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Protein

Olfactory receptor 5D13

Gene

OR5D13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5D13
Alternative name(s):
Olfactory receptor OR11-142
Olfactory receptor OR11-148
Gene namesi
Name:OR5D13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15280. OR5D13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27313ExtracellularSequence analysisAdd
BLAST
Transmembranei274 – 29421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini295 – 31420CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32572.

Polymorphism and mutation databases

BioMutaiOR5D13.
DMDMi38372723.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 5D13PRO_0000150591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8NGL4.
PaxDbiQ8NGL4.
PeptideAtlasiQ8NGL4.
PRIDEiQ8NGL4.

PTM databases

iPTMnetiQ8NGL4.
PhosphoSiteiQ8NGL4.

Expressioni

Gene expression databases

CleanExiHS_OR5D13.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354800.

Structurei

3D structure databases

ProteinModelPortaliQ8NGL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVN0. Eukaryota.
ENOG41116VK. LUCA.
GeneTreeiENSGT00550000074428.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGL4.
KOiK04257.
OMAiFSGCIMQ.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGL4.
TreeFamiTF352746.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMASERNQSS TPTFILLGFS EYPEIQVPLF LVFLFVYTVT VVGNLGMIII
60 70 80 90 100
IRLNSKLHTI MCFFLSHLSL TDFCFSTVVT PKLLENLVVE YRTISFSGCI
110 120 130 140 150
MQFCFACIFG VTETFMLAAM AYDRFVAVCK PLLYTTIMSQ KLCALLVAGS
160 170 180 190 200
YTWGIVCSLI LTYFLLDLSF CESTFINNFI CDHSVIVSAS YSDPYISQRL
210 220 230 240 250
CFIIAIFNEV SSLIIILTSY MLIFTTIMKM RSASGRQKTF STCASHLTAI
260 270 280 290 300
TIFHGTILFL YCVPNPKTSS LIVTVASVFY TVAIPMLNPL IYSLRNKDIN
310
NMFEKLVVTK LIYH
Length:314
Mass (Da):35,447
Last modified:October 10, 2003 - v2
Checksum:iCA6C3082912FD150
GO

Sequence cautioni

The sequence BAC05998.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621C → Y.
Corresponds to variant rs297118 [ dbSNP | Ensembl ].
VAR_024099
Natural varianti124 – 1241R → H.
Corresponds to variant rs11230983 [ dbSNP | Ensembl ].
VAR_024100
Natural varianti236 – 2361R → L.
Corresponds to variant rs7124871 [ dbSNP | Ensembl ].
VAR_034220

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065778 Genomic DNA. Translation: BAC05998.1. Different initiation.
BK004333 Genomic DNA. Translation: DAA04731.1.
BK004394 Genomic DNA. Translation: DAA04792.1.
CCDSiCCDS31507.1.
RefSeqiNP_001001967.1. NM_001001967.1.
UniGeneiHs.553743.

Genome annotation databases

EnsembliENST00000361760; ENSP00000354800; ENSG00000198877.
GeneIDi390142.
KEGGihsa:390142.
UCSCiuc010ril.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065778 Genomic DNA. Translation: BAC05998.1. Different initiation.
BK004333 Genomic DNA. Translation: DAA04731.1.
BK004394 Genomic DNA. Translation: DAA04792.1.
CCDSiCCDS31507.1.
RefSeqiNP_001001967.1. NM_001001967.1.
UniGeneiHs.553743.

3D structure databases

ProteinModelPortaliQ8NGL4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354800.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGL4.
PhosphoSiteiQ8NGL4.

Polymorphism and mutation databases

BioMutaiOR5D13.
DMDMi38372723.

Proteomic databases

EPDiQ8NGL4.
PaxDbiQ8NGL4.
PeptideAtlasiQ8NGL4.
PRIDEiQ8NGL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361760; ENSP00000354800; ENSG00000198877.
GeneIDi390142.
KEGGihsa:390142.
UCSCiuc010ril.2. human.

Organism-specific databases

CTDi390142.
GeneCardsiOR5D13.
HGNCiHGNC:15280. OR5D13.
neXtProtiNX_Q8NGL4.
PharmGKBiPA32572.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVN0. Eukaryota.
ENOG41116VK. LUCA.
GeneTreeiENSGT00550000074428.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGL4.
KOiK04257.
OMAiFSGCIMQ.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGL4.
TreeFamiTF352746.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5D13.
GenomeRNAii390142.
PROiQ8NGL4.

Gene expression databases

CleanExiHS_OR5D13.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5DD_HUMAN
AccessioniPrimary (citable) accession number: Q8NGL4
Secondary accession number(s): Q6IF68, Q6IFC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: July 6, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.