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Protein

Olfactory receptor 5D18

Gene

OR5D18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5D18
Alternative name(s):
Olfactory receptor OR11-143
Olfactory receptor OR11-152
Gene namesi
Name:OR5D18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15285. OR5D18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence analysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence analysis
Transmembranei56 – 7621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini77 – 10024ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini162 – 19736ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence analysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini294 – 31320CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32521.

Polymorphism and mutation databases

BioMutaiOR5D18.
DMDMi38372720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 5D18PRO_0000150594Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGL1.
PRIDEiQ8NGL1.

PTM databases

iPTMnetiQ8NGL1.

Expressioni

Gene expression databases

CleanExiHS_OR5D18.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335025.

Structurei

3D structure databases

ProteinModelPortaliQ8NGL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJQ6. Eukaryota.
ENOG4111ADM. LUCA.
GeneTreeiENSGT00550000074428.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGL1.
KOiK04257.
OMAiLCFHGFN.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGL1.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLTDRNTSG TTFTLLGFSD YPELQVPLFL VFLAIYNVTV LGNIGLIVII
60 70 80 90 100
KINPKLHTPM YFFLSQLSFV DFCYSSIIAP KMLVNLVVKD RTISFLGCVV
110 120 130 140 150
QFFFFCTFVV TESFLLAVMA YDRFVAICNP LLYTVNMSQK LCVLLVVGSY
160 170 180 190 200
AWGVSCSLEL TCSALKLCFH GFNTINHFFC EFSSLLSLSC SDTYINQWLL
210 220 230 240 250
FFLATFNEIS TLLIVLTSYA FIVVTILKMR SVSGRRKAFS TCASHLTAIT
260 270 280 290 300
IFHGTILFLY CVPNSKNSRH TVKVASVFYT VVIPMLNPLI YSLRNKDVKD
310
TVTEILDTKV FSY
Length:313
Mass (Da):35,348
Last modified:October 1, 2002 - v1
Checksum:i97C8EF3B0A6F259A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361Y → C.
Corresponds to variant rs7948629 [ dbSNP | Ensembl ].
VAR_048046
Natural varianti118 – 1181V → M.
Corresponds to variant rs11231180 [ dbSNP | Ensembl ].
VAR_034224
Natural varianti136 – 1361N → D.3 Publications
Corresponds to variant rs297081 [ dbSNP | Ensembl ].
VAR_048047
Natural varianti270 – 2701H → R.
Corresponds to variant rs55832853 [ dbSNP | Ensembl ].
VAR_062042

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065781 Genomic DNA. Translation: BAC06001.1.
CH471076 Genomic DNA. Translation: EAW73685.1.
BC136925 mRNA. Translation: AAI36926.1.
BC136927 mRNA. Translation: AAI36928.1.
AF399525 Genomic DNA. Translation: AAK95010.1.
BK004395 Genomic DNA. Translation: DAA04793.1.
BK004329 Genomic DNA. Translation: DAA04727.1.
CCDSiCCDS31510.1.
RefSeqiNP_001001952.1. NM_001001952.1.
XP_011543102.1. XM_011544800.1.
UniGeneiHs.553624.

Genome annotation databases

EnsembliENST00000333976; ENSP00000335025; ENSG00000186119.
GeneIDi219438.
KEGGihsa:219438.
UCSCiuc010rin.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065781 Genomic DNA. Translation: BAC06001.1.
CH471076 Genomic DNA. Translation: EAW73685.1.
BC136925 mRNA. Translation: AAI36926.1.
BC136927 mRNA. Translation: AAI36928.1.
AF399525 Genomic DNA. Translation: AAK95010.1.
BK004395 Genomic DNA. Translation: DAA04793.1.
BK004329 Genomic DNA. Translation: DAA04727.1.
CCDSiCCDS31510.1.
RefSeqiNP_001001952.1. NM_001001952.1.
XP_011543102.1. XM_011544800.1.
UniGeneiHs.553624.

3D structure databases

ProteinModelPortaliQ8NGL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000335025.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGL1.

Polymorphism and mutation databases

BioMutaiOR5D18.
DMDMi38372720.

Proteomic databases

PaxDbiQ8NGL1.
PRIDEiQ8NGL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333976; ENSP00000335025; ENSG00000186119.
GeneIDi219438.
KEGGihsa:219438.
UCSCiuc010rin.2. human.

Organism-specific databases

CTDi219438.
GeneCardsiOR5D18.
HGNCiHGNC:15285. OR5D18.
neXtProtiNX_Q8NGL1.
PharmGKBiPA32521.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJQ6. Eukaryota.
ENOG4111ADM. LUCA.
GeneTreeiENSGT00550000074428.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGL1.
KOiK04257.
OMAiLCFHGFN.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGL1.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5D18.
GenomeRNAii219438.
PROiQ8NGL1.

Gene expression databases

CleanExiHS_OR5D18.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-136.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-136.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284, VARIANT ASP-136.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5DI_HUMAN
AccessioniPrimary (citable) accession number: Q8NGL1
Secondary accession number(s): Q6IF67, Q6IFD3, Q96RB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.