ID   OR5DE_HUMAN             Reviewed;         314 AA.
AC   Q8NGL3; Q6IF69; Q6IFD4; Q96RB5;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 148.
DE   RecName: Full=Olfactory receptor 5D14;
DE   AltName: Full=Olfactory receptor OR11-141;
DE   AltName: Full=Olfactory receptor OR11-150;
GN   Name=OR5D14;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-285, AND VARIANT ALA-249.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5D14";
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DR   EMBL; AB065779; BAC05999.1; -; Genomic_DNA.
DR   EMBL; AF399523; AAK95008.1; -; Genomic_DNA.
DR   EMBL; BK004328; DAA04726.1; -; Genomic_DNA.
DR   EMBL; BK004393; DAA04791.1; -; Genomic_DNA.
DR   CCDS; CCDS31508.1; -.
DR   RefSeq; NP_001004735.1; NM_001004735.1.
DR   AlphaFoldDB; Q8NGL3; -.
DR   SMR; Q8NGL3; -.
DR   STRING; 9606.ENSP00000334456; -.
DR   GlyCosmos; Q8NGL3; 2 sites, No reported glycans.
DR   GlyGen; Q8NGL3; 2 sites.
DR   iPTMnet; Q8NGL3; -.
DR   PhosphoSitePlus; Q8NGL3; -.
DR   BioMuta; OR5D14; -.
DR   DMDM; 38372722; -.
DR   MassIVE; Q8NGL3; -.
DR   PaxDb; 9606-ENSP00000334456; -.
DR   PeptideAtlas; Q8NGL3; -.
DR   ProteomicsDB; 73547; -.
DR   Antibodypedia; 72059; 24 antibodies from 11 providers.
DR   DNASU; 219436; -.
DR   Ensembl; ENST00000335605.1; ENSP00000334456.1; ENSG00000186113.1.
DR   GeneID; 219436; -.
DR   KEGG; hsa:219436; -.
DR   MANE-Select; ENST00000335605.1; ENSP00000334456.1; NM_001004735.1; NP_001004735.1.
DR   UCSC; uc010rim.2; human.
DR   AGR; HGNC:15281; -.
DR   CTD; 219436; -.
DR   GeneCards; OR5D14; -.
DR   HGNC; HGNC:15281; OR5D14.
DR   HPA; ENSG00000186113; Not detected.
DR   neXtProt; NX_Q8NGL3; -.
DR   PharmGKB; PA32517; -.
DR   VEuPathDB; HostDB:ENSG00000186113; -.
DR   eggNOG; ENOG502T6WP; Eukaryota.
DR   GeneTree; ENSGT01100000263496; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q8NGL3; -.
DR   OMA; CMMQYFL; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NGL3; -.
DR   TreeFam; TF352746; -.
DR   PathwayCommons; Q8NGL3; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 219436; 8 hits in 736 CRISPR screens.
DR   GeneWiki; OR5D14; -.
DR   GenomeRNAi; 219436; -.
DR   Pharos; Q8NGL3; Tdark.
DR   PRO; PR:Q8NGL3; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGL3; Protein.
DR   Bgee; ENSG00000186113; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 1 other cell type or tissue.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15410; 7tmA_OR5D-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48018:SF65; OLFACTORY RECEPTOR 5D14; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Olfactory receptor 5D14"
FT                   /id="PRO_0000150592"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..273
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        295..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        7
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         249
FT                   /note="S -> A (in dbSNP:rs297054)"
FT                   /evidence="ECO:0000269|PubMed:12213199"
FT                   /id="VAR_034221"
FT   VARIANT         290
FT                   /note="L -> P (in dbSNP:rs297055)"
FT                   /id="VAR_034222"
SQ   SEQUENCE   314 AA;  35823 MW;  60990285FCD1CAD8 CRC64;
     MMMVLRNLSM EPTFALLGFT DYPKLQIPLF LVFLLMYVIT VVGNLGMIII IKINPKFHTP
     MYFFLSHLSF VDFCYSSIVT PKLLENLVMA DKSIFYFSCM MQYFLSCTAV VTESFLLAVM
     AYDRFVAICN PLLYTVAMSQ RLCALLVAGS YLWGMFGPLV LLCYALRLNF SGPNVINHFF
     CEYTALISVS GSDILIPHLL LFSFATFNEM CTLLIILTSY VFIFVTVLKI RSVSGRHKAF
     STWASHLTSI TIFHGTILFL YCVPNSKNSR QTVKVASVFY TVVNPMLNPL IYSLRNKDVK
     DAFWKLIHTQ VPFH
//