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Q8NGK9 (OR5DG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5D16
Alternative name(s):
Olfactory receptor OR11-154
Gene names
Name:OR5D16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328Olfactory receptor 5D16
PRO_0000150593

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 4821Helical; Name=1; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 10124Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 14119Cytoplasmic Potential
Transmembrane142 – 16221Helical; Name=4; Potential
Topological domain163 – 19836Extracellular Potential
Transmembrane199 – 21921Helical; Name=5; Potential
Topological domain220 – 23920Cytoplasmic Potential
Transmembrane240 – 26021Helical; Name=6; Potential
Topological domain261 – 27313Extracellular Potential
Transmembrane274 – 29421Helical; Name=7; Potential
Topological domain295 – 32834Cytoplasmic Potential

Amino acid modifications

Glycosylation71N-linked (GlcNAc...) Potential

Natural variations

Natural variant1561A → T.
Corresponds to variant rs6591700 [ dbSNP | Ensembl ].
VAR_034223

Sequences

Sequence LengthMass (Da)Tools
Q8NGK9 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 9833B589C043992E

FASTA32837,278
        10         20         30         40         50         60 
MFLTERNTTS EATFTLLGFS DYLELQIPLF FVFLAVYGFS VVGNLGMIVI IKINPKLHTP 

        70         80         90        100        110        120 
MYFFLNHLSF VDFCYSSIIA PMMLVNLVVE DRTISFSGCL VQFFFFCTFV VTELILFAVM 

       130        140        150        160        170        180 
AYDHFVAICN PLLYTVAISQ KLCAMLVVVL YAWGVACSLT LACSALKLSF HGFNTINHFF 

       190        200        210        220        230        240 
CELSSLISLS YPDSYLSQLL LFTVATFNEI STLLIILTSY AFIIVTTLKM PSASGHRKVF 

       250        260        270        280        290        300 
STCASHLTAI TIFHGTILFL YCVPNSKNSR HTVKVASVFY TVVIPLLNPL IYSLRNKDVK 

       310        320 
DAIRKIINTK YFHIKHRHWY PFNFVIEQ 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-285.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065783 Genomic DNA. Translation: BAC06003.1.
AF399524 Genomic DNA. Translation: AAK95009.1.
BK004397 Genomic DNA. Translation: DAA04795.1.
RefSeqNP_001005496.1. NM_001005496.1.
UniGeneHs.554527.

3D structure databases

ProteinModelPortalQ8NGK9.
SMRQ8NGK9. Positions 279-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000367649.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372718.

Proteomic databases

PaxDbQ8NGK9.
PRIDEQ8NGK9.

Protocols and materials databases

DNASU390144.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000378396; ENSP00000367649; ENSG00000205029.
GeneID390144.
KEGGhsa:390144.
UCSCuc010rio.2. human.

Organism-specific databases

CTD390144.
GeneCardsGC11P055607.
HGNCHGNC:15283. OR5D16.
HPAHPA046711.
neXtProtNX_Q8NGK9.
PharmGKBPA32519.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG133219.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGK9.
KOK04257.
OMAIYTFSVV.
OrthoDBEOG71K63J.
PhylomeDBQ8NGK9.
TreeFamTF352753.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR5D16.
GenevestigatorQ8NGK9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR5D16.
GenomeRNAi390144.
NextBio103435.
PROQ8NGK9.

Entry information

Entry nameOR5DG_HUMAN
AccessionPrimary (citable) accession number: Q8NGK9
Secondary accession number(s): Q6IF65, Q96RB4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries