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Q8NGL3 (OR5DE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5D14
Alternative name(s):
Olfactory receptor OR11-141
Olfactory receptor OR11-150
Gene names
Name:OR5D14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Olfactory receptor 5D14
PRO_0000150592

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 4821Helical; Name=1; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 10124Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 14119Cytoplasmic Potential
Transmembrane142 – 16221Helical; Name=4; Potential
Topological domain163 – 19836Extracellular Potential
Transmembrane199 – 21921Helical; Name=5; Potential
Topological domain220 – 23920Cytoplasmic Potential
Transmembrane240 – 26021Helical; Name=6; Potential
Topological domain261 – 27313Extracellular Potential
Transmembrane274 – 29421Helical; Name=7; Potential
Topological domain295 – 31420Cytoplasmic Potential

Amino acid modifications

Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential

Natural variations

Natural variant2491S → A. Ref.2
Corresponds to variant rs297054 [ dbSNP | Ensembl ].
VAR_034221
Natural variant2901L → P.
Corresponds to variant rs297055 [ dbSNP | Ensembl ].
VAR_034222

Sequences

Sequence LengthMass (Da)Tools
Q8NGL3 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 60990285FCD1CAD8

FASTA31435,823
        10         20         30         40         50         60 
MMMVLRNLSM EPTFALLGFT DYPKLQIPLF LVFLLMYVIT VVGNLGMIII IKINPKFHTP 

        70         80         90        100        110        120 
MYFFLSHLSF VDFCYSSIVT PKLLENLVMA DKSIFYFSCM MQYFLSCTAV VTESFLLAVM 

       130        140        150        160        170        180 
AYDRFVAICN PLLYTVAMSQ RLCALLVAGS YLWGMFGPLV LLCYALRLNF SGPNVINHFF 

       190        200        210        220        230        240 
CEYTALISVS GSDILIPHLL LFSFATFNEM CTLLIILTSY VFIFVTVLKI RSVSGRHKAF 

       250        260        270        280        290        300 
STWASHLTSI TIFHGTILFL YCVPNSKNSR QTVKVASVFY TVVNPMLNPL IYSLRNKDVK 

       310 
DAFWKLIHTQ VPFH 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-285, VARIANT ALA-249.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065779 Genomic DNA. Translation: BAC05999.1.
AF399523 Genomic DNA. Translation: AAK95008.1.
BK004328 Genomic DNA. Translation: DAA04726.1.
BK004393 Genomic DNA. Translation: DAA04791.1.
CCDSCCDS31508.1.
RefSeqNP_001004735.1. NM_001004735.1.
UniGeneHs.553622.

3D structure databases

ProteinModelPortalQ8NGL3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000334456.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGL3.

Polymorphism databases

DMDM38372722.

Proteomic databases

PaxDbQ8NGL3.
PRIDEQ8NGL3.

Protocols and materials databases

DNASU219436.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000335605; ENSP00000334456; ENSG00000186113.
GeneID219436.
KEGGhsa:219436.
UCSCuc010rim.2. human.

Organism-specific databases

CTD219436.
GeneCardsGC11P055563.
HGNCHGNC:15281. OR5D14.
neXtProtNX_Q8NGL3.
PharmGKBPA32517.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145188.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGL3.
KOK04257.
OMAHIPHLLL.
OrthoDBEOG71K63J.
PhylomeDBQ8NGL3.
TreeFamTF352746.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR5D14.
GenevestigatorQ8NGL3.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR5D14.
GenomeRNAi219436.
NextBio90611.
PROQ8NGL3.

Entry information

Entry nameOR5DE_HUMAN
AccessionPrimary (citable) accession number: Q8NGL3
Secondary accession number(s): Q6IF69, Q6IFD4, Q96RB5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries