60 70 80 90 100
HRLQTPMYFF LSNLSFLDIL YTTVITPKLL ACLLGEEKTI SFAGCMIQTY
110 120 130 140 150
FYFFLGTVEF ILLAVMSFDR YMAICDPLHY TVIMNSRACL LLVLGCWVGA
160 170 180 190 200
FLSVLFPTIV VTRLPYCRKE INHFFCDIAP LLQVACINTH LIEKINFLLS
210 220 230 240 250
ALVILSSLAF TTGSYVYIIS TILRIPSTQG RQKAFSTCAS HITVVSIAHG
260 270 280 290 300
SNIFVYVRPN QNSSLDYDKV AAVLITVVTP LLNPFIYSLR NEKVQEVLRE
310
TVNRIMTLIQ RKT
Length:313
Mass (Da):35,328
Last modified:October 1, 2002 - v1
Checksum:i52794CB2134202CF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053222276T → K.Corresponds to variant rs4936845dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065762 Genomic DNA. Translation: BAC05982.1.
CH471065 Genomic DNA. Translation: EAW67556.1.
BC136929 mRNA. Translation: AAI36930.1.
BC136931 mRNA. Translation: AAI36932.1.
AF399606 Genomic DNA. Translation: AAK95091.1.
BK004493 Genomic DNA. Translation: DAA04891.1.
CCDSiCCDS31696.1.
RefSeqiNP_001005325.1. NM_001005325.1.
UniGeneiHs.557924.

Genome annotation databases

EnsembliENST00000309154; ENSP00000311038; ENSG00000196099.
GeneIDi390261.
KEGGihsa:390261.
UCSCiuc010rzz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065762 Genomic DNA. Translation: BAC05982.1.
CH471065 Genomic DNA. Translation: EAW67556.1.
BC136929 mRNA. Translation: AAI36930.1.
BC136931 mRNA. Translation: AAI36932.1.
AF399606 Genomic DNA. Translation: AAK95091.1.
BK004493 Genomic DNA. Translation: DAA04891.1.
CCDSiCCDS31696.1.
RefSeqiNP_001005325.1. NM_001005325.1.
UniGeneiHs.557924.

3D structure databases

ProteinModelPortaliQ8NGM8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311038.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR6M1.

Proteomic databases

PaxDbiQ8NGM8.
PRIDEiQ8NGM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309154; ENSP00000311038; ENSG00000196099.
GeneIDi390261.
KEGGihsa:390261.
UCSCiuc010rzz.3. human.

Organism-specific databases

CTDi390261.
GeneCardsiOR6M1.
HGNCiHGNC:14711. OR6M1.
HPAiHPA048674.
neXtProtiNX_Q8NGM8.
OpenTargetsiENSG00000196099.
PharmGKBiPA32596.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJE. Eukaryota.
ENOG4111AZU. LUCA.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGM8.
KOiK04257.
OMAiCRKEINH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGM8.
TreeFamiTF336833.

Enzyme and pathway databases

BioCyciZFISH:G66-32704-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR6M1.
GenomeRNAii390261.
PROiQ8NGM8.

Gene expression databases

CleanExiHS_OR6M1.
ExpressionAtlasiQ8NGM8. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR6M1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGM8
Secondary accession number(s): B2RNK0, Q6IEW9, Q96R37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.