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Protein

Olfactory receptor 4A15

Gene

OR4A15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4A15
Alternative name(s):
Olfactory receptor OR11-118
Gene namesi
Name:OR4A15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15152. OR4A15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353ExtracellularSequence analysisAdd
BLAST
Transmembranei54 – 7724Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini78 – 858CytoplasmicSequence analysis
Transmembranei86 – 10722Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini108 – 12821ExtracellularSequence analysisAdd
BLAST
Transmembranei129 – 14820Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini149 – 16719CytoplasmicSequence analysisAdd
BLAST
Transmembranei168 – 18619Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini187 – 22337ExtracellularSequence analysisAdd
BLAST
Transmembranei224 – 24724Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini248 – 26316CytoplasmicSequence analysisAdd
BLAST
Transmembranei264 – 28623Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini287 – 29711ExtracellularSequence analysisAdd
BLAST
Transmembranei298 – 31720Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini318 – 34427CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32234.

Polymorphism and mutation databases

BioMutaiOR4A15.
DMDMi229462945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Olfactory receptor 4A15PRO_0000150525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi125 ↔ 217PROSITE-ProRule annotation
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8NGL6.
PaxDbiQ8NGL6.
PRIDEiQ8NGL6.

PTM databases

PhosphoSiteiQ8NGL6.

Expressioni

Gene expression databases

CleanExiHS_OR4A15.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000325065.

Structurei

3D structure databases

ProteinModelPortaliQ8NGL6.
SMRiQ8NGL6. Positions 57-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ82. Eukaryota.
ENOG41116C3. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGL6.
KOiK04257.
OMAiNFLCDLY.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NGL6.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLTNNLKF ITDPFVCRLR HLSPTPSEEH MKNKNNVTEF ILLGLTQNPE
60 70 80 90 100
GQKVLFVTFL LIYMVTIMGN LLIIVTIMAS QSLGSPMYFF LASLSFIDTV
110 120 130 140 150
YSTAFAPKMI VDLLSEKKTI SFQGCMAQLF MDHLFAGAEV ILLVVMAYDR
160 170 180 190 200
YMAICKPLHE LITMNRRVCV LMLLAAWIGG FLHSLVQFLF IYQLPFCGPN
210 220 230 240 250
VIDNFLCDLY PLLKLACTNT YVTGLSMIAN GGAICAVTFF TILLSYGVIL
260 270 280 290 300
HSLKTQSLEG KRKAFYTCAS HVTVVILFFV PCIFLYARPN STFPIDKSMT
310 320 330 340
VVLTFITPML NPLIYTLKNA EMKSAMRKLW SKKVSLAGKW LYHS
Length:344
Mass (Da):38,828
Last modified:May 5, 2009 - v3
Checksum:iAF3D1A6A05738B16
GO

Sequence cautioni

The sequence DAA04646.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261P → S.
Corresponds to variant rs1425193 [ dbSNP | Ensembl ].
VAR_055053
Natural varianti287 – 2871A → V.
Corresponds to variant rs7927370 [ dbSNP | Ensembl ].
VAR_055054

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065776 Genomic DNA. Translation: BAC05996.1.
AP005639 Genomic DNA. No translation available.
AF399578 Genomic DNA. Translation: AAK95063.1.
BK004248 Genomic DNA. Translation: DAA04646.1. Different initiation.
CCDSiCCDS31500.1.
RefSeqiNP_001005275.1. NM_001005275.1.
UniGeneiHs.554529.

Genome annotation databases

EnsembliENST00000314706; ENSP00000325065; ENSG00000181958.
GeneIDi81328.
KEGGihsa:81328.
UCSCiuc010rif.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065776 Genomic DNA. Translation: BAC05996.1.
AP005639 Genomic DNA. No translation available.
AF399578 Genomic DNA. Translation: AAK95063.1.
BK004248 Genomic DNA. Translation: DAA04646.1. Different initiation.
CCDSiCCDS31500.1.
RefSeqiNP_001005275.1. NM_001005275.1.
UniGeneiHs.554529.

3D structure databases

ProteinModelPortaliQ8NGL6.
SMRiQ8NGL6. Positions 57-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000325065.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGL6.

Polymorphism and mutation databases

BioMutaiOR4A15.
DMDMi229462945.

Proteomic databases

MaxQBiQ8NGL6.
PaxDbiQ8NGL6.
PRIDEiQ8NGL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314706; ENSP00000325065; ENSG00000181958.
GeneIDi81328.
KEGGihsa:81328.
UCSCiuc010rif.2. human.

Organism-specific databases

CTDi81328.
GeneCardsiOR4A15.
HGNCiHGNC:15152. OR4A15.
neXtProtiNX_Q8NGL6.
PharmGKBiPA32234.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ82. Eukaryota.
ENOG41116C3. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGL6.
KOiK04257.
OMAiNFLCDLY.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NGL6.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4A15.
GenomeRNAii81328.
NextBioi71598.
PROiQ8NGL6.

Gene expression databases

CleanExiHS_OR4A15.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 96-308.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO4A15_HUMAN
AccessioniPrimary (citable) accession number: Q8NGL6
Secondary accession number(s): Q6IFL4, Q96R65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: May 11, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-31 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.