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Protein

Olfactory receptor 5L2

Gene

OR5L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32132-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5L2
Alternative name(s):
HTPCRX16
Olfactory receptor OR11-153
Gene namesi
Name:OR5L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8351. OR5L2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 311CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205030.
PharmGKBiPA32545.

Polymorphism and mutation databases

BioMutaiOR5L2.
DMDMi38372719.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506031 – 311Olfactory receptor 5L2Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGL0.
PRIDEiQ8NGL0.

PTM databases

PhosphoSitePlusiQ8NGL0.

Expressioni

Gene expression databases

BgeeiENSG00000205030.
CleanExiHS_OR5L2.
GenevisibleiQ8NGL0. HS.

Organism-specific databases

HPAiHPA047524.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367650.

Structurei

3D structure databases

ProteinModelPortaliQ8NGL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9CC. Eukaryota.
ENOG4111BEJ. LUCA.
GeneTreeiENSGT00550000074428.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGL0.
KOiK04257.
OMAiMTALIQV.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGL0.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKENCTTVA EFILLGLSDV PELRVCLFLL FLLIYGVTLL ANLGMTALIQ
60 70 80 90 100
VSSRLHTPVY FFLSHLSFVD FCYSSIIVPK MLANIFNKDK AISFLGCMVQ
110 120 130 140 150
FYLFCTCGVT EVFLLAVMAY DRFVAICNPL LYMVTMSQKL RVELTSCCYF
160 170 180 190 200
CGTVCSLIHS SLALRILFYR SNVINHFFCD LPPLLSLACS DVTVNETLLF
210 220 230 240 250
LVATLNESVT IMIILTSYLL ILTTILKIHS AESRHKAFST CASHLTAITV
260 270 280 290 300
SHGTILYIYC RPSSGNSGDV DKVATVFYTV VIPMLNPLIY SLRNKDVNKA
310
LRKVMGSKIH S
Length:311
Mass (Da):34,682
Last modified:October 1, 2002 - v1
Checksum:iC680187C542C27DA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06204559V → M.Corresponds to variant rs56711116dbSNPEnsembl.1
Natural variantiVAR_03422981M → R.Corresponds to variant rs17148058dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065782 Genomic DNA. Translation: BAC06002.1.
AF399526 Genomic DNA. Translation: AAK95011.1.
X64990 mRNA. No translation available.
BK004396 Genomic DNA. Translation: DAA04794.1.
CCDSiCCDS31511.1.
RefSeqiNP_001004739.1. NM_001004739.1.
UniGeneiHs.528356.

Genome annotation databases

EnsembliENST00000378397; ENSP00000367650; ENSG00000205030.
GeneIDi26338.
KEGGihsa:26338.
UCSCiuc001nhy.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065782 Genomic DNA. Translation: BAC06002.1.
AF399526 Genomic DNA. Translation: AAK95011.1.
X64990 mRNA. No translation available.
BK004396 Genomic DNA. Translation: DAA04794.1.
CCDSiCCDS31511.1.
RefSeqiNP_001004739.1. NM_001004739.1.
UniGeneiHs.528356.

3D structure databases

ProteinModelPortaliQ8NGL0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367650.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8NGL0.

Polymorphism and mutation databases

BioMutaiOR5L2.
DMDMi38372719.

Proteomic databases

PaxDbiQ8NGL0.
PRIDEiQ8NGL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378397; ENSP00000367650; ENSG00000205030.
GeneIDi26338.
KEGGihsa:26338.
UCSCiuc001nhy.1. human.

Organism-specific databases

CTDi26338.
GeneCardsiOR5L2.
HGNCiHGNC:8351. OR5L2.
HPAiHPA047524.
neXtProtiNX_Q8NGL0.
OpenTargetsiENSG00000205030.
PharmGKBiPA32545.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9CC. Eukaryota.
ENOG4111BEJ. LUCA.
GeneTreeiENSGT00550000074428.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGL0.
KOiK04257.
OMAiMTALIQV.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGL0.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:G66-32132-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5L2.
GenomeRNAii26338.
PROiQ8NGL0.

Gene expression databases

BgeeiENSG00000205030.
CleanExiHS_OR5L2.
GenevisibleiQ8NGL0. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5L2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGL0
Secondary accession number(s): Q6IF66, Q96RB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.