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Q8NGL9

- OR4CG_HUMAN

UniProt

Q8NGL9 - OR4CG_HUMAN

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Protein

Olfactory receptor 4C16

Gene

OR4C16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C16
Alternative name(s):
Olfactory receptor OR11-135
Gene namesi
Name:OR4C16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15172. OR4C16.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 4C16PRO_0000150536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGL9.
PRIDEiQ8NGL9.

PTM databases

PhosphoSiteiQ8NGL9.

Expressioni

Gene expression databases

CleanExiHS_OR4C16.
GenevestigatoriQ8NGL9.

Organism-specific databases

HPAiHPA059128.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324913.

Structurei

3D structure databases

ProteinModelPortaliQ8NGL9.
SMRiQ8NGL9. Positions 23-299.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 23316CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini257 – 26711ExtracellularSequence AnalysisAdd
BLAST
Topological domaini288 – 31023CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei194 – 21724Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei234 – 25623Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei268 – 28720Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42331.
GeneTreeiENSGT00760000118773.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGL9.
KOiK04257.
OMAiQALKNPM.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NGL9.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGL9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLNNNVTEF ILLGLTQDPF WKKIVFVIFL RLYLGTLLGN LLIIISVKTS
60 70 80 90 100
QALKNPMFFF LFYLSLSDTC LSTSITPRMI VDALLKKTTI SFSECMIQVF
110 120 130 140 150
SSHVFGCLEI FILILTAVDR YVDICKPLHY MTIISQWVCG VLMAVAWVGS
160 170 180 190 200
CVHSLVQIFL ALSLPFCGPN VINHCFCDLQ PLLKQACSET YVVNLLLVSN
210 220 230 240 250
SGAICAVSYV MLIFSYVIFL HSLRNHSAEV IKKALSTCVS HIIVVILFFG
260 270 280 290 300
PCIFMYTCLA TVFPMDKMIA VFYTVGTSFL NPVIYTLKNT EVKSAMRKLW
310
SKKLITDDKR
Length:310
Mass (Da):34,991
Last modified:December 6, 2005 - v2
Checksum:i87BA28E6BAB087AF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251V → L.
Corresponds to variant rs12800642 [ dbSNP | Ensembl ].
VAR_053165
Natural varianti49 – 491T → A.1 Publication
Corresponds to variant rs558465 [ dbSNP | Ensembl ].
VAR_053166
Natural varianti76 – 761T → A.1 Publication
Corresponds to variant rs557590 [ dbSNP | Ensembl ].
VAR_034193
Natural varianti203 – 2031A → T.
Corresponds to variant rs12288690 [ dbSNP | Ensembl ].
VAR_053167
Natural varianti259 – 2591L → P.1 Publication
Corresponds to variant rs559449 [ dbSNP | Ensembl ].
VAR_053168

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065773 Genomic DNA. Translation: BAC05993.1.
AP001998 Genomic DNA. No translation available.
BK004504 Genomic DNA. Translation: DAA04902.1.
CCDSiCCDS31502.1.
RefSeqiNP_001004701.2. NM_001004701.2.
UniGeneiHs.553619.

Genome annotation databases

EnsembliENST00000314634; ENSP00000324913; ENSG00000181935.
GeneIDi219428.
KEGGihsa:219428.
UCSCiuc010rih.2. human.

Polymorphism databases

DMDMi83305198.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065773 Genomic DNA. Translation: BAC05993.1 .
AP001998 Genomic DNA. No translation available.
BK004504 Genomic DNA. Translation: DAA04902.1 .
CCDSi CCDS31502.1.
RefSeqi NP_001004701.2. NM_001004701.2.
UniGenei Hs.553619.

3D structure databases

ProteinModelPortali Q8NGL9.
SMRi Q8NGL9. Positions 23-299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000324913.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGL9.

Polymorphism databases

DMDMi 83305198.

Proteomic databases

PaxDbi Q8NGL9.
PRIDEi Q8NGL9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314634 ; ENSP00000324913 ; ENSG00000181935 .
GeneIDi 219428.
KEGGi hsa:219428.
UCSCi uc010rih.2. human.

Organism-specific databases

CTDi 219428.
GeneCardsi GC11P055340.
HGNCi HGNC:15172. OR4C16.
HPAi HPA059128.
neXtProti NX_Q8NGL9.
PharmGKBi PA32258.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42331.
GeneTreei ENSGT00760000118773.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGL9.
KOi K04257.
OMAi QALKNPM.
OrthoDBi EOG754HPT.
PhylomeDBi Q8NGL9.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR4C16.
GenomeRNAii 219428.
NextBioi 90595.
PROi Q8NGL9.

Gene expression databases

CleanExi HS_OR4C16.
Genevestigatori Q8NGL9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-49; ALA-76 AND PRO-259.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4CG_HUMAN
AccessioniPrimary (citable) accession number: Q8NGL9
Secondary accession number(s): Q6IEV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3