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Protein

Olfactory receptor 5D14

Gene

OR5D14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5D14
Alternative name(s):
Olfactory receptor OR11-141
Olfactory receptor OR11-150
Gene namesi
Name:OR5D14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000186113.1
HGNCiHGNC:15281 OR5D14
neXtProtiNX_Q8NGL3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 273ExtracellularSequence analysisAdd BLAST13
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 314CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32517

Polymorphism and mutation databases

BioMutaiOR5D14
DMDMi38372722

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505921 – 314Olfactory receptor 5D14Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGL3
PeptideAtlasiQ8NGL3
PRIDEiQ8NGL3
ProteomicsDBi73547

PTM databases

iPTMnetiQ8NGL3
PhosphoSitePlusiQ8NGL3

Expressioni

Gene expression databases

BgeeiENSG00000186113
CleanExiHS_OR5D14

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334456

Structurei

3D structure databases

ProteinModelPortaliQ8NGL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJQ6 Eukaryota
ENOG4111ADM LUCA
GeneTreeiENSGT00550000074428
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGL3
KOiK04257
OMAiCMMQYFL
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGL3
TreeFamiTF352746

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMVLRNLSM EPTFALLGFT DYPKLQIPLF LVFLLMYVIT VVGNLGMIII
60 70 80 90 100
IKINPKFHTP MYFFLSHLSF VDFCYSSIVT PKLLENLVMA DKSIFYFSCM
110 120 130 140 150
MQYFLSCTAV VTESFLLAVM AYDRFVAICN PLLYTVAMSQ RLCALLVAGS
160 170 180 190 200
YLWGMFGPLV LLCYALRLNF SGPNVINHFF CEYTALISVS GSDILIPHLL
210 220 230 240 250
LFSFATFNEM CTLLIILTSY VFIFVTVLKI RSVSGRHKAF STWASHLTSI
260 270 280 290 300
TIFHGTILFL YCVPNSKNSR QTVKVASVFY TVVNPMLNPL IYSLRNKDVK
310
DAFWKLIHTQ VPFH
Length:314
Mass (Da):35,823
Last modified:October 1, 2002 - v1
Checksum:i60990285FCD1CAD8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034221249S → A1 PublicationCorresponds to variant dbSNP:rs297054Ensembl.1
Natural variantiVAR_034222290L → P. Corresponds to variant dbSNP:rs297055Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065779 Genomic DNA Translation: BAC05999.1
AF399523 Genomic DNA Translation: AAK95008.1
BK004328 Genomic DNA Translation: DAA04726.1
BK004393 Genomic DNA Translation: DAA04791.1
CCDSiCCDS31508.1
RefSeqiNP_001004735.1, NM_001004735.1
UniGeneiHs.553622

Genome annotation databases

EnsembliENST00000335605; ENSP00000334456; ENSG00000186113
GeneIDi219436
KEGGihsa:219436
UCSCiuc010rim.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR5DE_HUMAN
AccessioniPrimary (citable) accession number: Q8NGL3
Secondary accession number(s): Q6IF69, Q6IFD4, Q96RB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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