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Q8NGL2

- OR5L1_HUMAN

UniProt

Q8NGL2 - OR5L1_HUMAN

Protein

Olfactory receptor 5L1

Gene

OR5L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5L1
    Alternative name(s):
    OST262
    Olfactory receptor OR11-151
    Gene namesi
    Name:OR5L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8350. OR5L1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32544.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 5L1PRO_0000150602Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGL2.
    PRIDEiQ8NGL2.

    Expressioni

    Gene expression databases

    CleanExiHS_OR5L1.
    GenevestigatoriQ8NGL2.

    Organism-specific databases

    HPAiHPA047524.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000335529.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGL2.
    SMRiQ8NGL2. Positions 25-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31119CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39978.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGL2.
    KOiK04257.
    OMAiELASCCY.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGL2.
    TreeFamiTF352753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKENCTTVA EFILLGLSDV PELRVCLFLL FLLIYGVTLL ANLGMIALIQ    50
    VSSRLHTPMY FFLSHLSSVD FCYSSIIVPK MLANIFNKDK AISFLGCMVQ 100
    FYLFCTCVVT EVFLLAVMAY DRFVAICNPL LYTVTMSWKV RVELASCCYF 150
    CGTVCSLIHL CLALRIPFYR SNVINHFFCD LPPVLSLACS DITVNETLLF 200
    LVATLNESVT IMIILTSYLL ILTTILKMGS AEGRHKAFST CASHLTAITV 250
    FHGTVLSIYC RPSSGNSGDA DKVATVFYTV VIPMLNSVIY SLRNKDVKEA 300
    LRKVMGSKIH S 311
    Length:311
    Mass (Da):34,559
    Last modified:October 1, 2002 - v1
    Checksum:i3F81C01BF5578119
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461I → F.
    Corresponds to variant rs2869020 [ dbSNP | Ensembl ].
    VAR_034227
    Natural varianti54 – 541R → W.
    Corresponds to variant rs34961497 [ dbSNP | Ensembl ].
    VAR_062044
    Natural varianti287 – 2871S → P.
    Corresponds to variant rs12790505 [ dbSNP | Ensembl ].
    VAR_034228

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065780 Genomic DNA. Translation: BAC06000.1.
    BC109249 mRNA. Translation: AAI09250.1.
    BC109250 mRNA. Translation: AAI09251.1.
    BC136939 mRNA. Translation: AAI36940.1.
    BK004332 Genomic DNA. Translation: DAA04730.1.
    CCDSiCCDS31509.1.
    RefSeqiNP_001004738.1. NM_001004738.1.
    UniGeneiHs.553623.

    Genome annotation databases

    EnsembliENST00000333973; ENSP00000335529; ENSG00000186117.
    GeneIDi219437.
    KEGGihsa:219437.
    UCSCiuc001nhw.1. human.

    Polymorphism databases

    DMDMi38372721.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065780 Genomic DNA. Translation: BAC06000.1 .
    BC109249 mRNA. Translation: AAI09250.1 .
    BC109250 mRNA. Translation: AAI09251.1 .
    BC136939 mRNA. Translation: AAI36940.1 .
    BK004332 Genomic DNA. Translation: DAA04730.1 .
    CCDSi CCDS31509.1.
    RefSeqi NP_001004738.1. NM_001004738.1.
    UniGenei Hs.553623.

    3D structure databases

    ProteinModelPortali Q8NGL2.
    SMRi Q8NGL2. Positions 25-240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000335529.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372721.

    Proteomic databases

    PaxDbi Q8NGL2.
    PRIDEi Q8NGL2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333973 ; ENSP00000335529 ; ENSG00000186117 .
    GeneIDi 219437.
    KEGGi hsa:219437.
    UCSCi uc001nhw.1. human.

    Organism-specific databases

    CTDi 219437.
    GeneCardsi GC11P055579.
    HGNCi HGNC:8350. OR5L1.
    HPAi HPA047524.
    neXtProti NX_Q8NGL2.
    PharmGKBi PA32544.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39978.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGL2.
    KOi K04257.
    OMAi ELASCCY.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGL2.
    TreeFami TF352753.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR5L1.
    GenomeRNAii 219437.
    NextBioi 90615.
    PROi Q8NGL2.

    Gene expression databases

    CleanExi HS_OR5L1.
    Genevestigatori Q8NGL2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR5L1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGL2
    Secondary accession number(s): B2RNK6, Q6IFD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3