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Q8NGL3

- OR5DE_HUMAN

UniProt

Q8NGL3 - OR5DE_HUMAN

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Protein
Olfactory receptor 5D14
Gene
OR5D14
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5D14
Alternative name(s):
Olfactory receptor OR11-141
Olfactory receptor OR11-150
Gene namesi
Name:OR5D14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15281. OR5D14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727Extracellular Reviewed prediction
Add
BLAST
Transmembranei28 – 4821Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini49 – 568Cytoplasmic Reviewed prediction
Transmembranei57 – 7721Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini78 – 10124Extracellular Reviewed prediction
Add
BLAST
Transmembranei102 – 12221Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini123 – 14119Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei142 – 16221Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini163 – 19836Extracellular Reviewed prediction
Add
BLAST
Transmembranei199 – 21921Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini220 – 23920Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei240 – 26021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini261 – 27313Extracellular Reviewed prediction
Add
BLAST
Transmembranei274 – 29421Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini295 – 31420Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 5D14
PRO_0000150592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...) Reviewed prediction
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGL3.
PRIDEiQ8NGL3.

PTM databases

PhosphoSiteiQ8NGL3.

Expressioni

Gene expression databases

CleanExiHS_OR5D14.
GenevestigatoriQ8NGL3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334456.

Structurei

3D structure databases

ProteinModelPortaliQ8NGL3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145188.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGL3.
KOiK04257.
OMAiHIPHLLL.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGL3.
TreeFamiTF352746.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGL3-1 [UniParc]FASTAAdd to Basket

« Hide

MMMVLRNLSM EPTFALLGFT DYPKLQIPLF LVFLLMYVIT VVGNLGMIII    50
IKINPKFHTP MYFFLSHLSF VDFCYSSIVT PKLLENLVMA DKSIFYFSCM 100
MQYFLSCTAV VTESFLLAVM AYDRFVAICN PLLYTVAMSQ RLCALLVAGS 150
YLWGMFGPLV LLCYALRLNF SGPNVINHFF CEYTALISVS GSDILIPHLL 200
LFSFATFNEM CTLLIILTSY VFIFVTVLKI RSVSGRHKAF STWASHLTSI 250
TIFHGTILFL YCVPNSKNSR QTVKVASVFY TVVNPMLNPL IYSLRNKDVK 300
DAFWKLIHTQ VPFH 314
Length:314
Mass (Da):35,823
Last modified:October 1, 2002 - v1
Checksum:i60990285FCD1CAD8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2491S → A.1 Publication
Corresponds to variant rs297054 [ dbSNP | Ensembl ].
VAR_034221
Natural varianti290 – 2901L → P.
Corresponds to variant rs297055 [ dbSNP | Ensembl ].
VAR_034222

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065779 Genomic DNA. Translation: BAC05999.1.
AF399523 Genomic DNA. Translation: AAK95008.1.
BK004328 Genomic DNA. Translation: DAA04726.1.
BK004393 Genomic DNA. Translation: DAA04791.1.
CCDSiCCDS31508.1.
RefSeqiNP_001004735.1. NM_001004735.1.
UniGeneiHs.553622.

Genome annotation databases

EnsembliENST00000335605; ENSP00000334456; ENSG00000186113.
GeneIDi219436.
KEGGihsa:219436.
UCSCiuc010rim.2. human.

Polymorphism databases

DMDMi38372722.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065779 Genomic DNA. Translation: BAC05999.1 .
AF399523 Genomic DNA. Translation: AAK95008.1 .
BK004328 Genomic DNA. Translation: DAA04726.1 .
BK004393 Genomic DNA. Translation: DAA04791.1 .
CCDSi CCDS31508.1.
RefSeqi NP_001004735.1. NM_001004735.1.
UniGenei Hs.553622.

3D structure databases

ProteinModelPortali Q8NGL3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000334456.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGL3.

Polymorphism databases

DMDMi 38372722.

Proteomic databases

PaxDbi Q8NGL3.
PRIDEi Q8NGL3.

Protocols and materials databases

DNASUi 219436.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335605 ; ENSP00000334456 ; ENSG00000186113 .
GeneIDi 219436.
KEGGi hsa:219436.
UCSCi uc010rim.2. human.

Organism-specific databases

CTDi 219436.
GeneCardsi GC11P055563.
HGNCi HGNC:15281. OR5D14.
neXtProti NX_Q8NGL3.
PharmGKBi PA32517.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145188.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGL3.
KOi K04257.
OMAi HIPHLLL.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGL3.
TreeFami TF352746.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR5D14.
GenomeRNAii 219436.
NextBioi 90611.
PROi Q8NGL3.

Gene expression databases

CleanExi HS_OR5D14.
Genevestigatori Q8NGL3.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-285, VARIANT ALA-249.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5DE_HUMAN
AccessioniPrimary (citable) accession number: Q8NGL3
Secondary accession number(s): Q6IF69, Q6IFD4, Q96RB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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