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Q8NGL9 (OR4CG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 4C16
Alternative name(s):
Olfactory receptor OR11-135
Gene names
Name:OR4C16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Olfactory receptor 4C16
PRO_0000150536

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4724Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7722Helical; Name=2; Potential
Topological domain78 – 9821Extracellular Potential
Transmembrane99 – 11820Helical; Name=3; Potential
Topological domain119 – 13719Cytoplasmic Potential
Transmembrane138 – 15619Helical; Name=4; Potential
Topological domain157 – 19337Extracellular Potential
Transmembrane194 – 21724Helical; Name=5; Potential
Topological domain218 – 23316Cytoplasmic Potential
Transmembrane234 – 25623Helical; Name=6; Potential
Topological domain257 – 26711Extracellular Potential
Transmembrane268 – 28720Helical; Name=7; Potential
Topological domain288 – 31023Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 187 By similarity

Natural variations

Natural variant251V → L.
Corresponds to variant rs12800642 [ dbSNP | Ensembl ].
VAR_053165
Natural variant491T → A. Ref.1
Corresponds to variant rs558465 [ dbSNP | Ensembl ].
VAR_053166
Natural variant761T → A. Ref.1
Corresponds to variant rs557590 [ dbSNP | Ensembl ].
VAR_034193
Natural variant2031A → T.
Corresponds to variant rs12288690 [ dbSNP | Ensembl ].
VAR_053167
Natural variant2591L → P. Ref.1
Corresponds to variant rs559449 [ dbSNP | Ensembl ].
VAR_053168

Sequences

Sequence LengthMass (Da)Tools
Q8NGL9 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 87BA28E6BAB087AF

FASTA31034,991
        10         20         30         40         50         60 
MQLNNNVTEF ILLGLTQDPF WKKIVFVIFL RLYLGTLLGN LLIIISVKTS QALKNPMFFF 

        70         80         90        100        110        120 
LFYLSLSDTC LSTSITPRMI VDALLKKTTI SFSECMIQVF SSHVFGCLEI FILILTAVDR 

       130        140        150        160        170        180 
YVDICKPLHY MTIISQWVCG VLMAVAWVGS CVHSLVQIFL ALSLPFCGPN VINHCFCDLQ 

       190        200        210        220        230        240 
PLLKQACSET YVVNLLLVSN SGAICAVSYV MLIFSYVIFL HSLRNHSAEV IKKALSTCVS 

       250        260        270        280        290        300 
HIIVVILFFG PCIFMYTCLA TVFPMDKMIA VFYTVGTSFL NPVIYTLKNT EVKSAMRKLW 

       310 
SKKLITDDKR 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-49; ALA-76 AND PRO-259.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065773 Genomic DNA. Translation: BAC05993.1.
AP001998 Genomic DNA. No translation available.
BK004504 Genomic DNA. Translation: DAA04902.1.
CCDSCCDS31502.1.
RefSeqNP_001004701.2. NM_001004701.2.
UniGeneHs.553619.

3D structure databases

ProteinModelPortalQ8NGL9.
SMRQ8NGL9. Positions 23-299.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000324913.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGL9.

Polymorphism databases

DMDM83305198.

Proteomic databases

PaxDbQ8NGL9.
PRIDEQ8NGL9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314634; ENSP00000324913; ENSG00000181935.
GeneID219428.
KEGGhsa:219428.
UCSCuc010rih.2. human.

Organism-specific databases

CTD219428.
GeneCardsGC11P055340.
HGNCHGNC:15172. OR4C16.
HPAHPA059128.
neXtProtNX_Q8NGL9.
PharmGKBPA32258.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42331.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGL9.
KOK04257.
OMAQALKNPM.
OrthoDBEOG754HPT.
PhylomeDBQ8NGL9.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR4C16.
GenevestigatorQ8NGL9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR4C16.
GenomeRNAi219428.
NextBio90595.
PROQ8NGL9.

Entry information

Entry nameOR4CG_HUMAN
AccessionPrimary (citable) accession number: Q8NGL9
Secondary accession number(s): Q6IEV8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries