ID   OR5DG_HUMAN             Reviewed;         328 AA.
AC   Q8NGK9; Q6IF65; Q96RB4;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 150.
DE   RecName: Full=Olfactory receptor 5D16;
DE   AltName: Full=Olfactory receptor OR11-154;
GN   Name=OR5D16;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-285.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5D16";
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DR   EMBL; AB065783; BAC06003.1; -; Genomic_DNA.
DR   EMBL; AF399524; AAK95009.1; -; Genomic_DNA.
DR   EMBL; BK004397; DAA04795.1; -; Genomic_DNA.
DR   CCDS; CCDS31512.1; -.
DR   RefSeq; NP_001005496.1; NM_001005496.1.
DR   AlphaFoldDB; Q8NGK9; -.
DR   SMR; Q8NGK9; -.
DR   STRING; 9606.ENSP00000367649; -.
DR   GlyCosmos; Q8NGK9; 1 site, No reported glycans.
DR   GlyGen; Q8NGK9; 1 site.
DR   BioMuta; OR5D16; -.
DR   DMDM; 38372718; -.
DR   MassIVE; Q8NGK9; -.
DR   PaxDb; 9606-ENSP00000367649; -.
DR   Antibodypedia; 58946; 57 antibodies from 18 providers.
DR   DNASU; 390144; -.
DR   Ensembl; ENST00000378396.1; ENSP00000367649.1; ENSG00000205029.1.
DR   GeneID; 390144; -.
DR   KEGG; hsa:390144; -.
DR   MANE-Select; ENST00000378396.1; ENSP00000367649.1; NM_001005496.1; NP_001005496.1.
DR   UCSC; uc010rio.2; human.
DR   AGR; HGNC:15283; -.
DR   CTD; 390144; -.
DR   GeneCards; OR5D16; -.
DR   HGNC; HGNC:15283; OR5D16.
DR   HPA; ENSG00000205029; Not detected.
DR   neXtProt; NX_Q8NGK9; -.
DR   PharmGKB; PA32519; -.
DR   VEuPathDB; HostDB:ENSG00000205029; -.
DR   eggNOG; ENOG502T9ND; Eukaryota.
DR   GeneTree; ENSGT01100000263496; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGK9; -.
DR   OMA; SGCMVQF; -.
DR   OrthoDB; 5257688at2759; -.
DR   PhylomeDB; Q8NGK9; -.
DR   TreeFam; TF352753; -.
DR   PathwayCommons; Q8NGK9; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390144; 7 hits in 735 CRISPR screens.
DR   GeneWiki; OR5D16; -.
DR   GenomeRNAi; 390144; -.
DR   Pharos; Q8NGK9; Tdark.
DR   PRO; PR:Q8NGK9; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NGK9; Protein.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15410; 7tmA_OR5D-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48018:SF3; OLFACTORY RECEPTOR 5D16; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..328
FT                   /note="Olfactory receptor 5D16"
FT                   /id="PRO_0000150593"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..273
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        295..328
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        7
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         156
FT                   /note="A -> T (in dbSNP:rs6591700)"
FT                   /id="VAR_034223"
SQ   SEQUENCE   328 AA;  37278 MW;  9833B589C043992E CRC64;
     MFLTERNTTS EATFTLLGFS DYLELQIPLF FVFLAVYGFS VVGNLGMIVI IKINPKLHTP
     MYFFLNHLSF VDFCYSSIIA PMMLVNLVVE DRTISFSGCL VQFFFFCTFV VTELILFAVM
     AYDHFVAICN PLLYTVAISQ KLCAMLVVVL YAWGVACSLT LACSALKLSF HGFNTINHFF
     CELSSLISLS YPDSYLSQLL LFTVATFNEI STLLIILTSY AFIIVTTLKM PSASGHRKVF
     STCASHLTAI TIFHGTILFL YCVPNSKNSR HTVKVASVFY TVVIPLLNPL IYSLRNKDVK
     DAIRKIINTK YFHIKHRHWY PFNFVIEQ
//