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Q8NGL9

- OR4CG_HUMAN

UniProt

Q8NGL9 - OR4CG_HUMAN

Protein

Olfactory receptor 4C16

Gene

OR4C16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 4C16
    Alternative name(s):
    Olfactory receptor OR11-135
    Gene namesi
    Name:OR4C16
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15172. OR4C16.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32258.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Olfactory receptor 4C16PRO_0000150536Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGL9.
    PRIDEiQ8NGL9.

    PTM databases

    PhosphoSiteiQ8NGL9.

    Expressioni

    Gene expression databases

    CleanExiHS_OR4C16.
    GenevestigatoriQ8NGL9.

    Organism-specific databases

    HPAiHPA059128.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000324913.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGL9.
    SMRiQ8NGL9. Positions 23-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 558CytoplasmicSequence Analysis
    Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 26711ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini288 – 31023CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei194 – 21724Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25623Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28720Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42331.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGL9.
    KOiK04257.
    OMAiQALKNPM.
    OrthoDBiEOG754HPT.
    PhylomeDBiQ8NGL9.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGL9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLNNNVTEF ILLGLTQDPF WKKIVFVIFL RLYLGTLLGN LLIIISVKTS    50
    QALKNPMFFF LFYLSLSDTC LSTSITPRMI VDALLKKTTI SFSECMIQVF 100
    SSHVFGCLEI FILILTAVDR YVDICKPLHY MTIISQWVCG VLMAVAWVGS 150
    CVHSLVQIFL ALSLPFCGPN VINHCFCDLQ PLLKQACSET YVVNLLLVSN 200
    SGAICAVSYV MLIFSYVIFL HSLRNHSAEV IKKALSTCVS HIIVVILFFG 250
    PCIFMYTCLA TVFPMDKMIA VFYTVGTSFL NPVIYTLKNT EVKSAMRKLW 300
    SKKLITDDKR 310
    Length:310
    Mass (Da):34,991
    Last modified:December 6, 2005 - v2
    Checksum:i87BA28E6BAB087AF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251V → L.
    Corresponds to variant rs12800642 [ dbSNP | Ensembl ].
    VAR_053165
    Natural varianti49 – 491T → A.1 Publication
    Corresponds to variant rs558465 [ dbSNP | Ensembl ].
    VAR_053166
    Natural varianti76 – 761T → A.1 Publication
    Corresponds to variant rs557590 [ dbSNP | Ensembl ].
    VAR_034193
    Natural varianti203 – 2031A → T.
    Corresponds to variant rs12288690 [ dbSNP | Ensembl ].
    VAR_053167
    Natural varianti259 – 2591L → P.1 Publication
    Corresponds to variant rs559449 [ dbSNP | Ensembl ].
    VAR_053168

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065773 Genomic DNA. Translation: BAC05993.1.
    AP001998 Genomic DNA. No translation available.
    BK004504 Genomic DNA. Translation: DAA04902.1.
    CCDSiCCDS31502.1.
    RefSeqiNP_001004701.2. NM_001004701.2.
    UniGeneiHs.553619.

    Genome annotation databases

    EnsembliENST00000314634; ENSP00000324913; ENSG00000181935.
    GeneIDi219428.
    KEGGihsa:219428.
    UCSCiuc010rih.2. human.

    Polymorphism databases

    DMDMi83305198.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065773 Genomic DNA. Translation: BAC05993.1 .
    AP001998 Genomic DNA. No translation available.
    BK004504 Genomic DNA. Translation: DAA04902.1 .
    CCDSi CCDS31502.1.
    RefSeqi NP_001004701.2. NM_001004701.2.
    UniGenei Hs.553619.

    3D structure databases

    ProteinModelPortali Q8NGL9.
    SMRi Q8NGL9. Positions 23-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000324913.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGL9.

    Polymorphism databases

    DMDMi 83305198.

    Proteomic databases

    PaxDbi Q8NGL9.
    PRIDEi Q8NGL9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314634 ; ENSP00000324913 ; ENSG00000181935 .
    GeneIDi 219428.
    KEGGi hsa:219428.
    UCSCi uc010rih.2. human.

    Organism-specific databases

    CTDi 219428.
    GeneCardsi GC11P055340.
    HGNCi HGNC:15172. OR4C16.
    HPAi HPA059128.
    neXtProti NX_Q8NGL9.
    PharmGKBi PA32258.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42331.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGL9.
    KOi K04257.
    OMAi QALKNPM.
    OrthoDBi EOG754HPT.
    PhylomeDBi Q8NGL9.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR4C16.
    GenomeRNAii 219428.
    NextBioi 90595.
    PROi Q8NGL9.

    Gene expression databases

    CleanExi HS_OR4C16.
    Genevestigatori Q8NGL9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-49; ALA-76 AND PRO-259.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR4CG_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGL9
    Secondary accession number(s): Q6IEV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3