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Q8NGL2 (OR5L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5L1
Alternative name(s):
OST262
Olfactory receptor OR11-151
Gene names
Name:OR5L1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Olfactory receptor 5L1
PRO_0000150602

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19636Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31119Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation1951N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant461I → F.
Corresponds to variant rs2869020 [ dbSNP | Ensembl ].
VAR_034227
Natural variant541R → W.
Corresponds to variant rs34961497 [ dbSNP | Ensembl ].
VAR_062044
Natural variant2871S → P.
Corresponds to variant rs12790505 [ dbSNP | Ensembl ].
VAR_034228

Sequences

Sequence LengthMass (Da)Tools
Q8NGL2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 3F81C01BF5578119

FASTA31134,559
        10         20         30         40         50         60 
MGKENCTTVA EFILLGLSDV PELRVCLFLL FLLIYGVTLL ANLGMIALIQ VSSRLHTPMY 

        70         80         90        100        110        120 
FFLSHLSSVD FCYSSIIVPK MLANIFNKDK AISFLGCMVQ FYLFCTCVVT EVFLLAVMAY 

       130        140        150        160        170        180 
DRFVAICNPL LYTVTMSWKV RVELASCCYF CGTVCSLIHL CLALRIPFYR SNVINHFFCD 

       190        200        210        220        230        240 
LPPVLSLACS DITVNETLLF LVATLNESVT IMIILTSYLL ILTTILKMGS AEGRHKAFST 

       250        260        270        280        290        300 
CASHLTAITV FHGTVLSIYC RPSSGNSGDA DKVATVFYTV VIPMLNSVIY SLRNKDVKEA 

       310 
LRKVMGSKIH S 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065780 Genomic DNA. Translation: BAC06000.1.
BC109249 mRNA. Translation: AAI09250.1.
BC109250 mRNA. Translation: AAI09251.1.
BC136939 mRNA. Translation: AAI36940.1.
BK004332 Genomic DNA. Translation: DAA04730.1.
RefSeqNP_001004738.1. NM_001004738.1.
UniGeneHs.553623.

3D structure databases

ProteinModelPortalQ8NGL2.
SMRQ8NGL2. Positions 25-240, 278-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000335529.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372721.

Proteomic databases

PaxDbQ8NGL2.
PRIDEQ8NGL2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333973; ENSP00000335529; ENSG00000186117.
GeneID219437.
KEGGhsa:219437.
UCSCuc001nhw.1. human.

Organism-specific databases

CTD219437.
GeneCardsGC11P055579.
HGNCHGNC:8350. OR5L1.
HPAHPA047524.
neXtProtNX_Q8NGL2.
PharmGKBPA32544.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39978.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGL2.
KOK04257.
OMAELASCCY.
OrthoDBEOG71K63J.
PhylomeDBQ8NGL2.
TreeFamTF352753.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR5L1.
GenevestigatorQ8NGL2.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR5L1.
GenomeRNAi219437.
NextBio90615.
PROQ8NGL2.

Entry information

Entry nameOR5L1_HUMAN
AccessionPrimary (citable) accession number: Q8NGL2
Secondary accession number(s): B2RNK6, Q6IFD0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries