ID   OR5L1_HUMAN             Reviewed;         311 AA.
AC   Q8NGL2; B2RNK6; Q6IFD0;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 154.
DE   RecName: Full=Olfactory receptor 5L1;
DE   AltName: Full=OST262;
DE   AltName: Full=Olfactory receptor OR11-151;
GN   Name=OR5L1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5L1";
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DR   EMBL; AB065780; BAC06000.1; -; Genomic_DNA.
DR   EMBL; BC109249; AAI09250.1; -; mRNA.
DR   EMBL; BC109250; AAI09251.1; -; mRNA.
DR   EMBL; BC136939; AAI36940.1; -; mRNA.
DR   EMBL; BK004332; DAA04730.1; -; Genomic_DNA.
DR   RefSeq; NP_001004738.1; NM_001004738.2.
DR   AlphaFoldDB; Q8NGL2; -.
DR   SMR; Q8NGL2; -.
DR   BioGRID; 128535; 8.
DR   STRING; 9606.ENSP00000485319; -.
DR   GlyCosmos; Q8NGL2; 2 sites, No reported glycans.
DR   GlyGen; Q8NGL2; 2 sites.
DR   iPTMnet; Q8NGL2; -.
DR   PhosphoSitePlus; Q8NGL2; -.
DR   BioMuta; OR5L1; -.
DR   DMDM; 38372721; -.
DR   MassIVE; Q8NGL2; -.
DR   PaxDb; 9606-ENSP00000335529; -.
DR   PeptideAtlas; Q8NGL2; -.
DR   Antibodypedia; 78667; 64 antibodies from 14 providers.
DR   DNASU; 219437; -.
DR   Ensembl; ENST00000625203.2; ENSP00000485319.1; ENSG00000279395.3.
DR   GeneID; 219437; -.
DR   KEGG; hsa:219437; -.
DR   MANE-Select; ENST00000625203.2; ENSP00000485319.1; NM_001004738.2; NP_001004738.1.
DR   UCSC; uc001nhw.1; human.
DR   AGR; HGNC:8350; -.
DR   CTD; 219437; -.
DR   GeneCards; OR5L1; -.
DR   HGNC; HGNC:8350; OR5L1.
DR   HPA; ENSG00000279395; Not detected.
DR   neXtProt; NX_Q8NGL2; -.
DR   PharmGKB; PA32544; -.
DR   VEuPathDB; HostDB:ENSG00000279395; -.
DR   eggNOG; ENOG502T9KN; Eukaryota.
DR   GeneTree; ENSGT01100000263496; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q8NGL2; -.
DR   OMA; ELASCCY; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NGL2; -.
DR   TreeFam; TF352753; -.
DR   PathwayCommons; Q8NGL2; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 219437; 8 hits in 682 CRISPR screens.
DR   GeneWiki; OR5L1; -.
DR   GenomeRNAi; 219437; -.
DR   Pharos; Q8NGL2; Tdark.
DR   PRO; PR:Q8NGL2; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGL2; Protein.
DR   Bgee; ENSG00000279395; Expressed in primordial germ cell in gonad.
DR   ExpressionAtlas; Q8NGL2; differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15410; 7tmA_OR5D-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48018:SF32; OLFACTORY RECEPTOR 5L1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..311
FT                   /note="Olfactory receptor 5L1"
FT                   /id="PRO_0000150602"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        195
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         46
FT                   /note="I -> F (in dbSNP:rs2869020)"
FT                   /id="VAR_034227"
FT   VARIANT         54
FT                   /note="R -> W (in dbSNP:rs34961497)"
FT                   /id="VAR_062044"
FT   VARIANT         287
FT                   /note="S -> P (in dbSNP:rs12790505)"
FT                   /id="VAR_034228"
SQ   SEQUENCE   311 AA;  34559 MW;  3F81C01BF5578119 CRC64;
     MGKENCTTVA EFILLGLSDV PELRVCLFLL FLLIYGVTLL ANLGMIALIQ VSSRLHTPMY
     FFLSHLSSVD FCYSSIIVPK MLANIFNKDK AISFLGCMVQ FYLFCTCVVT EVFLLAVMAY
     DRFVAICNPL LYTVTMSWKV RVELASCCYF CGTVCSLIHL CLALRIPFYR SNVINHFFCD
     LPPVLSLACS DITVNETLLF LVATLNESVT IMIILTSYLL ILTTILKMGS AEGRHKAFST
     CASHLTAITV FHGTVLSIYC RPSSGNSGDA DKVATVFYTV VIPMLNSVIY SLRNKDVKEA
     LRKVMGSKIH S
//