Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NGM8 (OR6M1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 6M1
Alternative name(s):
Olfactory receptor OR11-271
Gene names
Name:OR6M1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Olfactory receptor 6M1
PRO_0000150632

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4421Helical; Name=1; Potential
Topological domain45 – 528Cytoplasmic Potential
Transmembrane53 – 7321Helical; Name=2; Potential
Topological domain74 – 9724Extracellular Potential
Transmembrane98 – 11821Helical; Name=3; Potential
Topological domain119 – 13719Cytoplasmic Potential
Transmembrane138 – 15821Helical; Name=4; Potential
Topological domain159 – 19436Extracellular Potential
Transmembrane195 – 21420Helical; Name=5; Potential
Topological domain215 – 23420Cytoplasmic Potential
Transmembrane235 – 25521Helical; Name=6; Potential
Topological domain256 – 26813Extracellular Potential
Transmembrane269 – 28921Helical; Name=7; Potential
Topological domain290 – 31324Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 186 By similarity

Natural variations

Natural variant2761T → K.
Corresponds to variant rs4936845 [ dbSNP | Ensembl ].
VAR_053222

Sequences

Sequence LengthMass (Da)Tools
Q8NGM8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 52794CB2134202CF

FASTA31335,328
        10         20         30         40         50         60 
MGNWSTVTEI TLIAFPALLE IRISLFVVLV VTYTLTATGN ITIISLIWID HRLQTPMYFF 

        70         80         90        100        110        120 
LSNLSFLDIL YTTVITPKLL ACLLGEEKTI SFAGCMIQTY FYFFLGTVEF ILLAVMSFDR 

       130        140        150        160        170        180 
YMAICDPLHY TVIMNSRACL LLVLGCWVGA FLSVLFPTIV VTRLPYCRKE INHFFCDIAP 

       190        200        210        220        230        240 
LLQVACINTH LIEKINFLLS ALVILSSLAF TTGSYVYIIS TILRIPSTQG RQKAFSTCAS 

       250        260        270        280        290        300 
HITVVSIAHG SNIFVYVRPN QNSSLDYDKV AAVLITVVTP LLNPFIYSLR NEKVQEVLRE 

       310 
TVNRIMTLIQ RKT 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065762 Genomic DNA. Translation: BAC05982.1.
CH471065 Genomic DNA. Translation: EAW67556.1.
BC136929 mRNA. Translation: AAI36930.1.
BC136931 mRNA. Translation: AAI36932.1.
AF399606 Genomic DNA. Translation: AAK95091.1.
BK004493 Genomic DNA. Translation: DAA04891.1.
RefSeqNP_001005325.1. NM_001005325.1.
UniGeneHs.557924.

3D structure databases

ProteinModelPortalQ8NGM8.
SMRQ8NGM8. Positions 35-302.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000311038.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbQ8NGM8.
PRIDEQ8NGM8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309154; ENSP00000311038; ENSG00000196099.
GeneID390261.
KEGGhsa:390261.
UCSCuc010rzz.2. human.

Organism-specific databases

CTD390261.
GeneCardsGC11M123676.
HGNCHGNC:14711. OR6M1.
HPAHPA048674.
neXtProtNX_Q8NGM8.
PharmGKBPA32596.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG133881.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGM8.
KOK04257.
OMAVTRLPYC.
OrthoDBEOG71K63J.
PhylomeDBQ8NGM8.
TreeFamTF336833.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR6M1.
GenevestigatorQ8NGM8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR6M1.
GenomeRNAi390261.
NextBio103598.
PROQ8NGM8.

Entry information

Entry nameOR6M1_HUMAN
AccessionPrimary (citable) accession number: Q8NGM8
Secondary accession number(s): B2RNK0, Q6IEW9, Q96R37
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries