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Protein

Olfactory receptor 4C15

Gene

OR4C15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C15
Alternative name(s):
Olfactory receptor OR11-127
Olfactory receptor OR11-134
Gene namesi
Name:OR4C15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15171. OR4C15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4724Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 569CytoplasmicSequence analysis
Transmembranei57 – 7822Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 9921ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 11920Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15719Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini158 – 19437ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21723Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23417CytoplasmicSequence analysisAdd
BLAST
Transmembranei235 – 25723Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini258 – 26811ExtracellularSequence analysisAdd
BLAST
Transmembranei269 – 28820Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini289 – 31628CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiOR4C15.
DMDMi38372727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 4C15PRO_0000150535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGM1.
PeptideAtlasiQ8NGM1.
PRIDEiQ8NGM1.

PTM databases

iPTMnetiQ8NGM1.
PhosphoSiteiQ8NGM1.

Expressioni

Gene expression databases

CleanExiHS_OR4C15.

Organism-specific databases

HPAiHPA061939.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324958.

Structurei

3D structure databases

ProteinModelPortaliQ8NGM1.
SMRiQ8NGM1. Positions 21-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISER. Eukaryota.
ENOG411182G. LUCA.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGM1.
KOiK04257.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NGM1.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNQSFVTEF VLLGLSQNPN VQEIVFVVFL FVYIATVGGN MLIVVTILSS
60 70 80 90 100
PALLVSPMYF FLGFLSFLDA CFSSVITPKM IVDSLYVTKT ISFEGCMMQL
110 120 130 140 150
FAEHFFAGVE VIVLTAMAYD RYVAICKPLH YSSIMNRRLC GILMGVAWTG
160 170 180 190 200
GLLHSMIQIL FTFQLPFCGP NVINHFMCDL YPLLELACTD THIFGLMVVI
210 220 230 240 250
NSGFICIINF SLLLVSYAVI LLSLRTHSSE GRWKALSTCG SHIAVVILFF
260 270 280 290 300
VPCIFVYTRP PSAFSLDKMA AIFYIILNPL LNPLIYTFRN KEVKQAMRRI
310
WNRLMVVSDE KENIKL
Length:316
Mass (Da):35,667
Last modified:October 1, 2002 - v1
Checksum:i9A77A664A489AAE1
GO

Sequence cautioni

The sequence DAA04717 differs from that shown. Reason: Erroneous initiation. Curated
The sequence DAA04718 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065771 Genomic DNA. Translation: BAC05991.1.
AP001998 Genomic DNA. No translation available.
BK004319 Genomic DNA. Translation: DAA04717.1. Different initiation.
BK004320 Genomic DNA. Translation: DAA04718.1. Different initiation.
RefSeqiNP_001001920.1. NM_001001920.1.
UniGeneiHs.589003.

Genome annotation databases

EnsembliENST00000314644; ENSP00000324958; ENSG00000181939.
GeneIDi81309.
KEGGihsa:81309.
UCSCiuc010rig.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065771 Genomic DNA. Translation: BAC05991.1.
AP001998 Genomic DNA. No translation available.
BK004319 Genomic DNA. Translation: DAA04717.1. Different initiation.
BK004320 Genomic DNA. Translation: DAA04718.1. Different initiation.
RefSeqiNP_001001920.1. NM_001001920.1.
UniGeneiHs.589003.

3D structure databases

ProteinModelPortaliQ8NGM1.
SMRiQ8NGM1. Positions 21-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000324958.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGM1.
PhosphoSiteiQ8NGM1.

Polymorphism and mutation databases

BioMutaiOR4C15.
DMDMi38372727.

Proteomic databases

PaxDbiQ8NGM1.
PeptideAtlasiQ8NGM1.
PRIDEiQ8NGM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314644; ENSP00000324958; ENSG00000181939.
GeneIDi81309.
KEGGihsa:81309.
UCSCiuc010rig.2. human.

Organism-specific databases

CTDi81309.
GeneCardsiOR4C15.
HGNCiHGNC:15171. OR4C15.
HPAiHPA061939.
neXtProtiNX_Q8NGM1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISER. Eukaryota.
ENOG411182G. LUCA.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGM1.
KOiK04257.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NGM1.
TreeFamiTF352732.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4C15.
GenomeRNAii81309.
PROiQ8NGM1.

Gene expression databases

CleanExiHS_OR4C15.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4CF_HUMAN
AccessioniPrimary (citable) accession number: Q8NGM1
Secondary accession number(s): Q6IFE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.