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Q8NGL3

- OR5DE_HUMAN

UniProt

Q8NGL3 - OR5DE_HUMAN

Protein

Olfactory receptor 5D14

Gene

OR5D14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5D14
    Alternative name(s):
    Olfactory receptor OR11-141
    Olfactory receptor OR11-150
    Gene namesi
    Name:OR5D14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15281. OR5D14.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32517.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 5D14PRO_0000150592Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8NGL3.
    PRIDEiQ8NGL3.

    PTM databases

    PhosphoSiteiQ8NGL3.

    Expressioni

    Gene expression databases

    CleanExiHS_OR5D14.
    GenevestigatoriQ8NGL3.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000334456.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGL3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19836ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini295 – 31420CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145188.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGL3.
    KOiK04257.
    OMAiHIPHLLL.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGL3.
    TreeFamiTF352746.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMMVLRNLSM EPTFALLGFT DYPKLQIPLF LVFLLMYVIT VVGNLGMIII    50
    IKINPKFHTP MYFFLSHLSF VDFCYSSIVT PKLLENLVMA DKSIFYFSCM 100
    MQYFLSCTAV VTESFLLAVM AYDRFVAICN PLLYTVAMSQ RLCALLVAGS 150
    YLWGMFGPLV LLCYALRLNF SGPNVINHFF CEYTALISVS GSDILIPHLL 200
    LFSFATFNEM CTLLIILTSY VFIFVTVLKI RSVSGRHKAF STWASHLTSI 250
    TIFHGTILFL YCVPNSKNSR QTVKVASVFY TVVNPMLNPL IYSLRNKDVK 300
    DAFWKLIHTQ VPFH 314
    Length:314
    Mass (Da):35,823
    Last modified:October 1, 2002 - v1
    Checksum:i60990285FCD1CAD8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti249 – 2491S → A.1 Publication
    Corresponds to variant rs297054 [ dbSNP | Ensembl ].
    VAR_034221
    Natural varianti290 – 2901L → P.
    Corresponds to variant rs297055 [ dbSNP | Ensembl ].
    VAR_034222

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065779 Genomic DNA. Translation: BAC05999.1.
    AF399523 Genomic DNA. Translation: AAK95008.1.
    BK004328 Genomic DNA. Translation: DAA04726.1.
    BK004393 Genomic DNA. Translation: DAA04791.1.
    CCDSiCCDS31508.1.
    RefSeqiNP_001004735.1. NM_001004735.1.
    UniGeneiHs.553622.

    Genome annotation databases

    EnsembliENST00000335605; ENSP00000334456; ENSG00000186113.
    GeneIDi219436.
    KEGGihsa:219436.
    UCSCiuc010rim.2. human.

    Polymorphism databases

    DMDMi38372722.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065779 Genomic DNA. Translation: BAC05999.1 .
    AF399523 Genomic DNA. Translation: AAK95008.1 .
    BK004328 Genomic DNA. Translation: DAA04726.1 .
    BK004393 Genomic DNA. Translation: DAA04791.1 .
    CCDSi CCDS31508.1.
    RefSeqi NP_001004735.1. NM_001004735.1.
    UniGenei Hs.553622.

    3D structure databases

    ProteinModelPortali Q8NGL3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000334456.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGL3.

    Polymorphism databases

    DMDMi 38372722.

    Proteomic databases

    PaxDbi Q8NGL3.
    PRIDEi Q8NGL3.

    Protocols and materials databases

    DNASUi 219436.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335605 ; ENSP00000334456 ; ENSG00000186113 .
    GeneIDi 219436.
    KEGGi hsa:219436.
    UCSCi uc010rim.2. human.

    Organism-specific databases

    CTDi 219436.
    GeneCardsi GC11P055563.
    HGNCi HGNC:15281. OR5D14.
    neXtProti NX_Q8NGL3.
    PharmGKBi PA32517.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145188.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGL3.
    KOi K04257.
    OMAi HIPHLLL.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGL3.
    TreeFami TF352746.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR5D14.
    GenomeRNAii 219436.
    NextBioi 90611.
    PROi Q8NGL3.

    Gene expression databases

    CleanExi HS_OR5D14.
    Genevestigatori Q8NGL3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-285, VARIANT ALA-249.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR5DE_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGL3
    Secondary accession number(s): Q6IF69, Q6IFD4, Q96RB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3